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Quality of life in patients with esophageal stenting for the palliation of malignant dysphagia

World Journal of Gastroenterology 2011年第2期17卷 144-150页

作者： giorgio diamantis Marco Scarpa Paolo Bocus Stefano Realdon Carlo Castoro Ermanno Ancona giorgio Battaglia Veneto Oncological Institute(IOV-IRCCS) Department of Surgical and Gastroenterological Sciences University of Padua

diamantis G, Scarpa M, Castoro C, Ancona E and Battaglia G designed the research; diamantis G, Scarpa M, Bocus P, Realdon S and Castoro C performed the research; Castoro C, Ancona E and Battaglia G contributed analytic tools; diamantis G, Scarpa M, Bocus P, Realdon S and Castoro C analyzed the data; diamantis G and Scarpa M wrote the paper; all authors revised and approved the final version of the manuscript.

关键词： Esophageal cancer Health-related quality of life Self-expandable metal stents

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Systematic review of health-related quality of life after esophagectomy for esophageal cancer

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World Journal of Gastroenterology 2011年第42期17卷 4660-4674页

作者： Marco Scarpa Stefano Valente Rita Alfieri Matteo Cagol giorgio diamantis Ermanno Ancona Carlo Castoro Oncological Surgery Unit Veneto Institute of Oncology Department of Gastroint estinal and Surgical Sciences University of Padova

This study is aimed to assess the long-term healthrelated quality of life （HRQL） of patients after esophagectomy for esophageal cancer in comparison with established norms, and to evaluate changes in HRQL during the different stages of follow-up after esophageal resection. A systematic review was performed by searching medical databases （Medline, Embase and the Cochrane Library） for potentially relevant studies that appeared between January 1975 and March 2011. Studies were included if they addressed the question of HRQL after esophageal resection for esophageal cancer. Two researchers independently performed the study selection, data extraction and analysis processes. Twenty-one observational studies were included with a total of 1282 （12-355） patients. Five studies were performed with short form-36 （SF-36） and 16 with European Organization for Research and Treatment of Cancer （EORTC） QLQ c30 （14 of them also utilized the disease-specific OESI8 or its previous version OES24）.The analysis of long-term generic HRQL with SF-36 showed pooled scores for physical, role and social function after esophagectomy similar to United States norms, but lower pooled scores for physical function, vitality and general health perception. The analysis of HRQL conducted using the Global EORTC C30 global scale during a 6-mo follow-up showed that global scale and physical function were better at the baseline. The symptom scales indicated worsened fatigue, dyspnea and diarrhea 6 mo after esophagectomy. In contrast, however, emotional function had significantly improved after 6 mo. In conclusion, short- and long-term HRQL is deeply affected after esophagectomy for cancer. The impairment of physical function may be a long-term consequence of esophagectomy involving either the respiratory system or the alimentary tract. The short- and long-term improvement in the emotional function of patients who have undergone successful operations may be attributed to the impression that they have survive

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