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Metastatic multifocal melanoma of multiple organ systems:A case report

World Journal of Clinical Cases 2022年第28期10卷 10136-10145页

作者： Vaidota Maksimaityte Rosita Reivytyte Gabriele Milaknyte Ugnius Mickys gintare razanskiene Domantas Stundys Edita Kazenaite Jonas Valantinas Ieva Stundiene Institute of Clinical Medicine Faculty of MedicineVilnius UniversityVilnius 01513Lithuania Faculty of Medicine Vilnius UniversityVilnius 01513Lithuania Institute of Biomedical Sciences Faculty of MedicineVilnius UniversityVilnius 01513Lithuania

BACKGROUND Malignant melanoma is becoming more common among middle-aged individuals all over the *** metastasis can be found in various organs,although metastases to the spleen and stomach are *** we present a rare metastatic multifocal melanoma,clinically and histologically mimicking lymphoma,with metastases of multiple *** SUMMARY A 46-year-old Caucasian male with a history of nodular cutaneous malignant melanoma was presented with nausea,general weakness,shortness of breath,abdominal enlargement,and night *** abdominal ultrasound revealed enlarged liver and spleen with multiple *** tomography demonstrated multiple lesions in the lungs,liver,spleen,subcutaneous tissue,bones and a pathological lymphadenopathy of the *** biopsy and the biopsy from the enlarged lymph node were *** cells showed diffuse or partial positivity for melanocytic markers,such as microphthalmia-associated transcription factor,S100,HMB45 and *** tumor harbored BRAF V600E mutation,demonstrated by immunohistochemical labelling for BRAF V600E and detected by real-time polymerase chain reaction *** combined all the findings,a diagnosis was made of a metastatic multifocal melanoma of the stomach,duodenum,liver,spleen,lungs,lymph nodes and *** patient refused treatment and died a week *** This case report highlights the clinical relevance of rare metastatic multifocal melanoma of multiple organ systems.

关键词： Metastatic melanoma Gastrointestinal tract Nodular Multifocal BRAF V600E Case report

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Effects of COVID-19 on the liver:The experience of a single center

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World Journal of Gastroenterology 2022年第39期28卷 5735-5749页

作者： Valentina Liakina Ieva Stundiene Gabriele Milaknyte Ramune Bytautiene Rosita Reivytyte Roma Puronaite gintare Urbanoviciute Edita Kazenaite Centre of Hepatology Gastroenterology and DieteticsClinic of GastroenterologyNephrourology and SurgeryInstitute of Clinical MedicineFaculty of MedicineVilnius UniversityVilnius 01513Lithuania Department of Chemistry and Bioengineering Faculty of Fundamental SciencesVILNIUS TECHVilnius 10223Lithuania Faculty of Medicine Vilnius UniversityVilnius 01513Lithuania Clinic of Cardiac and Vascular Diseases Institute of Clinical MedicineFaculty of MedicineVilnius UniversityVilnius 01513Lithuania Institute of Data Science and Digital Technologies Faculty of Mathematics and InformaticsVilnius UniversityVilnius 01513Lithuania Department of Pathology Forensic Medicine and PharmacologyInstitute of Biomedical SciencesFaculty of MedicineVilnius UniversityVilnius 01513Lithuania

BACKGROUND The coronavirus disease 2019(COVID-19)was perhaps the most severe global health crisis in living *** respiratory symptoms,elevated liver enzymes,abnormal liver function,and even acute liver failure were reported in patients suffering from severe acute respiratory disease coronavirus 2 ***,the precise triggers of these forms of liver damage and how they affect the course and outcomes of COVID-19 itself remain *** To analyze the impact of liver enzyme abnormalities on the severity and outcomes of COVID-19 in hospitalized *** In this study,684 depersonalized medical records from patients hospitalized with COVID-19 during the 2020-2021 period were ***-19 was diagnosed according to the guidelines of the National Institutes of Health(2021).Patients were assigned to two groups:those with elevated liver enzymes(Group 1:603 patients),where at least one out of four liver enzymes were elevated(following the norm of hospital laboratory tests:alanine aminotransferase(ALT)≥40,aspartate aminotransferase(AST)≥40,gamma-glutamyl transferase≥36,or alkaline phosphatase≥150)at any point of hospitalization,from admission to discharge;and the control group(Group 2:81 patients),with normal liver enzymes during ***-19 severity was assessed according to the interim World Health Organization guidance(2022).Data on viral pneumonia complications,laboratory tests,and underlying diseases were also collected and *** In total,603(88.2%)patients produced abnormal liver test *** and AST levels were elevated by a factor of less than 3 in 54.9%and 74.8%of cases with increased enzyme levels,*** in Group 1 had almost double the chance of bacterial viral pneumonia complications[odds ratio(OR)=1.73,P=0.0217],required oxygen supply more often,and displayed higher biochemical inflammation indices than those in Group *** differences in other COVID-19 complications or underlying disea

关键词： COVID-19 SARS-CoV-2 Liver enzymes Complications Underlying disease Disease severity

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Relationship between Leadership and Strategic Management

Relationship between Leadership and Strategic Management

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作者： gintare Steponkute 山东大学

学位级别：硕士

One of the vaguest yet most important questions any scholar,entrepreneur,or business leader might ask is the following:What is corporate strategy?Kenneth Andrews,both a scholar and sociologist,explains that the strategy itself is not simple enough to be translated into *** corporate strategy is instead a network of ideas,goals,and purposes,along with an efficient system to incorporate them with an organization’s assets to ultimately bring positive outcomes for the employees,consumers,communities,and *** referenced literature resources,the goal of the Master’s study is to understand the fundamental relationships between strategic management styles,along with the efficient hierarchal leadership that needs to accompany it to properly implement and obtain creative ideas,corporate growth,and organizational success *** of taking a quantitative approach,a qualitative paradigm approach was used to understand how organizations properly manage their practice’s expectations,goals,and end *** author of this study followed the leadership styles of Kurt Lewin,a psychologist who devoted his career to understanding the effectiveness of three different leadership styles:Autocratic,Democratic,and *** thesis was obtained via literature *** conclusions of this study proved that corporate seniors have significant needs for alterations in regards to the "how" of integrating technological advances,diversity requirements,and effective management *** Yukl writes in his work "Leadership in Organizations"（2010）that leadership as a standalone word can be dissected into many more technical *** one of these terms however have their own sets of interpretations from the hundreds of well-known researchers and scientists seeking to crack the dos and don’ts of effective organization *** so many research sources on this topic,it becomes obvious that the term "leadership" is not one size fits all;instead,it’s imp

关键词：战略管理领导者领导能力企业管理

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