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Analysis of 12 variants in the development of gastric and colorectal cancers

World Journal of Gastroenterology 2017年第48期23卷 8533-8543页

作者： giovanna c cavalcante Marcos AT Amador Andre M Ribeiro dos Santos Darlen c carvalho Roberta B Andrade Esdras EB Pereira Marianne R Fernandes Danielle F costa Ney Pc Santos Paulo P Assumpcao Andrea Ribeiro dos Santos Sidney Santos Laboratório de Genética Humana e Médica Universidade Federal do Pará Núcleo de Pesquisas em Oncologia Universidade Federal do Pará

AIM To evaluate the relation between 12 polymorphisms and the development of gastric cancer(Gc) and colorectal cancer(cRc).METHODS In this study,we included 125 individuals with Gc diagnosis,66 individuals with cRc diagnosis and 475 cancer-free individuals. All participants resided in the North region of Brazil and authorized the use of their samples. The 12 polymorphisms(in cASP8,cYP2 E1,cYP19 A1,IL1 A,IL4,MDM2,NFKB1,PAR1,TP53,TYMS,UGT1 A1 and XRcc1 genes) were genotyped in a single PcR for each individual,followed by fragment analysis. To avoid misinterpretation due to population substructure,we applied a previously developed set of 61 ancestryinformative markers that can also be genotyped by multiplex PcR. The statistical analyses were performed in Structure v.2.3.4,R environment and SPSS *** After statistical analyses with the control of confounding factors,such as genetic ancestry,three markers(rs79071878 in IL4,rs3730485 in MDM2 and rs28362491 in NFKB1) were positively associated with the development of Gc. One of these markers(rs28362491) and the marker in the UGT1 A1 gene(rs8175347) were positively associated with the development of cRc. Therefore,we investigated whether the joint presence of the deleterious alleles of each marker could affect the development of cancer and we obtained positive results in all analyses. carriers of the combination of alleles RP1 + DEL(rs79071878 and rs28361491,respectively) are at 10-times greater risk of developing Gc than carriers of other combinations. Similarly,carriers of the combination of DEL + RARE(rs283628 and rs8175347) are at about 12-times greater risk of developing cRc than carriers of other *** These findings are important for the comprehension of gastric and cRc development,particularly in highly admixed populations,such as the Brazilian population.

关键词： Inflammatory processes Immune response Genomic and cellular stability Gastric cancer colorectal cancer Amazon

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chestnut tannin:New use,research and bioeconomy

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Journal of Bioresources and Bioproducts 2024年第3期9卷 246-252页

作者： Rosaria ciriminna Francesco Meneguzzo giovanna Li Petri cosimo Meneguzzo Giuseppe Angellotti Mario Pagliaro Istituto per lo Studio dei Materiali Nanostrutturati CNRvia U.La Malfa 15390146 PalermoItaly Istituto per la Bioeconomia CNRvia Madonna del Piano 1050019 Sesto Fiorentino(FI)Italy HyRes Srl via Salvator Rosa 1882100 BeneventoItaly

chestnut tannin,extracted from the bark or wood of chestnut trees,possesses unique properties that make it valuable in various *** serves as a natural source of tannins,which are widely used in the production of leather,textiles,and wood *** research continues to explore its potential applications,chestnut tannin remains a promising resource with diverse industrial *** new use,research and bioeconomy aspects,this study provides a unified perspective on chestnut *** advanced applications will likely emerge shortly.

关键词： Tannin chestnut Bioeconomy Tannin market Hydrolysable tannin

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Novel Brick Technology for carbon Reduction Footprint in Steel Shop Linings

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china's Refractories 2024年第2期33卷 16-21页

作者： carlos PAGLIOSA Leandro ROcHA Marcelo BORGES celio cavalcante RHI MAGNESITA Contagem32210-000Brazil

clean steel encompasses a multitude of concepts that are based on fulfilling customer requirements and can be produced in many ways depending on the existing equipment and detailed customer demands.A common feature of all clean steel production is tight process control along with continuous *** meet an increasing demand for cold-rolled(cR)steel sheets of improved mechanical properties,and to cope with the change of the annealing process from a batch-type to a continuous process,it is necessary to establish a technique for making ultralow carbon(ULc)steel with a c-concentration lower than 20 ppm for the steelmaking process associated with a major challenge to guarantee the competitiveness with observance of environmental *** ladle lining plays an important role on the energy consumption during the production and the refractory lining design contributes to minimize thermal bath loss,carbon pick up and shell temperature.A new generation of unfired zero carbon refractories was developed with two specific approaches:(1)replacement of firing bricks reducing cO_(2) footprint and(2)replacement of carbon containing with performance *** can be used in working and safety linings with a unique microstructure with better heat scattering and similar thermomechanical *** work presents customers’performance compared to traditional products highlighting energy savings.

关键词： steel ladle zero carbon energy saving

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corrigendum to ‘A novel STK11 gene mutation (c.388dupG,***130Glyfs∗33) in a Peutz-Jeghers family and evidence of higher gastric cancer susceptibility associated with alterations in STK11 region aa 107–170’ [Gene Dis (9) (2022) 288–291]

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Genes & Diseases 2024年第2期11卷 1082-1083页

作者： giovanna Forte Filomena cariola Katia De Marco Andrea Manghisi Filomena Anna Guglielmi Raffaele Armentano Giuseppe Lippolis Pietro Giorgio cristiano Simone Vittoria Disciglio Medical Genetics National Institute of Gastroenterology “S. de Bellis” Research Hospital Castellana Grotte Bari 70013 Italy Histopathology Unit National Institute of Gastroenterology “S. de Bellis” Research Hospital Castellana Grotte Bari 70013 Italy Department of General Surgery National Institute of Gastroenterology “S. de Bellis” Research Hospital Castellana Grotte Bari 70013 Italy Gastroenterology and Digestive Endoscopy Unit National Institute of Gastroenterology “S. de Bellis” Research Hospital Castellana Grotte Bari 70013 Italy Department of Biomedical Sciences and Human Oncology (DIMO) Medical Genetics University of Bari Aldo Moro Piazza Umberto I Bari 70124 Italy

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Growth mechanism of octahedron-like BaMoO_4 microcrystals processed in microwave-hydrothermal:Experimental observations and computational modeling

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Particuology 2009年第5期7卷 353-362页

作者： Laécio Santos cavalcante Júlio césar Sczancoski Rircado Luis Tranquilin José Arana Varela Elson Longo Marcelo Ornaghi Orlandi Departamento de Química UFSCarP.O. Box 67613565-905So CarlosSPBrazil Instituto de Química-UNESP P.O. Box 35514801-907AraraquaraSPBrazil

Octahedron-like BaMoO4 microcrystals were synthesized by the co-precipitation method at room temperature and processed in microwave-hydrothermal at 413 K for different times （from 30 min to 5 h）. These microcrystals were analyzed by X-ray diffraction （XRD）, field-emission gun scanning electron microscopy （FEG-SEM） and transmission electron microscopy （TEM）. XRD patterns showed that this material presents a tetragonal structure without the presence of deleterious phases. FEG-SEM and TEM micrographs revealed that the BaMoO4 microcrystals present an octahedron-like morphology with agglomerate nature and polydisperse particle size distribution. These micrographs also indicated that the microcrystals grow along the [0 01 ] direction. The observed crystallographic planes in these structures were modeled computationally and a crystal growth model was proposed in order to explain the morphological changes as a function of processing time.

关键词： BaMoO4 Growth process Microwave-hydrotherma Supersaturated solution

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Elucidating the pathological mechanisms of neurodegeneration in the lethal serpinopathy FENIB

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Neural Regeneration Research 2022年第8期17卷 1733-1734页

作者： Elena Miranda giovanna Galliciotti Department of Biology and Biotechnologies‘charles Darwin’and Pasteur Institute-cenci Bo-lognetti Foundation Sapienza University of RomeRomeItaly Institute of Neuropathology University Medical Center Hamburg-EppendorfHamburgGermany

The term serpinopathies was introduced to describe a family of diseases caused by point mutations in serine protease inhibitors,or *** inhibit their cognate protease by an irreversible suicide mechanism starting with the attack of the active site serine on the reactive center loop of the inhibitor,followed by formation of a covalent complex between both proteins,insertion of the reactive center loop of the serpin into its own beta-sheet A,and culminating in distortion of the active site of the serine protease and thus irreversible *** inhibitory mechanism,reminiscent of the movement of a mousetrap,requires a structural flexibility that proves to be unfavorable when the folding of the serpin is altered by mutations responsible for conformational rearrangements,allowing an intermolecular domain exchange characterized by the insertion of the c-terminal domain of a molecule into a second one,thus forming a *** of this insertion reaction leads to the formation of serpin polymers that accumulate within the endoplasmic reticulum(ER)of the cell and consequently reduces the secretion of the wild-type serpin(Greene et al.,2016).

关键词： insertion irreversible starting

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clinicopathological Description of a chronic Lymphocytic Leukemia in a Dog

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Open Journal of Veterinary Medicine 2024年第7期14卷 155-162页

作者： Maria clara Boni Raffi giovanna Valverde Magalhães Barbosa Alana carolina capais Rodrigues Sheila canevese Rahal John P. Kastelic Luíz Guilherme Dercore Benevenuto Iolanda Simões Braga Beatriz Poloni Batista Felipe césar Da Silva Brasileiro Fernanda Barthelson carvalho de Moura Priscylla Tatiana chalfun Guimarães Okamoto Regina Kiomi Takahira Alessandra Melchert Noeme Sousa Rocha Department of Veterinary clinics School of Veterinary Medicine and Animal Science So Paulo State UniversityUNESP Botucatu SP Brazil Independent Veterinary Practitioner Department of Veterinary Surgery and Animal Reproduction School of Veterinary Medicine and Animal Science So Paulo State UniversityUNESP Botucatu SP Brazil Faculty of Veterinary Medicine University of Calgary Calgary Canada

Hematopoietic tumors are associated with diagnostic and therapeutic challenges and a poor prognosis. Furthermore, their pathophysiology in dogs is not well understood. chronic lymphocytic leukemia has been rarely reported in golden retrievers, perhaps due to difficulties in diagnosis and care. An 8-year-old spayed female golden retriever was referred to our hospital with a 2-month history of fatigue, weakness, and selective appetite. The dog was diagnosed with chronic lymphocytic leukemia based on blood smear evaluation. Despite treatment, the dog deteriorated and the owners opted for euthanasia. Histopathological examination revealed atypical lymphocytes in the spleen, extramedullary hematopoiesis in the spleen and liver, bone marrow depletion, moderate neutrophilic myocarditis, and acute renal tubular necrosis. In an immunohistochemical panel, cells in the spleen and bone marrow were positive for anti-cD20, anti-cD45, anti-cD3, anti-IBA-1, anti-Ki67, anti-MUM-1, and anti-PAX-5. In conclusion, the leukemia diagnosis was confirmed through reactive histiocytosis, marked extramedullary hematopoiesis, and other clinical and laboratory findings. Herein, we report a case of chronic lymphocytic leukemia in a female dog with clinical, laboratory, and necroscopy findings.

关键词： canine cancer Neoplasia Therapeutics

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A useful toolbox for the detection of ScF E3 ligase activity

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Molecular Plant 2022年第11期15卷 1654-1655页

作者： Federica casagrande Qi Xie giovanna Serino Dipartimento di Biologia e Biotecnologie“c.Darwin ”Sapienza Universitàdi RomaPiazzale Aldo Moro 500185 RomeItaly State Key Laboratory of Plant Genomics Institute of Genetics and Developmental BiologyThe Innovative Academy of Seed DesignChinese Academy of SciencesBeijing 100101China

Since its discovery about 50 years ago,the ubiquitin-proteasome system(UPS)has not stopped to surprise us for its level of sophistication and complexity in achieving substrate-specific protein degradation(Vierstra,2009).At the heart of this system lies the concerted activity of three major classes of enzymes:ubiquitin activators(E1),ubiquitin conjugators(E2),and ubiquitin ligases(or E3).E3s,together with selected E2s,are responsible for promoting the formation of a ubiquitin chain on a specific protein substrate.

关键词： stopped ligase ubiquitin

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Rietveld refinement and optical properties of SrWO_4:Eu^(3+) powders prepared by the non-hydrolytic sol-gel method

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Journal of Rare Earths 2015年第2期33卷 113-128页

作者： P.F.S.Pereira I.c.Nogueira E.Longo E.J.Nassar I.L.V.Rosa L.S.cavalcante chemistry Institute University of the State of Sao Paulo Julio de Mesquita Filho-UNESP Francisco DegniAraraquara-SP 14800-900 Brazil LIEc-chemistry Department Federal University of Sao Carlos Via Washington Luis Km 235Sao Carlos-SP 13565-905 Brazil University of Franca-UNIFRAN Via Dr.Armando Sales de OliveiraNo.201 Franca-SP 14404-600 Brazil ccN-DQ-GERATEc University of the State of Piauí Joao Cabral 2231 P.O.Box 391Terezina PI 64002-150 Brazil

We investigated the effect of annealing time on the structure and optical properties of Sr WO4：Eu^3＋ powders prepared by the non-hydrolytic sol-gel method and heat treated at 800 ℃ for 2,4,8 and 16 *** and differential thermal analyses revealed that Sr WO4：Eu^3＋ powders were obtained at about 800 ℃.X-ray diffraction patterns and Rietveld refinement data confirmed that all powders had a scheelite-type tetragonal ***-Raman and Fourier transform infrared spectra indicated structural order at short range and anti-symmetric stretching vibrations of O-W-O bonds associated with tetrahedral[WO4]*** properties were investigated by ultraviolet-visible（UV-vis）diffuse reflectance,and photoluminescence（PL）data which provided the evolution of quantum efficiency（η）and lifetime（τ）.UV-vis spectroscopy evidenced intermediate energy levels within the band gap of Sr WO4：Eu^3＋ *** properties validated that the Eu^3＋ electric-dipole（^5D0→^7F2）transition in PL emission spectra was dominant which proved that Eu^3＋ ions were positioned in a site without an inversion center.[（^5D0→^7F2）/（^5D0→^7F1）]band ratios showed that Eu^3＋ ions were located in a low symmetry *** PL emission,ηandτproved the dependence on the annealing time in the behavior of Sr WO4：Eu3＋powders with a higher relative emission PL intensity as well as higherηandτvalues related to other samples when heat treated at 800℃ for 8 h.

关键词： SrWO4 Rietveld refinement optical band gap Eu^(3+) +-rare earth luminescence

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can Biochar Protect Labile Organic Matter Against Mineralization in Soil?

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Pedosphere 2017年第5期27卷 822-831页

作者： giovanna b.melas oriol ortiz josep m.alacaiz departament de biologia animal de biologia vegetal i d’ecologiafacultat de biociènciesuniversitat autònoma de barcelonaCerdanyola del Valles 08193(Spain) centre de recerca ecologica i aplicacions forestals(creaf) Cerdanyola del Valles E08193(Spain) dipartimento di agraria universitádegli studi di sassariViale Italia 39Sassari 071O0(halla) departamento de ciencias agrarias y del medio natural escuela politécnica superior de huescauniversidad de zaragozaHuesca E22071(Spain)

Biochar could help to stabilize soil organic （SOM） matter, thus sequestering carbon （c） into the soil. The aim of this work was to determine an easy method i） to estimate the effects of the addition of biochar and nutrients on the organic matter （SOM） mineralization in an artificial soil, proposed by the Organization for Economic co-operation and Development （OEcD）, amended with glucose and ii） to measure the amount of labile organic matter （glucose） that can be sorbed and thus be partially protected in the same soil, amended or not amended with biochar. A factorial experiment was designed to check the effects of three single factors （biochar, nutrients, and glucose） and their interactions on whole SOM mineralization. Soil samples were inoculated with a microbial inoculum and preincubated to ensure that their biological activities were not limited by a small amount of microbial biomass, and then they were incubated in the dark at 21 ~c for 619 d. Periodical measurements of c mineralized to carbon dioxide （cO2） were carried out throughout the 619-d incubation to allow the mineralization of both active and slow organic matter pools. The amount of sorbed glucose was calculated as the difference between the total and remaining amounts of glucose added in a soil extract. Two different models, the Freundlich and Langmuir models, were selected to assess the equilibrium isotherms of glucose sorption. The cO2-c release strongly depended on the presence of nutrients only when no biochar was added to the soil. The mineralization of organic matter in the soil amended with both biochar and glucose was equal to the sum of the mineralization of the two c sources separately. Furthermore, a significant amount of glucose can be sorbed on the biochar-amended soil, suggesting the involvement of physico-chemical mechanisms in labile organic matter protection.

关键词： c source glucose sorption microbial biomass nutrients soil respiration

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