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Impact of chronic kidney disease on mortality in older adults treated with pacemaker implantation

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Journal of Geriatric Cardiology 2017年第10期14卷 597-603页

作者： Fabio Fabbian Alfredo De giorgi Matteo Guarino Michele Malagu Matteo Bertini Department of Medical Sciences Clinical Medical Unit University Hospital St. Anna University of Ferrara Ferrara Italy Department of Medical Sciences Cardiology Unit University Hospital St. Anna University of Ferrara Ferrara Italy

Objective To investigate whether chronic kidney disease could negatively impact survival in older adults needing pacemaker implantation after admission for bradyarrhythmias. Methods This retrospective observational study considered 538 older adults consecutively admitted, who had been followed-up for 31 ± 20 months. Subjects with poor short-term prognosis were excluded. Charlson comorbidity index （CCI） and estimated glomerular filtration rate （eGFR） was calculated, along with the independent relationship between all-cause mortality and clinical data. Hazard Ratio （HR） was calculated by Cox regression analysis. Results Mean age of the population was 85 ± 3.7 years, and causes for implantation were atrioventricular block in 51.9% and other bradyarrhythmias in 48.1% of cases. Mean eGFR was 58.3 ± 24 mL/min per 1.73 m2, and mean CCI was 3.65 ± 2.28. Death for all-causes was recorded in 213 subjects. Deceased patients were older, had lower eGFR, higher comorbidity, higher prevalence of myocardial infarction, congestive heart failure, cerebrovascular disease, dementia and chronic pulmonary disease. Age （HR： 1.081, 95% CI： 1.044-1.119; P 〈 001）, CCI （HR： 1.651, 95% CI： 1.286-2.121, P 〈 001） and eGFR 〈 45 mL/min per 1.73 m2 （HR： 1.360, 95% CI： 1.024-1.806; P = 0.033） were predictors of death. Conclusions Renal dysftmction, as well as comorbidity, impacts negatively survival of older adults treated with pacemaker implantation because of bradyarrhythmias.

关键词： Bradyarrhythmias Charlson comorbidity index Chronic kidney disease Comorbidity Glomerular filtration rate Mortality Pacemaker

Transient Ablation Regime in Circuit Breakers

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Plasma Science and Technology 2007年第6期9卷 653-656页

作者： Alexandre MARTIN Jean-Yves TREPANIER marcelo REGGIO Ecole Polytechnique MontrealQuebecCanada

Nozzle wall ablation caused by high temperature electric arcs is studied in the context of high voltage SF6 circuit breakers. The simplified ablation model used in litterature has been updated to take into account the unsteady state of ablation. Ablation rate and velocity are now calculated by a kinetic model using two layers of transition, between the bulk plasma and the ablating wall. The first layer （Knudsen layer）, right by the wall, is a kinetic layer of a few mean-free path of thickness. The second layer is collision dominated and makes the transition between the kinetic layer and the plasma bulk. With this new coupled algorithm, it is now possible to calculate the temperature distribution inside the wall, as well as more accurate ablation rates.

关键词： circuit breakers electric arc ablation Teflon radiation

Topology-Based Recommendation of Users in Micro-Blogging Communities

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Journal of Computer Science & Technology 2012年第3期27卷 624-634页

作者： marcelo G.Armentano Daniela Godoy Analía Amandi High Institute of Software Engineering Tandil National University of the Center of Buenos Aires ProvinceTandil Buenos AiresArgentina National Council of Scientific and Technological Research Av.Rivadavia 1917CABAArgentina

Nowadays, more and more users share real-time news and information in micro-blogging communities such as Twitter, Tumblr or Plurk. In these sites, information is shared via a followers/followees social network structure in which a follower will receive all the micro-blogs from the users he/she follows, named followees. With the increasing number of registered users in this kind of sites, finding relevant and reliable sources of information becomes essential. The reduced number of characters present in micro-posts along with the informal language commonly used in these sites make it difficult to apply standard content-based approaches to the problem of user recommendation. To address this problem, we propose an algorithm for recommending relevant users that explores the topology of the network considering different factors that allow us to identify users that can be considered good information sources. Experimental evaluation conducted with a group of users is reported, demonstrating the potential of the approach.

关键词： social networking social technology recommender system

Lattice Boltzmann Modeling of Viscous Elementary Flows

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Advances in Applied Mathematics and Mechanics 2010年第4期2卷 467-482页

作者： Mohammed A.Boraey marcelo Epstein Mechanical and Manufacturing Engineering Department University of Calgary2500 University Drive NWCalgaryAlbertaT2N 1N4Canada

A lattice Boltzmann method is developed for modeling viscous elementary *** adjustable source term is added to the lattice Boltzmann equation,which can be tuned to model different elementary flow features like a doublet or a point source of any strength,including a negative source(sink).The added source term is dimensionally consistent with the lattice Boltzmann *** proposed model has many practical applications,as it can be used in the framework of the potential flow theory of viscous and viscoelastic *** model can be easily extended to the three dimensional *** model is verified by comparing its results with the analytical solution for some benchmark *** results are in good agreement with the analytical solution of the potential flow theory.

关键词： The Lattice Boltzmann method Chapman-Enskog expansion source term point source point sink doublet viscous elementary flows potential flow theory symmetry

Germination strategies under climate change scenarios along an aridity gradient

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Journal of Plant Ecology 2020年第4期13卷 470-477页

作者： Alexander Zogas Evsey Kosman marcelo Sternberg Porter School of Environmental Studies Tel Aviv UniversityTel AvivIsrael School of Plant Sciences and Food Security George S.Wise Faculty of Life SciencesTel Aviv UniversityTel AvivIsrael Institute for Cereal Crops Improvement School of Plant Sciences and Food SecurityGeorge S.Wise Faculty of Life SciencesTel Aviv UniversityTel AvivIsrael

Aims Climate change in the eastern Mediterranean region will have a strong impact on ecosystem functioning and plant community dynamics due to a reduction in annual rainfall and increased *** aim to understand the role of seed banks as potential buffers against climatic uncertainty determined by climate *** We examined germination strategies of 18 common species present along an aridity *** were obtained from soil seed banks germinated during nine consecutive years from arid,semi-arid,Mediterranean and mesic Mediterranean *** the semi-arid and Mediterranean sites,rainfall manipulations simulating 30%drought and 30%rainfall increase were *** strategies were tested under optimal irrigation conditions during three consecutive germination seasons to determine overall seed germinability in each soil *** in germination strategy were examined using a novel statistical approach that considers the climatic and biotic factors that may affect seed *** Findings The results showed that dominant species controlled their germination fractions by producing seeds with a different yearly germination fraction *** amount of rainfall under which the seeds were produced led to two major seed types with respect to germinability:high germinability,seeds leading to transient seed banks,and low germinability,seeds leading to persistent seed *** conclude that differential seed production among wet and dry years of both seed types creates a stable balance along the aridity gradient,enabling the soil seed bank to serve as a stabilizing mechanism buffering against rainfall ***,we present a general model of germination strategies of dominant annual species in Mediterranean and arid ecosystems that strengthens the notion of soil seed banks as buffers against climatic uncertainty induced by climate change in the region.

关键词： climate change desert drought Mediterranean rainfall manipulations seed bank

Climate Change over China in the 21st Century as Simulated by BCC_CSM1.1-RegCM4.0

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Atmospheric and Oceanic Science Letters 2013年第5期6卷 381-386页

作者： GAO Xue-Jie WANG Mei-Li Filippo giorgi The Laboratory of Climate Study National Climate Center China Meteorological Administration Chinese Academy of Meteorological Science Abdus Salam International Centre for Theoretical Physics

Driven by the global model,Beijing Climate Center Climate System Model version 1.1(BCC_CSM1.1),climate change over China in the 21st century is simulated by a regional climate model(RegCM4.0)under the new emission scenarios of the Representative Concentration Pathways—RCP4.5 and *** is based on a period of transient simulations from 1950 to2099,with a grid spacing of 50 *** present paper focuses on the annual mean temperature and precipitation in China over this period,with emphasis on their future *** of model performance reveals marked improvement of the RegCM4.0 model in reproducing present day temperature and precipitation relative to the driving BCC_CSM1.1 *** warming is simulated by both BCC_CSM1.1 and RegCM4.0,however,spatial distribution and magnitude differ between the *** high emission scenario RCP8.5 results in greater warming compared to *** two models project different precipitation changes,characterized by a general increase in the BCC_CSM1.1,and broader areas with decrease in the RegCM4.0 simulations.

关键词： climate change regional climate model RCP scenarios China

Atacama Field Campaign: laboratory and in-situ measurements for remote sensing applications

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International Journal of Digital Earth 2019年第1期12卷 43-61页

作者： Cristian Mattar Andrés Santamaría-artigas Flavio Ponzoni Cibele T.Pinto Carolina Barrientos Glynn Hulley Laboratory for Analysis of the Biosphere(LAB) University of ChileSantiagoChile Department of Geographical Sciences University of MarylandCollege ParkMDUSA Divisão de Sensoriamento Remoto(DSR) Instituto Nacional de Pesquisas Espaciais(INPE)São PauloBrasil Aerial Photogrammetric Service(SAF) Chilean Air ForceSantiagoChile Jet Propulsion Laboratory(JPL) California Institute of TechnologyPasadenaCAUSA

This work presents the preliminary results of the first field calibration campaign performed in the Atacama Desert,Chile,between the 18 and 22 August 2014,called the Atacama Field Campaign(ATAFIC 2014).In situ measurements were performed in order to spectrally characterize the surface reflectance spectra between 0.3 and 2.5μm,radiometric temperature(8.0–14.0μm)and atmospheric measurements.A soil sample was collected and analyzed using Fourier Transform Infrared Spectroscopy and X-Ray Diffraction techniques to characterize the surface reflectance spectra and mineralogical composition,*** land surface emissivity in addition to GOES,MODIS and Landsat-8 land surface temperature(LST)were also *** showed that the spectral features of the Atacama soil and the characteristics of this geographical zone,which is featured as the most hyper-arid and cloudless place in the world,make this area a potential target for surface reflectance *** and night LST comparison between field and remote sensing data are lower than 2 K and the Root Mean Square Error for land surface emissivity is close to 2%.This work opens the possibilities to consider the Atacama Desert as a reference target for calibration and validation activities for earth observation missions’purposes.

关键词： Atacama spectroradiometry emissivity temperature surface reflectance

Prospects for bone marrow cell therapy in amyotrophic lateral sclerosis：how far are we from a clinical treatment？

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Neural Regeneration Research 2016年第8期11卷 1216-1219页

作者： Fernanda Gubert marcelo F.Satiago Instituto de Biofisica Carlos Chagas Filho Universidade Federal do Rio de Janeiro Rio de Ianeiro RJ Brasil

Amyotrophic lateral sclerosis（ALS） is a fatal neurodegenerative disease that causes progressive muscular atrophy and death within 3–5 years after its *** the significant advances in knowledge of ALS pathology,no effective treatment is ***,it is imperative to search for new alternatives to treat *** therapy,especially using bone-marrow cells,has showed to be very useful to protect the neural tissue in different brain disease or traumatic *** ALS,most published results show beneficial effects of the use bone marrow cells,especially mesenchymal stromal ***,until now,the best outcome extends animal＇s lifespan by only a few *** is essential to continue the search for a really effective therapy,testing different cells,routes and time-windows of *** the mechanisms that initiate and spread the degenerative process is also important to find out an effective ***,we discussed here some progresses that have been made using bone-marrow cell therapy as a therapeutic tool for ALS.

关键词： amyotrophic lateral sclerosis cell therapy bone-marrow mononuclear cells mesenchymal stromal cells neuroinflammation motor neurons

Sequencing of systemic treatment for hepatocellular carcinoma: Second line competitors

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World Journal of Gastroenterology 2020年第16期26卷 1888-1900页

作者： Federico Pinero marcelo Silva Massimo Iavarone Hospital Universitario Austral Facultad de Ciencias BiomédicasUniversidad AustralBuenos Aires B1629HJArgentina Latin American Liver Research Educational and Awareness Network Buenos Aires B1629HJArgentina Division of Gastroenterology and Hepatology CRC“A.M.e A.Migliavacca”Center for the Study of Liver DiseaseUniversity of MilanFondazione IRCCS Ca’Granda Maggiore HospitalMilan 20121Italy

During the last decades,further knowledge of hepatocellular carcinoma(HCC)molecular mechanisms has led to development of effective systemic treatments including tyrosine kinase inhibitors(TKIs)and *** this review,we describe first and second line systemic treatment options for advanced *** trials have evaluated new drugs for the treatment of HCC patients:In first line,lenvatinib resulted non-inferior to sorafenib and it can be used as alternative,even in the lack of evidence for sequential treatment options in second line after ***,atezolizumab plus bevacizumab have shown superiority over sorafenib in ***-regorafenib sequential administration in selected patients has opened a new paradigm of treatment in advanced HCC with a life expectancy exceeding two *** TKIs for second line treatment include cabozantinib and ramucirumab(specifically for patients with Alpha-fetoprotein values≥400 ng/mL).The combination of TKIs with immunotherapy may represent a big step forward for these patients in the near future.

关键词： Hepatocellular carcinoma Systemic Options Sequencing Advanced Future