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Hepatocellular carcinoma in non-alcoholic steatohepatitis without cirrhosis

World Journal of Gastroenterology 2023年第2期29卷 343-356页

作者： Cristiane Valle Tovo Angelo Zambam de Mattos Gabriela Perdomo Coral giovana D P sartori Livia Villela Nogueira Gustavo Tovo Both Cristiane A Villela-Nogueira Angelo A de Mattos Department of Internal Medicine Universidade Federal de Ciências da Saúde de Porto AlegrePorto Alegre 90050170RSBrazil Department of Internal Medicine Fundação Técnico Educacional Souza MarquesRJ 21491-630RJBrazil Department of Internal Medicine Universidade Luterana do BrasilCanoas 92425-350RSBrazil Department of Internal Medicine Universidade Federal do Rio de JaneiroRio de Janeiro 21491-630RJBrazil

Cirrhosis is an emerging major cause of the development of hepatocellular carcinoma(HCC),but in non-alcoholic fatty liver disease(NAFLD),up to 50%of patients with HCC had no clinical or histological evidence of *** is currently challenging to propose general recommendations for screening patients with NAFLD without cirrhosis,and each patient should be evaluated on a caseby-case basis based on the profile of specific risk factors *** HCC screening in NAFLD,a valid precision-based screening is ***,when evaluating this population of patients,the use of non-invasive methods can guide the selection of those who should undergo a screening and surveillance ***,the objective of the present study is to review the epidemiology,the pathophysiology,the histopathological aspects,the current recommendations,and novel perspectives in the surveillance of non-cirrhotic NAFLD-related HCC.

关键词： Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Hepatocellular carcinoma Genetic variants Microbiota Obesity

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Phytochemical Analysis and Antifungal Activity of Extracts from Leaves and Fruit residues of Brazilian savanna Plants Aiming Its Use as safe Fungicides

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Natural Products and Bioprospecting 2016年第4期6卷 195-204页

作者： Caroline Alves Breda Alessandra Marcon Gasperini Vera Lucia Garcia Karin Maia Monteiro giovana Anceski Bataglion Marcos Nogueira Eberlin Marta Cristina Teixeira Duarte School of Food Engineering State University of CampinasUNICAMPMonteiro Lobato Street80BaraōGeraldoCampinasSaōPaulo 13083-862Brazil Microbiology Division of research Center for Chemistry Biology and Agriculture–CPQBAUniversity of CampinasUNICAMPAlexandre Cazelatto Street999BetelPaulı´niaSaöPaulo 13148-218Brazil Organic Chemistry and Pharmaceutical Division of research Center for Chemistry Biology and Agriculture–CPQBAUniversity of CampinasUNICAMPAlexandre Cazelatto Street999BetelPaulíniaSaöPaulo 13148-218Brazil Pharmacology and Toxicology Division of research Center for Chemistry Biology and Agriculture–CPQBAUniversity of CampinasUNICAMPAlexandre Cazelatto Street999BetelPaulíniaSaöPaulo 13148-218Brazil ThoMSon Mass Spectrometry Laboratory Institute of ChemistryState University of CampinasUNICAMPCampinasSaōPaulo 13084-971Brazil

The increasing demand for.safe food without preservatives or pesticides residues has encouraged several studies on natural products with antifungal activity and low *** this study,ethanolic extracts from leaves and fruit residues(peel and seeds)of three Brazilian savanna species(Acrocomia aculeata,Campomanesia adamantium and Caryocar brasiliense)were evaluated against phytopathogenic ***,the most active extract was chemically characterized by ESI-MS and its oral acute toxicity was *** from ***(pequi)peel and leaves were active against Alternaria alternata,Alternaria solani and Venturia pirina with minimal inhibitory concentrations between 350 and 1000 lg/*** incorporated in solid media,these extracts extended the lag phase of *** and *** and reduced the growth rate of *** peel extract showed better antifungal activity and their ESI-MS analysis revealed the presence of substances widely reported as antifungal such as gallic acid,quinic acid,ellagic acid,glucogalin and *** oral acute toxicity was relatively low,being considered safe for use as a potential natural fungicide.

关键词： Brazilian savanna fruits residues Natural fungicides Phytopathogens

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Metabolic Syndrome and DNA Damage: The Interplay of Environmental and Lifestyle Factors in the Development of Metabolic Dysfunction

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Open Journal of Endocrine and Metabolic Diseases 2015年第7期5卷 65-76页

作者： Giuseppe Potrick Stefani giovana Baldissera ramiro Barcos Nunes Thiago Gomes Heck Cláudia ramos rhoden Laboratory of Physiology Universidade Federal de Ciências da Saúde de Porto Alegre Porto Alegre Brazil Laboratory of Oxidative Stress and Atmospheric Pollution Universidade Federal de Ciências da Saúde de Porto Alegre Porto Alegre Brazil Laboratory of Toxicological Genetics Universidade Federal de Ciências da Saúde de Porto Alegre Porto Alegre Brazil research Group in Physiology Regional University of Northwestern State’s Rio Grande do Sul (UNIJUI) Ijuí Brazil Postgraduate Program in Integral Attention to Health Regional University of Northwestern State’s Rio Grande do Sul (UNIJUI) Ijuí Brazil Department of Pharmacologic Sciences Universidade Federal de Ciências da Saúde de Porto Alegre Porto Alegre Brazil

The Metabolic Syndrome (MetS) is a complex condition which is characterized by increased risk factor for cardiovascular diseases, such as dyslipidemia, hypertension and central obesity, in addition to increased risk for type 2 diabetes mellitus (T2DM). All of these factors alone have a notable relationship with DNA damage. However, when the risks are combined, the extent for major outcomes being related to DNA damage (cancer), the consequence can be accelerated by the metabolic dysfunction. This article will illustrate the scientific evidence of the role of DNA damage in MetS, as well as discuss the interplay of major risks factors (air pollution, physical inactivity and dietary interventions) in genomic stability.

关键词： Metabolic Syndrome DNA Damage Diet Physical Activity Air Pollution

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