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Accelerating material design with the generative toolkit for scientific discovery

npj Computational Materials 2023年第1期9卷 1649-1654页

作者： Matteo Manica Jannis Born Joris Cadow Dimitrios Christofidellis Ashish Dave Dean Clarke Yves Gaetan Nana Teukam giorgio giannone Samuel C.Hoffman Matthew Buchan Vijil Chenthamarakshan Timothy Donovan Hsiang Han Hsu Federico Zipoli Oliver Schilter Akihiro Kishimoto Lisa Hamada Inkit Padhi Karl Wehden Lauren McHugh Alexy Khrabrov Payel Das Seiji Takeda John R.Smith IBM Research Europe-Zurich RüschlikonSwitzerland IBM Research-UK HursleyUK IBM Research-Yorktown Heights New YorkUSA IBM Research-Tokyo TokyoJapan IBM Research-Almaden San JoseUSA

With the growing availability of data within various scientific domains,generative models hold enormous potential to accelerate scientific *** harness powerful representations learned from datasets to speed up the formulation of novel hypotheses with the potential to impact material discovery *** present the Generative Toolkit for Scientific Discovery(GT4SD).This extensible open-source library enables scientists,developers,and researchers to train and use state-of-the-art generative models to accelerate scientific discovery focused on organic material design.

关键词： enable scientific formulation

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Role of Mediterranean diet in preventing platinum based gastrointestinal toxicity in gynecolocological malignancies: A single Institution experience

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World Journal of Clinical Oncology 2019年第12期10卷 391-401页

作者： Eleonora Ghisoni Valentina Casalone Gaia giannone Gloria Mittica Valentina Tuninetti giorgio Valabrega Candiolo Cancer Institute FPO-IRCCSTorino 10060 Italy University of Torino Torino 10060Italy

BACKGROUND Gynecological malignancies represent a major cause of death in women and are often treated with platinum-based *** undergoing chemotherapy suffer from alterations in nutritional status which may worsen gastrointestinal(GI)toxicities,quality of life and affect the overall ***,assuring a good nutritional status and limiting toxicities during treatment are still major goals for *** To assess the role of Mediterranean Diet(MD)in reducing GI toxicities in patients with gynecological cancers treated with platinum-based *** We conducted an observational study on 22 patients with gynecological tumors treated with a platinum-based chemotherapy at Candiolo Cancer Institute FPO/IRCCS between January 2018 and June *** food and frequency(FFQ)and the Patient-Reported Outcomes Common Terminology Criteria For Adverse Events(PRO-CTCAE)questionnaires were administered at baseline and at every Day 1 of each *** evaluate the differences in GI toxicities the study population was divided in two groups according to the currently validated Mediterranean Diet Serving Score(MDSS)at *** Patients with high MDSS reported a trend toward lower GI toxicities according to PRO-CTCAE at each timepoint(first evaluation:P=0.7;second:P=0.52;third:P=0.01).In particular,difference in nausea frequency and gravity(P<0.001),stomach pain frequency and gravity(P=0.01 and P=0.02),abdomen bloating frequency and gravity(P=0.02 and P=0.03),and interference with daily activities(P=0.02)were highly statistically significant at the end of *** than 60%of patients changed their food habits during chemotherapy mainly because of GI toxicities.A higher reduction of food intake,both in terms of caloric(P=0.29)and of single nutrients emerged in the group experiencing higher *** Our results show that adherence to MD possibly reduces GI toxicity and prevents nutritional status impairment during chemotherapy treatmen

关键词： Mediterranean diet Gynecological malignancies Gastrointestinal toxicities Platinum-based chemotherapy Nutritional status

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