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Long-term implications of fetal growth restriction

World Journal of Clinical Cases 2023年第13期11卷 2855-2863页

作者： Martina D'Agostin Chiara Di Sipio Morgia giovanni vento Stefano Nobile Department of Pediatrics University of TriesteTrieste 34100Italy Department of Woman and Child Health and Public Health UniversitàCattolica del Sacro CuoreRome 00168Italy Department of Woman and Child Health and Public Health Fondazione Policlinico Universitario A.Gemelli IRCCS-UniversitàCattolica del Sacro CuoreRome 000168Italy

Fetal growth restriction(FGR),or intrauterine growth restriction(IUGR),is a complication of pregnancy where the fetus does not achieve its genetic growth *** is characterized by a pathological retardation of intrauterine growth velocity in the curve of intrauterine ***,the FGR definition is still debated,and there is a lack of a uniform definition in the *** IUGR,compared to constitutional smallness,is a pathological condition in which the placenta fails to deliver an adequate supply of oxygen and nutrients to the developing *** with IUGR,compared to appropriately grown gestational age infants,have a significantly higher risk of mortality and neonatal complications with long-term *** studies have demonstrated how suboptimal fetal growth leads to long-lasting physiological alterations for the developing fetus as well as for the newborn and adult in the *** long-term effects of fetal growth retardation may be adaptations to poor oxygen and nutrient supply that are effective in the fetal period but deleterious in the long term through structural or functional *** studies showed that FGR could be a contributing factor for adult chronic diseases including cardiovascular disease,metabolic syndrome,diabetes,respiratory diseases and impaired lung function,and chronic kidney *** this review we discussed pathophysiologic mechanisms of FGR-related complications and potential preventive measures for FGR.

关键词： Fetal growth restriction Intrauterine chronic hypoxia Long-lasting physiological alterations Cardiovascular disease Metabolic syndrome Obstructive pulmonary disease

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COVID-19 pandemic in the intensive care unit:Psychological implications and interventions,a systematic review

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World Journal of Psychiatry 2023年第4期13卷 191-217页

作者： Laura Monti Elisa Marconi Maria Grazia Bocci Georgios Demetrios Kotzalidis Marianna Mazza Carolina Galliani Sara Tranquilli giovanni vento Giorgio Conti Gabriele Sani Massimo Antonelli Daniela Pia Rosaria Chieffo UOS Psicologia Clinica Governo ClinicoFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy UOC Anestesia RianimazioneTerapia Intensiva e Tossicologia ClinicaDipartimento di Scienze Dell’EmergenzaAnestesiologiche e Della RianimazioneFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy UOC Psichiatria Clinica e d’Urgenza Dipartimento di Scienze Dell’InvecchiamentoNeurologicheOrtopediche e Della Testa-colloFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy NESMOS Department Facoltàdi Medicina e PsicologiaSant’Andrea University HospitalRome 00189Italy Department of Psychiatry UniversitàCattolica del Sacro CuoreRome 00168Italy Department of Psychology UniversitàCattolica del Sacro CuoreRome 00168Italy UOC Neonatologia Dipartimento di Scienze Della Salute Della DonnaDel Bambino e di SanitàPubblicaFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy UOC Neonatologia UniversitàCattolica del Sacro CuoreRome 00168Italy UOC Terapia Intensiva Pediatrica e Trauma Center Pediatrico Dipartimento di Scienze Dell’EmergenzaAnestesiologiche e Della RianimazioneFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy UOC Terapia Intensiva Pediatrica e Trauma Center Pediatrico UniversitàCattolica del Sacro CuoreRome 00168Italy Department of Anesthesiology and Intensive Care Medicine UniversitàCattolica del Sacro CuoreRome 00168Italy

BACKGROUND The coronavirus disease 2019(COVID-19) pandemic produced changes in intensive care units(ICUs) in patient care and health organizations. The pandemic event increased patients’ risk of developing psychological symptoms during and after hospitalisation. These consequences also affected those family members who could not access the hospital. In addition, the initial lack of knowledge about the virus and its management, the climate of fear and uncertainty, the increased workload and the risk of becoming infected and being contagious, had a strong impact on healthcare staff and organizations. This highlighted the importance of interventions aimed at providing psychological support to ICUs, involving patients, their relatives, and the staff;this might involve the reorganisation of the daily routine and rearrangement of ICU staff *** To conduct a systematic review of psychological issues in ICUs during the COVID-19 pandemic involving patients, their relatives, and ICU *** We investigated the PubMed and the *** databases and found 65 eligible articles,upon which we *** Our results point to increased perceived stress and psychological distress in staff, patients and their relatives and increased worry for being infected with severe acute respiratory syndrome coronavirus-2 in patients and relatives. Furthermore, promising results were obtained for some psychological programmes aiming at improving psychological measures in all ICU *** As the pandemic limited direct inter-individual interactions, the role of interventions using digital tools and virtual reality is becoming increasingly important. All considered, our results indicate an essential role for psychologists in ICUs.

关键词： COVID-19 Intensive care unit Psychological interventions Pandemic Mental health Health care professionals

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Contralateral axillary metastasis:is surgical treatment the best option?

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Journal of Cancer Metastasis and Treatment 2019年第4期4卷 26-30页

作者： María Julia Giménez Jesús Manuel Patrón giovanni vento Ana Bayón Vincenzo Maisto Isidro Bolumar Rosa Ferrer Josep Asensi Joaquin Gavila Rafael Estevan Department of Surgery Fundación Instituto Valenciano de Oncología(IVO)Valencia 46007Espana

Contralateral axillary metastasis (CAM) is a rare entity normally treated as a systemic disease. Recent publications have proposed aggressive surgical treatment with benefits to the patients in terms of survival. We present a case of a 74-year-old patient with a history of unilateral breast cancer, recurrence on the ipsilateral breast and then development of a CAM. The patient was treated with aggressive surgical treatment, but she developed an early recurrence of the disease with distant metastasis. There is limited evidence of the correct management of CAM, although proposed to treat it as a loco regional disease, individualized and multidisciplinary management is the best option for these patients.

关键词： Breast cancer contralateral axillary metastasis lymphatic routes blockage

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Deep learning to develop zero-equation based turbulence model for CFD simulations of the built environment

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Building Simulation 2024年第3期17卷 399-414页

作者： giovanni Calzolari Wei Liu Division of Sustainable Buildings Department of Civil and Architectural EngineeringKTH Royal Institute of TechnologyBrinnelvägen 23Stockholm11428Sweden

This study aims to improve the accuracy and speed of predictions for thermal comfort and air quality in built environments by creating a coupled framework between computational fluid dynamics(CFD)simulations and deep learning *** coupling approach is showcased by the development of a data-driven turbulence *** new turbulence model is built using a deep learning neural network,whose mapping structure is based on a zero-equation turbulence model for built environment simulations,and is coupled with the CFD software OpenFOAM to create a hybrid *** neural network is a standard shallow multi-layer *** number of hidden layers and nodes per layer was optimized using Bayesan optimization *** framework is trained on an indoor environment case study,as well as tested on an indoor office simulation and an outdoor building array *** show that the deep learning based turbulence model is more robust and faster than traditional two-equation Reynolds average Navier-Stokes(RANS)turbulence models,while maintaining a similar level of *** model also outperforms the standard algebraic zero-equation model due to its superior ability to generalize to various flow *** some challenges,namely the mapping constraint,the limited training dataset size and the source of generation of training data,the hybrid framework demonstrates the viability of the coupling technique and serves as a starting point for future development of more reliable and advanced models.

关键词： neural networks computational fluid dynamics(CFD) turbulence model OpenFOAM

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Experimental evaluation of mechanical compression of lattice trusses made with Ti6Al4V for aerospace use

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Chinese Journal of Aeronautics 2024年第5期37卷 520-532页

作者： Carlo giovanni FERRO Sara VARETTI Paolo MAGGIORE Department of Mechanical and Aerospace Engineering Politecnico di TorinoCorso Duca degli AbruzziTorino 10124Italy

Lattice structures are three-dimensional structures composed of repeated geometrical shapes with multiple interconnected nodes,providing high strength-to-weight ratios,customizable properties,and efficient use of materials.A smart use of materials leads to reduced fuel consumption and lower operating costs,making them highly desirable for aircraft ***,the customizable properties of lattice structures allow for tailoring to specific design requirements,leading to improved performance and safety for *** advantages make lattice structures an important focus for research and development in the aviation *** paper presents an experimental evaluation of the mechanical compression properties of lattice trusses made with Ti6Al4V,designed for use in an anti-ice *** truss structures were manufactured using additive manufacturing techniques and tested under compressive loads to determine mechanical *** showed that lattice trusses exhibited high levels of compressive strength,making them suitable for use in applications where mechanical resistance and durability are critical,such as in anti-ice *** also highlight the potential of additive manufacturing techniques for the fabrication of lattice trusses with tailored mechanical *** study provides valuable insights into the mechanical behavior of Ti6Al4V lattice trusses and their potential applications in anti-ice systems,as well as other areas where high strength-to-weight ratios are *** results of this research contribute to the development of lightweight,efficient,and durable anti-ice systems for use in aviation and other industries.

关键词： Additive Manufacturing(AM) Selective Laser Sintering(SLM) Anti ice systems Lattice structures Aircraft on board systems Design of Experiments(DOE)

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Polymerization of 1,3-Butadiene with Catalysts Based on Cobalt Dichloride Complexes with Aminophosphines: Switching the Regioselectivity by Varying the MAO/Co Molar Ratio

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Chinese Journal of Polymer Science 2024年第4期42卷 501-510页

作者： giovanni Ricci Anna Sommazzi Francesco Masi Alessandra Forni CNR-Istituto di Scienze e Tecnologie Molecolari“Giulio Natta”(SCITEC) via A.Corti 1220133MilanoItaly Viale giovanni XXIII 34 I-28100NovaraNOItaly Via Galvani 7 I-26866Sant’Angelo LodigianoLOItaly CNR-Istituto di Scienze e Tecnologie Molecolari“Giulio Natta”(SCITEC) via C.Golgi 1920133MilanoItaly

Several novel cobalt dichloride complexes with amino-phosphine bidentate ligands were synthesized and *** some of them single crystals were obtained and their molecular structure was determined by X-ray diffraction *** the complexes were then used in combination with MAO for the polymerization of 1,3-butadiene,obtaining polymers with different structures(i.e.,predominantly 1,2 or cis-1,4)mainly depending on the type of ligand and on the MAO/Co molar *** behavior of these novel catalysts was compared with that exhibited,in the polymerization of the same monomer,by the systems CoCl_(2)(PR3)2-MAO and CoCl_(2)(PRPh2)2-MAO(R=alkyl or cycloalkyl group),and by the systems based on cobalt dichloride complexes with various bi-and tridentate ligands(e.g.,diphosphines,bis-imines,pyridyl-imines,bis-iminopyridines).The comparison between the different systems allowed us to make some clarity about the actual and effective role played by the various types of ligands in the polymerization of conjugated dienes with catalytic systems CoCl_(2)(L)-MAO,in which L=mono-,bi-,or tri-dentate ligand.

关键词： 1,3-Butadiene Stereospecific polymerization Cobalt catalysts Regioselectivity Aminophosphine ligands Crystal structures Chelate rings

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CBE Clima Tool:A free and open-source web application for climate analysis tailored to sustainable building design

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Building Simulation 2024年第3期17卷 493-508页

作者： giovanni Betti Federico Tartarini Christine Nguyen Stefano Schiavon Center for the Built Environment University of California BerkeleyBerkeleyUSA Berkeley Education Alliance for Research in Singapore SingaporeSingapore Heat and Health Research Incubator Faculty of Medicine and HealthThe University of SydneyCamperdownAustralia College of Letters and Sciences University of California BerkeleyBerkeleyUSA

Climate-responsive building design holds immense potential for enhancing comfort,energy efficiency,and environmental ***,many social,cultural,and economic obstacles might prevent the wide adoption of designing climate-adapted *** of these obstacles can be removed by enabling practitioners to easily access,visualize and analyze local climate *** CBE Clima Tool(Clima)is a free and open-source web application that offers easy access to publicly available weather files and has been created for building energy simulation and *** provides a series of interactive visualizations of the variables contained in the EnergyPlus Weather Files and several derived ones like the UTCI or the adaptive comfort *** is aimed at students,educators,and practitioners in the architecture and engineering *** its inception,Clima’s user base has exhibited robust growth,attracting over 25,000 unique users annually from across 70 *** tool is poised to revolutionize climate-adaptive building design,transcending geographical boundaries and fostering innovation in the architecture and engineering fields.

关键词： architectural design climate analysis sustainable building design web application building energy simulation open-source software

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On the optimisation of age of the air in the breathing zone of floor heating systems:The role of ventilation design

Energy and Built Environment

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Energy and Built Environment 2024年第1期5卷 130-142页

作者： Aminhossein Jahanbin giovanni Semprini Department of Industrial Engineering(DIN) Alma Mater Studiorum-University of BolognaViale Risorgimento 240136 BolognaItaly CIRI-Centro Interdipartimentale di Ricerca Industriale Edilizia e Costruzioni Alma Mater Studiorum-University of BolognaVia del Lazzaretto 15/540131 BolognaItaly

For a mechanically ventilated space,the nominal age of the air can be obtained by the reciprocal of the air change ***,values of the local mean age of the air in practice may differ to some extent from the nominal one since the nominal time constant employs as reference the theoretical optimum *** discrepancy could become more prominent in spaces conditioning with both ventilation and heating system where the indoor air pattern is affected by turbulent mixed convection *** importance of knowledge on the distribution of age of the air in these spaces,the present study provides insights on how ventilation design in floor heating systems can optimise the delivery of fresh air into the breathing *** this context,by establishing a computational fluid dynamic(CFD)model validated against experimental data,the local mean age of the air as well as the indoor air quality(IAQ)indices in the breathing zone of the floor heating system are examined under different ventilation *** different ventilation scenarios are regarded in order to find the optimal ventilation design in terms of the delivery of the fresh air and ventilation effectiveness in occupied ***,the integrated effects of the floor temperature and inlet supply temperature along with the ventilation design on the distribution of local age of the air are *** obtained results indicate that the up-supply ventilation strategy is more efficient than down-supply one in the ventilation effectiveness and delivery of fresh air into the breathing ***,it is shown that the mean age of the air in the breathing zone of the up-supply ventilation increases with increment of the Ri(Richardson number),whereas an increase in Ri improves the delivery of fresh air in down-supply *** a given floor temperature,the similar trend is also observed in the variation of age of the air with the characteristic temperature of supply inlet,namely the temperature difference between

关键词： Age of the air Indoor air quality Ventilation Floor heating CFD

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A novel approach to the dynamic response analysis of Euler-Bernoulli beams resting on a Winkler soil model and subjected to impact loads

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Earthquake Engineering and Engineering Vibration 2024年第2期23卷 389-401页

作者： Adolfo Foriero Filippo Santucci de Magistris giovanni Fabbrocino Département de génie civil et de génie des eaux Pavillon Adrien-PouliotUniversitéLavalQuébecCanada Dipartimento di Bioscienze e Territorio Universitàdegli Studi del MoliseCampobassoItaly Construction Technologies Institute National Research CouncilITC-CNRL’AquilaItaly

This work presents a novel approach to the dynamic response analysis of a Euler-Bernoulli beam resting on a Winkler soil model and subjected to an impact *** approach considers that damping has much less importance in controlling the maximum response to impulsive loadings because the maximum response is reached in a very short time,before the damping forces can dissipate a significant portion of the energy input into the *** development of two sine series solutions,relating to different types of impulsive loadings,one involving a single concentrated force and the other a distributed line load,are *** study revealed that when a simply supported Euler-Bernoulli beam,resting on a Winkler soil model,is subject to an impact load,the resulting vertical displacements,bending moments and shear forces produced along the span of the beam are considerably *** particular,the quantification of this effect is best observed,relative to the corresponding static solution,via an amplification *** computed impact amplification factors,for the sub-grade moduli used in this study,were in magnitude greater than 2,thus confirming the multiple-degree-of-freedom nature of the problem.

关键词： beam-Winkler-soil model sub-grade moduli impact load impact distributed line load dynamic solution impact amplification factor

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Predicting the activity of single atom catalysts

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Science China Chemistry 2024年第9期67卷 2792-2793页

作者： giovanni Di Liberto Gianfranco Pacchioni Dipartimento di Scienza dei Materiali Universitàdi Milano-Bicoccavia R.Cozzi 5520125 MilanoItaly

For a long time,the existence of single-atom catalysts(SACs),consisting of isolated atoms stabilized in a specific support,was not detected due to limitations in available characterization *** the past two decades,however,the ability to synthesize and characterize these systems has opened the way toward designing and testing a new class of potential catalysts[1].

关键词： catalysts limitations testing

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