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Prevalence of Helicobacter pylori infection and intestinal metaplasia in subjects who had undergone surgery for gastric adenocarcinoma in Northwest Italy

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World Journal of Gastroenterology 2005年第45期11卷 7131-7135页

作者： giorgio Palestro Rinaldo Pellicano Gian Ruggero Fronda Guido Valente Marco de Giuli Tito Soldati Agostino Pugliese Stefano Taraglio Mauro Garino Donata Campra Miguel Angel Cutufia Elena Margaria Giancarlo Spinzi Aldo Ferrara giorgio Marenco Mario Rizzetto Antonio Ponzetto department of Oncology department of Gastro-Hepatology department of Surgery department of Pathology department of Infectious Diseases department of Biology Gastroenterology Unit General Medicine Unit

AIM： To investigate the seroprevalence of Helicobacter pylori （Hpylori） infection and its more virulent strains as well as the correlation with the histologic features among patients who had undergone surgery for gastric cancer （GC）. METHODS： Samples from 317 （184 males, 133 females, mean age 69±3.4 years） consecutive patientswho had undergone surgery for gastric non-cardia adenocarcinoma were included in the study. Five hundred and fifty-five （294 males, 261 females, mean age 57.3±4.1 years） patients consecutively admitted to the Emergency Care Unit served as control. Histological examination of tumor, lymph nodes and other tissues obtained at the time of surgery represented the diagnostic ＂gold standard＇： An enzyme immunosorbent assay was used to detect serum anti-H pylori （IgG） antibodies and Western blotting technique was utilized to search for anti-CagA protein （IgG）. RESULTS： Two hundred and sixty-one of three hundred and seventeen （82.3%） GC patients and 314/555 （56.5%） controls were seropositive for anti-H pylori （P〈0.0001; OR, 3.58; 95%CI, 2.53-5.07）. Out of the 317 cases, 267 （84.2%） were seropositive for anti-CagA antibody vs 100 out of 555 （18%） controls （P〈0.0001; OR, 24.30; 95%CI, 16.5-35.9）. There was no difference between the frequency of H pylori in intestinal type carcinoma （76.2%） and diffuse type cancer （78.8%）. Intestinal metaplasia （IM） was more frequent but not significant in the intestinal type cancer （83.4% vs 75.2% in diffuse type and 72.5% in mixed type）. Among the patients examined for IM, 39.8% had IM type Ⅰ, 8.3% type Ⅱ and 51.9% type Ⅲ （type IU vs others, P = 0.4）. CONCLUSION： This study confirms a high seroprevalence of H pylori infection in patients suffering from gastric adenocarcinoma and provides further evidence that searching for CagA status over H pylori infection might confer additional benefit in identifying populations at greater risk for this tumor.

关键词： Hpylori infection Gastric cancer Intestinal metaplasia Italy

Surgery for hepatocellular carcinoma can provide the same life-expectancy as transplant of that of general population

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Hepatobiliary Surgery and Nutrition 2019年第2期8卷 151-152页

作者： giorgio Ercolani Michele Cucchi department of Medical and Surgical Sciences DIMECAlma Mater StudiorumUniversity of BolognaBolognaItaly General Surgery MorgagniPierantoni HospitalForlì(FC)Italy

When deciding for the optimal treatment to adopt in patients suffering from hepatocellular carcinoma(HCC),the surgical approach is commonly considered as the most curative option(1,2).The scarcity of donors for liver transplantation(LT)led surgeons to bridge patients until an eventual future transplant(salvage LT),opting in first instance and when feasible for hepatic resection(HR)also for those patients otherwise transplantable(2).In the study published by Pinna and colleagues in Annals of Surgery 2018,it was verified in what measure LT and HR can provide for HCC the same mortality expected in the general population,defining the so called"statistical cure"(3).

关键词： Surgery hepatocellular otherwise

Pancreatic metastases from renal cell carcinoma:The state of the art

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World Journal of Gastroenterology 2011年第43期17卷 4747-4756页

作者： Roberto Ballarin Mario Spaggiari Nicola Cautero Nicola de Ruvo Roberto Montalti Cristina Longo Anna Pecchi Patrizia Giacobazzi Giuseppina de Marco Giuseppe D’Amico giorgio Enrico Gerunda Fabrizio Di Benedetto Liver and Multivisceral Transplant Center University of Modena and Reggio Emilia department of Radiology University of Modena and Reggio Emilia Unit of Oncological Radiotherapy University of Modena and Reggio Emilia

Pancreatic metastases are rare,with a reported incidence varying from 1.6%to 11%in autopsy studies of patients with advanced *** clinical series,the frequency of pancreatic metastases ranges from 2%to 5%of all pancreatic malignant ***,the pancreas is an elective site for metastases from carcinoma of the kidney and this peculiarity has been reported by several *** epidemiology,clinical presentation,and treatment of pancreatic metastases from renal cell carcinoma are known from singleinstitution case reports and literature *** currently very limited experience with the surgical resection of isolated pancreatic metastasis,and the role of surgery in the management of these patients has not been clearly *** fact,for many years pancreatic resections were associated with high rates of morbidity and mortality,and metastatic disease to the pancreas was considered to be a terminal-stage *** recently,a significant reduction in the operative risk following major pancreatic surgery has been demonstrated,thus extending the indication for these operations to patients with metastatic disease.

关键词： Pancreatic metastases Renal cell carcinoma Pancreatic surgery Prognostic factors Therapeutic approach Radiological findings

Stone-scoring systems for predicting complications in percutaneous nephrolithotomy:A systematic review of the literature

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Asian Journal of Urology 2023年第3期10卷 226-238页

作者： giorgio Mazzon Simon Choong Antonio Celia department of Urology AULSS7 PedemontanaSan Bassiano HospitalBassano Del GrappaItaly Institute of Urology University College Hospitals of LondonLondonUK

Objective:Percutaneous nephrolithotomy is a treatment of choice for larger stones of the upper urinary ***,several nephrolithometric nomograms for prediction of post-operative surgical outcomes have been proposed,although uncertainties still exist regarding their roles in the estimation of ***:We conducted a systematic review on PubMed and Web of Sciences databases including English studies with at least 100 cases and published between January 2010 and december *** identified original articles evaluating correlations between the Guy’s stone score,the stone size(S),tract length(T),obstruction(O),number of involved calices(N),and essence or stone density(E)(S.T.O.N.E.),Clinical Research Office of the Endourological Society(CROES),and Seoul National University Renal Stone Complexity(S-ReSC)scores and post-operative complications in adult *** also included newly designed nomograms for prediction of specific ***:After an initial search of 549 abstracts,we finally included a total of 18 *** them,11 investigated traditional nephrolithometric nomograms,while seven newly designed nomograms were used to predict specific ***,7316 patients have been *** total,14 out of 18 papers are derived from retrospective single-center ***’s stone score obtained correlation with complications in five,*** score in four,while CROES score and S-ReSC score in three and two,*** of the studies investigated minimally invasive percutaneous nephrolithotomy(PCNL)and all cases have been conducted in prone *** newly designed nomograms,none of them is currently externally validated;five of them predict post-operative infections;the remaining two have been designed for thromboembolic events and urinary ***:This review presents all nomograms currently available in the PCNL field and highlights a certain number of *** data ha

关键词： Percutaneous nephrolithotomy Complications Nomogram Stone-scoring system Clavien-Dindo

Occurrence of human pathogenic viruses in drinking water and in its sources:A review

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Journal of Environmental Sciences 2023年第10期132卷 145-161页

作者： Marco Panizzolo Marta Gea Elisabetta Carraro giorgio Gilli Silvia Bonetta Cristina Pignata department of Public Health and Pediatrics University of TorinoPiazza Polonia 9410126TorinoItaly department of Life Sciences and Systems Biology University of Torinovia Accademia Albertina 1310123TorinoItaly

Since many waterborne diseases are caused by human pathogenic viruses,virus monitoring of drinking water(DW)and DW sources is crucial for public ***,the aim of this review was to describe the occurrence of human pathogenic viruses in DW and DW sources;the occurrence of two viruses proposed as novel indicators of human faecal contamination(Peppermild mottle virus and Tobacco mosaic virus)was also *** research was focused on articles that assessed viral occurrence using molecular methods in the surface water used for DW production(SW-D),groundwater used for DW production(GW-D),DW and bottled-DW(BW).A total of 1544 studies published in the last 10 years were analysed,and 79 were ultimately *** considering the detection methods,filtration is the most common concentration technique,while quantitative polymerase chain reaction is the most common quantification *** virus occurrence in SW-D,GW-D,and DW,high percentages of positive samples were reported for adenovirus,polyomavirus and Pepper mild mottle *** genomes were frequently detected in SW-D and rarely in GW-D,suggesting that GW-D may be a safe DW *** genomes were also detected in DW,posing a possible threat to human *** lowest percentages of positive samples were found in Europe,while the highest were found in Asia and South *** three articles assessed viral occurrence in *** review highlights the lack of method standardization and the need for legislation updates.

关键词： Drinking water Enteric virus Human health Microbial water quality Molecular methods Surface water

The Belt and Road Initiative Impact on Europe： An Italian Perspective

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China & World Economy 2017年第5期25卷 125-138页

作者： Enrico Fardella giorgio Prodi Tenured Associate Professor and Executive Director Centre for Mediterranean Area Studies History Department Peking University China Associate Professor. department of Economics and Management Ferrara University Italy

This paper analyzes the impact of the Belt and Road Initiative on Europe with a specificfocus on ltaly. We concentrate on the impact of new railways and port infrastructures onbilateral trade. Our analysis suggests that the development of new railway connectionswill benefit most of the Northern and Central European countries. Some industries likeautomotive and electronics that have a higher value to weight ratio will benefit morethan others. However, due to higher costs, railway services will never reach a highpercentage of total import^export flows. Investment in new port facilities, although less＂new＂ compared with railways, may be a bigger game changer. The development ofthe Port of Piraeus has already increased the importance of the Mediterranean Sea asan import^export hub for China. If the other planned investments in Egypt and Algeriaare completed, this phenomenon will be magnified. This presents a huge challenge forItaly. The ltalian port in the high Adriatic Sea could be displaced by Piraeus capacity,especially if this port linked through railways with the center of Europe. Italy needsto coordinate its ports together with its railway network to take advantage of Belt andRoad Initiative opportunities.

关键词： Belt and Road, China, Europe, infrastructure, Mediterranean

Jejuno-jejunal invagination due to intestinal melanoma

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World Journal of Gastroenterology 2007年第2期13卷 310-312页

作者： Giuseppe Resta Gabriele Anania Federico Messina Damiano de Tullio Gloria Ferrocci Federico Zanzi Davide Pellegrini Rocco Stano giorgio Cavallesco Gianfranco Azzena Savino Occhionorelli Università degli Studi di Ferrara Dipartimento di Scienze Chirurgiche Anestesiologiche e Radiologiche Istituto di Clinica Chirurgica Arcispedale "S. Anna" Ferrara Italy

Cutaneous melanoma is one of the most studied neoplastic lesions in biology and clinical oncology. It has been well documented that this type of neoplasm presents a high metastatic rate, and is able to involve nearly every tissue. Non-cutaneous melanoma represents an unusual pattern of melanoma, and the small intestine is an uncommon anatomic localization. Herein we report an extremely rare clinical case of a young woman affected by a bleeding jejunal melanoma, whose early clinical presentation was an intestinal invagination.

关键词： Cutaneous melanoma Intestinal obstruction Intestinal melanoma Invagination

Chronic intestinal pseudo-obstruction

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World Journal of Gastroenterology 2008年第19期14卷 2953-2961页

作者： Alexandra Antonucci Lucia Fronzoni Laura Cogliandro Rosanna F Cogliandro Carla Caputo Roberto de giorgio Francesca Pallotti Giovanni Barbara Roberto Corinaldesi Vincenzo Stanghellini department of Internal Medicine and Gastroenterology University of Bologna

Chronic intestinal pseudo-obstruction (CIPO) is a se- vere digestive syndrome characterized by derangement of gut propulsive motility which resembles mechanical obstruction, in the absence of any obstructive process. Although uncommon in clinical practice, this syndrome represents one of the main causes of intestinal failure and is characterized by high morbidity and mortality. It may be idiopathic or secondary to a variety of diseases. Most cases are sporadic, even though familial forms with either dominant or recessive autosomal inheritance have been described. Based on histological features in- testinal pseudo-obstruction can be classified into three main categories:neuropathies, mesenchymopathies, and myopathies, according on the predominant involvement of enteric neurones, interstitial cells of Cajal or smooth muscle cells, respectively. Treatment of intestinal pseu- do-obstruction involves nutritional, pharmacological and surgical therapies, but it is often unsatisfactory and the long-term outcome is generally poor in the majority of cases.

关键词： Chronic intestinal pseudo-obstruction Smallbowel manometry Immunohistochemistry Prokinetics Intestinal transplantation

Spouting behaviour of binary mixtures in square-based spouted beds

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Particuology 2019年第2期17卷 193-201页

作者： Cristina Moliner Filippo Marchelli Massimo Curti Barbara Bosio giorgio Rovero Elisabetta Arato department of Civil Chemical and Environmental Engineering (DICCA) University of Genova (UNIGE) Genova Italy Faculty of Science and Technology Free University of Bolzano (UNIBZ) Bolzano Italy department of Applied Science and Technology (DISAT) Polytechnic University of Turin (POLITO) Turin Italy

From experime nts, the influe nee of the physical characteristics of different bin ary mixtures of solids on the spouting regime of a pyramidal square-based spouted bed reactor is assessed. The applied methodology permits a more precise evaluation of the effects of the tested variables (diameter, density, sphericity) on the response variables (minimum air flows at which spouting begins and at which to maintain spouting con ditions). The associated pressure drops along the bed of particles a nd the height of the formed fountai n are analysed in each case. During the initial stages of fluidisation, binary mixtures containing different density ratios show dead zones. Segregation becomes more evident at large-size and high-density ratios. The lack of sphericity was found to be the main reason leading to blocking, channelling, and start-up problems when system failures occur. Nevertheless, the extent of segregation in all cases decreases with increasing the spouting velocity. In addition, a computational fluid dynamic model based on the discrete element method, previously validated for a single solid bed, is proposed as a tool to predict and evaluate potential segregation phenomena in binary mixtures. This model reproduced with high accuracy the encountered segregation phenomena. Its use may help define the technical limts inherent in the pyramidal spouted bed reactor.

关键词： Spouted bed reactor Segregation Computational fluid dynamics