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Shear-wave elastography to predict hepatocellular carcinoma after hepatitis C virus eradication:A systematic review and meta-analysis

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World Journal of Gastroenterology 2024年第10期30卷 1450-1460页

作者： giorgio Esposto Paolo Santini Linda Galasso Irene Mignini Maria Elena Ainora Antonio Gasbarrini Maria Assunta Zocco CEMAD Digestive Disease Center Fondazione Policlinico Universitario“A.Gemelli”IRCCSCatholic University of RomeRome 00168Italy Fondazione Policlinico Universitario Agostino Gemelli IRCCS Fondazione Policlinico Universitario Agostino Gemelli IRCCS-UniversitàCattolica del Sacro CuoreRome 00168Italy Medicina Interna e Gastroenterologia CEMAD Digestive Disease CenterUniversitàCattolica del Sacro CuoreFondazione Policlinico Universitario A Gemelli IRCCSRome 00168Italy

BACKGROUND Direct-acting antiviral agents(DAAs)are highly effective treatment for chronic hepatitis C(CHC)with a significant rate of sustained virologic response(SVR).The achievement of SVR is crucial to prevent additional liver damage and slow down fibrosis *** assessment of fibrosis degree can be performed with transient elastography,magnetic resonance elastography or shear-wave elastography(SWE).Liver elastography could function as a predictor for hepato-cellular carcinoma(HCC)in CHC patients treated with *** To explore the predictive value of SWE for HCC development after complete clearance of hepatitis C virus(HCV).METHODS A comprehensive literature search of clinical studies was performed to identify the ability of SWE to predict HCC occurrence after HCV *** accordance with the study protocol,a qualitative and quantitative analysis of the evidence was *** At baseline and after 12 wk of follow-up,a trend was shown towards greater liver stiffness(LS)in those who go on to develop HCC compared to those who do not[baseline LS standardized mean difference(SMD):1.15,95%confidence interval(95%CI):020-2.50;LS SMD after 12 wk:0.83,95%CI:0.33-1.98].The absence of a statistically significant difference between the mean LS in those who developed HCC or not may be related to the inability to correct for confounding factors and the absence of raw source *** was a statist-ically significant LS SMD at 24 wk of follow-up between patients who developed HCC vs not(0.64;95%CI:0.04-1.24).CONCLUSION SWE could be a promising tool for prediction of HCC occurrence in patients treated with *** studies with larger cohorts and standardized timing of elastographic evaluation are needed to confirm these data.

关键词： Shear-wave elastography Hepatocellular carcinoma Hepatitis C virus Sustained virologic response

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Neoadjuvant strategies for pancreatic cancer

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World Journal of Gastroenterology 2014年第28期20卷 9374-9383页

作者： Francesco Polistina Giuseppe Di Natale giorgio Bonciarelli Giovanni Ambrosino Mauro Frego Department of General Surgery Monselice Hospital Rome University "La Sapienza" School of Surgery Piazzale Aldo Moro Department of Clinical Oncology Monselice Hospital Department of Surgery Malzoni Hospital

Pancreatic cancer(PC)is the fourth cause of cancer death in Western countries,the only chance for long term survival is an R0 surgical resection that is feasible in about 10%-20%of all *** years cumulative survival is less than 5%and rises to 25%for radically resected *** 40%has locally advanced in PC either borderline resectable(BRPC)or unresectable locally advanced(LAPC).Since LAPC and BRPC have been recognized as a particular form of PC neoadjuvant therapy(NT)has increasingly became a valid treatment *** aim of NT is to reach local control of disease but,also,it is recognized to convert about40%of LAPC patients to R0 resectability,thus providing a significant improvement of prognosis for responding *** R0 resection is achieved,survival is comparable to that of early stage PCs treated by upfront *** it is crucial to look for a proper patient *** strategies are multiples and include neoadjuvant chemotherapy(nCT),and the association of nCT with radiotherapy(nCRT)given as either a combination of a radio sensitizing drug as gemcitabine or capecitabine or and concomitant irradiation or as upfront nCT followed by nRT associated to a radio sensitizing *** latter seem to be most promising as it may select patients who do not go on disease progression during initial treatment and seem to have a better *** clinical relevance of nCRT may be enhanced by the application of higher active protocols as FOLFIRINOX.

关键词： Pancreatic cancer Neoadjuvant Chemotherap Radiotherapy Chemoradiation

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Highly dispersed NiMo@rgo nanocomposite catalysts fabricated by a two-step hydrothermal method for hydrogen evolution

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International Journal of Minerals,Metallurgy and Materials 2023年第12期30卷 2432-2440页

作者： Duanhao Cao Xiaofeng Ma Yipeng Zhang La ta Yakun Yang Chao Xu Feng Ye Jianguo Liu School of Energy Power and Mechanical Engineering North China Electric Power UniversityBeijing 102206China

Exploring and designing a high-performance non-noble metal catalyst for hydrogen evolution reaction(HER)are crucial for the large-scale application of H2 by water ***,novel catalysts with NiMo nanoparticles decorated on reduced graphene oxide(NiMo@r go)synthesized by a two-step hydrothermal method were *** characterization results showed that the prepared NiMo@r go-1 had an irregular lamellar structure,and the NiMo nanoparticles were uniformly dispersed on the ***@rgo-1 exhibited outstanding HER performance in an alkaline environment and required only 93 and 180 mV overpotential for HER in 1.0 M KOH solution to obtain current densities of-10 and-50 mA·cm^(-2),*** tests showed that NiMo@rgo-1 had a certain operating stability for32 *** the same condition,the performance of NiMo@rgo-1 can be comparable with that of commercial Pt/C catalysts at high current *** synergistic effect between NiMo particles and lamellate graphene can remarkably promote charge transfer in electrocatalytic *** a result,NiMo@rgo-1 presented the advantages of high intrinsic activity,large specific surface area,and small electrical *** lamellar graphene played a role in dispersion to prevent the aggregation of *** prepared NiMo@rgo-1 can be used in anion exchange membrane water electrolysis to produce *** study provides a simple preparation method for efficient and low-cost water electrolysis to produce hydrogen in the future.

关键词： hydrogen evolution reaction NiMo nanocomposite reduced graphene oxide synergistic effect

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Complications of goitre Surgery in “A” Surgery at the Chu of Point G

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Surgical Science 2021年第3期12卷 46-52页

作者： Moussa Sissoko Mahamadou Coulibaly Oumar Sacko Sekou Koumaré Adaman F. Traoré Soumaîla Keïta Sidiki Keita Siaka Diallo Mossa Camara Lamine Soumaré Adama K. Koïta A. Camara H. Dicko D. goïta Zimogo Zié Sanogo General Surgery “A” Department Hospital Point-G. Bamako Mali

Total or partial thyroidectomy has been proposed as the initial treatment for benign euthyroid oiter. The aim of this study is to determine the complications associated with surgical procedures for goiter, based on our experience. Material and method: A retrospective study over 10 years concerning 409 patients operated on for goiters in the department with 48 cases of complications. Results: 409 patients operated on for goiter in the department with 48 cases of complications (11.82%). The per- and post-operative complications were: hemorrhage (18: 4.40%), recurrent lesions (1;0.24%), 8 cases of infection (1.96%), 5 cases of transient hypocalcemia (1.22%) and phonation disorders 9 cases (2.20%). Conclusion: Complications from goiter surgery seem to be more related to thyroid disease and the surgeon’s experience than to the surgical procedure. Better knowledge of the factors leading to complications will improve the outcome of goiter surgery.

关键词： goiter Complications Surgery Bamako

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Therapy to Obese Type 2 Diabetes Mellitus:How Far Will We go Down the Wrong Road?

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Chinese Journal of Integrative Medicine 2020年第1期26卷 62-71页

作者： HENG Xian-pei LI Xiu-jun LI Liang YANG Liu-qing WANG Zi-ta HUANG Su-ping Department of Endocrinology People's Hospital Affiliated to Fujian University of Traditional Chinese MedicineFuzhou 350004China West China Medical Center of Sichuan Medical University(West China University of Medical Science) Chengdu 610041China Academy of Integrative Medicine Fujian Fujian University of Traditional Chinese MedicineFuzhou 350122China

Traditional glucose-lowering chemical agents, including various types of insulin and insulin secretagogues, insulin sensitizers, gliptins, etc., are based on diabetic pathogenesis of insulin resistance(IR) and islet insufficiency. Numerous evidence-based medical studies have shown that these traditional hypoglycemic chemical agents do not provide cardiovascular benefit to patients with type 2 diabetes mellitus(T2 DM) and may even increase the risk of all-cause mortality. Based on research evidence published to date, these studies show that overload of energy could increase the incidence and prevalence of T2 DM, and reduction in the heat load can significantly reduce the incidence of T2 DM. Therefore, the essence of T2 DM is heat overload, meaning heat overload is the etiology of obese T2 DM. At the same time, results of numerous studies show that heat overloading is the cause of IR. IR and islet dysfunction are protective factors in intervening with heat *** drugs, which are based on the mechanisms of IR and islet insufficiency, increase caloric reserve and cause or worsen obesity, which is equivalent to exacerbating the basic etiology and the cardiovascular risk factor of T2 DM. Thus, a reasonable strategy for prevention and treatment of obese T2 DM appears to promote the negative balance of calories and the elimination of caloric reserves. Chinese herbal medicines can promote negative balance of heat in many aspects, which can bring new hope for prevention and treatment of T2 DM.

关键词： obese type 2 diabetes mellitus etiology prevention and treatment Chinese herbal medicine

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Prognostic criteria for postoperative mortality in 170 patients undergoing major right hepatectomy

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Hepatobiliary & Pancreatic Diseases International 2012年第5期11卷 507-512页

作者： Filippo Filicori Xavier M Keutgen Matteo Zanello giorgio Ercolani Salomone Di Saverio Federico Sacchetti Antonio Daniele Pinna Gian Luca Grazi General Surgery and Transplant Unit Department of General Surgery and Organ TransplantationUniversity of BolognaVia Massarenti 940138 BolognaItaly Department of Surgery New York Presbyterian Hospital Weill Cornell Medical College Department of Surgery New York Presbyterian HospitalWeill Cornell Medical College Department of Emergency Surgery Maggiore HospitalL.go Nigrisoli 240133 BolognaItaly Hepato-Biliary Surgery Unit Istituto Nazionale Tumori Regina ElenaVia Elio Chianesi5300144 RomaItaly

BACKGROUND: Postoperative hepatic failure is a dreadful complication after major hepatectomy and carries high morbidity and mortality rates. In this study, we assessed the accuracy of the 50/50 criteria (bilirubin >2.9 mg/dL and international normalized ratio >1.7 on postoperative day 5) and the Mullen criteria (bilirubin peak >7 mg/dL on postoperative days 1-7) in predicting death from hepatic failure in patients undergoing right hepatectomy only. In addition, we identified prognostic factors linked to intra-hospital morbidity and mortality in these patients. METHODS: One hundred seventy consecutive patients underwent major right hepatectomy at a tertiary medical center from 2000 to 2008. Nineteen (11.2%) patients suffered from liver cirrhosis. Univariate and multivariate analyses were performed to identify predictors of intra-hospital mortality, morbidity and death from hepatic failure. RESULTS: The intra-hospital mortality was 6.5% (11/170). Of the six patients who died from hepatic failure, one was positive for the 50/50 criteria, but all six patients were positive for the Mullen criteria. Multivariate analysis showed that male gender, hepatitis C (HCV), hepatocellular carcinoma, postoperative bilirubin >7 mg/dL and ALT65 years, HCV, reoperation, andrenal failure were significant predictors of overall intra-hospital mortality on multivariate analysis. CONCLUSIONS: The Mullen criteria were more accurate than the 50/50 criteria in predicting death from hepatic failure in patients undergoing right hepatectomy. A bilirubin peak >7 mg/dL in the postoperative period, HCV positivity, hepatocellular carcinoma, and an ALT level <188 U/L on postoperative day 1 were associated with death from hepatic failure in our patient population.

关键词： hepatectomy liver diseases liver failure postoperative complications prothrombin time bilirubin

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Epidemiological and Clinical Aspects of Chronic Renal Failure in the Medical Department at the Hospital of Sikasso

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Open Journal of Nephrology 2023年第1期13卷 57-66页

作者： Djénéba Maïga Drissa goïta Magara Samaké Aboudou Messoum Dolo Yohanna Koné Aboubacar Sidiki Fofana Seydou Sy Moctar Coulibaly Atabième Kodio Sahdit Baba Coulibaly Saharé Fongoro Nephrology Unit of Sikasso Hospital Sikasso Mali National Center for Scientific and Technological Research (CNRST) Bamako Mali Service de Médecine CHU Mère-Enfant le Luxembourg Bamako Mali Nephrology Unit of the Fousseyni DAOU Hospital Kayes Mali Nephrology and Hemodialysis Service CHU du Point-G Bamako Mali Faculty of Medicine of Bamako Bamako Mali Nephrology Unit of Mali GAVARDO Hospital of Sebenicoro Bamako Mali

Introduction: Chronic renal failure is a real public health problem because of its prevalence, the cost of its management and the high morbidity and mortality rate associated with it. The objective of this study was to determine the frequency, causes and main aggravating factors of chronic renal failure in the medical department of the hospital of Sikasso. Materials and Methods: This was a cross-sectional, retrospective, descriptive study conducted in the medical department of the Sikasso hospital from January 1, 2021 to November 30, 2022. It covered all the records of patients with chronic renal failure hospitalized in the department during this period. The MDRD formula was used to estimate the glomerular filtration rate. The KDIgo 2012 classification was used to stage CKD. Results: Of 820 patient records reviewed, we retained 197 records. The mean age of our patients was 42.25 ± 10 years. The male sex represented 114 (57.9%). The socio-economic level was considered low and precarious in 79.8% of cases. The frequency of chronic renal failure was 24%. The reason for hospitalization was mostly hyper creatinine > 185 μmol/l (92.4%). Herbal medicine was reported in 103 cases (52.3%). Medical history was hypertension 101 cases (51.3%), undocumented gastro duodenal ulcer (UGD) 14 cases (7.6%), hypertension and diabetes 11 cases (5.1%), diabetes 8 cases (4%), lower limb edema 9 cases (4.6%). Hypocalcemia was 147 cases (75.6%) with hyper phosphoremia was 153 cases (77.7%). Hemoglobin level was: tage 5, 171 cases (86.8%), stage 4, 11 cases (5.6%), stage 3, 13 cases (6.6%) and stage 2, 2 cases (1%.) Dialysis was performed in 1095

关键词： Epidemiology Clinical Chronic Renal Failure Sikasso Mali

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大叶桉根、茎、叶转录组比较和AP 2/ERF基因家族分析

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福建林业科技 2024年第1期51卷 1-8页

作者：陈欢张健黄恒成唐正涛韦联健周韬邓紫宇广西林业集团有限公司桂钦林浆纸有限公司广西南宁530022 广西壮族自治区林业科学研究院、广西南宁桉树森林生态系统定位观测研究站广西优良用材林资源培育重点实验室广西南宁530002 海南大学林学院海南海口570228

2021年对广西六峰山林场的大叶桉(Eucalyptus robusta)进行采样,采用Hiseq 2000对大叶桉根、茎、叶组织分别进行转录组测序。结果获得40786个Unigene;通过数据库比对,共注释了31662个Unigene。go注释结果最多的条目为膜组成部分;KEGG注... 详细信息

2021年对广西六峰山林场的大叶桉(Eucalyptus robusta)进行采样,采用Hiseq 2000对大叶桉根、茎、叶组织分别进行转录组测序。结果获得40786个Unigene;通过数据库比对,共注释了31662个Unigene。go注释结果最多的条目为膜组成部分;KEGG注释结果表明,5654条序列参与129条代谢通路,参与基因最多的通路为核糖体。对比分析大叶桉根部和茎,以及根部和叶之间的转录差异,发现多条富集的通路,包括α-亚麻酸代谢和萜类骨架生物合成等。鉴定出AP 2/ERF家族基因84个,其中AP 2家族含有9个基因,RAV家族含有2个基因,ERF家族包含73个基因,各基因家族在根茎叶中的表达模式有所差异。

关键词：大叶桉转录组比较 AP 2/ERF基因家族

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Species Identification by Means of Mitochondrial Cytochrome <i>b</i>DNA Sequencing in Processed Anchovy, Sardine and Tuna Products

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Food and Nutrition Sciences 2018年第4期9卷 369-375页

作者： Anna Cutarelli giorgio Galiero Federico Capuano Federica Corrado Istituto Zooprofilattico Sperimentale del Mezzogiorno Napoli Italy

Identifying the contents of processed food products is essential to correct labelling. In processed foodstuffs, species identification through morphological analysis is difficult. Several factors hinder the identification of fish species in processed foods: proteins or other materials subjected to analysis may be denatured during heat treatments;the presence of other ingredients (e.g., olive and other vegetable oils) may interfere with the analysis. Consequently, possible frauds perpetrated by replacing valuable species with less precious ones may go undetected. In most processed samples (e.g. canned products), DNA is degraded into small fragments, which considerably reduces the sensitivity of molecular analysis. The main goal of our research was to develop an analytical method able to identify fish species in highly processed products, such as canned fish. The assay was developed by combining an effective method of DNA recovery from samples with the detection of small-sized sequences of the mitochondrial Cytb gene. This method appears particularly suitable when morphological characterization is difficult, to carry out such as in canned products where DNA is degraded or present in small quantities. We have analyzed 60 samples of seafood commercial products identifying 3 different genera and five different species. All analyzed samples revealed a correct species declaration, for one sample we highlighted important commercial fraud. We also used bio-informatic identification systems for the Sequence Alignment and the construction of phylogenetic tree to better confirm the revealed fraud.

关键词： Species Identification Processed Seafood Commercial Fraud Dna Sequencing Cytochrome b (Cytb)

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乡村振兴背景下农村生态经济发展对有机饲料生产的影响

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中国饲料 2022年第24期 127-130页

作者：郑芳他淑君福建农业职业技术学院经济管理学院福建福州350000

乡村振兴战略背景下,推进农业供给侧结构性改革是提高农业综合效益和竞争力的重大举措。加速农业生产模式已成为推动农业发展的必然方向。养殖业作为我国农业产业体系的重要组成部分,加速养殖业供给侧结构性改革、构建全新的生态养殖业... 详细信息

乡村振兴战略背景下,推进农业供给侧结构性改革是提高农业综合效益和竞争力的重大举措。加速农业生产模式已成为推动农业发展的必然方向。养殖业作为我国农业产业体系的重要组成部分,加速养殖业供给侧结构性改革、构建全新的生态养殖业生产模式,是未来养殖业发展的主流方向。因此,养殖业供给侧的饲料加工制造产业必然受到冲击。因此,新时期有机饲料加工制造企业该何去何从,该如何更好地适应生态养殖业的发展,是农业生产领域研究的重点课题。本文就农业生态经济发展对有机饲料生产的影响进行研究,探索新时期有机饲料加工制造企业的转型和发展方向,进而更好地助力生态农业、绿色农业、可持续发展农业。

关键词：乡村振兴农村生态经济有机饲料生产影响

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