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Calcineurin-B-Like Protein CBL9 Interacts with Target kinase CIPk3 in the Regulation of ABA Response in Seed Germination

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Molecular Plant 2008年第2期1卷 238-248页

作者： girdhar k. pandey John J. Grant Yong Hwa Cheong Beom-Gi kim Le Gong Li Sheng Luan Department of Plant and Microbial Biology University of California Berkeley CA 94720 USA Department of Plant Molecular Biology University of Delhi South Campus Benito Juarez Road New Delhi-110021 India Present address: Department of Bio-Environmental Science Sunchon National University Suncheon Jeonnam 540-742 Korea Present address: Department of Molecular Physiology and Biochemistry National institute of Agricultural Biotechnology Suwon 441-707 Korea

Calcium plays a vital role as a second messenger in many signaling pathways in plants. The calcineurin B-like proteins （CBLs） represent a family of plant calcium-binding proteins that function in calcium signaling by interacting with their interacting protein kinases （CIPks）. In our previous study, we have reported a role for one of the CBLs （CBL9） and one of the CIPks （CIPk3） in ABA signaling. Here, we have shown that CBL9 and CIPk3 physically and functionally interact with each other in regulating the ABA responses. The CBL9 and CIPk3 proteins interacted with each other in the yeast two- hybrid system and when expressed in plant cells. The double mutant cbl9cipk3 showed the similar hypersensitive response to ABA as observed in single mutants （cbl9 or cipk3）. The constitutively active form of CIPk3 genetically complemented the cbl9 mutant, indicating that CIPk3 function downstream of CBL9. Based on these findings, we conclude that CBL9 and CIPk3 act together in the same pathway for regulating ABA responses.

关键词： ABA calcium CBL CIPk osmotic stress signal transduction.

Multi-wavelength nanowire micro-LEDs for future high speed optical communication

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Opto-Electronic Advances 2024年第3期7卷 1-3页

作者： Ayush pandey Zetian Mi Department of Electrical Engineering and Computer Science University of MichiganAnn ArborMI 48109USA

The future of optoelectronics is directed towards small-area light sources,foremost being ***,their use has been inhibited so far primarily due to fabrication and integration challenges,which impair efficiency and ***,bottom-up nanostructures grown using selective area epitaxy have garnered attention as a solution to the aforementioned *** Fu *** used this technique to demonstrate uniform p-i-n core-shell InGaAs/InP nanowire array light emitting *** devices are capable of voltage and geometry-controlled multi-wavelength and high-speed *** publication accentuates the wide capabilities of bottom-up nanostructures to resolve the difficulties of nanoscale optoelectronics.

关键词： communication high operations

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Understanding poromechanical response of a biogenic coalbed methane reservoir

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International Journal of Coal Science & Technology 2024年第3期11卷 32-50页

作者： Rohit pandey Satya Harpalani Virginia Tech BlacksburgUSA Southern Illinois University CarbondaleUSA

Biogenic coalbed methane(BCBM)reservoirs aim to produce methane from in situ coal deposits following microbial conversion of *** of BCBM reservoirs requires economic methane production within an acceptable *** work reported here quantifies the findings of previously published qualitative work,where it was found that bioconversion induces strains in the pore,matrix and bulk *** imaging and dynamic strain monitoring techniques,the bioconversion induced strain is quantified *** understand the effect of these strains from a reservoir geomechanics perspective,a corresponding poromechanical model is ***,findings of imaging experiments are validated using core-flooding flow ***,expected field-scale behavior of the permeability response of a BCBM operation is modeled and *** results of the study indicated that,for Illinois coals,bioconversion induced strains result in a decrease in fracture porosity,resulting in a detrimental permeability drop in excess of 60%during bioconversion,which festers itself exponentially throughout its producing *** indicate that reservoirs with high initial permeability that will support higher Darcian flowrates,would be better suited for coal bioconversion,thereby providing a site-selection criteria for BCBM operations.

关键词： Coal bioconversion Poromechanical model Reservoir response Bioconversion induced strain

A Dual-Specific protein phosphatase 5 Regulates the Development of Root growth and root hair through modulation of ROS homeostasis during oxidative stresses in Arabidopsis

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A Dual-Specific protein phosphatase 5 Regulates the Developm...

Function and dysfunction of GEMIN5:understanding a novel neurodevelopmental disorder

江苏省遗传学会2014年学术研讨会

作者： Pingzhi Zhao Lubomir N.Sokolov girdhar k.pandey Cheng-Yi Tang Jisen Shi Yan Zhen Wenzhi Lan Zhi Hong Jinliang Qi Gui-Hua Lu Yong-Hua Yang NJU–NJFU Joint Institute for Plant Molecular Biology State Key Laboratory of Pharmaceutical BiotechnologySchool of Life SciencesNanjing University Department of Plant Molecular Biology University of Delhi South Campus NJU–NJFU Joint Institute for Plant Molecular Biology MOE Key Laboratory of Forest Genetics and BiotechnologyNanjing Forestry University

ROS(reactive oxygen species) homeostasis is critical for normal root development in plants,and a threshold level of ROS acts as a signal for elongation of root cell and differentiation of root *** phosphorylation and dephosphorylation of proteins play a key role in signal transduction,and often alter ROS homeostasis in *** studied the function of a dual specificity protein phosphatase,DSP5,which is known to regulate starch metabolism in Arabidopsis,and identified its role in the regulation of ROS homeostasis and root development in response to oxidative ***5 protein was localized in chloroplast,and also in amyloplast of *** of dsp5 mutant plants with ROS-generating agents such as SA(salicylic acid),HO(hydrogen peroxide),and an herbicide-MV(methyl viologen),led to more inhibition in the generation rate of O,but significantly,increased levels of *** activities of several antioxidant enzymes,including Cu/Zn-SODs(copper-zinc superoxide dismutase),CAT(catalase) and APX(ascorbate peroxidase),were affected in dsp5 mutant under oxidative ***,dsp5 mutant plants showed a reduced growth of roots but less inhibition of root hair formation compared with Col-0 *** results suggested that DSP5 exerted its effect on root development mainly through modulation of ROS levels in response to exogenous oxidative stresses.

关键词： Dual specificity phosphatase ROS Root development Antioxidant enzymes Signal transduction

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Neural Regeneration Research 2024年第11期19卷 2377-2386页

作者： Charles H.Nelson Udai B.pandey Department of Pediatrics Division of Child NeurologyChildren’s Hospital of PittsburghUniversity of Pittsburgh Medical CenterPittsburghPAUSA Children’s Neuroscience Institute Children’s Hospital of PittsburghUniversity of Pittsburgh Medical CenterPittsburghPAUSA

The recent identification of a neurodevelopmental disorder with cerebellar atrophy and motor dysfunction(NEDCAM)has resulted in an increased interest in GEMIN5,a multifunction RNA-binding *** the largest member of the survival motor neuron complex,GEMIN5 plays a key role in the biogenesis of small nuclear ribonucleoproteins while also exhibiting translational regulatory functions as an independent *** many questions remain regarding both the pathogenesis and pathophysiology of this new disorder,considerable progress has been made in the brief time since its *** this review,we examine GEMIN5 within the context of NEDCAM,focusing on the structure,function,and expression of the protein specifically in regard to the disorder ***,we explore the current animal models of NEDCAM,as well as potential molecular pathways for treatment and future directions of *** review provides a comprehensive overview of recent advances in our understanding of this unique member of the survival motor neuron complex.

关键词： cerebellar atrophy GEMIN5 neurodevelopmental disorder neurological disease SMN complex

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Small activating RNA delivery in vivo:Challenges,prospects,and lessons learned from siRNA delivery

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Nano Research 2024年第10期17卷 8990-9002页

作者： Shalini pandey Patrick T.Bednarz Matthias A.Oberli Omid Veiseh Department of Bioengineering William Marsh Rice UniversityHouston 77030USA Xibus Systems 199 Dexter AveWatertown 02472USA

Over the last two decades,small activating RNAs(saRNAs)have quickly moved from discovery to clinical *** as 20 nucleotide long,double stranded RNA,saRNAs have the unique ability to increase gene transcription at the chromatin *** therapeutic modality has great potential as a safe and redosable alternative to gene therapy by increasing target protein expression without changing the genetic *** describe the successful in vivo saRNA delivery vectors and found that similar to small interfering RNA(siRNA)and mRNA targeting tissues outside the liver works best at the end of a *** highlight nanoparticle vectors and RNA-conjugates,where some success has been reported for non-hepatic delivery of saRNAaptamers.

关键词： small activating RNA hepatic bias lipid nanoparticles RNA-conjugates

Colorimetric Sensor for Detection of Tabun Mimic Diethyl Cyanophosphonate

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Journal of Analysis and Testing 2024年第03期8卷 374-384页

作者： Madhu Bala Dheeraj pandey Nikita Patel Sheetal Yadav Abha Sharma Department of Medicinal Chemistry National Institute of Pharmaceutical Education and Research RaebareliTransit Campus

Herein,a colorimetric chemosensor （probe 7） was designed and synthesized for sensing diethyl cyanophosphonate （DCNP）,a Tabun nerve agent *** sensitive,selective,fast response and photostable probe 7 in dimethylsulfoxide （DMSO）responded to DCNP at low concentrations with visual naked eye color change from pink to pale yellow and displayed unresponsive behaviour against various interferences except for copper ions,which can be di?erentiated by adding ethylene diamine where the yellow color persisted in the case of DCNP but turned to pink in the case of copper ***,the yellow aqueous solution of probe 7 at pH 10 and 12 turned colorless against the response of *** limit of detection（LOD） of probe 7 was found to be 50 nmol/L in an aqueous basic solution at pH 10 for the detection of *** formation of the cyclized product was elucidated by1H and31P NMR nuclear magnetic resonance (1H NMR,31P NMR),Fourier transform infrared spectroscopy （FTIR）,and high-resolution mass spectrometry （HRMS） ***?lter paper and silica plate loaded with probe 7 were fabricated for real-time and on-site detection of DCNP.

关键词： Chemosensor Colorimetric Fluorescence Tabun mimic

Dynamics of a delay-induced prey-predator system with interaction between immature prey and predators

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International Journal of Biomathematics 2024年第2期17卷 139-176页

作者： Soumik pandey Abhijit Sarkar Debashis Das Sarbani Chakraborty Department of Mathematics West Bengal State University Barasat-7000126West BengalIndia Department of Basic Science&Humanities JIS College of Engineering Kalyani-741235West BengalIndia

In biological pest control systems,several pests(including insects,mites,weeds,etc.)are controlled by biocontrol agents that rely primarily on *** this biocontrol management ecology,we have created a three-tier prey-predator model with prey phase structure and predator gestation *** studies have demonstrated that predators with Holling type-II functional responses sometimes consume immature prey.A study of the well-posedness and local bifurcation(such as saddle-node and transcritical)near the trivial and planer equilibrium points is carried *** any time lag,the prey development coeficient has a stabilizing impact,while increasing attack rate accelerates *** transformation rate and handling time are shown to cause multiple stability switches in the *** results demonstrate time delay is the key destabilizer that destroys *** model can replicate more realistic events by including time-dependent factors and exploring the dynamic behavior of nonautonomous *** the presence of time delay,sufficient conditions of permanence and global attractivity of the nonautonomous system are ***,MATLAB simulations are performed to validate the analytical findings.

关键词： Holling type-II functional response stage-structure bifurcation time delay seasonality

Investigating the Evolution of Amati Parameters with Redshift

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Research in Astronomy and Astrophysics 2024年第1期24卷 188-200页

作者： Meghendra Singh Darshan Singh kanhaiya Lal pandey Dinkar Verma Shashikant Gupta Delhi Metro Rail Corporation Limited New Delhi 110001India GD Goenka University Gurugram 122103India Department of Physics Mata Raj Kaur Institute of Engineering and TechnologyRewari 123401India Department of Physics School of Advanced SciencesVellore Institute of TechnologyVellore 632014India

Gamma-ray bursts(GRBs) are among the brightest objects in the Universe and, hence, can be observed up to a very high redshift. Properly calibrated empirical correlations between intensity and spectral correlations of GRBs can be used to estimate the cosmological parameters. However, the possibility of the evolution of GRBs with redshift is a long-standing puzzle. In this work, we used 162 long-duration GRBs to determine whether GRBs below and above a certain redshift have different properties. The GRBs are split into two groups, and we fit the Amati relation for each group separately. Our findings demonstrate that estimations of the Amati parameters for the two groups are substantially dissimilar. We perform simulations to investigate whether the selection effects could cause the difference. Our analysis shows that the differences may be either intrinsic or due to systematic errors in the data, and the selection effects are not their true origin. However, in-depth analysis with a new data set comprised of 119 long GRBs shows that intrinsic scatter may partly be responsible for such effects.

关键词： Cosmology gamma rays:general (cosmology:)large-scale structure of universe galaxies:high-redshift

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