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门诊膝关节镜检查患者应用利多卡因或无防腐剂2-氯普鲁卡因行脊麻的一项前瞻随机双盲对照的比较研究

麻醉与镇痛 2009年第2期5卷 72-77页

作者： Andrea Casati, md Guido Fanelli, md giorgio danelli, md Marco Berti, md Daniela Ghisi, md Matteo Brivio, md Marta Putzu, md Alessia Barbagallo, md 徐伟(译) University of Parma-Department of Anesthesiology and Pain Therapy Ospedale Maggiore di Parma-Via Gramsci 14 43100 Parma Italy and University of Messina-Department of Anesthesiology 不详

背景在本前瞻、随机、双盲研究中，我们检验了50mg 1％无防腐剂的2-氯普鲁卡因可以提供比相同剂量1％单纯利多卡因恢复更快的脊髓阻滞这一假设。方法30例ASAⅠ-Ⅱ级准备接受膝关节镜检查的门诊患者随机分组接受50mg 1％单纯利多卡因（n... 详细信息

背景在本前瞻、随机、双盲研究中，我们检验了50mg 1％无防腐剂的2-氯普鲁卡因可以提供比相同剂量1％单纯利多卡因恢复更快的脊髓阻滞这一假设。方法30例ASAⅠ-Ⅱ级准备接受膝关节镜检查的门诊患者随机分组接受50mg 1％单纯利多卡因（n=15）或1％无防腐剂单纯氯普鲁卡因（n=15），手术前静脉注射咪哒唑仑（0．03mg／kg）。由一位不知道分组情况的观察者记录感觉（针刺感觉消失）和运动（改良Bromage评分）阻滞的进程直至阻滞完全消退，同时记录可以自主行走和排尿的时间。手术后24小时和第7天进行电话回访。结果氯普鲁卡因组2例患者（13％）和利多卡组1例患者（7％）手术中需要辅助芬太尼（100μg Ⅳ）（P=0．99），但没有患者需要改行全麻完成手术。2-氯普鲁卡因的感觉恢复、运动恢复和自主行走时间的中位数（范围）[95（68-170）分钟、60（45-120）分钟和103（70-191）分钟]均比利多卡因者[120（80-175）分钟、100（60-140）分钟和152（100～185）分钟]要快（分别为P=0．019，P=0．0005和P=0．003）。氯普鲁卡因组的初次排尿时间[180（100-354）分钟]和利多卡因组[190（148-340）分钟]并无不同（P=0．191）。短暂神经症状在利多卡因组患者有5例（33％）而氯普鲁卡因组没有（0％）（P=0．042）。结论50mg 1％无防腐剂2-氯普鲁卡因鞘内注射后感觉和运动功能恢复和自主行走时间比相同剂量1％利多卡因更快，同时较少发生短暂神经症状。

关键词： 1%利多卡因氯普鲁卡因随机双盲对照膝关节镜检查门诊患者防腐剂感觉恢复脊麻

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Gate-controlled supercurrent effect in dry-etched Dayem bridges of non-centrosymmetric niobium rhenium

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Nano Research 2024年第7期17卷 6575-6581页

作者： Jennifer Koch Carla Cirillo Sebastiano Battisti Leon Ruf Zahra Makhdoumi Kakhaki Alessandro Paghi Armen Gulian Serafim Teknowijoyo giorgio De Simoni Francesco Giazotto Carmine Attanasio Elke Scheer Angelo Di Bernardo Department of Physics University of KonstanzUniversitätsstraße 1078464 KonstanzGermany CNR-Spin c/o Universitàdegli Studi di Salernovia Giovanni Paolo II 13284084 Fisciano(SA)Italy NEST Istituto Nanoscienze-CNR and Scuola Normale SuperiorePiazza San Silvestro 1256127 PisaItaly Dipartimento di Fisica“E.R.Caianiello” Universitàdegli Studi di SalernoVia Giovanni Paolo II 13284084 Fisciano(SA)Italy Advanced Physics Laboratory Institute for Quantum StudiesChapman UniversityBurtonsvilleMD 20866USA

The application of a gate voltage to control the superconducting current flowing through a nanoscale superconducting constriction,named as gate-controlled supercurrent(GCS),has raised great interest for fundamental and technological *** gain a deeper understanding of this effect and develop superconducting technologies based on it,the material and physical parameters crucial for the GCS effect must be ***-down fabrication protocols should also be optimized to increase device scalability,although studies suggest that top-down fabricated devices are more resilient to show a ***,we investigate gated superconducting nanobridges made with a top-down fabrication process from thin films of the noncentrosymmetric superconductor niobium rhenium with varying ratios of the constituents(NbRe).Unlike other devices previously reported and made with a top-down approach,our NbRe devices systematically exhibit a GCS effect when they were fabricated from NbRe thin films with small grain size and etched in specific *** observations pave the way for the realization of top-down-made GCS devices with high *** results also imply that physical parameters like structural disorder and surface physical properties of the nanobridges,which can be in turn modified by the fabrication process,are crucial for a GCS observation,providing therefore also important insights into the physics underlying the GCS effect.

关键词： superconductivity non-centrosymmetric superconductors superconducting devices gated devices gate-controlled supercurrent top-down fabrication

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Role of Mediterranean diet in preventing platinum based gastrointestinal toxicity in gynecolocological malignancies: A single Institution experience

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World Journal of Clinical Oncology 2019年第12期10卷 391-401页

作者： Eleonora Ghisoni Valentina Casalone Gaia Giannone Gloria Mittica Valentina Tuninetti giorgio Valabrega Candiolo Cancer Institute FPO-IRCCSTorino 10060 Italy University of Torino Torino 10060Italy

BACKGROUND Gynecological malignancies represent a major cause of death in women and are often treated with platinum-based *** undergoing chemotherapy suffer from alterations in nutritional status which may worsen gastrointestinal(GI)toxicities,quality of life and affect the overall ***,assuring a good nutritional status and limiting toxicities during treatment are still major goals for *** To assess the role of Mediterranean Diet(md)in reducing GI toxicities in patients with gynecological cancers treated with platinum-based *** We conducted an observational study on 22 patients with gynecological tumors treated with a platinum-based chemotherapy at Candiolo Cancer Institute FPO/IRCCS between January 2018 and June *** food and frequency(FFQ)and the Patient-Reported Outcomes Common Terminology Criteria For Adverse Events(PRO-CTCAE)questionnaires were administered at baseline and at every Day 1 of each *** evaluate the differences in GI toxicities the study population was divided in two groups according to the currently validated Mediterranean Diet Serving Score(mdSS)at *** Patients with high mdSS reported a trend toward lower GI toxicities according to PRO-CTCAE at each timepoint(first evaluation:P=0.7;second:P=0.52;third:P=0.01).In particular,difference in nausea frequency and gravity(P md possibly reduces GI toxicity and prevents nutritional status impairment during chemotherapy treatmen

关键词： Mediterranean diet Gynecological malignancies Gastrointestinal toxicities Platinum-based chemotherapy Nutritional status

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International study of the Complex Stress Reaction Syndrome:Implications for transdiagnostic clinical practice

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World Journal of Psychiatry 2023年第10期13卷 803-815页

作者： Sari Goldstein Ferber Aron Weller Adele M Hayes Tracy D Vannorsdall Yaroup Ajlouni Mo'nes Qudah Gil Zalsman Gal Shoval Tommaso Benedetto Jannini Racquel Fiedler Lily X Chen Danielle R Shayani Elin Kachuki Dory Dana Stolowicz-Melman Connor Evans Megan Trow giorgio Di Lorenzo Rodolfo Rossi Department of Psychological and Brain Sciences University of DelawareNewarkDE 19716United States Department of Psychology Bar Ilan UniversityRamat Gan 5290002Israel Department of Psychology and The Gonda Brain Research Center Bar Ilan UniversityRamat Gan 5290002Israel Department of Psychiatry and Behavioral Sciences Department of NeurologyThe Johns Hopkins University School of MedicineBaltimoreMD 21287United States Jordan Health Aid-International Amman 1234Jordan Geha Mental Health Center Petah TiqvaIsrael and Faculty of MedicineTel Aviv UniversityRamat Aviv 6997801Israel Division of Molecular Imaging and Neuropathology Department of PsychiatryColumbia UniversityNew YorkNY 10032United States Department of Neuroscience Princeton UniversityPrincetonNJ 08544United States Department of Systems Medicine Tor Vergata University of RomeRome 00133Italy UNSW School of Psychology UNSW SydneySydney 2052Australia Department of Biology Pacific UniversityForest GroveOR 97116United States Oregon Chapter of Fulbright Association OregonOR 97045United States Department of Systems Medicine Tor Vergata University of RomeRome 00179Italy IRCCS Fondazione Santa LuciaRome 00179Italy

BACKGROUND The debate regarding diagnostic classification systems in psychiatry(categorial vs dimensional systems)has essential implications for the diagnosis,prevention and treatment of stress *** previously found a unique pattern of stress reaction in a study executed during the coronavirus disease 2019 pandemic using large representative samples in two countries,and termed it the Complex Stress Reaction Syndrome(CSRS).AIM To investigate CSRS,Type A(psychiatric symptoms,spanning anxiety,depression,stress symptoms,and posttraumatic stress disorder(PTSD)),with or without long-coronavirus disease(COVID)residuals(CSRS,Type B,neuropsychiatric symptoms spanning cognitive deficits and fatigue,excluding systemic symptoms).Our two-tailed hypothesis was that CSRS is a condition related to an unrecognized type of stress reaction in daily life in the general population(Type A)or that it is related to the severe acute respiratory syndrome coronavirus 2 infection and its long-COVID residuals(Type B).METHODS 977 individuals in four continents(North America,Europe,Australia and the Middle East)completed the online study questionnaire in six languages using the Qualtrics *** study was managed by six teams in six countries that promoted the study on social *** questionnaire assessed anxiety,depression,stress symptoms and PTSD(CSRS,Type A),cognitive deficits and fatigue(CSRS,Type B).The data were analyzed using Proportion Analyses,Multivariate Analysis of Co-Variance(MANCOVA),linear regression analyses and validated clinical cutoff *** The results of the Proportion Analyses showed that the prevalence of 4 symptoms spanning anxiety,depression,stress symptoms,and PTSD was significantly higher than the most prevalent combinations of fewer symptoms across 4 continents,age groups,and *** supports the transdiagnostic argument embedded in the CSRS(Type A).The same pattern of results was found in infected/recovered *** prevalence of the

关键词： Transdiagnostic Complex Stress Reaction Syndrome Stress reactivity Affective disorders Debate in psychiatry

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