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大尺寸CFRP约束混凝土方柱的轴心抗压试验研究

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湖南大学学报（自然科学版） 2016年第3期43卷 75-82页

作者：单波蔡静肖岩 giorgio Monti 湖南大学土木工程学院湖南长沙410082 罗马第一大学意大利罗马00917

试件的尺寸对于碳纤维增强塑料(CFRP)约束混凝土柱的性能具有重要影响,但目前在CFRP约束混凝土尺寸效应方面的研究基本上还处于空白.基于对7种不同倒角半径的大尺寸CFRP约束混凝土方柱的轴心抗压试验,获取了各组试件的破坏模式、抗压强... 详细信息

试件的尺寸对于碳纤维增强塑料(CFRP)约束混凝土柱的性能具有重要影响,但目前在CFRP约束混凝土尺寸效应方面的研究基本上还处于空白.基于对7种不同倒角半径的大尺寸CFRP约束混凝土方柱的轴心抗压试验,获取了各组试件的破坏模式、抗压强度、应力-应变曲线、外包CFRP应变分布等基本力学性能,并与已有小尺寸试件的试验结果进行比较和分析.研究结果表明,试件的抗压强度随倒角半径比的增大而增大,外包CFRP对直角试件几乎无增强作用;所有试件的破坏都是由外包CFRP的拉断所导致,断裂位置均位于倒角范围内,应力集中的现象明显;约束效应比MCR可以较好地反映尺寸效应对抗压强度影响,试件尺寸的增大显著降低CFRP的约束效应;外包CFRP的极限应变低于其材性试验结果35%以上,明显大于对应的小试件试验结果;已有模型的计算结果与本试验的实测结果存在显著差异,故有必要考虑尺寸效应的影响.

关键词： FRP 约束混凝土方柱轴心受压尺寸效应

Overcoming endocrine resistance in metastatic breast cancer: Current evidence and future directions

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World Journal of Clinical Oncology 2014年第5期5卷 990-1001页

作者： Andrea Milani Elena Geuna Gloria Mittica giorgio Valabrega Institute for cancer Research and Treatment at candiolo University of Torino Medical School FPO(Fondazione del Piemonte per l'Oncologia) Department of Oncology University of Torino Medical School

About 75% of all breast cancers are estrogen receptor(ER)-positive. They generally have a more favorable clinical behavior, prognosis, and pattern of recurrence, and endocrine therapy forms the backbone of treatment. Anti-estrogens(such as tamoxifen and fulvestrant) and aromatase inhibitors(such as anastrozole, letrozole, and exemestane) can effectively control the disease and induce tumor responses in a large proportion of patients. However, the majority of patients progress during endocrine therapy(acquired resistance) and a proportion of patients may fail to respond to initial therapy(de novo resistance). Endocrine resistance is therefore of clinical concern and there is great interest in strategies that delay or circumvent it. A deeper knowledge of the molecular mechanisms that drive endocrine resistance has recently led to development of new strategies that have the promise to effectivelyovercome it. Many resistance mechanisms have been described, and the crosstalk between ER and growth factor receptor signaling pathways seems to represent one of the most relevant. Compounds that are able to inhibit key elements of these pathways and restore endocrine sensitivity have been studied and more are currently under development. The aim of this review is to summarize the molecular pathophysiology of endocrine resistance in breast cancer and its impact on current clinical management.

关键词： Everolimus Mammalian target of rapamycin PI3K inhibitors Estrogen receptor Endocrine resistance

can post-mortem computed tomography be considered an alternative for autopsy in deaths due to hemopericardium？

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Journal of Geriatric cardiology 2014年第4期11卷 363-367页

作者： Lorenzo Gitto Serenella Serinelli Francesco P. Busardo Valeria Panebianco giorgio Bolino Aniello Maiese Department of Anatomy Histology Forenxic Medicine and Orthopaedics Sap ienza University of Rome Viale Regina Elena 336 Rome 00185 Italy Department of Radiological Sciences Oncology and Pathology Sapienza University of Rome Rome 00161 Italy

Hemopericardium is a common finding at autopsy, but it may represent a challenge for the forensic pathologist when the etiopathologi-cal relationship in causing death is requested. Hemopericardium and cardiac tamponade can be evaluated in living people using radiological techniques, in particular computer tomography （CT）. Only a few studies are reported in literature involving post-mortem （PM） cases, where PMCT imaging has been used in order to investigate acute hemopericardium, and they have shown a good accuracy of this technique. Here we report a case involving a 70-year-old white male found dead on the beach, with a medical history of hepatitis C and chronic hypertension with a poor pharmacological response. A PMCT was performed about 3 h after the discovery of the body. The PMCT examination showed an intrapericardial aortic dissection associated to a periaortic hematoma, a sickle-shaped intramural hematoma, a false lumen, and a hemop-ericardium consisting in fluid and clotted blood. In this case, the PMCT was able to identify the cause of death, even though a traditional autopsy was required to confirm the radiological findings. PMCT is a reliable technique, which in chosen cases, can be performed without the need for a traditional autopsy to be carried out.

关键词： Hemopericardium cardiac tamponade Aortic dissection Computer tomography

Multiple immune disorders in unrecognized celiac disease:a case report

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World Journal of Gastroenterology 2003年第6期9卷 1377-1380页

作者： giorgio LaVilla Pietro Pantaleo Roberto Tarquini Lino Cirami Federico Perfetto Francesco Mancuso Giacomo Laffi Dipartimento di Medicina Interna Università degli Studi di FirenzeFirenzeItalia Unità Operativa di Nefrologia Dialisi e TrapiantoAzienda Ospedaliera CareggiFirenzeItalia

We reported a female patient with unrecognized celiac disease and multiple extra intestinal manifestations, mainly related to a deranged immune function, including macroamilasemia, macrolipasemia, IgA nephropathy,thyroiditis, and anti-b2-glicoprotein-1 antibodies, that disappeared or improved after the implementation of a gluten-free diet.

关键词： Abortion, Habitual Adult Celiac Disease Diet Female Glomerulonephritis, IGA Gluten dosage Humans Hyperamylasemia Immune System Diseases Lipase Thyroiditis, Autoimmune

Pilot study to determine improvements in subjective penile morphology and personal relationships following a Nesbit plication procedure for men with congenital penile curvature

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Asian Journal of Andrology 2008年第3期10卷 512-519页

作者： giorgio cavallini Stefano caracciolo Andrological Operative Unit Headquarters of Societg7 ltaliana di Studi di Medicina della Riproduzione via Mazzini 12Bologna 40138 Italy Section of General and Clinical Psychology University of Ferrara - Medical School Via Fossato di Mortara 64bFerrara 44100 Italy

Aim： To determine whether the surgical straightening of congenital penile curvature can improve intromission comfort, penile features, personal relationships and psychogenic erectile dysfunction （ED）. Methods： Fifty-four patients （mean age 24 years, range 20-31 years） whose congenital penile deviation due to physiological curvature was ≥ 25 degrees, as measured on a graph, and who were experiencing penetration discomfort were assessed specifically for the present study. Of these, 14 patients suffered from psychogenic ED. The assessment included a case history, an objective examination, a pharmacologically-induced erection with prostaglandin E1 10-20 g, a graph taken during erection, a basal and dynamic Duplex ultrasonograph, penile length measurement, nocturnal penile tumescence recording, hormonal profiles and a psychological interview to evaluate the quality of their personal relationships according to Hinde＇s parameters （contents, number, features, frequency, ability to perceive limits of mutuality, subjective perception of the other person[s], and reliability）. All patients underwent the Nesbit procedure. The initial assessment was repeated at 3 and 12 months after surgery. Data analyses were carried out using the z test. Results： Subjective judgement of cosmetic penile features and vaginal intromission comfort improved significantly after surgery whereas the quality of personal relationships and ED did not. Conclusion： The surgical straightening of congenital penile curvature improved intromission comfort and penile features, but it failed to improve interpersonal relationships or psychogenic ED.

关键词： congenital penile curvature Nesbit procedure penile surgery personal relationships

Free triiodothyronine level correlates with statin responsiveness in acute myocardial infarction

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Journal of Geriatric cardiology 2018年第4期15卷 290-297页

作者： Wen-Yao WANG Kuo ZHANG Wei ZHAO A. Martin Gerdes giorgio Iervasi Yi-Da TANG Departments of cardiology State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of Biomedtcal Sciences New York Institute of Technology-College of Osteopathic Medicine Northern Blvd. Old Westbury New York USA Clinical Physiology Institute Consiglio Nazionale delle Ricerche (CNR) Pisa Italy

Background Although thyroid hormone （TH） has important effects on lipid metabolism, the relationship between TH and statin responsiveness has never been investigated. We hypothesize that TH plays an important role in statin responsiveness in patients with acute myocardial infarction （AMI）. Methods Consecutive 1091 hospitalized AMI patients in Fuwai hospital （Beijing, China） were enrolled into this current study. The study population was divided into three groups based on the intensity of statin treatment： low-intensity （n = 221）, moderate-intensity （n = 712） and high-intensity （n = 158）. Lipid levels were measured after statin therapy lasting for 10-14 days. The association between TH, lipid profile levels and achievement of low-density lipoprotein cholesterol （LDL-C） lowering goals was explored in patients with AMI on statin therapy. Results By general linear analysis, a significant linear trend between free triiodothyronine （FT3） and LDL-C level （linear coefficient r = -0.082, P = 0.001） and FT3 and total cholesterol （TC） level （r = -0.105, P = 0.031） was observed in the moderate-intensity statin group. A more apparent linear trend was detected in the high-intensity statin group （for LDL-C： r = -0.113, P = 0.005; for TC： r = -0.172, P = 0.029, respectively）. However, no significant correlation was observed in the low-intensity statin group. Compared with the low-FT3 group （defined as FT3 〈 1.79 pg/mL）, the OR （95% CI） for attaining a LDL-C 〈 3.0mmol/L was found to be 2.217 （1.001–4.839） in the higher FT3 group （〉 2.95 pg/mL）. The OR （95% CI） for attaining the more intensive goal （LDL-C 〈 1.8mmol/L） was 2.836 （1.014–5.182）. Conclusions Our study reveals that variation in FT3 levels is related to the cholesterol-lowering responsiveness of statins in AMI patients. These findings suggest that low FT3 may be a factor responsible for lack of LDL-C goal attainment and patients’ poor responsiveness to statin treatment.

关键词： Acute myocardial infarction Free triiodothyronine Hypothyroid Statin

Histologic evaluation of bone healing of adjacent alveolar sockets grafted with bovineand porcine-derived bone:a comparative case report in humans

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Regenerative Biomaterials 2017年第2期4卷 125-128页

作者： Renzo Guarnieri Patricia DeVilliers Maurizio Grande Luigi Vito Stefanelli Stefano Di carlo giorgio Pompa Adjunct Professor Department of Dental and Maxillofacial SciencesSchool of DentistryUniversity La SapienzaRomeItaly Adjunct Assistant Professor of Pathology University of Alabama at BirminghamBirminghamALUSA Private Dental Implant Practice RomaItaly Assistant Professor Department of Dental and Maxillofacial SciencesSchool of DentistryUniversity La SapienzaRomeItaly Professor Director Department of Dental and Maxillofacial SciencesSchool of DentistryUniversity La SapienzaRomeItaly.

To evaluate and compare histomorphometrically the bone response to two xenografts,one bovine and the other porcine,grafted in adjacent extraction sockets in a *** this case report,two adjacent maxillary premolars were extracted,and the sockets were filled with two different xenogeneic bone substitutes(first premolar with bovine bone,and second premolar with porcine bone)to counteract post-extraction volume *** 6 months bone core specimens were harvested during the placement of implants at the regenerated ***,for the bovine xenograft the percentage of newly formed bone(osteoid)was 26.85%,the percentage of the residual graft material was 17.2%and the percentage of connective tissue 48.73%,while for the porcine xenograft,newly formed bone(osteoid)represented 32.19%,residual graft material was 6.57%and non-mineralized connective tissue was 52.99%.Histological results indicated that both biomaterials assessed in this study as grafts for socket preservation technique are biocompatible and *** bone derived demonstrated to be less resorbable than porcine bone *** xenogenic biomaterials did not interfere with the normal bone reparative processes.

关键词： socket preservation bovine bone-derived porcine bone-derived histology

Radioisotope production using lasers:From basic science to applications

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Matter and Radiation at Extremes 2024年第3期9卷 31-44页

作者： M.R.D.Rodrigues A.Bonasera M.Scisciò J.A.Pérez-Hernández M.Ehret F.Filippi P.L.Andreoli M.Huault H.Larreur D.Singappuli D.Molloy D.Raffestin M.Alonzo G.G.Rapisarda D.Lattuada G.L.Guardo C.Verona Fe.Consoli G.Petringa A.McNamee M.La Cognata S.Palmerini T.carriere M.Cipriani G.Di giorgio G.Cristofari R.De Angelis G.A.P.Cirrone D.Margarone L.Giuffrida D.Batani P.Nicolai K.Batani R.Lera L.Volpe D.Giulietti S.Agarwal M.Krupka S.Singh Fa.Consoli Cyclotron Institute Texas A&M UniversityCollege StationTexas 77840USA Laboratori Nazionali del Sud Istituto Nazionale di Fisica Nucleare(LNS-INFN)CataniaItaly ENEA Fusion and Technologies for Nuclear Safety and Security Department-CFrascatiItaly Centro de Láseres Pulsados(clpu) VillamayorSpain Universidad de Salamanca SalamancaSpain Centre Lasers Intenses et Applications(CELIA) Universitéde BordeauxCNRSCEATalenceFrance HB11 Energy Holdings Pty FreshwaterNew South WalesAustralia School of Mathematics and Physics Queen’s University BelfastBelfastUnited Kingdom Dipartimento di Fisica e Astronomia“E.Majorana ”Università di CataniaCataniaItaly Facoltàdi Ingegneria e Architettura Universitàdegli Studi di Enna“Kore”EnnaItaly Dipartimento di Ingegneria Industriale Universitàdi Roma“Tor Vergata”RomaItaly Dipartimento di Fisica e Geologia Universitàdegli Studi di PerugiaPerugiaItaly Istituto Nazionale di Fisica Nucleare Sezione di PerugiaPerugiaItaly ELI Beamlines Facility the Extreme Light Infrastructure ERICDolni BrezanyCzech Republic ETSIA Universidad Politécnica de MadridMadridSpain Dipartimento Fisica “E.Fermi”Universitàdi Pisa and INFNPisaItaly FZU–Institute of Physics of Czech Academy of Sciences PragueCzech Republic Institute of Plasma Physics of Czech Academy of Sciences PragueCzech Republic

The discovery of chirped pulse amplification has led to great improvements in laser technology,enabling energetic laser beams to be compressed to pulse durations of tens of femtoseconds and focused to a few *** with energies of tens of MeV can be accelerated using,for instance,target normal sheath acceleration and focused on secondary *** such conditions,nuclear reactions can occur,with the production of radioisotopes suitable for medical *** use of high-repetition lasers to produce such isotopes is competitive with conventional methods mostly based on *** this paper,we study the production of^(67)Cu,^(63)Zn,^(18)F,and^(11)C,which are currently used in positron emission tomography and other *** the same time,we study the reactions^(10)B(p,α)^(7)Be and^(70)Zn(p,4n)^(67)Ga to put further constraints on the proton distributions at different angles,as well as the reaction^(11)B(p,α)^(8)Be relevant for energy *** experiment was performed at the 1 PW laser facility at VegaⅢin Salamanca,*** distributions of radioisotopes in the forward(with respect to the laser direction)and backward directions were measured using a high purity germanium *** results are in reasonable agreement with numerical estimates obtained following the approach of Kimura and Bonasera[*** ***.,Sect.A 637,164–170(2011)].

关键词： purity estimates backward

Ion Beam Figuring System for Synchrotron X-Ray Mirrors Achieving Sub-0.2-µrad and Sub-0.5-nm Root Mean Square

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Nanomanufacturing and Metrology 2023年第3期6卷 1-11页

作者： Tianyi Wang Lei Huang Yi Zhu Stefano giorgio Philip Boccabella Nathalie Bouet Mourad Idir Brookhaven National Laboratory National Synchrotron Light Source II(NSLS-II)PO Box 5000UptonNY11973USA

Optics with high-precision height and slope are increasingly desired in numerous industrial *** instance,Kirkpatrick-Baez(KB)mirrors play an important role in synchrotron X-ray applications.A KB system is composed of two aspherical,grazing-incidence mirrors used to focus an X-ray *** fabrication of KB mirrors is challenging due to the aspherical departure of the mirror surfaces from base geometries and the high-quality requirements for slope and height *** this paper,we present the process of manufacturing an elliptical cylinder KB mirror using our in-house-developed ion beam figuring(IBF)and metrology ***,the key aspects of figuring and finishing processes with IBF are illustrated in *** effect of positioning error on the convergence of the residual slope error is highlighted and ***,inspection and cross-validation using different metrology instruments are performed and used as the final validation of the *** confirm that relative to the requested off-axis ellipse,the mirror has achieved 0.15-μrad root mean square(RMS)and 0.36-nm RMS residual slope and height errors,respectively,while maintaining the initial 0.3-nm RMS microroughness.

关键词： Ion beam figuring Kirkpatrick-Baez Synchrotron X-ray mirrors Stitching interferometry Optical fabrication Optical metrology