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Epidemiology,therapy and outcome of hepatocellular carcinoma between 2010 and 2019 in Piedmont,Italy

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 761-772页

作者： Christian Bracco Marta Gallarate Marco Badinella Martini Corrado Magnino salvatore D'Agnano Roberta Canta Giulia Racca Remo Melchio Cristina Serraino Valentina Polla Mattiot giovanni Gollè Luigi Fenoglio Department of Internal Medicine Santa Croce e Carle General HospitalCuneo 12100Italy Department of Medical Sciences "City of Health and Science"University HospitalTorino 10100Italy

BACKGROUND Hepatocellular carcinoma(HCC)is the most common primary liver malignancy and the second leading cause of cancer deaths *** is often diagnosed at an advanced stage and therefore its prognosis remains poor with a low 5-year survival *** patients have increasingly complex and constantly changing characteristics,thus up-to-date and comprehensive data are *** To analyze the epidemiology and main clinical characteristics of HCC patients in a referral center hospital in the northwest of Italy between 2010 and *** In this retrospective study,we analyzed the clinical data of all consecutive patients with a new diagnosis of HCC recorded at"Santa Croce e Carle"Hospital in Cuneo(Italy)between 1 January 2010 and 31 December *** highlight possible changes in HCC patterns over the 10-year period,we split the population into two 5-year groups,according to the diagnosis period(2010-2014 and 2015-2019).RESULTS Of the 328 HCC patients who were included(M/F 255/73;mean age 68.9±11.3 years),154 in the first period,and 174 in the *** C virus infection was the most common HCC risk factor(41%,135 patients).The alcoholic etiology rate was 18%,the hepatitis B virus infection etiology was 5%,and the non-viral/non-alcoholic etiology rate was 22%.The Child-Pugh score distribution of the patients was:class A 75%,class B 21%and class C 4%.The average Mayo end-stage liver disease score was 10.6±3.7.A total of 55 patients(17%)were affected by portal vein thrombosis and 158(48%)by portal *** average nodule size of the HCC was 4.6±3.1 cm.A total of 204 patients(63%)had more than one nodule<3,and 92%(305 patients)had a non-metastatic stage of the *** Barcelona Clinic Liver Cancer(BCLC)staging distribution of all patients was:4%very early,32%early,23%intermediate,34%advanced,and 7%*** survival rate was 1.6±0.3 *** 20%of the patients underwent ***,presence of ascites,BCLC stage and therapy w

关键词： Hepatocellular carcinoma Hepatitis virus Alcoholic hepatitis Non-alcoholic fatty liver disease Diagnosis Etiology Treatment

Frequency of and reasons behind non-listing in adult patients referred for liver transplantation: Results from a retrospective study

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World Journal of Transplantation 2024年第2期14卷 99-106页

作者： Marco Biolato Luca Miele Giuseppe Marrone Claudia Tarli Antonio Liguori Rosaria Calia giovanni Addolorato salvatore Agnes Antonio Gasbarrini Maurizio Pompili Antonio Grieco Department of Medical and Surgical Sciences CEMADFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy Department of Translational Medicine and Surgery Catholic University of Sacred HeartRome 00168Italy

BACKGROUND Few studies have evaluated the frequency of and the reasons behind the refusal of listing liver transplantation *** To assess the ineligibility rate for liver transplantation and its *** A single-center retrospective study was conducted on adult patients which entailed a formal multidisciplinary assessment for liver transplantation *** predictors for listing were evaluated using multivariable logistic *** In our center,314 patients underwent multidisciplinary work-up before liver transplantation enlisting over a three-year *** most frequent reasons for transplant evaluation were decompensated cirrhosis(51.6%)and hepatocellular carcinoma(35.7%).The non-listing rate was 53.8%and the transplant rate was 34.4%for the whole *** hundred and five motivations for ineligibility were *** most common contraindications were psychological(9.3%),cardiovascular(6.8%),and surgical(5.9%).Inappropriate or premature referral accounted for 76(37.1%)*** multivariable analysis,a referral from another hospital(OR:2.113;95%CI:1.259–3.548)served as an independent predictor of *** A non-listing decision occurred in half of our cohort and was based on an inappropriate or premature referral in one case out of *** referral from another hospital was taken as a strong predictor of non-listing.

关键词： Controindication Eligibility Evaluation Referral Personalized medicine

Epidermal radio frequency electronics for wireless power transfer

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Microsystems & Nanoengineering 2016年第1期2卷 52-60页

作者： Xian Huang Yuhao Liu Gil Woo Kong Jung Hun Seo Yinji Ma Kyung-In Jang Jonathan A.Fan Shimin Mao Qiwen Chen Daizhen Li Hank Liu Chuxuan Wang Dwipayan Patnaik Limei Tian giovanni a.salvatore Xue Feng Zhenqiang Ma Yonggang Huang John A.Rogers Department of Biomedical Engineering School of Precision Instrument and Opto-electronics EngineeringTianjin UniversityTianjin 300072China Department of Materials Science and Engineering University of Illinois at Urbana-ChampaignUrbanaIL 61801USA Department of Electrical and Computer Engineering University of Wisconsin-MadisonMadisonWI 53706USA Department of Civil and Environmental Engineering Northwestern UniversityEvanstonIL 60208USA Department of Engineering Mechanics Center for Mechanics and MaterialsTsinghua UniversityBeijing 100084China Department of Mechanical Engineering Northwestern UniversityEvanstonIL 60208USA Department of Robotics Engineering Daegu Gyeongbuk Institute of Science and TechnologyDaegu 42988Republic of Korea Department of Electrical Engineering Stanford UniversityStanfordCA 94305USA

Epidermal electronic systems feature physical properties that approximate those of the skin,to enable intimate,long-lived skin interfaces for physiological measurements,human–machine interfaces and other applications that cannot be addressed by wearable hardware that is commercially available today.A primary challenge is power supply;the physical bulk,large mass and high mechanical modulus associated with conventional battery technologies can hinder efforts to achieve epidermal characteristics,and near-field power transfer schemes offer only a limited operating *** we introduce an epidermal,farfield radio frequency(RF)power harvester built using a modularized collection of ultrathin antennas,rectifiers and voltage *** components,separately fabricated and tested,can be integrated together via methods involving soft contact *** studies of the individual components and the overall performance in various dielectric environments highlight the key operational features of these systems and strategies for their *** results suggest robust capabilities for battery-free RF power,with relevance to many emerging epidermal technologies.

关键词： antenna design epidermal electronics modularization silicon nanomembrane soft-contact lamination specific absorption rate wireless power

Nonalcoholic fatty liver disease and diabetes

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World Journal of Diabetes 2022年第9期13卷 668-682页

作者： Maria Irene Bellini Irene Urciuoli giovanni Del Gaudio Giorgia Polti giovanni Iannetti Elena Gangitano Eleonora Lori Carla Lubrano Vito Cantisani salvatore Sorrenti Vito D’Andrea Department of Surgical Sciences Sapienza University of RomeRome 00161Italy Department of Radiological Sciences Oncology and PathologySapienza University of RomeRome 00161Italy Department of Experimental Medicine Section of Medical PhysiopathologyFood Science and EndocrinologySapienza University of RomeRome 00161Italy

Nonalcoholic fatty liver disease(NAFLD)is the most prevalent chronic liver disease in the world and represents a clinical-histopathologic entity where the steatosis component may vary in degree and may or may not have fibrotic *** key concept of NAFLD pathogenesis is excessive triglyceride hepatic accumulation because of an imbalance between free fatty acid influx and *** epidemiological,biochemical,and therapeutic evidence supports the premise that the primary pathophysiological derangement in most patients with NAFLD is insulin resistance;thus the association between diabetes and NAFLD is widely recognized in the *** NAFLD is the hepatic manifestation of a metabolic disease,it is also associated with a higher cardiovascular *** B-mode ultrasound is widely adopted as a first-line imaging modality for hepatic steatosis,although magnetic resonance imaging represents the gold standard noninvasive modality for quantifying the amount of fat in these *** of NAFLD patients depends on the disease severity,ranging from a more benign condition of nonalcoholic fatty liver to nonalcoholic *** from alcohol,a Mediterranean diet,and modification of risk factors are recommended for patients suffering from NAFLD to avoid major cardiovascular events,as per all diabetic *** addition,weight loss induced by bariatric surgery seems to also be effective in improving liver features,together with the benefits for diabetes control or resolution,dyslipidemia,and ***,liver transplantation represents the ultimate treatment for severe nonalcoholic fatty liver disease and is growing rapidly as a main indication in Western *** review offers a comprehensive multidisciplinary approach to NAFLD,highlighting its connection with diabetes.

关键词： Bariatric surgery Diabetes Hepatic steatosis Liver fibrosis Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis

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World Journal of Gastroenterology 2022年第12期28卷 1226-1238页

作者： Nadia Marascio salvatore Rotundo Angela Quirino giovanni Matera Maria Carla Liberto Chiara Costa Alessandro Russo Enrico Maria Trecarichi Carlo Torti Department of Health Sciences Unit of MicrobiologyUniversity“Magna Graecia”of CatanzaroCatanzaro 88100Italy Department of Medical and Surgical Sciences Unit of Infectious and Tropical Diseases"Magna Graecia"University of CatanzaroCatanzaro 88100Italy

Hepatitis E virus(HEV)and hepatitis C virus(HCV)are both RNA viruses with a tropism for liver parenchyma but are also capable of extrahepatic *** E is usually a viral acute fecal-oral transmitted and self-limiting disease presenting with malaise,jaundice,nausea and ***,HEV causes a chronic infection in immunocompromised persons and severe fulminant hepatitis in pregnant *** HCV infection is typically asymptomatic for decades until chronic complications,such as cirrhosis and cancer,*** being two very different viruses in terms of phylogenetic and clinical presentations,HEV and HCV show many similarities regarding possible transmission through organ transplantation and blood transfusion,pathogenesis(production of antinuclear antibodies and cryoglobulins)and response to treatment with some direct-acting antiviral *** both HEV and HCV are well studied individually,there is a lack of knowledge about coinfection and its *** aim of this review is to analyze current literature by evaluating original articles and case reports and to hypothesize some interactions that can be useful for research and clinical practice.

关键词： Hepatitis C virus Hepatitis E virus Co-infection Genomic variability Extrahepatic diseases Vaccine

Hericium erinaceus,a medicinal fungus with a centuries-old history:Evidence in gastrointestinal diseases

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World Journal of Gastroenterology 2023年第20期29卷 3048-3065页

作者： Antonietta Gerarda Gravina Raffaele Pellegrino salvatore Auletta Giovanna Palladino giovanni Brandimarte Rossella D'Onofrio Giusi Arboretto Giuseppe Imperio Andrea Ventura Marina Cipullo Marco Romano Alessandro Federico Department of Precision Medicine University of Campania“Luigi Vanvitelli”Naples 80138Italy Division of Internal Medicine and Gastroenterology Cristo Re HospitalRome 00167Italy

Hericium erinaceus is an edible and medicinal mushroom commonly used in traditional Chinese medicine for *** studies have highlighted its therapeutic potential for gastrointestinal disorders such as gastritis and inflammatory bowel *** addition,some components of this mushroom appear to possess strong antineoplastic capabilities against gastric and colorectal *** review aims to analyse all available evidence on the digestive therapeutic potential of this fungus as well as the possible underlying molecular mechanisms.

关键词： Hericium erinaceus Fungus Gastritis Inflammatory bowel diseases Gastric cancer Colorectal cancer

Clinical applications of hepatocyte transplantation

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World Journal of Gastroenterology 2009年第17期15卷 2074-2077页

作者： Giada Pietrosi giovanni Battista Vizzini salvatore Gruttadauria Bruno Gridelli Department of Gastroenterology and Hepatology Mediterranean Institute for Transplantation and Advanced Specialized Therapies (IsMeTT) University of Pittsburgh Medical Center Palermo 90127 Italy Department of Surgery Mediterranean Institute for Transplantation and Advanced Specialized Therapies (IsMeTT) University of Pittsburgh Medical Center Palermo 90127 Italy

The shortage of organ donors is a problem worldwide, with approximately 15% of adult patients with lifethreatening liver diseases dying while on the waiting list. The use of cell transplantation for liver disease is an attempt to correct metabolic defects, or to support liver function as a bridge to liver transplantation and, as such, has raised a number of expectations. Most of the available studies briefly reported here focus on adult hepatocyte transplantation (HT), and the results are neither reproducible nor comparable, because the means of infusion, amount of injected cells and clinical variability differ among the studies. To better understand the specif ic role of HT in the management of end-stage liver disease, it is important that controlled studies, designed on the principles of evidence-based medicine, be done in order to guarantee the reproducibility of results.

关键词：肝细胞移植临床应用终末期肝病可重复性世界范围成年患者代谢缺陷肝脏疾病

A pediatric non-protein losing Menetrier's disease successfully treated with octreotide long acting release

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World Journal of Gastroenterology 2012年第21期18卷 2727-2729页

作者： giovanni Di Nardo salvatore Oliva Marina Aloi Federica Ferrari Simone Frediani Adriana Marcheggiano salvatore Cucchiara Department of Pediatrics Pediatric Gastroenterology and Liver Unit Sapienza University of Rome00161 Rome Italy Department of Medical Science Sapienza University of Rome00161 Rome Italy

Pediatric Menetrier's disease (MD) is an uncommon, acute, self-limited hypertrophic gastropathy characterized by enlarged gastric folds associated with epithelial hyperplasia and usually accompanied by protein losing gastropathy. Gastric cytomegalovirus infection is found in one third of MD children and its treatment is often associated with remission. Diagnosis often requires fullthickness biopsy due to inability to detect typical histological findings with conventional endoscopic biopsy. We report an uncommon case of non self-limited pediatric MD needing endoscopic mucosal resection for diagnosis which was then successfully treated with octreotide long-acting release (LAR). To the best of our knowledge, this is the first pediatric MD case successfully treated with octreotide LAR. Our experience suggests octreotide LAR as treatment for refractory MD before gastrectomy.

关键词：治疗蛋白儿童肽发行代理细胞增生病毒感染

Evaluation of the potential exposure of butterflies to genetically modified maize pollen in protected areas in Italy

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Insect Science 2018年第4期25卷 549-561页

作者： salvatore Arpaia Ferdinando Baldacchino Sara Bosi giovanni Burgio Simona Errico Rosaria Alessandra Magarelli Antonio Masetti salvatore Santorsola ENEA-Italian National Agency for New Technologies Energy and Sustainable Economic Development Research Centre Trisaia Rotondella (MT) Italy Dipartimento di Scienze Agrarie Alma Mater Studiorum Universita di Bologna Bologna Italy

Environmental impacts of genetically modified crops are mandatorily assessed during their premarket phase. One of the areas of concern is the possible impact on nontar- get organisms. Crops expressing Cry toxins might affect Lepidoptera larvae living outside cultivated fields, through pollen deposition on wild plants, which constitute their food source. While pollen toxicity varies among different events, possible exposure ofnontarget species depends on the agro-environmental conditions. This study was conducted in two protected areas in Italy, characterized by different climatic conditions, where many Lepi- doptera species thrive in proximity to maize cultivations. To estimate the possible exposure in absence of the actual stressor （e.g., Cryl-expressing maize plants）, we conducted a two-year field survey of butterflies and weeds. Indicator species were selected--Aglais （Inachis） io in the Northern site and Vanessa cardui in the Southern site--and their phe- nology was investigated. Pollen dispersal from maize fields was measured by collection in Petri dishes. Duration and frequency of exposure was defined by the overlap between pollen emission and presence of larvae on host plants. Different risk scenarios are expected in the two regions： highest exposure is foreseen forA. io in the Northern site, while minimal exposure is estimated for V. cardui in the Southern site. In the latter case, locally grown maize cultivars flower in mid-summer in coincidence with an aestivation period for several butterfly species due to hot and dry conditions. Moreover, host plants of V. cardui are at the end of their life cycle thus limiting food availability.

关键词： environmental risk assessment exposure assessment genetically modified plants Lepidoptera nontarget organisms receiving environment