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2018世界肾脏日：关注女性和肾脏疾病

肾脏病与透析肾移植杂志 2018年第1期27卷 1-6页

作者： giorgina B.piccoli Mona Alrukhaimi Zhi-Hong Liu Elena Zakharova Adeera Levin Philip Kam Tao Li Guillermo Garcia-Garcia Mohammed Benghanem-Gharbi Kamyar Kalantar-Zadeh Charles Kernahan Latha Kumaraswami giorgina barbara piccoli Gamal Saadi Louise Fox Sharon Andreoli 陈樱花 Department of Clinical and Biological Sciences University of Torino Nephrology Centre Hospitalier Le Mans Department of Medicine Dubai Medical College National Clinical Research Center of Kidney Diseases Jinling Hospital Nanjing University School of Medicine Nephrology Moscow City Hospital n.a. S.P. Botkin Nephrology Moscow State University of Medicine and Dentistry Nephrology Russian Medical Academy of Continuous Professional Education the World Kidney Day Steering Committee Department of Medicine Division of NephrologyUniversity of British Columbia 国家肾脏疾病临床医学研究中心南京总医院

女性是现代家庭和社会的重要贡献者。但目前在世界范围内,男性和女性在受教育程度、医疗保健等方面仍存在显著差异。2018年第13个世界肾脏日恰逢国际妇女节,其主题是"肾脏和女性健康",给我们提供了一个关注女性健康,尤其是女性肾脏健康... 详细信息

女性是现代家庭和社会的重要贡献者。但目前在世界范围内,男性和女性在受教育程度、医疗保健等方面仍存在显著差异。2018年第13个世界肾脏日恰逢国际妇女节,其主题是"肾脏和女性健康",给我们提供了一个关注女性健康,尤其是女性肾脏健康的重要契机。为此,世界肾脏日指导委员会(World Kidney Day Steering Committee)特别组织了全球具有代表性的5位女性肾脏病学家,撰写了述评文章,借机呼吁肾脏病学术领域和全社会更加重视女性健康,让更多女性从肾脏病学术研究中获益。关注女性肾脏健康,利在当代功在千秋!

关键词：女性健康肾脏疾病世界范围肾脏病学学术研究国际妇女节现代家庭医疗保健

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Autoimmmune hepatitis

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Cellular & Molecular Immunology 2022年第2期19卷 158-176页

作者： Benedetta Terziroli Beretta-piccoli giorgina Mieli-Vergani Diego Vergani Epatocentro Ticino&Facoltàdi Scienze Biomediche Universitàdella Svizzera ItalianaLuganoSwitzerland Institute for Research in Biomedicine BellinzonaSwitzerland. King’s College London Faculty of Life Sciences&Medicine at King’s College Hospital LondonUK. Paediatric Liver GI and Nutrition CentreMowatLabsKing’s College HospitalLondonUK. Institute of Liver Studies MowatLabsKing’s College HospitalLondonUK.

Autoimmune hepatitis(AIH)is a T-cell mediated,inflammatory liver disease affecting all ages and characterized by female preponderance,elevated serum transaminase and immunoglobulin G levels,positive circulating autoantibodies,and presence of interface hepatitis at liver *** type 1,affecting both adults and children,is defined by positive anti-nuclear and/or antismooth muscle antibodies,while type 2 AIH,affecting mostly children,is defined by positive anti-liver-kidney microsomal type 1 and/or anti-liver cytosol type 1 *** the autoantigens of type 2 AIH are well defined,being the cytochrome P4502D6(CYP2D6)and the formiminotransferase cyclodeaminase(FTCD),in type 1 AIH they remain to be ***-1 predisposition is conferred by possession of the MHC class II HLA DRB1*03 at all ages,while DRB1*04 predisposes to late onset disease;AIH-2 is associated with possession of DRB1*07 and DRB1**** majority of patients responds well to standard immunosuppressive treatment,based on steroid and azathioprine;second-and third-line drugs should be considered in case of intolerance or insufficient *** review offers a comprehensive overview of pathophysiological and clinical aspects of AIH.

关键词： Autoimmune Hepatitis Immunopathophysiology Treatment Genetic Predisposition

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Autoimmune hepatitis: standard treatment and systematic review of alternative treatments

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World Journal of Gastroenterology 2017年第33期23卷 6030-6048页

作者： Benedetta Terziroli Beretta-piccoli giorgina Mieli-Vergani Diego Vergani Epatocentro Ticino Paediatric Liver GI and Nutrition CentreMowat LabsKing’s College Hospital Institute of Liver Studies Mowat LabsKing’s College Hospital

Autoimmune hepatitis is a rare chronic inflammatory liver disease,affecting all ages,characterised by elevated transaminase and immunoglobulin G levels,positive autoantibodies,interface hepatitis at liver histology and good response to immunosuppressive treatment. If untreated,it has a poor prognosis. The aim of this review is to summarize the evidence for standard treatment and to provide a systematic review on alternative treatments for adults and children. Standard treatment is based on steroids and azathioprine,and leads to disease remission in 80%-90% of patients. Alternative first line treatment has been attempted with budesonide or cyclosporine,but their superiority compared to standard treatment remains to be demonstrated. Second-line treatments are needed for patients not responding or intolerant to standard treatment. No randomized controlled trials have been performed for second-line options. Mycophenolate mofetil is the most widely used second-line drug,and has good efficacy particularly for patients intolerant to azathioprine,but has the major disadvantage of being teratogenic. Only few and heterogeneous data on cyclosporine,tacrolimus,everolimus and sirolimus are available. More recently,experience with the anti-tumour necrosis factoralpha infliximab and the anti-CD20 rituximab has been published,with ambivalent results; these agents may have severe side-effects and their use should be restricted to specialized centres. Clinical trials with new therapeutic options are ongoing.

关键词： Autoimmune hepatitis Standard treatment Second-line treatment Adults Children

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