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Impact of hepatitis B immunoglobulin mode of administration on treatment experiences of patients after liver transplantation: Results from an online survey

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World Journal of Transplantation 2024年第3期14卷 144-155页

作者： giorgia Rizza Kyriaki Glynou Masha Eletskaya General surgery and Liver Transplant Center S.Giovanni Battista HospitalTurin I-10126Italy Medical Affairs Biotest AGDreieich 63303Germany Lumanity Insight(Cello Health Insight) London SE11PPUnited Kingdom

BACKGROUND Hepatitis B immunoglobulin(HBIG)in combination with a potent nucleos(t)ide analog is considered the standard of care for prophylaxis against hepatitis B virus(HBV)reinfection after liver transplantation for HBV-associated *** To evaluate patients’satisfaction,preferences,and requirements for subcutaneous(sC),intramuscular(IM),and intravenous(IV)HBIG *** A self-completion,cross-sectional,online,22-question survey was conducted to examine perceptions and satisfaction with current HBIG treatment in adults receiving HBIG treatment following liver transplantation for HBV-associated disease in France,Italy,and *** HBIG products with different administration modes were evaluated using target product profile assessment and a conjoint(trade-off)*** Ninety patients were enrolled;32%,17%,and 51%were sC,IM,and IV HBIG users,*** duration of treatment was 36.2 *** HBIG had the least negative impact on emotional well-being and social life and was perceived as the most convenient,easiest to administer,least painful,and had the highest self-rating of treatment *** IM HBIG users than sC or IV HBIG users reported that administration frequency was excessive(67%,28%,and 28%,respectively).In the target product profile assessment,76%of patients were likely to use hypothetical sC *** the conjoint exercise,administration route,frequency,and duration were key drivers of treatment *** Ease,frequency,duration,and side effects of HBIG treatment administration were key drivers of treatment preferences,and sC HBIG appeared advantageous over IM and IV HBIG for administration ease,convenience,and pain.A hypothetical sC HBIG product elicited a favorable *** demographics,personal preferences,and satisfaction with HBIG treatment modalities may influence long-term treatment compliance.

关键词： Hepatitis B immunoglobulin Liver transplantation subcutaneous Intramuscular Intravenous Patient satisfaction

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Therapeutic advances in neural regeneration for Huntington’s disease

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Neural Regeneration Research 2024年第9期19卷 1991-1997页

作者： Francesco D’Egidio Vanessa Castelli giorgia Lombardozzi Fabrizio Ammannito Annamaria Cimini Michele d’Angelo Department of Life Health and Environmental SciencesUniversity of L’AquilaL’AquilaItaly

Huntington’s disease is a neurodegenerative disease caused by the expansion mutation of a cytosine-adenine-guanine triplet in the exon 1 of the HTT gene which is responsible for the production of the huntingtin (Htt) protein. In physiological conditions, Htt is involved in many cellular processes such as cell signaling, transcriptional regulation, energy metabolism regulation, DNA maintenance, axonal trafficking, and antiapoptotic activity. When the genetic alteration is present, the production of a mutant version of Htt (mHtt) occurs, which is characterized by a plethora of pathogenic activities that, finally, lead to cell death. Among all the cells in which mHtt exerts its dangerous activity, the GABAergic Medium spiny Neurons seem to be the most affected by the mHtt-induced excitotoxicity both in the cortex and in the striatum. However, as the neurodegeneration proceeds ahead the neuronal loss grows also in other brain areas such as the cerebellum, hypothalamus, thalamus, subthalamic nucleus, globus pallidus, and substantia nigra, determining the variety of symptoms that characterize Huntington’s disease. From a clinical point of view, Huntington’s disease is characterized by a wide spectrum of symptoms spanning from motor impairment to cognitive disorders and dementia. Huntington’s disease shows a prevalence of around 3.92 cases every 100,000 worldwide and an incidence of 0.48 new cases every 100,000/year. To date, there is no available cure for Huntington’s disease. several treatments have been developed so far, aiming to reduce the severity of one or more symptoms to slow down the inexorable decline caused by the disease. In this context, the search for reliable strategies to target the different aspects of Huntington’s disease become of the utmost interest. In recent years, a variety of studies demonstrated the detrimental role of neuronal loss in Huntington’s disease condition highlighting how the replacement of lost cells would be a reasonable strategy to o

关键词： cell therapy exosomes extracellular vesicles Huntingtin Huntington’s disease medium spiny neurons neurodegenerative disease neurogenesis neuronal loss stem cells

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Cross-Cutting Approach for the Characterization of Microbial Emerging Hazards in Agriculture settings from Circular Economy-Driven Wastewater streams

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Environment & Health 2024年第2期2卷 68-75页

作者： giorgia Barbieri Federica Gigliucci Gianfranco Brambilla stefano Morabito Department of Veterinary Public Health and Food safety Istituto Superiore di Sanità29900161 RomeItaly

The recycling of biowaste from municipal wastewater treatment plants(WWTPs)in agriculture represents a circular economy-driven source of water and nutrients to support food system ***,biowaste may represent the source of emerging hazards of anthropogenic and animal origin that can transfer from agricultural soils to related food production,posing a risk to consumers’health,as in the case of outbreaks due to the consumption of ready-to-eat leafy vegetables contaminated with pathogenic *** this perspective,we propose a combined strategy based on both classical methods and culture-independent metagenomics approaches to identify microbial hazards relevant to foodborne diseases in WWTP-related *** virulence genes targeted by real-time PCR,performed before and after the enrichment of the raw samples,may represent a proxy for the viability of pathogens,the presence of which is then confirmed via classical microbiological *** analysis of shotgun metagenomic sequences could assess the presence of genes associated with resistance to specific antimicrobials followed by phenotypic confirmation via cultivation of the raw samples in the presence of the predicted *** 16s rDNA analysis supports biowaste traceability based on their taxonomic *** strategy would support a“One Health”Action based on a cross-cutting assessment of emerging food-borne risks along the food chain.

关键词： Emerging hazards Foodborne pathogens Metagenomics Circular economy One Health Cross-cutting approach

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Building Tresigallo:The City of Edmondo Rossoni(1933-1939)

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Journal of Civil Engineering and Architecture 2024年第7期18卷 311-317页

作者： giorgia sala Department of Architecture University of FerraraFerrara 44121Italy

Between 1933 and 1939 Minister Edmondo Rossoni transformed his hometown,a modest village,into a modern center of industrialized *** wanted to experiment a new economic,political,and social model within the Ferrara countryside and,at the same time,aimed to consolidate his power over the *** Minster asked the young and trusted engineer Carlo Frighi to give substance to his project.A provincial construction site was quickly transformed into a dynamic workshop that attracts many workers and involves designers and craftsmen from all over *** has emerged from a bibliographic and archival survey that refocused the history of a town that still confronts,through its architecture,its history,and a difficult legacy.

关键词： Tresigallo Edmondo Rossoni city of autarky urban refunding

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surgical management of tegmen defects of the temporal bone and meningoencephalic herniation: our experience

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Journal of Otology 2024年第1期19卷 30-34页

作者： Giuseppe De Donato Emanuela Fuccillo Alberto Maria saibene Elena Ferrari giorgia Carlotta Pipolo Antonia Pisani Liliana Colletti Anastasia Urbanelli Luigi De Donato Giovanni Felisati Otorhinolaryngology Unit Head and Neck DepartmentASST Santi Paolo e Carlo HospitalVia Antonio di Rudinì820142MilanItaly Department of Health sciences University of MilanVia Festa del Perdono720122MilanItaly Department of Biomedical Surgical and Dental SciencesUniversity of MilanVia Festa del Perdono720122MilanItaly ENT Unit Department of Surgical SciencesUniversity of TurinVia Verdi810124TurinItaly

1. Introduction The tegmental wall of the tympanic cavity is a thin plate of the temporal bone that separates the middle cranial fossa(MCF) from the ear. This anatomical region consists of two areas: an anterior one, comprised of the tegmen tympani(To′th et al., 2007), and a posterior one, formed by the tegmen antri and the tegmen mastoideum(Makki et al., 2011). In some patients, the tegmental region of the temporal bone can be interrupted, causing a tegmen defect(TD). A TD is sometimes associated with a meningoencephalic herniation(MEH), in which brain tissue herniates through a TD.

关键词： al. herniation bone

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Determination of particulate polycyclic aromatic hydrocarbons in ambient air by gas chromatography-mass spectrometry after molecularly imprinted polymer extraction

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Journal of Environmental sciences 2023年第2期124卷 644-654页

作者： Maria Chiara Pietrogrande giorgia Demaria Mara Russo Department of Chemical Pharmaceutical and Agraricultural SciencesUniversity of FerraraVia Fossato di Mortara 17/1944121 FerraraItaly

A solid phase extraction procedure(sPE)is described for the quantitative analysis of polycyclic aromatic hydrocarbons(PAHs)in atmospheric particulate matter(PM),as ubiquitous environmental pollutants routinely measured in air qualitymonitoring.A sPE cartridge was used based on a molecular imprinted polymer(MIP-sPE)properly tailored for selective retention of PAHs with 4 and more benzene fused *** performance of the clean-up procedure was evaluated with the specific concern of selective purification towards saturated hydrocarbons,which are the PM components mostly interfering GC analysis of target *** optimized operative conditions,the MIP-sPE provided analyte recovery close to 95%for heavier PAHs,from benzo(α)pyrene to benzo(ghi)perylene,and close to 90%for four benzene rings PAHs,with good reproducibility(RsDs:2.5%-5.9%).Otherwise,C_(17)-C_(32) n-alkanes were nearly completely *** proposed method was critically compared with solid Phase Micro Extraction(sPME)using a polyacrylate *** methods were successfully applied to the analysis of ambient PM2.5 samples collected at an urban polluted *** the two procedures,the MIP-sPE provided the highest recovery(R%≥93%)for PAHs with 5 and more benzene rings,but lower for lighter *** contrast,sPME showed a mean acceptable R%value(∼80%)for all the investigated PAHs,except for the heaviest PAHs in the most polluted samples(R%:110%-138%),suggesting an incomplete purification from the interfering n-hydrocarbons.

关键词： Polycyclic aromatic hydrocarbons Atmospheric particle matter Molecularly imprinted polymers-solid-phase extraction solid phase micro extraction GC/Ms analysis

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Taste sensitivity and divergence in host plant acceptance between adult females and larvae of Papilio hospiton

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Insect science 2018年第5期25卷 809-822页

作者： giorgia sollai Maurizio Biolchini Roberto Crnjar Department of Biomedical sciences Section of Physiology University of Cagliari 09042 Monserrato (CA) Italy

On the island of sardinia the lepidopteran Papilio hospiton uses Ferula com- munis as exclusive host plant. However, on the small island of Tavolara, adult females lay eggs on seseli tortuosum, a plant confined to the island. When raised in captivity on seseli only few larvae grew beyond the first-second instar. Host specificity of lepidopterans is determined by female oviposition preferences, but also by larval food acceptance, and adult and larval taste sensitivity may be related to host selection in both cases. Aim of this work was：（i） to study the taste sensitivity of larvae and ovipositing females to saps of Ferula and seseli; （ii） to cross-compare the spike activity of gustatory receptor neurons （GRNs） to both taste stimuli; （iii） to evaluate the discriminating capability between the two saps and determine which neural code/s is/are used. The results show that：（i） the spike responses of the tarsal GRNs of adult females to both plant saps are not different and therefore they cannot discriminate the two plants; （ii） larval L-lat GRN shows a higher activity in response to seseli than Ferula, while the opposite occurs for the phagostimulant neurons, and larvae may discriminate between the two saps by means of multiple neural codes; （iii） the number of eggs laid on the two plants is the same, but the larval growth performance is better on Ferula than seseli. Taste sensitivity differences may explain the absence of a positive relationship between oviposition preferences by adult females and plant acceptance and growth performance by larvae.

关键词： chemoreception feeding acceptance host-plant discrimination neural cod-ing oviposition preference Papilionidae

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Multiallelic and multilocus simple sequence repeats(ssRs)to assess the genetic diversity of a salix *** collection

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Journal of Forestry Research 2021年第1期32卷 263-271页

作者： giorgia Carletti Luigi Cattivelli Lorenzo Vietto Giuseppe Nervo Council for Agricultural Research and Economics(CREA)-Research Centre for Forestry and Wood Casale MonferratoALItaly Council for Agricultural Research and Economics(CREA)-Research Centre for Genomics and Bioinformatics Fiorenzuola d’ArdaPCItaly

salix L.(willow)is the largest genus of the family salicaceae and plays an important role in riparian habitats,wetlands and in shrub *** to the diff erent implications for the species belonging to this family,it is fundamental to identify molecular tools characterizing relevant clones.A set of six multilocus and multiallelic simple sequence repeat(ssRs)markers are presented,leading to 390 polymorphic fragments considered as single dominant markers and able to discriminate successfully 92 *** *** 24 salix *** polymorphic fragments have been used to perform genetic diversity studies,and to investigate population structures and cluster analysis in a germplasm *** results highlight the capability of the six ssRs to be powerful genetic resources in applied forestry research,both to distinguish *** clones from salix *** to perform genetic population studies for breeding programs.

关键词： Microsatellites salix Genetic diversity

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Testicular ultrasound inhomogeneity is an informative parameter for fertility evaluation

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Asian Journal of Andrology 2020年第3期22卷 302-308页

作者： giorgia spaggiari Antonio R M Granata Daniele santi Unit of Endocrinology Department of BiomedicalMetabolic and Neural SciencesUniversity of Modena and Reggio EmiliaModena 41126Italy Unit of Endocrinology Department of Medical SpecialtiesAzienda Ospedaliero-Universitaria of ModenaOspedale Civile of BaggiovaraModena 41126Italy.

Testicular volume(TV)is proposed to be a positive predictor of male fertility status,because of the relation known between the TV and the seminiferous tubule *** of the measurement methodology,the role of TV and testicular ultrasound(Us)assessments is still debated in andrological clinical *** this retrospective cohort study,we evaluated TV and testis Us role in the diagnostic workup of andrological *** consecutive outpatients undergoing single-operator testis Us(Modena,Italy)from March 2012 to March 2018 were enrolled,matching sonographic,hormonal,and seminal data.A total of 302 men were referred and evaluated for gynecomastia,suspected hypogonadism,couple infertility(Cl),or sexual *** the hypogonadal group,TV was lower compared to that in other groups(Psignificant,direct correlation between TV and testosterone level was observed in nonandrogen-treated patients(R=0.911,Psuggesting that testicular size could be related to the testosterone-secreting *** the Cl group,normozoospermic patients showed higher TV compared to men with impaired semen quality(P=0.003)and azoospermia(P=0.003).However,TV was not able to discriminate between patients presenting normal and altered semen *** the contrary,testis Us inhomogeneity was more frequent in patients with impaired sperm quality(55.0%;P=0.007)and azoospermia(40.0%;P=0.012),compared to patients with normozoospermia(5%),identifying thereby the sonographic pattern as an informative parameter of the fertility ***,in the Cl workup,Us evaluation seems to be more informative than the TV assessment alone.

关键词： male hypogonadism male infertility testicular diseases testis

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Mature versus emerging technologies for CO2 capture in power plants： Key open issues in post-combustion amine scrubbing and in chemical looping combustion

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Frontiers of Chemical science and Engineering 2018年第2期12卷 315-325页

作者： giorgia De Guido Matteo Compagnoni Laura A. Pellegrini Ilenia Rossetti Department of Chemistry Materials and Chemical Engineering "Giulio Natta" Politecnico di Milano Piazza Leonardo da Vinci 32 20133 MilanItaly Department of Chemistry Universita degli Studi di Milano INSTM Unit Milano-Universita and CNR-ISTM Via Camillo Golgi 19 20133 Milan Italy

Carbon capture and storage （CCs） have acquired an increasing importance in the debate on global wanning as a mean to decrease the environmental impact of energy conversion technologies, by capturing the CO2 produced from the use of fossil fuels in electricity generation and industrial processes. In this respect, post-combustion systems have received great attention as a possible near-term CO2 capture technology that can be retrofitted to existing power plants. This capture technology is, however, energy-intensive and results in large equipment sizes because of the large volumes of the flue gas to be treated. To cope with the demerits of other CCs technologies, the chemical looping combustion （CLC） process has been recently considered as a solution for CO2 separation. It is typically referred to as a technology without energy penalty. Indeed, in CLC the fuel and the combustion air are never mixed and the gases from the oxidation of the fuel （i.e., CO2 and H2O） leave the system as a separate stream and can be separated by condensation of H2O without any loss of energy. The key issue for the CLC process is to find a suitable oxygen carrier, which provides the fuel with the activated oxygen needed for combustion. The aim of this work is to explore the feasibility of using perovskites as oxygen carriers in CLC and to consider the possible advantages with respect to the scrubbing process with amines, a mature post-combustion technology for CO2 separation.

关键词： CO2 capture monoethanolamine chemical looping combustion oxygen carder perovskites

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