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Beyond peripheral nerve injury:spina gliopathy and maladaptive synaptic plasticity

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Neural Regeneration Research 2016年第9期11卷 1422-1423页

作者： giovanni Cirillo Michele Papa Laboratory of Neuronal Networks Department of Mental and Physical Health and Preventive Medicine Second University of Naples Naples Italy

Who drew the borders between central and peripheral nervous sys tem？ A complex question but a simple answer. Human anatomy and clinical neurology need to differentiate peripheral nerves from central nervous system （CNS）, peripheral or central disorders, respectively. However, there are no anatomical and functional clefts between peripheral axons and central synaps- es. There is a direct continuity from the periphery to the center, from the receptor to the sensory neuron, from the spinal motor neuron to the muscle, just the neuromuscular junction.

关键词： NGF PNI Beyond peripheral nerve injury

Minimal crystallographic descriptors of sorption properties in hypothetical MOFs and role in sequential learning optimization

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npj Computational Materials 2022年第1期8卷 1154-1167页

作者： giovanni Trezza Luca Bergamasco Matteo Fasano Eliodoro Chiavazzo Department of Energy Politecnico di TorinoC.so Duca degli Abruzzi 24Torino10129Italy

We focus on gas sorption within metal-organic frameworks(MOFs)for energy applications and identify the minimal set of crystallographic descriptors underpinning the most important properties of MOFs for CO_(2)and H_(2)O.A comprehensive comparison of several sequential learning algorithms for MOFs properties optimization is performed and the role played by those descriptors is *** energy transformations,thermodynamic limits of important figures of merit crucially depend on equilibrium properties in a wide range of sorbate coverage values,which is often only partially accessible,hence possibly preventing the computation of desired objective *** propose a fast procedure for optimizing specific energy in a closed sorption energy storage system with only access to a single water Henry coefficient value and to the specific surface *** are thus able to identify hypothetical candidate MOFs that are predicted to outperform state-of-the-art water-sorbent pairs for thermal energy storage applications.

关键词： functions sorption optimization

Hepatitis C virus lymphotropism and peculiar immunological phenotype:Effects on natural history and antiviral therapy

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World Journal of Gastroenterology 2009年第19期15卷 2305-2308页

作者： Paolo Conca giovanni Tarantino Department of Clinical and Experimental Medicine Federico University Medical School of Naples

Hepatitis C virus （HCV） has been recognized to be both a hepato- and lymphotropic virus. HCV lymphotropism represents an essential lap in the pathogenesis of virus-related autoimmune and lymphoproliferative disorders, ranging from clonal expansion of B-cells with organ-and non-organ-specific autoantibody production up to overt non-Hodgkin＇s lymphoma along a continuous step-by-step model of B-cell lymphomagenesis, where the intermediated mixed cryoglobulinemia could be considered as a stage of suppressible antigen-driven lymphoproliferation. HCV infection of lymphoid ceils could set up privileged reservoirs able to interfere with the host viral clearance efficiency and may be implicated in viral recurrence after apparently successful antiviral therapy. The HCV long-lasting extrahepatic replicative state generates an abnormal systemic immunological response, easily detectable by searching simple laboratory and clinical parameters, mainly represented by vasculitis-like skin features and *** presence or absence of this hypersensitivity pattern seems to correlate with the antiviral response and could be identified as a novel immunological cofactor. Further research is required to fully verify the real impact on therapeutic choice/regimen.

关键词： Hepatitis C virus Lymphotropism Naturalhistory Antiviral therapy Immunological co-factor

Familial colorectal cancer: A review

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World Journal of Gastroenterology 2014年第28期20卷 9292-9298页

作者： Franco Armelao giovanni de Pretis Department of Gastroenterology Ospedale Santa ChiaraAzienda Provinciale per i Servizi Sanitari38122 TrentoItaly

Familial colorectal cancer constitutes a heterogeneous group of patients in whom the underlying molecular mechanism is still *** to a such neoplasms in this setting seems to be due to common low-penetrance genetic components,but the role of genetic testing in clinical practice has to be *** screening guidelines in this moderate-risk population are empiric,data obtained in epidemiologic,meta-analyses and cohort studies and,more recently,the increased risk of advanced adenomas in first degree relatives who underwent screening colonoscopy support the need to include these individuals in specific screening ***,data to determine what test to use,how often to use and which organizational strategy to implement are *** present,screening uptake in this population is less than optimal;offering the opportunity to access to screening and improving screening uptake is a first significant step.

关键词： Colorectal cancer Familial risk Heterogeneous Risk population Screening uptake

High prevalence of nonalcoholic fatty liver in patients with idiopathic venous thromboembolism

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World Journal of Gastroenterology 2010年第48期16卷 6119-6122页

作者： Matteo Nicola Dario Di Minno Antonella Tufano Anna Rusolillo giovanni Di Minno giovanni Tarantino Department of Clinical and Experimental Medicine Federico II University Medical School of Naples

AIM:To assess the prevalence of nonalcoholic fatty liver disease (NAFLD) in patients with idiopathic venous thromboembolism (VTE). METHODS:In a case-control study,after excluding subjects with well-consolidated risk factors for VTE,idiopathic VTE was documented in 138 consecutive patients who were referred to our department. Two hundred and seventy-six healthy sex/age/body-massindex-matched subjects,without any clinical/instrumental evidence of VTE,served as controls. All underwent a clinical/laboratory/ultrasound assessment for the presence of metabolic syndrome and NAFLD. RESULTS:NAFLD was detected in 112/138 cases (81%) and in 84/276 controls (30%) [risk ratio:2.7,95% confidence interval (CI):2.2-3.2,P < 0.0001]. Metabolic syndrome and smoking habit were more prevalent in patients with idiopathic VTE. The high prevalence of NAFLD in VTE was also confirmed after adjustment for inherited thrombophilia. NAFLD was clearly predicted by VTE (odds ratio:1.8,95% CI:1.2-2.7,P < 0.0001).

关键词： Thromboembolism Metabolic syndrome Nonalcoholic fatty liver disease

Contrast-free endoscopic stent insertion in malignant biliary obstruction

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World Journal of Gastroenterology 2007年第29期13卷 3973-3976页

作者： giovanni D De Palma giovanni Lombardi Maria Rega Immacolata Simeoli Stefania Masone Saverio Siciliano Francesco Maione Francesca Salvatori Antonio Balzano giovanni Persico Department of General Surgery Oncologic Surgery and Advanced Technologies-Center for Technical Innovation in Surgery University of Naples Federico Ⅱ School of Medicine Naples Italy Division of Gastroenterology General Hospital A. Cardarelli Naples Italy

AIM： To present a case series of MRCP-guided endoscopic biliary stent placement, performed entirely without contrast injection. METHODS： Contrast-free endoscopic biliary drainage was attempted in 20 patients with malignant obstruction, unsuitable for resection on the basis of tumor extent or medical illness. MRCP images were used to confirm the diagnosis of tumor, to exclude other biliary diseases and to demonstrate the stenoses as well as dilation of proximal liver segments. The procedure was carried out under conscious sedation. Patients were placed in the left lateral decubitus position. The endoscope was inserted, the papilla identified and cannulated by a papiUotome. A guide wire was inserted and guided deeply into the biliary tree, above the stenosis, by fluoroscopy. A papillotomy approximately 1 cm. long was performed and the papillotome was exchanged with a guiding-catheter. A 10 Fr＇ Amsterdam-type plastic stent, 7 to 15 cm long, was finally inserted over the guide wire/ guiding catheter by a pusher tube system. RESULTS： Successful stent insertion was achieved in all patients. There were no major complications. Successful drainage, with substantial reduction in bilirubin levels, was achieved in all patients. CONCLUSION： This new method of contrast-free endoscopic stenting in malignant biliary obstruction is a safe and effective method of palliation. However＇ a larger, randomized study comparing this new approach with the standard procedure is needed to confirm the findings of the present study.

关键词： Endoscopic retrograde cholangiopancreatography Biliary stenoses Biliary drainage Endoscopy Stents

Actively bleeding Dieulafoy's lesion of the small bowel identified by capsule endoscopy and treated by push enteroscopy

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World Journal of Gastroenterology 2006年第24期12卷 3936-3937页

作者： giovanni D De Palma Francesco Patrone Maria Rega Immacolata Simeoli Stefania Masone giovanni Persico Centro per l'Innovazione Tecnologica in Chirurgia-Dipartimento di Chirurgia Generale Oncologica e Tecnologie Avanzate Universita degli Studi di Napoli Federico Ⅱ Facoltà di Medicina e ChirurgiaNapoliItaly

Dieulafoy＇s lesion is an unusual cause of recurrent GI bleeding. This report describes a case of actively bleeding Dieulafoy＇s lesion of the small bowel in which the diagnosis was made by capsule endoscopy, followed by treatment with the use of push enteroscopy. The case illustrates that capsule endoscopy and enteroscopy are highly complementary in patients with small bowel diseases.

关键词： Dieulafoy's lesion GI hemorrhage Smallbowel Capsule endoscopy Push enteroscopy

Exercise-Dependent Modulation of Bone Metabolism and Bone Endocrine Function:New Findings and Therapeutic Perspectives

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Journal of Science in Sport and Exercise 2019年第1期1卷 20-28页

作者： giovanni Lombardi IRCCS Istituto Ortopedico Galeazzi Laboratory of Experimental Biochemistry and Molecular BiologyVia Riccardo Galeazzi420161 MilanItaly Department of Physiology and Pharmacology Gdańsk University of Physical Education and SportKazimierza Górskiego 180-336 GdańskPomorskiePoland

Physical inactivity is the fourth leading cause of mortality worldwide;regardless of geographic location and income,it is a contributing risk factor to the other three *** activity is really a drug,a poly-pill;its“regular use”can reduce this risk throughout the activation of a plethora of responses in virtually all the body *** beneficial effects of physi-cal activity on cardiovascular function and hemodynamics are mainly mediated by skeletal muscle,adipose tissue and the immune system via the usage,delivery and distribution of metabolic substrates and improvement in inflammatory *** is emerging evidence for exercise-dependent changes in bone metabolism as well;with improved bone quality,reduced fracture risk and increased bone endocrine function,the last of which modulates energy metabolism through its effects on pancreatic islet cells,skeletal muscle and adipose *** endocrine function relies on the integration of biomechani-cal stimuli and endocrine signals from other organs and *** I review current concepts about exercise-dependent modulation of bone endocrine function and its beneficial effects on whole-body *** molecular mechanisms have been identified that support this exercise-stimulated bone-mediated metabolic effect and,among these,Wnt signaling,fibroblast growth factor-23,bone morphogenic protein-7,osteocalcin,RANK/RANKL/OPG axis,and lipocalin-2 gave the largest *** conclusion,beside the controversies surrounding technical aspects of the exercise,the efficacy of physi-cal activity in preventing/treating metabolic and inflammatory dysfunctions also passes throughout the bone.

关键词： Bone metabolism Bone endocrine function Osteokines Biomechanical loading

The existence spectrum of Meta(K_4^((3))>K_4^((3))-e)

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Science China Mathematics 2010年第11期53卷 2865-2876页

作者： LO FARO giovanni TRIPODI Antoinette Department of Mathematics University of Messina

Let H and J1 be both t-uniform hypergraphs. Let J2 be a sub-hypergraph of J1. In this paper, the metamorphosis of a hypergraph decomposition is introduced, denoted by (H, J1 > J2)-design, which is a generalization of the concept of metamorphosis of a graph decomposition. Let Meta(J1>J2) denote the set of all integers v such that there exists a (Kv((3)), J1>J2)-design. We completely determine the set Meta(K4((3))>K4((3))-e).

关键词： hypergraph decomposition metamorphosis t-GDD group divisible (Γ t)-design candelabra (Γ t)-system