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How does the brown mussel Perna perna respond to environmental pollution?A review on pollution biomarkers

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Journal of Environmental Sciences 2022年第1期34卷 412-428页

作者： fernanda silva dos Santos Raquel A.f.Neves Mirian Araújo Carlos Crapez Valéria Laneuville Teixeira Natascha Krepsky fluminense federal University(Uff) Institute of BiologyGraduate Program in Science and BiotechnologyMario Santos Braga Streets/n.CentroNiteróiRJ CEP 24.020-141Brazil federal University of the State of Rio de Janeiro(UNIRIO) Institute of Biosciences(IBIO)Graduate Program in Neotropical Biodiversity(PPGBIO)Pasteur Avenue458.UrcaRio de JaneiroRJ CEP 22.290-255Brazil fluminense federal University(Uff) Institute of BiologyGraduate Program in Marine Biology and Coastal EnvironmentsMario Santos Braga Streets/n.CentroNiteróiRJ CEP 24.020-141Brazil federal University of the State of Rio de Janeiro(UNIRIO) Institute of Biosciences(IBIO)Graduate Program in Ecotourism and ConservationPasteur Avenue458.UrcaRio de JaneiroRJ CEP 22.290-255Brazil

The brown mussel Perna perna(Linnaeus,1758)is a valuable resource for aquaculture in tropical and subtropical coastal *** presents desirable characteristics for biomonitoring,including being sessile,widely distributed and abundant,and is a filter-feeder able to accumulate several classes of pollutants(e.g.,metals,hydrocarbons,among others).Mussels’biological responses to pollution exposure can be measured as biomarkers,which include alterations ranging from molecular to physiological levels,to estimate the degree of environmental contamination and its effects on *** full review compiles two decades(2000–2020)of literature concerning biological effects on *** mussel caused by environmental pollutants(i.e.,metals,hydrocarbons,and emerging pollutants),considering environmental and farm-based *** markers related to mussels’oxidative status were efficient for the biomonitoring of metals(i.e.,antioxidant enzymes associated with oxidative damage in biomolecules).Genotoxicity and cytotoxicity indicators(i.e.,comet,micronucleus,and neutral red assays)provided a depiction of hydrocarbon *** neutral red assay gave a time-concentration cytotoxic response to a wide range of pollutants,including emerging pollutants(e.g.,pharmaceuticals and biocides)and *** perna hemocyte parameters provided a useful approach for biocide *** paper summarizes useful biomarkers from molecular to physiological levels in this mussel species used to identify and quantify the degree of coastal *** integrated biomarker analysis may provide a way to overcome possible biomarker variations and assess multi-polluted ***,it is necessary to investigate biomarker variations according to natural factors(e.g.,season and gonad maturation stage)to standardize them for trustworthy biomonitoring.

关键词： Biological indexes Biomonitoring Emerging pollutants Hydrocarbons Metals Sentinel species

Microbiological biostimulant promotes rooting of olive cuttings

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International Journal of Agricultural and Biological Engineering 2021年第6期14卷 207-212页

作者： Giovana Ritter fabíola Villa Daniel fernandes da silva Odair Alberton fernanda Jaqueline Menegusso Tatiane Eberling Joyce Dória Western ParanáState University(Unioeste) Campus Marechal Cândido Rondon.Marechal Cândido RondonPR85960-000Brazil Paranaense University(UNIPAR) UmuaramaPR87502-210Brazil federal University of Lavras LavrasMG37200-000Brazil

The most widely used method of olive propagation is cutting,although for some cultivars the technique is still *** objective of this work was to evaluate the use of plant growth promoter bacteria and arbuscular mycorrhizal fungi in the rooting of olive *** experiments were conducted from October 2017 to January 2018 with cuttings from 4 olive cultivars(Ascolano 315,Koroneiki,Maria da féand Picual)from four-year-old *** first experiment consisted of 4 olive cultivars and 3 mycorrhizal species plus the control and the second experiment of 3 concentrations of commercial inoculant(Nitro1000®),containing Azospirillum brasilense plus *** cuttings were treated with 3000 mg/L of indolebutyric acid(IBA).The experimental design used in the two experiments was randomized blocks,in a 4×4 factorial scheme,containing 25 stakes per replicate and 3 *** cuttings were kept under weaver conditions and within a low rooting *** 75 d,the percentage of rooted cuttings,callus and sprouts,length of the largest root,number and length of shoots were *** use of fMA in Maria da féand Picual has a positive response to cutting rooting and the fungi benefit the quality of the seedlings by the higher number of shoots and larger root *** relation of Azospirillum brasilense cultivar is specific,being that,the cultivar Picual does not respond to inoculation of the bacterium having less viability in the propagation by *** da féand Koroneiki have the best percentages of rooting with the use of 75.00 and 52.00 mL/L of inoculant,respectively.

关键词： Azospirillum brasilense Arbuscular mycorrhizal fungi Propagation Olea europaea L. microorganism

Maternal hyperthyroidism increases the synthesis activity and the osteogenic markers expression of calvarial osteoblasts from offspring in a murine model

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BIOCELL 2023年第2期47卷 423-430页

作者： fABIANA ROCHA ARAÚJO BRUNO MACHADO BERTASSOLI ISABELLA CRISTINA SOUZA fÉLIX DOUGLAS MARINHO ABREU NATÁLIA MELO OCARINO AMANDA MAria SENA REIS JUNEO fREITAS silva ROGÉria SERAKIDES Núcleo de Células Tronco e Terapia Celular Animal(NCT-TCA) Veterinay SchoolUniversidade Federal de Minas GeraisBelo HorizonteMinas Gerais31270-901Brasil Universidade de Uberaba(UNIUBE) UberabaMinas Gerais38065-300Brasil Instituto de Ciências Biológicas Universidade Federal de Minas GeraisBelo HorizonteMinas Gerais31270-901Brasil Universidade Estadual de Santa Cruz Campus Soane Nazare de AndradeIlheusBahiaBrasil

To evaluate the characteristics and synthesis activity of osteoblasts extracted from the calvaria of offspring of rats exposed to maternal *** adult Wistar rats were divided into two groups,one control and one treated with daily administration of L-thyroxine by an orogastric tube(50μg/animal/day)during *** days after delivery and confirmation of the mothers’hyperthyroidism,the offspring were euthanized for the extraction of osteoblasts from the *** 7,14,and 21 days,proliferation activity was assessed using MTT assay,while alkaline phosphatase(ALP)activity was assessed by the BCIP/NBT *** 21 days,the total area of the mineralized matrix stained by von Kossa was evaluated by *** expression of gene transcripts for Runx2,Bmp2,fgfr1,collagen type 1(Col1),osteocalcin(Oc),and osteopontin(Op)were evaluated by real-time *** were compared using the Student’s *** activity was significantly higher at 14 and 21 days in cultures of osteoblasts extracted from offspring exposed to maternal hyperthyroidism,while MTT conversion was significantly lower at 21 days in this *** cultures of neonates exposed to maternal hyperthyroidism also showed a larger total area of mineralized matrix and greater expression of gene transcripts for Oc and *** hyperthyroidism increases the activity of matrix synthesis,alkaline phosphatase activity,and expression of gene transcripts for osteocalcin and osteopontin in the osteoblasts,extracted from the calvaria of the offspring,which may be one of the mechanisms of premature fusion of cranial sutures.

关键词： Craniosynostosis Intramembranous growth Ossification Rat Thyroid dysfunction

Social Support Provided to Women Undergoing Breast Cancer Treatment:A Study Review

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Advances in Breast Cancer Research 2014年第2期3卷 47-53页

作者： Ana fátima fernandes Amanda Cruz Camila Moreira Míria Conceicao Santos Tiago silva Department of Nursing Federal University of CearáFortalezaBrazil

Breast cancer treatment may have implications for women’s quality of life and social support, which refers to mechanisms through which interpersonal relationships protect people from the detrimental effects of stress. This study’s objective was to analyze evidence available in the literature concerning social support provided to women with breast cancer undergoing chemotherapy. The Latin American and Caribbean Literature on Health Sciences (LILACS), PubMed, Web of Science, Psycinfo and Cumulative Index to Nursing and Allied Health Literature (CINAHL) databases were used to select the studies. The papers were pre-selected after reading titles and abstracts and ten papers were ultimately selected after fully reading the texts. The studies were summarized, while their methodological designs and results were noted. The analysis of the studies shows that social support can be provided to women with breast cancer, such as emotional, instrumental and informational support. It is apparent that emotional and instrumental support is provided in the first phase of the treatment. The main sources of support include the spouses, family members and friends. Spouses provide emotional support, but mainly provide instrumental support, while family members and friends are the most important source of emotional support. The conclusion is that emotional support greatly contributes to the health-disease continuum, favoring treatment adherence and creating opportunities for women to express their feelings, positively influencing the treatment.

关键词： Breast Cancer Oncological Treatment Social Support

Dietary supplementation with curcumin-loaded nanocapsules in lambs:Nanotechnology as a new tool for nutrition

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Animal Nutrition 2021年第2期7卷 521-529页

作者： Hiam Marcon Luiz G.Griss Vitor L.Molosse Bruno G.O.Cecere Davi f.Alba Karoline W.Leal Gabriela M.Galli Carine f.Souza Matheus D.Baldissera Samanta Gundel Vitória de A.Bassotto Aline f.Ourique Marcelo Vedovatto Aleksandro S.Da silva Department of Animal Science Universidade Do Estado de Santa Catarina(UDESC)ChapecóSCBrazil Graduate Program in Animal Science UDESCChapecóSCBrazil Department of Physiology and Pharmacology Universidade Federal de Santa Maria(UFSM)RSBrazil Universidade franscicana Santa MariaRSBrazil Graduate Program in Animal Science Universidade Estadual de Mato Grosso Do SulAquidauanaMSBrazil

Curcumin-containing nanocapsule powder formulations have not been used in ruminant feed to date,despite the fact that curcumin is known to be a functional food *** objective of this study was to determine whether ethyl polymethacrylate(Eudragit L-100)nanocapsules loaded with curcumin(N-CU)would improve health and growth of ***-two male Lacaune lambs(body weight[BW]=16±0.99 kg;45 d of age)were randomly assigned to 1 of 4 treatments:T0,T1,T2 and T4,representing supplementation of curcumin at 0,1,2,and 4 mg/kg concentrate,*** animals in each treatment were allocated in 4 pens of 2 lambs each(8 lambs per treatment).The experiment lasted 17 d,with samples and measurements collected on d 0,7,12,and *** T2 lambs had greater average daily gain than T0 *** analysis showed that the ideal dose of N-CU to enhance weight gain was 1.89 mg/kg *** were significant interactions(Pfor hematological variables,particularly for increases in erythrocytes(T2)and re-ductions in counts of leukocytes,neutrophils,and lymphocytes in T1 and *** were significant interactions between treatment×time for total protein,globulin,urea,and triglyceride ***-lation of the antioxidant system was also *** were increased levels of non-protein thiols(NPSH),as well as increased activities of superoxide dismutase(SOD)and glutathione S-transferase(GST)in the supplemented *** of reactive oxygen species(ROS)were lower in the serum of sup-plemented *** general,the 4 mg/kg dose had no positive effects on growth or *** was an unexpected result,given the known properties of *** together,these findings suggest that addition of low concentrations of nanoencapsulated curcumin(T1 and T2)in lamb feed improves health,minimizing oxidative stress and generates anti-inflammatory effects that may have contributed indi-rectly to greater weight *** potentiate the effe

关键词： Antioxidant Anti-inflammatory Curcuma longa Performance Sheep

Embolization of splenorenal shunt associated to portal vein thrombosis and hepatic encephalopathy

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World Journal of Gastroenterology 2014年第42期20卷 15910-15915页

作者： Letícia de Campos franzoni fábio Cardoso de Carvalho Rafael Gomes de Almeida Garzon fábio da silva Yamashiro Laís Augusti Lívia Alves Amaral Santos Mariana de Souza Dorna Júlio Pinheiro Baima Talles Bazeia Lima Carlos Antonio Caramori giovanni f.ria silva fernando Gomes Romeiro Internal Medicine Department Gastroenterology Division Botucatu Medical School UNESP 18 618 970 Botucatu Sao Paulo Brazil Hospital do Cora??o do Instituto de Moléstias Cardiovasculares S?o José do Rio Preto Sao Paulo 15015-210 Brazil Department of Internal Medicine Division of Cardiology Botucatu School of Medicine UNESP Univ Estadual Paulista

Hepatic encephalopathy(HE)is a cognitive disturbance characterized by neuropsychiatric *** occurs in acute and chronic hepatic disease and also in patients with portosystemic *** presence of these portosystemic shunts allows the passage of nitrogenous substances from the intestines through systemic veins without liver ***,the embolization of these shunts has been performed tocontrol HE manifestations,but the presence of portal vein thrombosis is considered a *** this presentation we show a cirrhotic patient with severe HE and portal vein thrombosis who was submitted to embolization of a large portosystemic *** report:a 57 years-old cirrhotic patient who had been hospitalized many times for persistent HE and hepatic coma,even without precipitant *** had a wide portosystemic shunt and also portal vein *** abdominal angiography confirmed the splenorenal shunt and showed other *** larger shunt was embolized through placement of microcoils,and the patient had no recurrence of overt *** was a little increase of esophageal and gastric varices,but no endoscopic treatment was *** portosystemic shunts are frequent causes of recurrent HE in cirrhotic patients,portal vein thrombosis should be considered a relative contraindication to perform a shunt ***,in particular cases with many shunts and severe HE,we found that one of these shunts can be safely embolized and this procedure can be sufficient to obtain a good HE *** conclusion,we reported a case of persistent HE due to a wide portosystemic shunt associated with portal vein *** the patient had other shunts,she was successfully treated by embolization of the larger shunt.

关键词： Recurrent hepatic encephalopathy Liver cirrhosis Port systemic shunt Shunt embolization Portal vein thrombosis

Metabolomics in chronic hepatitis C:Decoding fibrosis grading and underlying pathways

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World Journal of Hepatology 2023年第11期15卷 1237-1249页

作者： Adriana Camargo ferrasi Samara Vitória Granja Lima Aline f.ria Galvani Jeany Delafiori flavia Luísa Dias-Audibert Rodrigo Ramos Catharino giovanni f.ria silva Roberta Rodrigues Praxedes Driele Bretones Santos Dayane Trevisan de Macedo Almeida Estela Oliveira Lima Department of Internal Medicine Sao Paulo State UniversityBotucatu 18618-686Brazil Innovare Biomarkers Laboratory University of CampinasCampinas 13083-877Brazil

BACKGROUND Chronic Hepatitis C(CHC)affects 71 million people globally and leads to liver issues such as fibrosis,cirrhosis,cancer,and death.A better understanding and prognosis of liver involvement are vital to reduce morbidity and *** accurate identification of the fibrosis stage is crucial for making treatment decisions and predicting *** used to grade fibrosis include histological analysis and imaging but have *** markers such as molecular biomarkers can offer valuable insights into *** To identify potential biomarkers that might stratify these lesions and add information about the molecular mechanisms involved in the *** Plasma samples were collected from 46 patients with hepatitis C and classified into fibrosis grades f1(n=13),f2(n=12),f3(n=6),and f4(n=15).To ensure that the identified biomarkers were exclusive to liver lesions(CHC fibrosis),healthy volunteer participants(n=50)were also *** untargeted metabolomic technique was used to analyze the plasma metabolites using mass spectrometry and database *** analyses were performed to identify differential biomarkers among *** Six differential metabolites were identified in each grade of *** six-metabolite profile was able to establish a clustering tendency in patients with the same grade of fibrosis;thus,they showed greater efficiency in discriminating *** This study suggests that some of the observed biomarkers,once validated,have the potential to be applied as prognostic ***,it suggests that liquid biopsy analyses of plasma metabolites are a good source of molecular biomarkers capable of stratifying patients with CHC according to fibrosis grade.

关键词： Chronic Hepatitis C fibrosis Metabolome Biomarkers Plasma Liquid biopsy

Assessment of periportal fibrosis in Schistosomiasis mansoni patients by proton nuclear magnetic resonance-based metabonomics models

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World Journal of Hepatology 2022年第4期14卷 719-728页

作者： Milena Lima Rodrigues Tatiane Priscila Santos Rodrigues da Luz Caroline Louise Diniz Pereira Andrea Dória Batista Ana Lúcia Coutinho Domingues Ricardo Oliveira silva Edmundo Pessoa Lopes Programa de Pós-Graduação em Medicina Tropical Centro de Ciências MédicasUniversidade Federal de PernambucoRecife 50670-901PernambucoBrazil Programa de Pós-Graduação em Química Centro de Ciências Exatas e da NaturezaUniversidade Federal de PernambucoRecife 50670-740PernambucoBrazil Hospital das Clínicas Departamento de Medicina ClínicaUniversidade Federal de PernambucoRecife 50670-901PernambucoBrazil

BACKGROUND The evaluation of periportal fibrosis(PPf)is essential for a prognostic assessment of patients with Schistosomiasis *** WHO Niamey Protocol defines patterns of fibrosis from abdominal ultrasonography,^(1)H-nuclear magnetic resonance(NMR)-based metabonomics has been employed to assess liver fibrosis in some *** To build 1H-NMR-based metabonomics models(MM)to discriminate mild from significant periportal PPf and identify differences in the metabolite *** A prospective cross-sectional study was performed on schistosomiasis patients at a University Hospital in Northeastern *** evaluated 41 serum samples from 10 patients with mild PPf(C Niamey pattern)and 31 patients with significant PPf(D/E/f Niamey patterns).MM were built using partial least squares-discriminant analysis(PLS-DA)and orthogonal projections to latent structures discriminant analysis(OPLS-DA)*** PLS-DA and OPLS-DA resulted in discrimination between mild and significant PPf groups with R2 and Q2 values of 0.80 and 0.38 and 0.72 and 0.42 for each model,*** OPLS-DA model presented accuracy,sensitivity,and specificity values of 92.7%,90.3%,and 100%to discriminate significant *** metabolites identified as responsible by discrimination were:Nacetylglucosamines,alanine,glycolaldehyde,carbohydrates,and *** MMs discriminated mild from significant PPf patterns in patients with Schistosomiasis mansoni through identification of differences in serum metabolites profiles.

关键词： Metabolomics Portal hypertension Schistosoma mansoni Biomarkers Neglected disease Nuclear magnetic resonance

Construction and Validation of an Educational Technology for Mammary Health Promotion

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Open Journal of Nursing 2015年第11期5卷 965-970页

作者： Izabel Cristina falcao Juvenal Barbosa Ana fatima Carvalho fernandes Camila Brasil Moreira Míria Conceicao Lavinas Santos Altamira Mendonca félix Gomes Ivna silva Andrade Anna Paula Sousa da silva Department of Nursing Federal University of PiauíFlorianoPiauíBrazil

Mammary health is issue faced by public health nurses and the science follows new ways into this thematic area of learning course wares. The purpose of this study was to construct and to validate a distance course for mammary health promotion for nurses. Methodological proposal has been composed of five stages: 1) analysis and planning, 2) modeling, 3) implementation, 4) evaluation and maintenance and 5) distribution. A total of nine experts as research population were consulted who were expert judges of nursing, pedagogy and web designer, three of each specific area, which were included in the study. The variables that had concordance index of 50% were: graphic designer pages favors learning, the user has easy navigation, the learning of the student experience, the environment provides interdisciplinary, content is built on process rather than there is a unique sequence, allows access to the available environment and holds a discussion on the subject. The distance learning course is intended to broaden and to enrich the living spaces and construct their own knowledge, favors interactivity, communication, autonomy and cooperation between the participants and provides access to educational technologies.

关键词： Distance Education Educational Technology Breast Neoplasms Health Promotion Nursing