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New imaging technologies for robotic kidney cancer surgery

Asian Journal of Urology 2022年第3期9卷 253-262页

作者： Stefano Puliatti Ahmed Eissa Enrico Checcucci Pietro Piazza Marco Amato Stefania Ferretti Simone Scarcella Juan Gomez Rivas Mark Taratkin Jose Marenco Ines Belenchon Rivero Karl-Friedrich Kowalewski giovanni Cacciamani Ahmed El-Sherbiny Ahmed Zoeir Abdelhamid MEl-Bahnasy Ruben De Groote Alexandre Mottrie salvatore Micali Urology Department University of Modena&Reggio EmiliaModenaItaly ORSI Academy MelleBelgium Urology Department Faculty of MedicineTanta UniversityTantaEgypt Department of Surgery Candiolo Cancer InstituteFPO-IRCCSCandioloTurinItaly Division of Urology IRCCS Azienda Ospedaliero-Universitaria di BolognaBolognaItaly Department of Urology Polytechnic University of Marche RegionUmberto I Hospital“Ospedali Riuniti”AnconaItaly Uro-technology and SoMe Working Group of the Young Academic Urologists Working Party European Association of UrologyArnhemthe Netherlands Department of Urology Hospital Clinico San CarlosMadridSpain Institute for Urology and Reproductive Health Sechenov UniversityMoscowRussia Department of Urology Fundacio´n Instituto Valenciano de Oncologı´aValenciaSpain Urology and Nephrology Department Virgen del Rocı´o University HospitalManuel Siurot Sin NumeroSevilleSpain Department of Urology and Urological Surgery University Medical Centre MannheimMannheimGermany USC Institute of Urology University of Southern CaliforniaLos AngelesCAUSA Department of Urology Onze-Lieve-VrouwziekenhuisAalstBelgium

Objective:Kidney cancers account for approximately 2%of all newly diagnosed cancer in *** the primary treatment options for kidney cancer,urologist may choose between radical or partial nephrectomy,or ablative ***,robotic-assisted partial nephrectomy(RAPN)for the management of renal cancers has gained popularity,up to being considered the gold ***,RAPN is a challenging procedure with a steep learning ***:In this narrative review,different imaging technologies used to guide and aid RAPN are ***:Three-dimensional visualization technology has been extensively discussed in RAPN,showing its value in enhancing robotic-surgery training,patient counseling,surgical planning,and intraoperative *** imaging technologies such as intracorporeal ultrasound,near-infrared fluorescent imaging,and intraoperative pathological examination can also be used to improve the outcomes following ***,artificial intelligence may play a role in the field of RAPN ***:RAPN is a complex surgery;however,many imaging technologies may play an important role in facilitating it.

关键词： Kidney cancer Imaging Technology Robotic

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Benign intratesticular schwannoma:a rare finding

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Asian Journal of Andrology 2006年第1期8卷 101-103页

作者： Maria Chiara Sighinolfi Alessandro Mofferdin Stefano S.De Stefani Antonio Celia.salvatore Micali giovanni Saredi Giulio Rossi Riccardo Valli Giampaolo Bianchi Division of Urology Department of Pathology Section of Anatomic Pathology University of Modena 41100 ModenaItaly

Schwannoma is a peripheral nerve tumour, occasionally located in the genitourinary tract. We described an extremely rare case of intratesticular neurinoma in a 79-year-old patient. （Asian JAndrol 2006 Jan; 8： 101-103）

关键词： schwannoma Schwann cells testicular neoplasm S 100 protein

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Early graft dysfunction following adult-to-adult livingrelated liver transplantation:Predictive factors and outcomes

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World Journal of Gastroenterology 2009年第36期15卷 4556-4560页

作者： salvatore Gruttadauria Fabrizio di Francesco giovanni Battista Vizzini Angelo Luca Marco Spada Davide Cintorino Sergio Li Petri Giada Pietrosi Duilio Pagano Bruno Gridelli Department of Surgery University of PittsburghCoordinator Abdominal Adult Transplant.ISMETT (Mediterranean Institute for Transplant and Advanced Specialized TherapiesUniversity of Pittsburgh Medical Center in Italy)Via E. Tricomi N.190127 PalermoItaly Thomas Starzl Transplantation Institute University of Pittsburgh Medical CenterPittsburgh15213 PAUnited States

AIM:To describe a condition that we define as early graft dysfunction(EGD)which can be identified preoperatively. METHODS:Small-for-size graft dysfunction following living-related liver transplantation(LRLT)is characterized by EGD when the graft-to-recipient body weight ratio(GRBWR)is below 0.8%.However, patients transplanted with GRBWR above 0.8%can develop dysfunction of the *** 73 recipients of LRLT(GRBWR>0.8%),we identified 10 patients who developed *** main measures of outcomes analyzed were overall mortality,number of re-transplants and length of stay in days(LOS).Furthermore we analyzed other clinical pre-transplant variables,intraoperative parameters and post transplant ***:A trend in favor of the non-EGD group(3-mo actuarial survival 98%vs 88%,P=0.09;3-mo graft mortality 4.7%vs 20%,P=0.07)was observed as well as shorter LOS(13 d vs 41.5 d;P=0.001)and smaller requirement of peri-operative Units of Plasma (4 vs 14;P=0.036).Univariate analysis of pre- transplant variables identified platelet count,serum bilirubin,INR and Meld-Na score as predictors of EGD. In the multivariate analysis transplant Meld-Na score (P=0.025,OR:1.175)and pretransplant platelet count(P=0.043,OR:0.956)were independently associated with EGD. CONCLUSION:EGD can be identified preoperatively and is associated with increased morbidity after LRLT. A prompt recognition of EGD can trigger a timely treatment.

关键词：功能障碍肝移植成年人预测早期血小板计数十二指肠多因素分析

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Effectiveness of very low-volume preparation for colonoscopy:A prospective, multicenter observational study

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World Journal of Gastroenterology 2020年第16期26卷 1950-1961页

作者： Marcello Maida Emanuele Sinagra Gaetano Cristian Morreale Sandro Sferrazza Giuseppe Scalisi Dario Schillaci Marco Ventimiglia Fabio salvatore Macaluso giovanni Vettori Giuseppe Conoscenti Concetta Di Bartolo Serena Garufi Domenico Catarella Michele Manganaro Clara Maria Virgilio salvatore Camilleri Gastroenterology and Endoscopy Unit S.Elia-Raimondi HospitalCaltanissetta 93100Italy Gastroenterology and Endoscopy Unit Istituto San Raffaele GiglioCefalu 90015Italy Gastroenterology and Endoscopy Unit Santa Chiara HospitalTrento 38014Italy Gastroenterology Unit ARNAS GaribaldiCatania 95100Italy Gastroenterology Unit Basarocco HospitalNiscemi 93015CaltanissettaItaly Department of Internal Medicine Villa Sofia-Cervello HospitalPalermo 90100Italy

BACKGROUND The effectiveness of colonoscopy strictly depends on adequate bowel ***,a 1 L polyethylene glycol plus ascorbate(PEG-ASC)solution(Plenvu;Norgine,Harefield,United Kingdom)has been introduced on the evidence of three phase-3 randomized controlled trials,but it had never been tested in the *** To assess the effectiveness and tolerability of the 1 L preparation compared to 4 L and 2 L-PEG solutions in a real-life *** All patients undergoing a screening or diagnostic colonoscopy after a 4,2 or 1 L PEG preparation,were consecutively enrolled in 5 Italian centers from September 2018 to February *** primary endpoints of the study were the assessment of bowel cleansing success and high-quality cleansing of the right *** secondary endpoints were the evaluation of tolerability,adherence and safety of the different bowel *** cleansing was assessed through the Boston Bowel Preparation *** was defined as consumption of at least 75%of each dose,while tolerability was evaluated through a semiquantitative *** was systematically monitored through adverse events *** Overall,1289 met the inclusion criteria and were enrolled in the *** these,490 patients performed a 4 L-PEG preparation(Selgesse^■),566 a 2 L-PEG cleansing(Moviprep^■or Clensia^■)and 233 a 1 L-PEG preparation(Plenvu^■).Bowel cleansing by Boston Bowel Preparation Scale was 6.5±1.5 overall and 6.3±1.5,6.2±1.5,7.3±1.5(P<0.001)in the subgroups of 4 L,2 L and 1 L-PEG preparation,*** success was achieved in 72.4%,74.1%and 90.1%(P<0.001),while a high-quality cleansing of the right colon in 15.9%,12.0%and 41.4%(P<0.001)for 4 L,2 L and 1 L-PEG preparation groups,*** 1 L preparation was the most tolerated compared to the 2 and 4 L-PEG solutions in the absence of serious adverse events within any of the three *** regression models confirmed 1 L PEG-ASC preparation as an independ

关键词： Colonoscopy Bowel preparation Polyethylene glycol Polyethylene glycolplus ascorbate Effectiveness Tolerability

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The Company Clusters Power in Tourism Destinations: The Network Configuration and the Business Organisation

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Chinese Business Review 2022年第1期21卷 5-15页

作者： giovanni Ruggieri salvatore Iannolino University of Palermo PalermoItaly

Better and greater coordination and integration between companies are essential for tourist destination development processes improving ***,it is difficult to imagine that all companies can *** this way,we can imagine finding a group of companies that,for several reasons,decide to cooperate,creating some clusters as small *** with stable connections with other clusters or relevant companies could be relevant and central to Tourism Destination(TD)*** this way,the knowledge of network articulation seems to be critical for TD management business *** most cases,the relationships are hidden and not formalised,increasing the complexity in TD *** presence of clusters is possibly vitrificated using the Social Network Analysis(SNA)*** present work could be framed in cooperative networks since it analyses the companies’commercial networks and clusters *** article focuses on how groupings of small firms can govern Tourism *** paper uses network indexes and metrics to emphasise structural features regarding the density and centrality of *** the main result,in the case study analysed,there is a relational framework where three clusters of companies with a high density of exchanges *** groups can influence the tourism business at the destination.

关键词： Social Network Analysis Tourism Destination(TD) family relationships cooperation

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Evaluation and comparison of short chain fatty acids composition in gut diseases

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World Journal of Gastroenterology 2019年第36期25卷 5543-5558页

作者： Elena Niccolai Simone Baldi Federica Ricci Edda Russo Giulia Nannini Marta Menicatti giovanni Poli Antonio Taddei Gianluca Bartolucci Antonino salvatore Calabrò Francesco Claudio Stingo Amedeo Amedei Department of Experimental and Clinical Medicine University of Florence Florence 50134 Italy Department of Biomedical Experimental and Clinical Sciences “Mario Serio” University of Florence Florence 50134 Italy Department of Neurosciences Psychology Drug Research and Child Health Section of Pharmaceutical and Nutraceutical Sciences University of Florence Florence 50134 Italy Department of Statistics Computer Science Applications “G.Parenti” Florence 50134 Italy Department of Biomedicine Azienda Ospedaliera Universitaria Careggi Florence 50134 Italy

BACKGROUND An altered (dysbiosis) and unhealthy status of the gut microbiota is usually responsible for a reduction of short chain fatty acids (SCFAs) concentration. SCFAs obtained from the carbohydrate fermentation processes are crucial in maintaining gut homeostasis and their determination in stool samples could provide a faster, reliable and cheaper method to highlight the presence of an intestinal dysbiosis and a biomarker for various gut diseases. We hypothesize that different intestinal diseases, such as celiac disease (CD), adenomatous polyposis (AP) and colorectal cancer (CRC) could display a particular fecal SCFAs’ signature. AIM To compare the fecal SCFAs’ profiles of CD, AP, CRC patients and healthy controls, using the same analytical method. METHODS In this cross-sectional study, we defined and compared the SCFAs’ concentration in fecal samples of 9 AP, 16 CD, 19 CRC patients and 16 healthy controls (HC). The SCFAs’ analysis were performed using a gas-chromatography coupled with mass spectrometry method. Data analysis was carried out using Wilcoxon ranksum test to assess pairwise differences of SCFAs’ profiles, partial least squaresdiscriminate analysis (PLS-DA) to determine the status membership based on distinct SCFAs’ profiles, and Dirichlet regression to determine factors influencing concentration levels of SCFAs. RESULTS We have not observed any difference in the SCFAs’ amount and composition between CD and healthy control. On the contrary, the total amount of SCFAs was significantly lower in CRC patients compared to HC (P = 0.044) and CD (P = 0.005). Moreover, the SCFAs’ percentage composition was different in CRC and AP compared to HC. In detail, HC displayed higher percentage of acetic acid (P value = 1.3 × 10-6) and a lower amount of butyric (P value = 0.02192), isobutyric (P value = 7.4 × 10-5), isovaleric (P value = 0.00012) and valeric (P value = 0.00014) acids compared to CRC patients. AP showed a lower abundance of acetic acid (P value = 0.

关键词： Short chain fatty acids Microbiota Colorectal cancer Adenoma Celiac disease

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Comparison of imaging-based and pathological dimensions in pancreatic neuroendocrine tumors

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World Journal of Gastroenterology 2017年第17期23卷 3092-3098页

作者： salvatore Paiella Harmony Impellizzeri Elisabetta Zanolin giovanni Marchegiani Marco Miotto Anna Malpaga Riccardo De Robertis Mirko D'Onofrio Borislav Rusev Paola Capelli Sara Cingarlini giovanni Butturini Maria Vittoria Davì Antonio Amodio Claudio BassiAldo Scarpa Roberto Salvia Luca Landoni General and Pancreatic Surgery Department Pancreas InstituteUniversity and Hospital Trust of Verona Department of Public Health and Community Medicine University and Hospital Trust of Verona Department of Radiology Casa di Cura Pederzoli Department of Radiology Pancreas InstituteUniversity and Hospital Trust of Verona Department of Diagnostics and Public Health Section of PathologyUniversity and Hospital Trust of Verona ARC-NET Research Center University and Hospital Trust of Verona Department of Oncology Pancreas InstituteUniversity and Hospital Trust of Verona Hepato-bilio-pancreatic Surgery Unit Casa di Cura Pederzoli Section of Endocrinology Medicina Generale e Malattie Aterotrombotiche e DegenerativeDepartment of MedicineUniversity and Hospital Trust of Verona Gastroenterology B Department Pancreas InstituteUniversity and Hospital Trust of Verona

AIM To establish the ability of magnetic resonance(MR) and computer tomography(CT) to predict pathologic dimensions of pancreatic neuroendocrine tumors(Pan NET) in a caseload of a tertiary referral *** Patients submitted to surgery for Pan NET at the Surgical Unit of the Pancreas Institute with at least 1 preoperative imaging examination(MR or CT scan) from January 2005 to December 2015 were included and data retrospectively collected. Exclusion criteria were: multifocal lesions, genetic syndromes, microadenomas or mixed tumors, metastatic disease and neoadjuvant therapy. Bland-Altman(BA) and Mountain-Plot(MP) statistics were used to compare size measured by each modality with the pathology size. Passing-Bablok(PB) regression analysis was used to check the agreement between MR and *** Our study population consisted of 292 patients. Seventy-nine(27.1%) were functioning Pan NET. The mean biases were 0.17 ± 7.99 mm, 1 ± 8.51 mm and 0.23 ± 9 mm, 1.2 ± 9.8 mm for MR and CT, considering the overall population and the subgroup of non-functioning-Pan NET, respectively. Limits of agreement(LOA) included the vast majority of observations, indicating a good agreement between imaging and pathology. The MP further confirmed this finding and showed that the two methods are unbiased with respect to each other. Considering ≤ 2 cm non-functioning-Pan NET, no statistical significance was found in the size estimation rate of MR and CT(P = 0.433). PBR analysis did not reveal significant differences between MR, CT and *** MR and CT scan are accurate and interchangeable imaging techniques in predicting pathologic dimensions of Pan NET.

关键词：胰腺的瘤 Neuroendocrine 肿瘤磁性的回声成像诊断成像病理学的尺寸

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Pancreaticoduodenectomy in patients ≥ 75 years of age:Are there any differences with other age ranges in oncological and surgical outcomes? Results from a tertiary referral center

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World Journal of Gastroenterology 2017年第17期23卷 3077-3083页

作者： salvatore Paiella Matteo De Pastena Tommaso Pollini giovanni Zancan Debora Ciprani Giulia De Marchi Luca Landoni Alessandro Esposito Luca Casetti Giuseppe Malleo giovanni Marchegiani Massimiliano Tuveri Enrico Marrano Laura Maggino Erica Secchettin Deborah Bonamini Claudio Bassi Roberto Salvia General and Pancreatic Surgery Department Pancreas InstituteUniversity and Hospital Trust of Verona Gastroenterology B Department Pancreas InstituteUniversity and Hospital Trust of Verona

AIM To compare surgical and oncological outcomes after pancreaticoduodenectomy(PD) in patients ≥ 75 years of age with two younger cohorts of patients. METHODS The prospectively maintained Institutional database of pancreatic resection was queried for patients aged ≥ 75 years(late elderly, LE) submitted to PD for any disease from January 2010 to June 2015. We compared clinical, demographic and pathological features and survival outcomes of LE patients with 2 exact matched cohorts of younger patients [≥ 40 to 64 years of age(adults, A) and ≥ 65 to 74 years of age(young elderly, YE)] submitted to PD, according to selected variables. RESULTS The final LE population, as well as the control groups, were made of 96 subjects. Up to 71% of patients was operated on for a periampullary malignancy and pancreatic cancer(PDAC) accounted for 79% of them. Intraoperative data(estimated blood loss and duration of surgery) did not differ among the groups. The overall complication rate was 65.6%, 61.5% and 58.3% for LE, YE and A patients, respectively, P = NS). Reoperation and cardiovascular complications were significantly more frequent in LE than in YE and A groups(P = 0.003 and P = 0.019, respectively). When considering either all malignancies and PDAC only, the three groups did not differ in survival. Considering all benign diseases, the estimated mean survival was 58 and 78 mo for ≥ and < 75 years of age(YE + A groups), respectively(P = 0.012). CONCLUSION Age is not a contraindication for PD. A careful selection of LE patients allows to obtain good surgical and oncological results.

关键词：胰腺的癌症 Periampullary 癌症 Pancreaticoduodenectomy 老胰腺的外科

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Capsule endoscopy in pediatrics: A 10-years journey

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World Journal of Gastroenterology 2014年第44期20卷 16603-16608页

作者： salvatore Oliva Stanley A Cohen giovanni Di Nardo Gianfranco Gualdi salvatore Cucchiara Emanuele Casciani Department of Pediatrics Pediatric Gastroenterology Unit Sapienza University of Rome Children’s Center for Digestive Health Care Radiology DEA Sapienza University of Rome University Hospital Umberto I

Video capsule endoscopy(CE) for evaluation the esophagus(ECE), small bowel(SBCE) and the colon(CCE) is particularly useful in pediatrics, because this imaging modality does not require ionizing radiation, deep sedation or general anesthesia. The risk of capsule retention appears to be dependent on indication rather than age and parallels the adult experience by indication, making SBCE a relatively safe procedure with a significant diagnostic yield. The newest indication, assessment of mucosal change, greatly enhances and expands its potential benefit. The diagnostic role of CE extends beyond the SB. The use of ECE also may enhance our knowledge of esophageal disease and assist patient care. Colon CCE is a novel minimally invasive and painless endoscopic technique allowing exploration of the colon without need for sedation, rectal intubation and gas insufflation. The limited data on ECE and CCE in pediatrics does not yet allow the same conclusions regarding efficacy; however, both appear to provide safe methods to assess and monitor mucosal change in their respective areas with little discomfort. Moreover, although experience has been limited, the patency capsule may help lessen the potential of capsule retention; and newly researched protocols for bowel cleaning may further enhance CE's diagnostic yield. However, further research is needed to optimize the use of the various CE procedures in pediatric populations.

关键词： Capsule endoscopy Children Small bowel Pediatric e

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Atherosclerosis,inflammation and Chlamydia pneumoniae

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World Journal of Cardiology 2009年第1期1卷 31-40页

作者： giovanni Fazio Maria Giovino Alessandro Gullotti Daniela Bacarella Giuseppina Novo salvatore Novo Division of Cardiology University of Palermo90100PalermoItaly

Coronary heart disease is the single most common cause of illness and death in the developed *** atherosclerosis is by far the most frequent cause of ischemic heart disease,and plaque disruption with superimposed thrombosis is the main cause of the acute coronary syndromes of unstable angina,myocardial infarction,and sudden *** is the result of a complex interaction between blood elements,disturbed flow,and vessel wall abnormality,involving several pathological processes:inflammation,with increased endothelial permeability,endothelial activation,and monocyte recruitment;growth,with smooth muscle cell proliferation,migration,and matrix synthesis;degeneration,with lipid accumulation;necrosis,possibly related to the cytotoxic effect of oxidized lipid;calcification/ossification,which may represent an active rather than a dystrophic process;and thrombosis,with platelet recruitment and fibrin *** this review we discuss these processes and the possible pathological effects of Chlamydia infection and the ensuing phlogosis.

关键词： Chlamydia Coronary heart disease Coronary atherosclerosis Phlogosis

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