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Stability of Nonlinear Differential-Algebraic Systems Via Additive Identity

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Characterization of Gauss–Markov stochastic sequences for mission analysis

IEEE/CAA Journal of Automatica Sinica 2020年第4期

作者： Pierluigi Di Franco giordano scarciotti Member IEEE Alessandro Astolfi Fellow IEEE

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Astrodynamics 2024年第1期8卷 135-148页

作者： Carmine giordano Department of Aerospace Science and Technology Politecnico di MilanoMilano20156Italy

In real scenarios,the spacecraft deviates from the intended paths owing to uncertainties in dynamics,navigation,and command *** quantifying these uncertainties is crucial for assessing the observability,collision risks,and mission *** issue is further magnified for CubeSats because they have limited control authority and thus require accurate dispersion estimates to avoid rejecting viable trajectories or selecting unviable *** uncertainties arise from random variables(e.g.,measurement errors and drag coefficients)and processes(e.g.,solar radiation pressure and low-thrust acceleration).Although random variables generally present minimal computational complexity,handling stochastic processes can be challenging because of their noisy ***,accurately modeling these processes is essential,as they significantly influence the uncertain propagation of space trajectories,and an inadequate representation can result in either underestimation or overestimation of the stochastic characteristics associated with a given *** study addresses the gap in characterizing process uncertainties,represented as Gauss–Markov processes in mission analysis,by presenting models,evaluating derived quantities,and providing results on the impact of spacecraft *** study emphasizes the importance of accurately modeling random processes to properly characterize stochastic spacecraft paths.

关键词： Gauss-Markov process uncertainty quantification stochastic dynamics Monte Carlo simulation

SPLITTING SCHEMES FOR A NAVIER-STOKES-CAHN-HILLIARD MODEL FOR TWO FLUIDS WITH DIFFERENT DENSITIES

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Journal of Computational Mathematics 2014年第6期32卷 643-664页

作者： Francisco Guillen-Gonzalez giordano Tierra Departamento de Ecuaciones Diferenciales y Andlisis Numgrico and IMUS Universidad de Sevilla 41012 Seville Spain Department of Applied and Computational Mathematics and Statistics University of Notre Dame Notre Dame IN 46556 USA

In this work, we focus on designing efficient numerical schemes to approximate a ther- modynamically consistent Navier-Stokes/Cahn-Hilliard problem given in [3] modeling the mixture of two incompressible fluids with different densities. The model is based on a diffuse-interface phase-field approach that is able to describe topological transitions like droplet coalescense or droplet break-up in a natural way. We present a splitting scheme, decoupling computations of the Navier-Stokes part from the Cahn-Hilliard one, which is unconditionally energy-stable up to the choice of the potential approximation. Some nu- merical experiments are carried out to validate the correctness and the accuracy of the scheme, and to study the sensitivity of the scheme with respect to different physical pa- rameters.

关键词： Two-phase flow Diffuse-interface phase-field Cahn-Hilliard Navier-Stokes,Energy stability Variable density Mixed finite element Splitting scheme.

Modern management of anal fistula

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World Journal of Gastroenterology 2015年第1期21卷 12-20页

作者： Elsa Limura Pasquale giordano Department of Colorectal Surgery Whipps Cross HospitalBarts Health NHS TrustLondon E11 1NRUnited Kingdom

Ideal surgical treatment for anal fistula should aim to eradicate sepsis and promote healing of the tract,whilst preserving the sphincters and the mechanism of *** the simple and most distal fistulae,conventional surgical options such as laying open of the fistula tract seem to be relatively safe and therefore,well accepted in clinical ***,for the more complex fistulae where a significant proportion of the anal sphincter is involved,great concern remains about damaging the sphincter and subsequent poor functional outcome,which is quite inevitable following conventional surgical *** this reason,over the last twodecades,many sphincter-preserving procedures for the treatment of anal fistula have been introduced with the common goal of minimising the injury to the anal sphincters and preserving optimal *** them,the ligation of intersphincteric fistula tract procedure appears to be safe and effective and may be routinely considered for complex anal *** technique,the anal fistula plug,derived from porcine small intestinal submucosa,is safe but modestly effective in long-term follow-up,with success rates varying from 24%-88%.The failure rate may be due to its extrusion from the fistula *** obviate that,a new designed plug(GORE BioA ) was introduced,but long term data regarding its efficacy are *** glue showed poor and variable healing rate(14%-74%).Fi La C and video-assisted anal fistula treatment procedures,respectively using laser and electrode energy,are expensive and yet to be thoroughly assessed in clinical ***,a therapy using autologous adiposederived stem cells has been *** properties of regenerating tissues and suppressing inflammatory response must be better investigated on anal fistulae,and studies remain in *** aim of this present article is to review the pertinent literature,describing the advantages and limitations of new sphincterpreserving techniques.

关键词： Anal fistula management Ligation of intersphincter

Ferrierite vs. γ-Al_2O_3: The superiority of zeolites in terms of water-resistance in vapour-phase dehydration of methanol to dimethyl ether

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Journal of Energy Chemistry 2019年第3期28卷 162-169页

作者： Enrico Catizzone Massimo Migliori Antonio Purita Girolamo giordano Department of Environmental and Chemical Engineering University of Calabria

The catalytic conversion of methanol to dimethyl ether(DME) over a series of home-made FER-type zeolites having different acidities and commercial γ-Al_2O_3 has been studied with the aim to understand the impact of adding water in the reactant stream on the catalytic behavior on investigated materials. Cofeeding water with methanol, the alcohol conversion was slightly reduced over the investigated zeolites while the catalytic activity of γ-Al_2O_3, the traditional catalyst of MeOH-to-DME conversion, was strongly inhibited. It was also found that, for the investigated zeolites, both the amount and the initial deposition rate of the coke formed during the reaction were reduced when water was co-fed with methanol while no significant effects on both methanol conversion and DME selectivity were observed under the investigated conditions.

关键词： Ferrierite Zeolites Methanol dehydration Dimethyl ether Coke

The effect of FER zeolite acid sites in methanol-to-dimethyl-ether catalytic dehydration

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Journal of Energy Chemistry 2017年第3期26卷 406-415页

作者： Enrico Catizzone Alfredo Aloise Massimo Migliori Girolamo giordano Department of Environmental and Chemical Engineering University of CalabriaVia P.BucciCubo 42aI-87036 RendeCSItaly

In this paper, the effect of acidity of zeolites with FER framework was studied in the methanol dehydration to dimethyl ether reaction, by comparing catalysts with different Si/Al ratios(namely 8, 30 and60). The aim of this work was to investigate how the acid sites concentration, strength, distribution and typology(Br?nsted and Lewis) affect methanol conversion, DME selectivity and coke formation. It was found that the aluminium content affects slightly acid sites strength whilst a relevant effect on acid sites concentration and distribution(Br?nsted/Lewis) was observed as 24% of Lewis sites were found on Alrichest samples, whilst less than 10% of Lewis acid sites were observed on FER at higher Si/Al ratio. All the investigated catalyst samples showed a selectivity toward DME always greater than 0.9 and samples with the lowest Si/Al ratio exhibit the best performances in terms of methanol conversion, approaching the theoretical equilibrium value(around 0.85) at temperatures below 200 °C. Turnover-frequency analysis suggests that this result seems to be related not only to the higher amount of acid sites but also that the presence of Lewis acid sites may play a significant role in converting methanol. On the other hand, the presence of Lewis acid sites, combined with a high acidity, promote the formation of by-products(mainly methane) and coke deposition during the reaction. As final evidence, all the investigated catalysts exhibit very high resistance to deactivation by coke deposition, over 60 h continuous test, and a GC–MS analysis of the coke deposited on the catalyst surface reveals tetra-methyl benzene as main component.

关键词： Methanol dehydration Dimethyl ether Lewis acid sites FER zeolite Coke formation

Gene editing using CRISPR/Cas9： implications For dual-use and biosecurity

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Protein & Cell 2018年第3期9卷 239-240页

作者： Diane DiEuliis James giordano Center for the Study of Weapons of Mass Destruction National Defense University Washington DC 20057 USA Departments of Neurology and Biochemistry and Neuroethics Studies Program-Pellegrino Center for Clinical Bioethics Georgetown University Medical Center Washington DC 20057 USA

We have read with interest the recent paper by Kang, et al （2017）, addressing clinical and ethical issues related to the safe and responsible use of CRISPR/Cas. The authors provide a number of important considerations about the current capabilities offered by this novel gene-editing tool, including germ line editing in embryos, and potential diverse uses in adult human applications. The authors posit that the tool in of itself does not represent a threat, and that periodic assessment will ensure its responsible use.

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Instrumental and bio-monitoring of heavy metal and nanoparticle emissions from diesel engine exhaust in controlled environment

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Journal of Environmental Sciences 2010年第9期22卷 1357-1363页

作者： Simonetta giordano Paola Adamo Valeria Spagnuolo Bianca Maria Vaglieco Department of Structural and Functional Biology University of Naples Federico II Department of Soil Plant Environment and Animal Production Sciences University of Naples Federico II Istituto Motori CNR Via Marconi 8 I-80125 Napoli Italy

In the present article we characterized the emissions at the exhaust of a Common Rail （CR） diesel engine, representative of lightduty class, equipped with a catalyzed diesel particulate filter （CDPF） in controlled environment. The downstream exhausts were directly analyzed （for PM, CO, CO/, Oz, HCs, NOx） by infrared and electrochemical sensors, and SEM-EDS microscope; heavy metals were chemically analyzed using mosses and lichens in bags, and glass-fibre filters all exposed at the engine exhausts. The highest particle emission value was in the 7-54 nm size range; the peak concentration rose until one order of magnitude for the highest load and speed. Particle composition was mainly carbonaceous, associated to noticeable amounts of Fe and silica fibres. Moreover, the content of Cu, Fe, Na, Ni and Zn in both moss and lichen, and of A1 and Cr in moss, was significantly increased. Glass-fibre filters were significantly enriched in A1, B, Ba, Cu, Fe, Na, and Zn. The role of diesel engines as source of carbonaceous nanoparticles has been confirmed, while further investigations in controlled environment are needed to test the catalytic muffler as a possible source of silica fibres considered very hazardous for human health.

关键词： common rail diesel engine exhaust and non-exhaust emissions moss and lichen bags particulate matter

Tuning mesenchymal stem cell secretome therapeutic potential through mechanotransduction

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BIOCELL 2022年第6期46卷 1375-1381页

作者： giordano WOSGRAU CALLONI MARCO AUGUSTO STIMAMIGLIO Laboratório de Plasticidade e Diferenciação de Células da Crista Neural Departamento de Biologia CelularEmbriologia e GenéticaCentro de Ciências BiológicasUniversidade Federal de Santa CatarinaCampus Universitário–TrindadeCEPFlorianópolis88040-900Brazil Laboratório de Biologia Básica de Células-Tronco Instituto Carlos ChagasFiocruz/PRCEPCuritiba81350-010Brazil

Mesenchymal stem cells(MSCs)and their byproducts have been widely validated as potential therapeutic products for regenerative *** therapeutic effects result mainly from the paracrine activity of MSCs,which consists of the secretion of bioactive molecules,whether dispersed in medium conditioned by cell culture or encapsulated in extracellular *** composition of the MSC secretome,which represents the set of these secreted cellular products,is crucial for the performance of the desired therapeutic *** cell culture strategies have been employed to adjust the secretome composition of MSCs to obtain the best therapeutic responses for different clinical ***,the manipulation of culture conditions has focused mainly on the use of different biochemical elements for the preconditioning of MSCs and less on the physical conditions of the cell culture ***,we offer our point of view regarding the importance of the physical properties of cell culture substrates and their mechanotransduction responses in preconditioning the MSCs *** highlight the relevance of studying mechanotransduction events associating cell morphology and the modulation of gene expression to customize and expand the use of MSCs secretomes.

关键词： Mesenchymal stem cells Mechanotransduction Scaffolds Secretome Bioengineering