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World Journal of Stem Cells 2024年第2期16卷 89-101页

作者： pier Luigi Surico Anna Scarabosio giovanni Miotti Martina Grando Carlo Salati pier Camillo parodi Leopoldo Spadea Marco Zeppieri Schepens Eye Research Institute of Mass Eye and Ear Harvard Medical SchoolBostonMA 02114United States Department of Ophthalmology Campus Bio-Medico UniversityRome 00128Italy Department of plastic Surgery University Hospital of UdineUdine 33100Italy Department of Internal Medicine Azienda Sanitaria Friuli OccidentaleSan Vito al Tagliamento 33078Italy Department of Ophthalmology University Hospital of UdineUdine 33100Italy Eye Clinic Policlinico Umberto I“Sapienza”University of RomeRome 00142Italy

This review comprehensively explores the versatile potential of mesenchymal stem cells(MSCs)with a specific focus on adipose-derived *** and oculoplastic surgery,encompassing diverse procedures for ocular and periocular enhancement,demands advanced solutions for tissue restoration,functional and aesthetic refinement,and *** immunomodulatory,regenerative,and healing capacities of MSCs,this review underscores the potential use of adipose-derived MSCs as a cost-effective alternative from bench to bedside,addressing common unmet needs in the field of reconstructive and regenerative surgery.

关键词： Stem cells Adipose stem cell Ocular therapy Oculoplastics Regenerative

Combining thermal scanning probe lithography and dry etching for grayscale nanopattern amplification

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Microsystems & Nanoengineering 2024年第1期10卷 335-344页

作者： Berke Erbas Ana Conde-Rubio Xia Liu Joffrey pernollet Zhenyu Wang Arnaud Bertsch Marcos penedo Georg Fantner Mitali Banerjee Andras Kis giovanni Boero Juergen Brugger Microsystems Laboratory École Polytechnique Fédérale de Lausanne(EPFL)Lausanne 1015Switzerland Center of MicroNanoTechnology(CMi) EPFLLausanne 1015Switzerland Laboratory of Nanoscale Electronics and Structures École Polytechnique Fédérale de Lausanne(EPFL)Lausanne 1015Switzerland Laboratory for Bio-and Nano-Instrumentation École Polytechnique Fédérale de Lausanne(EPFL)Lausanne 1015Switzerland Laboratory of Quantum physics Topology and CorrelationsÉcole Polytechnique Fédérale de Lausanne(EPFL)Lausanne 1015Switzerland present address:Institute of Materials Science of Barcelona ICMAB-CSIC Campus UABBellaterra 08193Spain present address:School of Integrated Circuits and Electronics MIIT Key Laboratory for Low-Dimensional Quantum Structure and DevicesBeijing Institute of TechnologyBeijing 100081China

Grayscale structured surfaces with nanometer-scale features are used in a growing number of applications in optics and *** scanning probe lithography achieves a lateral resolution below 10 nm and a vertical resolution below 1 nm,but its maximum depth in polymers is ***,we present an innovative combination of nanowriting in thermal resist and plasma dry etching with substrate cooling,which achieves up to 10-fold amplification of polymer nanopatterns into SiO_(2) without proportionally increasing surface *** nanopatterns in SiO_(2) with 400 nm pitch and 150 nm depth are fabricated free of shape distortion after dry *** exemplify the possible applications of the proposed method,grayscale dielectric nanostructures are used for scalable manufacturing through nanoimprint lithography and for strain nanoengineering of 2D *** a method for aspect ratio amplification and smooth grayscale nanopatterning has the potential to find application in the fabrication of photonic and nanoelectronic devices.

关键词： lithography thermal pattern

An Original Didactic of the Standard Model “The particle’s Geometric Model” (Nucleons and K-Mesons)

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Journal of High Energy physics, Gravitation and Cosmology 2024年第3期10卷 1054-1078页

作者： giovanni Guido Abele Bianchi Gianluigi Filippelli External Contact Referent of the EEE project at the High Scholl C. Cavalleri Parabiago Italy External Contact Referent of the Extreme Energy Events (EEE) project at the High Scholls Gandini Lodi Italy Astronomic Observatory Brera Milan Italy

This paper shows a didactic model (pGM), and not only, but representative of the Hadrons described in the Standard Model (SM). In this model, particles are represented by structures corresponding to geometric shapes of coupled quantum oscillators (IQuO). By the properties of IQuO one can define the electric charge and that of color of quarks. Showing the “aurea” (golden) triangular shape of all quarks, we manage to represent the geometric combinations of the nucleons, light mesons, and K-mesons. By the geometric shape of W-bosons, we represent the weak decay of pions and charged Kaons and neutral, highlighting in geometric terms the possibilities of decay in two and three pions of neutral Kaon and the transition to anti-Kaon. In conclusion, from this didactic representation, an in-depth and exhaustive phenomenology of hadrons emerges, which even manages to resolve some problematic aspects of the SM.

关键词： Golden particle Quark Sub-Oscillator Semi-Quanta IQuO Geometric Structure Golden Number Massive Coupling Interpenetration Nucleon Kaon Boson

Forcing in Christian Events: The Turin Shroud Case

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Open Journal of Applied Sciences 2024年第9期14卷 2351-2359页

作者： giovanni Fazio Marcello Leonello Francesca Riotto Department of Mathematical and Computer Sciences Physical Sciences and Earth Sciences University of Messina Messina Italy Diocese of Oppido Mamertina-palmi Palmi Italy

In its totality and complexity, the theme of forcing in Christian events is almost impossible to investigate. In fact, a lot of scholars and a very long time would be necessary to analyse the numerous events. Thus, we decided to investigate such events only in the study of the Shroud of Turin, an archaeological find known worldwide. The above topic is essential for Christianity. Furthermore, we must take into account that also among the followers of other religions, atheists and agnostics, there is a considerable interest. We think this is due to the unexpected characteristics that the Body Image, which appears on the Burial Linen of the Nazarene, shows. In this article, we would like to demonstrate that the practice of forcing is still in use. These actions, which are also present on the other side, in the non-Christian world, are the result of conflicts of religious interests. To confirm the presence of the Almighty is not necessarily the forcing. Finding a solution to these problems is not our job. However, we want to highlight them through scientific literature.

关键词： Shroud of Turin Forcing Sindonology Aromas pollens Radiative Hypothesis

An Original Didactic about Standard Model (Geometric Model of particle: The Quarks)

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Journal of High Energy physics, Gravitation and Cosmology 2024年第2期10卷 854-874页

作者： giovanni Guido Abele Bianchi Gianluigi Filippelli High Scholl “ C. Cavalleri&#8221 Parabiago (Milan) Italy High Scholls “ Gandini&#8221 Lodi Italy INAF Astronomic Observatory “ Brera&#8221 Milan Italy

This work shows a didactic model representative of the quarks described in the Standard Model (SM). In the model, particles are represented by structures corresponding to geometric shapes of coupled quantum oscillators (GMp). From these didactic hypotheses emerges an in-depth phenomenology of particles (quarks) fully compatible with that of SM, showing, besides, that the number of possible quarks is six.

关键词： Golden particle Quark Sub-Oscillator Semi-Quanta IQuO Geometric Structure Golden Number Massive Coupling Interpenetration IQuO pion Meson

First SHRIMp zircon U-pb dating constraints for the Ediacaran Wenghui Biota

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Journal of Earth Science 2024年

作者： Mingsheng Zhao Feng Tang giovanni Mussini Yulan Li Heng Zhang Jianshu Chen Linzhi Gao Department of Earth Sciences， University of Cambridge State Key Laboratory of palaeobiology and Stratigraphy (Nanjing Institute of Geology and palaeontology， CAS) 111 Geological Brigade， Guizhou Bureau of Geology and Mineral Resources College of paleontology， Shenyang Normal University Institute of Geology， Chinese Academy of Geological Sciences Guizhou Geological Survey

The Ediacaran period records a significant turning point in the evolution of life on Earth， witnessing the rise to ecological dominance of macroscopic tissue-grade organisms. The Wenghui biota from the Doushantuo Formation of South China hosts abundant multicellular algal macrofossils and problematica， some of which might be closely related to taxa from classic late Ediacaran assemblages from South Australia and the White Sea biota of Russia. However， a lack of well-resolved isotopic age estimates has hampered efforts to constrain the timing of appearance of the Wenghui biota， obfuscating its significance to our understanding of Ediacaran macroevolution in the aftermath of the Snowball Earth events. Here， we present the first SHRIMp zircon U-pb dating results for samples obtained from a laminated tuff ash layer at the base of the Wenghui biota in the Doushantuo Formation， Jiangkou County， Tongren City， Guizhou province， China. Our analyses yield an age of 595.4 ± 5.3 Ma for the first appearance of Wenghui biota， suggesting that its appearance postdated that of the Lantian- and Weng’an biotas， but preceded that of the Miaohe biota. These newly obtained age proxies offer an independent test of previous isotopic estimates for the age of the Wenghui biota， providing new chronostratigraphic evidence to map the succession of Ediacaran fossil assemblages on the Yangtze platform during the Doushantuo interval. These data suggest that the Lantian， Weng’an， Wenghui， and Miaohe biotas may record a sequence of biotic assemblages attesting to successive phases in the radiation of Ediacaran macroscopic organisms， particularly macroalgae.

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二维范德华磁体的拓扑自旋结构的研究进展

Science Bulletin 2024年第11期69卷 1612-1616页

作者：许洪军刘艺舟 giovanni Finocchio Kang LWang 于国强 Beijing National Laboratory for Condensed Matter physics Institute of PhysicsUniversity of Chinese Academy of SciencesChinese Academy of SciencesBeijing 100190China RIKEN Center for Emergent Matter Science(CEMS) Wako 351-0198Japan Department of Mathematical and Computer Sciences Physical Sciences and Earth SciencesUniversity of MessinaMessina 98166Italy Department of Electrical Engineering University of CaliforniaLos Angeles CA 90095USA

The importance of topological spin textures(TSTs), such as skyrmions, merons, hopfions, etc., is due to their static and dynamic properties [1]. They carry a topological number that characterizes the homotopy group Π_(n)(S^(2))(n ∈ Z) and classifies maps from S^(n) to S^(2)(e.g., the skyrmion winding number corresponds to Π_(2)(S^(2))).

关键词：自旋结构 topological homotopy

Epidemiology,therapy and outcome of hepatocellular carcinoma between 2010 and 2019 in piedmont,Italy

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 761-772页

作者： Christian Bracco Marta Gallarate Marco Badinella Martini Corrado Magnino Salvatore D'Agnano Roberta Canta Giulia Racca Remo Melchio Cristina Serraino Valentina polla Mattiot giovanni Gollè Luigi Fenoglio Department of Internal Medicine Santa Croce e Carle General HospitalCuneo 12100Italy Department of Medical Sciences "City of Health and Science"University HospitalTorino 10100Italy

BACKGROUND Hepatocellular carcinoma(HCC)is the most common primary liver malignancy and the second leading cause of cancer deaths *** is often diagnosed at an advanced stage and therefore its prognosis remains poor with a low 5-year survival *** patients have increasingly complex and constantly changing characteristics,thus up-to-date and comprehensive data are *** To analyze the epidemiology and main clinical characteristics of HCC patients in a referral center hospital in the northwest of Italy between 2010 and *** In this retrospective study,we analyzed the clinical data of all consecutive patients with a new diagnosis of HCC recorded at"Santa Croce e Carle"Hospital in Cuneo(Italy)between 1 January 2010 and 31 December *** highlight possible changes in HCC patterns over the 10-year period,we split the population into two 5-year groups,according to the diagnosis period(2010-2014 and 2015-2019).RESULTS Of the 328 HCC patients who were included(M/F 255/73;mean age 68.9±11.3 years),154 in the first period,and 174 in the *** C virus infection was the most common HCC risk factor(41%,135 patients).The alcoholic etiology rate was 18%,the hepatitis B virus infection etiology was 5%,and the non-viral/non-alcoholic etiology rate was 22%.The Child-pugh score distribution of the patients was:class A 75%,class B 21%and class C 4%.The average Mayo end-stage liver disease score was 10.6±3.7.A total of 55 patients(17%)were affected by portal vein thrombosis and 158(48%)by portal *** average nodule size of the HCC was 4.6±3.1 cm.A total of 204 patients(63%)had more than one nodulepatients)had a non-metastatic stage of the *** Barcelona Clinic Liver Cancer(BCLC)staging distribution of all patients was:4%very early,32%early,23%intermediate,34%advanced,and 7%*** survival rate was 1.6±0.3 *** 20%of the patients underwent ***,presence of ascites,BCLC stage and therapy w

关键词： Hepatocellular carcinoma Hepatitis virus Alcoholic hepatitis Non-alcoholic fatty liver disease Diagnosis Etiology Treatment

Surgical management of tegmen defects of the temporal bone and meningoencephalic herniation: our experience

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Journal of Otology 2024年第1期19卷 30-34页

作者： Giuseppe De Donato Emanuela Fuccillo Alberto Maria Saibene Elena Ferrari Giorgia Carlotta pipolo Antonia pisani Liliana Colletti Anastasia Urbanelli Luigi De Donato giovanni Felisati Otorhinolaryngology Unit Head and Neck DepartmentASST Santi Paolo e Carlo HospitalVia Antonio di Rudinì820142MilanItaly Department of Health Sciences University of MilanVia Festa del Perdono720122MilanItaly Department of Biomedical Surgical and Dental SciencesUniversity of MilanVia Festa del Perdono720122MilanItaly ENT Unit Department of Surgical SciencesUniversity of TurinVia Verdi810124TurinItaly

1. Introduction The tegmental wall of the tympanic cavity is a thin plate of the temporal bone that separates the middle cranial fossa(MCF) from the ear. This anatomical region consists of two areas: an anterior one, comprised of the tegmen tympani(To′th et al., 2007), and a posterior one, formed by the tegmen antri and the tegmen mastoideum(Makki et al., 2011). In some patients, the tegmental region of the temporal bone can be interrupted, causing a tegmen defect(TD). A TD is sometimes associated with a meningoencephalic herniation(MEH), in which brain tissue herniates through a TD.

关键词： al. herniation bone

Hepatitis B virus reactivation in patients treated with monoclonal antibodies

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World Journal of Virology 2024年第1期13卷 33-37页

作者： Silvia De pauli Martina Grando giovanni Miotti Marco Zeppieri Department of Internal Medicine Azienda Sanitaria Friuli OccidentaleSan Vito al TagliamentoPordenone 33170Italy Department of plastic Surgery University Hospital of UdineUdine 33100Italy Department of Ophthalmology University Hospital of UdineUdine 33100Italy

Hepatitis B virus(HBV)reactivation poses a significant clinical challenge,espe-cially in patients undergoing immunosuppressive therapies,including mono-clonal antibody *** manuscript briefly explores the complex rela-tionship between monoclonal antibody therapy and HBV reactivation,drawing upon current literature and clinical case *** delves into the mechanisms underlying this phenomenon,highlighting the importance of risk assessment,monitoring,and prophylactic measures for patients at *** manuscript aims to enhance the understanding of HBV reactivation in the context of monoclonal antibody therapy,ultimately facilitating informed clinical decision-making and improved patient *** paper will also briefly review the definition of HBV activation,assess the risks of reactivation,especially in patients treated with monoclonal antibodies,and consider management for patients with regard to screening,prophylaxis,and treatment.A better understanding of patients at risk can help clinicians provide optimum management to ensure successful patient outcomes and prevent morbidity.

关键词： Hepatitis B virus Reactivation Acute infection Chronic infection Monoclonal antibodies