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Materials Sciences and Applications 2024年第4期15卷 53-65页

作者： Francesco Rosalbino giorgio Scavino Graziano Ubertalli Dipartimento di Scienza Applicata e Tecnologia (DISAT) Politecnico di Torino Torino Italy

The influence of sodium silicate on the corrosion behaviour of aluminium alloy 7075-T6 in 0.1 M sodium chloride solution was studied by open circuit potential (OCP) and electrochemical impedance spectroscopy (EIS) techniques. Scanning electron microscopy (SEM) was used to characterize the AA7075-T6 surface. Silicate can significantly reduce corrosion deterioration and the inhibition efficiency increases with the concentration of Na2SiO3. The corrosion inhibition mechanism involves the formation of a protective film over the alloy surface by adsorption of aluminosilicate anions from solution, as has also been suggested by others in literature.

关键词： Aluminium Alloy 7075-T6 Silicate Sodium Chloride Electrochemical Impedance Spectroscopy (EIS) Scanning Electron Microscopy (SEM)

Conversion therapy for hepatocellular carcinoma to improve treatment strategies for intermediate and advanced stages

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World Journal of Clinical Cases 2024年第28期12卷 6241-6243页

作者： Antonio giorgio Massimo De Luca Athena Clinic Center Via MatesePiedimonte Matese(CE)81016CampaniaItaly Liver Unit AORN CardarelliVia A.CardarelliNapoli 80131CampaniaItaly

This manuscript is based on a case reported by Song et al published in the World Journal of Clinical *** challenges remain in the field of hepatocellular carcinoma(HCC)conversion ***,only a limited number of patients with HCC accompanied by portal vein tumor thrombosis(PVTT)and hepatic vein tumor thrombosis(HVTT)are eligible for *** clinical case demonstrates that considering the complexity of the disease,a multimodal and multidisciplinary approach is essential for managing HCC accompanied by PVTT and ***,the outcomes of such surgeries remain *** conclusion,research on HCC conversion therapy is extremely useful for impro-ving treatment strategies for intermediate and advanced HCC,which currently have disappointing clinical outcomes.

关键词： Hepatocellular carcinoma Portal vein Inferior vena cava Tumor thrombus Conversion surgery

What Is the Convenience of Treating a Wetland as an Agricultural Area?

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Open Journal of Ecology 2024年第6期14卷 544-561页

作者： Roberto De Pietro Renzo Ientile giorgio Sabella Independent Researcher Via Messina Catania Italy Department of Biological Geological and Environmental Sciences Section Animal Biology University of Catania Catania Italy

The Gelsari and Lentini marshes, in east-central Sicily, are wetland under heavy anthropogenic pressure. This area is regularly subjected to water withdrawals and agriculture is practiced. Periodic bird census activities had been conducted in this area between 2016 and 2022 with collected data being supplemented with the data from a previous survey conducted between 2010 and 2016. During the censuses, numerous photographs were collected, which were later used for counts. In total, 121 surveys were carried out, with visits occurring approximately 20 times per year, covering all seasons. The data collected, both from bibliography and unpublished observations, were organised in table. 120 species and subspecies have been reported, 41 of which are in Annex I of the Birds Directive. Between 2021 and 2022, a water column measurement was taken in a central area of the Lentini marsh and compared with rainfall data in the area. It was found that water removal, occurring in both marshes in different modes, produced different effects on habitat conservation. Of the two marshes, Lentini is the one in which the existing favorable conditions in its most depressed areas, located below sea level, have allowed for the adequate conservation of the wetland. This environmental improvement having occurred with respect to the previous period has restored to the marsh its historically recognized possibility of not drying up completely during the summer period, allowing permanence of numerous birds. The obtained results suggest total elimination of agriculture and discontinuation of water withdrawals in the Lentini marsh as well as regulation of withdrawals in the Gelsari marsh.

关键词： Sicily Checklist Conservation Important Coastal Salt Marsh under the Sea Level Pantano Lentini

Gate-controlled supercurrent effect in dry-etched Dayem bridges of non-centrosymmetric niobium rhenium

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Nano Research 2024年第7期17卷 6575-6581页

作者： Jennifer Koch Carla Cirillo Sebastiano Battisti Leon Ruf Zahra Makhdoumi Kakhaki Alessandro Paghi Armen Gulian Serafim Teknowijoyo giorgio De Simoni Francesco Giazotto Carmine Attanasio Elke Scheer Angelo Di Bernardo Department of Physics University of KonstanzUniversitätsstraße 1078464 KonstanzGermany CNR-Spin c/o Universitàdegli Studi di Salernovia Giovanni Paolo II 13284084 Fisciano(SA)Italy NEST Istituto Nanoscienze-CNR and Scuola Normale SuperiorePiazza San Silvestro 1256127 PisaItaly Dipartimento di Fisica“E.R.Caianiello” Universitàdegli Studi di SalernoVia Giovanni Paolo II 13284084 Fisciano(SA)Italy Advanced Physics Laboratory Institute for Quantum StudiesChapman UniversityBurtonsvilleMD 20866USA

The application of a gate voltage to control the superconducting current flowing through a nanoscale superconducting constriction,named as gate-controlled supercurrent(GCS),has raised great interest for fundamental and technological *** gain a deeper understanding of this effect and develop superconducting technologies based on it,the material and physical parameters crucial for the GCS effect must be ***-down fabrication protocols should also be optimized to increase device scalability,although studies suggest that top-down fabricated devices are more resilient to show a ***,we investigate gated superconducting nanobridges made with a top-down fabrication process from thin films of the noncentrosymmetric superconductor niobium rhenium with varying ratios of the constituents(NbRe).Unlike other devices previously reported and made with a top-down approach,our NbRe devices systematically exhibit a GCS effect when they were fabricated from NbRe thin films with small grain size and etched in specific *** observations pave the way for the realization of top-down-made GCS devices with high *** results also imply that physical parameters like structural disorder and surface physical properties of the nanobridges,which can be in turn modified by the fabrication process,are crucial for a GCS observation,providing therefore also important insights into the physics underlying the GCS effect.

关键词： superconductivity non-centrosymmetric superconductors superconducting devices gated devices gate-controlled supercurrent top-down fabrication

Corrigendum to ‘A novel STK11 gene mutation (c.388dupG,***130Glyfs∗33) in a Peutz-Jeghers family and evidence of higher gastric cancer susceptibility associated with alterations in STK11 region aa 107–170’ [Gene Dis (9) (2022) 288–291]

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Genes & Diseases 2024年第2期11卷 1082-1083页

作者： Giovanna Forte Filomena Cariola Katia De Marco Andrea Manghisi Filomena Anna Guglielmi Raffaele Armentano Giuseppe Lippolis Pietro giorgio Cristiano Simone Vittoria Disciglio Medical Genetics National Institute of Gastroenterology “S. de Bellis” Research Hospital Castellana Grotte Bari 70013 Italy Histopathology Unit National Institute of Gastroenterology “S. de Bellis” Research Hospital Castellana Grotte Bari 70013 Italy Department of General Surgery National Institute of Gastroenterology “S. de Bellis” Research Hospital Castellana Grotte Bari 70013 Italy Gastroenterology and Digestive Endoscopy Unit National Institute of Gastroenterology “S. de Bellis” Research Hospital Castellana Grotte Bari 70013 Italy Department of Biomedical Sciences and Human Oncology (DIMO) Medical Genetics University of Bari Aldo Moro Piazza Umberto I Bari 70124 Italy

Resampling approaches for the quantitative analysis of spatially distributed cells

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Data Intelligence 2024年第1期6卷 104-119页

作者： giorgio Bertolazzi Michele Tumminello Gaia Morello Beatrice Belmonte Claudio Tripodo Department of Economics Business and StatisticsUniversity of PalermoPalermoItaly Tumor Immunology Unit Department of Health SciencesUniversity of PalermoPalermoItaly Histopathology Unit Institute of Molecular Oncology Foundation(IFOM)ETS-The AIRC Institute of Molecular OncologyMilanItaly

Image segmentation is a crucial step in various image analysis pipelines and constitutes one of the cutting-edge areas of digital *** advent of quantitative analysis has enabled the evaluation of millions of individual cells in tissues,allowing for the combined assessment of morphological features,biomarker expression,and spatial *** recorded cells can be described as a point pattern ***,the classical statistical approaches to point pattern processes prove unreliable in this context due to the presence of multiple irregularly-shaped interstitial cell-devoid spaces in the domain,which correspond to anatomical features(***,lipid vacuoles,glandular lumina)or tissue artefacts(*** fractures),and whose coordinates are *** interstitial spaces impede the accurate calculation of the domain area,resulting in biased clustering ***,the mistaken inclusion of empty regions of the domain can directly impact the results of hypothesis *** literature currently lacks any introduced bias correction method to address interstitial cell-devoid *** address this gap,we propose novel resampling methods for testing spatial randomness and evaluating relationships among different cell *** methods obviate the need for domain area estimation and provide non-biased clustering *** created the SpaceR software(https://***/GBertolazzi/SpaceR)to enhance the accessibility of our methodologies.

关键词： Digital pathology spatial cytometry spatial clustering spatial randomness resampling

Intraplaque injections of hyaluronic acid for the treatment of stable-phase Peyronie’s disease:a retrospective single-center experience

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Asian Journal of Andrology 2024年第3期26卷 268-271页

作者： Simone Cilio Roberto La Rocca Giuseppe Celentano Claudio Marino Massimiliano Creta Gianluigi Califano Celeste Manfredi giorgio Ivan Russo Afonso Morgado Marco Falcone Marco Capece YAU Working Group Sexual and Reproductive Health Department of Neurosciences Reproductive Sciences and OdontostomatologyUrology UnitUniversity of Naples“Federico II”Naples 80131Italy Urology Unit Department of WomenChild and General and Specialized Surgery“Luigi Vanvitelli”UniversityNaples 80131Italy Urology Section Department of SurgeryUniversityof CataniaCatania 95131Italy Department of Urology Centro Hospitalar Universitário São JoãoPorto 4200-319Portugal Urology Clinic-A.O.U.“Cittàdella Salute edella Scienza”-Molinette Hospital University of TurinTurin 10100Italy 不详

Peyronie’s disease(PD)is a condition of penile connective tissue affecting up to 10%of men *** the complexity ofits management,nonsurgical treatments,such as intraplaque injections,are gaining *** current literature shows dataon the efficacy of intraplaque injections of hyaluronic acid(HA)mainly in acute-phase ***,data on injections of HA instable-phase PD are *** for this retrospective study were derived from a prospectively maintained database of privatepatients presenting at a private medical practice affiliated to the University of Naples“Federico II”(Naples,Italy)with stable-phasePD between January 2020 and March *** underwent a standard protocol of three injections,each administered at atwo-week *** the intervals,patients performed vacuum device therapy,penile stretching,and modeling *** compiled the Peyronie’s Disease Questionnaire(PDQ)and Global Assessment of Peyronie’s Disease(GAPD)at baselineand 2 weeks after the third injection.A penile Doppler ultrasound was performed 2 weeks after the last injection to record thefinal ***,we recruited 62 patients with stable-phase PD and a mean(±standard deviation[s.d.])curvature of52.7°(±9.7°).After 6 weeks,eight(12.9%)patients did not experience any curvature *** remaining 54 patientshad a final mean(±s.d.)curvature of 40.3°(±9.1°)with P<0.001,compared to that before *** found improvement inall PDQ domains(all P≤0.01),and 50(80.6%)patients reported subjective improvement of the penile curvature according to *** conclusion,we demonstrated that after three injections of HA administered according to the adopted protocol,patientswith stable-phase PD could experience significant improvements in penile curvature,and physical and psychological consequencesof the disease without significantly relevant side effects.

关键词： hyaluronic acid intraplaque injection Peyronie’s disease stable-phase therapy

Galvanic Skin Response—Extinction Biofeedback Training for Psychogenic Abdominal Pain: A Validation Protocol

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Journal of Biosciences and Medicines 2024年第5期12卷 190-201页

作者： Maddalena Castelletti Enrico Berné Erasmo Dionigio Carlo Castagnoli Alberto Montagna giorgio Tonon Magenta Medical Center Milan Italy Castagnoli Medical Center Garlasco Italy GEA Soluzioni Turin Italy

Abdominal and pelvic pain of psychogenic origin is a widespread, disabling, difficult to identify, and often inadequately treated medical condition. This condition is often associated with poor quality of life due to high pain interference with daily activities. Cognitive behavioral psychological therapy and neuromodulation with biofeedback are validated therapies for the treatment of this condition. Aim of the present research work is the validation of a therapeutic protocol that involves the use of both techniques in combination. 20 patients diagnosed with psychogenic abdominal pain, of both sexes, aged between 18 and 60 years who had not benefited from pharmacological therapies were enrolled. 10 patients were randomly assigned to the control group (psychological treatment only), another 10 patients were assigned to the study group (neuromodulation with biofeedback-Galvanic skin response-extinction in combination with psychological therapy). For both groups, the pain score, interference of pain with daily living activities, pain relief, and the share of anxiety associated with the pain condition were evaluated (pre- and post-treatment). The patients who underwent the combined treatment achieved statistically significant better scores than patients in the control group, respectively −4.9 ± 0.9 vs −1.0 ± 0.4 for Pain;−5.1 ± 1.1 vs −0.9 ± 0.3 for Interference with life;−7.2 ± 3.7 vs −2.2 ± 2.1 for HAMA;4.6 ± 1.2 vs 1.1 ± 0.6 for Relief.

关键词： Chronic Abdominal and Pelvic Psychogenic Pain (PAP) Biofeedback Training Pain Management Galvanic Skin Response (GSR)

A Structured Method of Teaching Epidural Block reduces the incidence of accidental dural puncture in inexperienced trainees.

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Open Journal of Anesthesiology 2024年第4期14卷 131-135页

作者： Marco Scorzoni Gianluigi Gonnella Emanuele Capogna Marina Campione Gaetano Draisci Matteo Velardo giorgio Capogna Department of Anesthesiology Fondazione Policlinico Gemelli IRCCS Rome Italy Department of Economics and Law Enna Kore University Enna Italy European School of Obstetric Anesthesia Rome Italy

Background: The rate of accidental dural puncture is particularly high during the period of training, especially in novices. The structured epidural teaching model (SETM) includes three standardized video lessons, the construction of a 3D epidural module by trainees and practical training by using an epidural simulator with and without the CompuFlo™ Epidural instrument. In this study we report the retrospective analysis of the accidental dural puncture rate of inexperienced trainees during their 6 months clinical practice rotation in obstetrics before and after the introduction of the SETM in our Institution. Method: We evaluated the incidence of accidental dural puncture before the introduction of the SETM methodology and afterwards by analyzing our departmental database from February 2019 to January 2023. All epidural blocks were executed by trainees who had never previously performed an epidural block and were about to begin their obstetrics rotation. Results: We analyzed 7415 epidurals: 3703 were performed before the introduction of the SETM methodology (control group) and 3712 afterwards (study group). The incidence of accidental dural puncture was 0.37% for the control group and 0.13% for the study group (p<.05). The probability of making an accidental dural puncture was 64% (OR: 0.36) lower for trainees who had the training than for those who did not. Conclusions: After the introduction of the structured teaching method, we observed a significant reduction of accidental dural puncture during the training period. We hope that our observation will encourage a constructive discussion among experts about the need to use standardized and validated tools as a valuable aid in teaching epidural anesthesia.

关键词： teaching epidural Anesthesia obstetrical Anesthesia Anesthesia

Dehydrated Natural Feed for Cats: Influence on Apparent Digestibility Coefficient, Feces Scores, and Serum Immune, Antioxidant, and Metabolic Biomarkers

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Food and Nutrition Sciences 2024年第7期15卷 594-611页

作者： Bruno giorgio de Oliveira Cécere Guilherme Luiz Deolindo Bianca F. Bissacotti Priscila Marquezin Copetti Maria Rosa Chitolina Schetinger Bruna Klein Matheus Delamea Baldissera Thiago Pereira Ribeiro Walter Hugo Cuelho Suarez Daniel Pigatto Monteiro Aleksandro Schafer Da Silva Graduate Multicenter Program in Biochemistry and Molecular Biology University of the State of Santa Catarina Lages Brazil Department of Biochemistry and Molecular Biology Universidade Federal de Santa Maria (UFSM) Santa Maria Brazil Department of Animal Science Universidade Federal de Santa Maria (UFSM) Chapec Brazil Department of Health Science Universidade Franciscana (UFN) Santa Maria Brazil Department of Animal Nutrition Tectron-Tecnologia e Inovao Toledo Brazil

The present study aimed to determine whether natural dehydrated feed (DNF) can replace dry extruded feed while preserving the required daily intake, nutrient digestibility and benefits for immunity and antioxidant response in cats. The animals were divided into two groups of seven animals each. One group received DNF, and the other consumed commercial extruded dry feed (DCF). The experiment lasted 45 days and we measured daily consumption and collected blood and feces samples. The animals in the DNF group showed greater digestibility of fiber and mineral matter than DCF. Cats in the DNF group had a higher volume of feces. DNF cats had lower leukocyte and granulocyte counts and cholesterol levels. Serum enzymatic antioxidant responses and non-enzymatic were higher in DNF cats. Cats in the DNF group showed lower serum acute phase proteins in addition to a tendency toward a higher concentration of transferrin than in the DCF group. Fecal Escherichia coli and total coliform counts of cats fed DNF were higher than DCF. We conclude that the daily consumption of cats is adequate. This feed had greater digestibility of fiber and mineral matter, in addition to an improvement in antioxidant and immunological responses.

关键词： Alternative Feed Antioxidant Companion Animals Health