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Real-world characteristics of hospitalized frail elderly patients with atrial fibrillation： can we improve the current prescription of anticoagulants？

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Journal of Geriatric Cardiology 2016年第3期13卷 226-232页

作者： giorgio Annoni Paolo Mazzola School of Medicine and Surgery University of Milano-Bicocca and Acute Geriatric Unit San Gerardo Hospital ASST Monza Monza Italy NeuroMI-Milan Center for Neuroscience Clinical Neurosciences Research Area Milano Italy

Background In elderly patients, especially those older than 80 years, atrial fibrillation （AF） is associated with an almost 25% in- creased risk of stroke. Stroke prophylaxis with anticoagulants is therefore highly recommended. The prevalence of factors that have been associated with a lower rate of prescription and adherence to anticoagulant therapy in these patients is little known. The objective of this study was to explore the clinical characteristics of elderly subjects, with and without AF, consecutively admitted to an acute geriatric unit, discussing factors that may decrease the persistence on stroke prophylaxis therapy. We also highlight possible strategies to overcome the barriers conditioning the current underuse of oral anticoagulants in this segment of the population. Methods A retrospective observational study was performed on a cohort of elderly patients with and without AF admitted to the Acute Geriatric Unit of San Gerardo Hospital （Monza, Italy）. Results Compared to patients without AF （n = 1216）, those with AF （n = 403） had a higher Charlson Comorbidity Index （3 vs. 2, P 〈 0.001）, number of administered drugs （4 vs. 3, P 〈 0.001）, rate of heart failure （36.5% vs. 12%, P 〈 0.001） and chronic kidney disease （20.6 vs. 13.2, P 〈 0.001）. Many patients with AF were frail （54%） or pre-frail （29%）. Conclusions Elderly patients with AF have higher rates of conditions that affect adherence to traditional anticoagulant therapy （vitamin K antagonists, VKA）. New direct oral anticoagulants （DOAs） can help overcome this problem. In order to prescribe the most appropriate VKA or DOAs, with the best efficacy/safety profile and the highest compliance, a comprehensive geriatric assessment should always accompany the scores for thrombotic and hemorrhagic risk stratification.

关键词： Anticoagulant prescription Atrial fibrillation Comorbidity Comprehensive geriatric assessment Frailty

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Kinetics of Molecular Recognition Mediated Nanoparticle Self-Assembly

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Nano Research 2009年第1期2卷 78-84页

作者： Chinmay Soman Todd giorgio Interdisciplinary Program in Materials Science Vanderbilt University201 West End AvenueNashvilleTN 37240USA Department of Biomedical Engineering Vanderbilt University201 West End AvenueNashvilleTN 37240USA

Nanoscale quantum dot-antibody conjugates have been shown to self-assemble to form micron-scale aggregates in the presence of specific proteomic *** self-assembly process exhibits sigmoidal kinetics,suggesting that nucleation limits ***-assembly kinetics in this study is characterized by flow cytometric analysis of the aggregation reaction over time.A range of physiologically relevant concentrations of the protein angiopoietin-2,a candidate cancer biomarker,are incubated with quantum dots conjugated with a polyclonal mixture of anti-angiopoietin-2 *** concentration modulates the slopes and inflection times of the sigmoidal kinetics *** understanding of self-assembly kinetics in this system may lead to improvements in sensitivity and specificity of this novel proteomic biomarker detection technique and improve the screening,diagnostics,and therapy response monitoring for cancers and other *** approach to studying the kinetics of nanoparticle self-assembly may also provide a valuable tool for understanding the fundamental characteristics of nanoscale particle aggregation.

关键词： Quantum dot self-assembly kinetics proteomics diagnostics has

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Pilot study to determine improvements in subjective penile morphology and personal relationships following a Nesbit plication procedure for men with congenital penile curvature

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Asian Journal of Andrology 2008年第3期10卷 512-519页

作者： giorgio Cavallini Stefano Caracciolo Andrological Operative Unit Headquarters of Societg7 ltaliana di Studi di Medicina della Riproduzione via Mazzini 12Bologna 40138 Italy Section of General and Clinical Psychology University of Ferrara - Medical School Via Fossato di Mortara 64bFerrara 44100 Italy

Aim： To determine whether the surgical straightening of congenital penile curvature can improve intromission comfort, penile features, personal relationships and psychogenic erectile dysfunction （ED）. Methods： Fifty-four patients （mean age 24 years, range 20-31 years） whose congenital penile deviation due to physiological curvature was ≥ 25 degrees, as measured on a graph, and who were experiencing penetration discomfort were assessed specifically for the present study. Of these, 14 patients suffered from psychogenic ED. The assessment included a case history, an objective examination, a pharmacologically-induced erection with prostaglandin E1 10-20 g, a graph taken during erection, a basal and dynamic Duplex ultrasonograph, penile length measurement, nocturnal penile tumescence recording, hormonal profiles and a psychological interview to evaluate the quality of their personal relationships according to Hinde＇s parameters （contents, number, features, frequency, ability to perceive limits of mutuality, subjective perception of the other person[s], and reliability）. All patients underwent the Nesbit procedure. The initial assessment was repeated at 3 and 12 months after surgery. Data analyses were carried out using the z test. Results： Subjective judgement of cosmetic penile features and vaginal intromission comfort improved significantly after surgery whereas the quality of personal relationships and ED did not. Conclusion： The surgical straightening of congenital penile curvature improved intromission comfort and penile features, but it failed to improve interpersonal relationships or psychogenic ED.

关键词： congenital penile curvature Nesbit procedure penile surgery personal relationships

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CFD Study of Ejector Flow Behavior in a Blast Furnace Gas Galvanizing Plant

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Journal of Thermal Science 2015年第1期24卷 58-66页

作者： giorgio Besagni Riccardo Mereu Fabio Inzoli Politecnico di Milano Department of EnergyVia Lambruschini 4 Milan 20156 Italy

In recent years, there has been a growing interest toward Blast Furnace Gas （BFG） as a low-grade energy source for industrial furnaces. This paper considers the revamping of a galvanic plant furnace converted to BFG from natural gas. In the design of the new system, the ejector on the exhaust line is a critical component. This paper studies the flow behavior of the ejector using a Computational Fluid Dynamics （CFD） analysis. The CFD model is based on a 3D representation of the ejector, using air and exhaust gases as working fluids. This paper is divided in three parts. In the first part, the galvanic plant used as case study is presented and discussed, in the second part the CFD approach is outlined, and in the third part the CFD approach is validated using experimental data and the numerical results are presented and discussed. Different Reynolds-Averaged Navier-Stokes （RANS） turbulence models （k-to SST and k-e Realizable） are evaluated in terms of convergence capability and accuracy in predicting the pressure drop along the ejector. Suggestions for future optimization of the system are also provided.

关键词： CFD Ejector Blast Furnace Gas Galvanic plant RANS Turbulence models

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On the nonlinear transformation of breaking and non-breaking waves induced by a weakly submerged shelf

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Journal of Hydrodynamics 2018年第4期30卷 592-604页

作者： giorgio Contento Guido Lupieri Thomas Puzzer Department of Engineering and Architecture University of Trieste

The interaction of regular quasi-monochromatic waves with a weakly submerged rectangular shelf is studied by means of CFD simulations. The fundamental incident wave frequency is kept constant for the full set of simulated cases, while the incident wave amplitude is made increase progressively, so that the interaction with the shelf is dominated by almost inviscid non-linear flow for the smallest and by breaking for the highest incident waves. A parameter identification（PI） procedure is used to adapt a reduced model to the highly resolved time-space matrix of wave elevations obtained from the numerical simulations, on the weather and lee side respectively. In particular the wave number and the frequency of the component waves in the reduced model are left uncoupled, thus computed by the PI independently. The comparison of simulated data with experiments generally shows a very good agreement. Free/locked, incident/reflected, first/higher order wave components are quantified accurately by the PI and the energy transfer to super-harmonics is clearly evidenced. Moreover the results of the PI show clearly a very large increase in the phase speed of the higher order free waves on the lee side of the shelf, with increasing deviation from the linear behavior with increasing incident wave amplitude.

关键词： Nonlinear wave transformation submerged shelf wave breaking coupled space-time domain analysis reduced model parameter identification

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Heavy metals adsorption by banana peels micro-powder: Equilibrium modeling by non-linear models

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Chinese Journal of Chemical Engineering 2018年第3期26卷 455-464页

作者： giorgio Vilardi Luca Di Palma Nicola Verdone Sapienza University of Rome Department of Chemical Engineering Materials Environment

In this study the copper and lead adsorption efficiency onto banana peels powder was investigated. The agroindustrial waste recovery represents one of the Circular Economy pillars. In the view of the synthesis of an environmentally friendly adsorbent material, the powder was used without any preliminary chemical or thermal activation, but only after simple washing, drying and grinding. The bio-adsorbent was characterized by the FTIR technique and tested in batch mode on synthetic aqueous solutions containing Pb and Cu in the range 10–90 mg·L^(-1). A selection of two(Langmuir, Freundlich) and three(Sips, Redlich–Peterson, Koble–Corrigan) parameter isotherm models was chosen to fit adsorption equilibrium data by non-linear regression procedure. The best fit isotherm model was selected relying on the error function with the lowest average percentage error(APE) value, among those characterized by the highest R^2 values. As expected, the three-parameter models are found to better represent both metals bio-adsorption, with APE and R^2 values always lower and higher, respectively, than the corresponding values obtained for the two-parameter models.

关键词： Banana peel Heavy metals Bio-adsorbent Non-linear model FIIR

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What are the odds?On the determinants of high residential energy expenditure

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能源与人工环境(英文) 2020年第3期1卷 288-295页

作者： giorgio Besagni Marco Borgarello Power System Development Department Ricerca sul Sistema Energetico-RSE S.p.A.via Rubattino 5420134 MilanoItaly

A precise understanding of the relationships between the household characteristics and the residential energy consumption is needed to support the implementation of effective top-bottom energy strategies and to improve the prediction of forecasting *** paper contributes to the present-day discussion and analyses the build-ing factors,socio-demographic variables and appliances contributing to high-energy expenditures(viz.,electrical energy expenditure,thermal energy expenditure and total energy expenditure)in the Italian *** proposed study builds on an earlier work proposed by the authors,which identified the determinants of the household energy expenditures,based on a nationally representative survey(the“household Budget Survey:mi-crodata for research purposes-2015”performed by the Italian National Institute of Statistics).In particular,the present paper completes and extends the previous research by applying the odds-ratio analysis to the previously identified determinants,in order to identify the factors that led to high electricity consumption(viz.,electrical energy expenditure,thermal energy expenditure and total energy expenditure).In conclusion,this paper aims to providing a more precise understanding of the factors that certainly affect the energy expenditure.

关键词： Energy expenditure Residential sector Odd-ratio Household variables Determinants

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Relationships between biological aging and male reproductive monitors

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Asian Journal of Andrology 2020年第3期22卷 330-332页

作者： giorgio Cavallini Fabrizio Scroppo Private Outpatient Clinic Via Mascheraio 46Ferrara 44121Italy Department of Urology and Andrology Ospedale di Circolo and Macchi FoundationViale L.Borri 57Varese 21100Italy

Dear Editor,Advanced paternal age affects testicular function,reproductive hormones,and sperm parameters,but it is unclear whether chronological age or biological age exercises a greater sway on reproductive ***,the authors carried out this prospective,multicenter,observational study,in which sperm concentration;motility and morphology;ejaculated volume;testicular volume;and the blood concentrations of follicle-stimulating hormone(FSH),luteinizing hormone(LH),and total testosterone(T)were related to chronological and biological age.

关键词： function. stimulating aging

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Post-liver transplant hepatitis C virus recurrence: An unresolved thorny problem

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World Journal of Gastroenterology 2014年第32期20卷 11095-11115页

作者： Alberto Grassi giorgio Ballardini Internal Medicine and Hepatology Division Department of Internal Medicine "Infermi" Hospital Internal Medicine and Hepatology Division Department of Internal Medicine "Infermi" Hospita

Hepatitis C virus (HCV)-related cirrhosis represents the leading cause of liver transplantation in developed, Western and Eastern countries. Unfortunately, liver transplantation does not cure recipient HCV infection: reinfection universally occurs and disease progression is faster after liver transplant. In this review we focus on what happens throughout the peri-transplant phase and in the first 6-12 mo after transplantation: during this crucial period a completely new balance between HCV, liver graft, the recipient’s immune response and anti-rejection therapy is achieved that will deeply affect subsequent outcomes. Nearly all patients show an early graft reinfection, with HCV viremia reaching and exceeding pre-transplant levels; in this setting, histological assessment is essential to differentiate recurrent hepatitis C from acute or chronic rejection; however, differentiating the two patterns remains difficult. The host immune response (mainly cellular mediated) appears to be crucial both in the control of HCV infection and in the genesis of rejection, and it is also strongly influenced by immunosuppressive treatment. At present no clear immunosuppressive strategy could be strongly recommended in HCV-positive recipients to prevent HCV recurrence, even immunotherapy appears to be ineffective. Nonetheless it seems reasonable that episodes of rejection and over-immunosuppression are more likely to enhance the risk of HCV recurrence through immunological mechanisms. Both complete prevention of rejection and optimization of immunosuppression should represent the main goals towards reducing the rate of graft HCV reinfection. In conclusion, post-transplant HCV recurrence remains an unresolved, thorny problem because many factors remain obscure and need to be better determined.

关键词： Hepatitis C virus Liver transplantation Hepatitis C antigens Graft rejection Immunosuppression

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On singular Lüroth quartics

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Science China Mathematics 2011年第8期54卷 1757-1766页

作者： OTTAVIANI giorgio SERNESI Edoardo Dipartimento di Matematica "U.Dini" Università di Firenzeviale Morgagni 67/A50134 FirenzeItaly Dipartimento di Matematica Università Roma TreLargo S.L.Murialdo 100146 RomaItaly

Plane quartics containing the ten vertices of a complete pentalateral and limits of them are called Lüroth *** locus of singular Lüroth quartics has two irreducible components,both of codimension two in *** compute the degree of them and discuss the consequences of this computation on the explicit form of the Lüroth *** important tool is the Cremona hexahedral equations of the cubic *** also compute the class in M 3 of the closure of the locus of nonsingular Lüroth quartics.

关键词： plane quartics Lueroth quartics invariant moduli space of curves

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