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Study of Nanoskin ECM-Bacterial Cellulose Wound Healing/United Arab Emirates

Journal of Biomaterials and Nanobiotechnology 2016年第2期7卷 109-117页

作者： Saqer Al Mualla Raed Farahat Pierre Basmaji Gabriel Molina de Olyveira Ligia Maria Manzine Costa José Domingos da Costa Oliveira gino bruno francozo Al Qassimi Hospital/Kuwait Hospital Sharjah United Arab Emirates Innovatec’s-Biotechnology Research and Development S&atilde o Carlos Brazil Department of Physical Chemistry Universidade Estadual Paulista (UNESP) Araraquara Brazil Materials Engineering Department S&atilde o Carlos School of Engineering University of S&atilde o Paulo S&atilde o Carlos Brazil

Natural extracellular matrices (ECMs) perform the tasks necessary for tissue formation, maintenance, regulation and function, providing a powerful means of controlling the biological performance of regenerative materials. In addition, biomedical materials have claimed attention because of the increased interest in tissue engineering materials for wound care and regenerative medicine. Moreover, the nanostructure and morphological similarities with collagen make BC attractive for cell immobilization, cell support and Natural Extracellular Matrix (ECM) Scaffolds. In this work, we present the extracellular matrix (ECM) using the bacterial cellulose (Nanoskin®) which regulates cell behavior by influencing cell proliferation, survival, shape, migration and differentiation. Bacterial cellulose fermentation process is modified before the bacteria are inoculated for mimicking ECM to cells support and built new local material for wound healing. Chemical groups influences and thermal behavior in bacterial cellulose were analyzed using transmission infrared spectroscopy (FTIR) and thermogravimetric analysis (TGA), respectively. Besides, In vivo analysis was evaluated with clinical study at Sharjah Kuwait Hospital.

关键词： Bacterial Cellulose (Nanoskin) Natural Nanocomposites Regenerative Medicine Stem Cells

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Natural ECM-Bacterial Cellulose Wound Healing—Dubai Study

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Journal of Biomaterials and Nanobiotechnology 2015年第4期6卷 237-246页

作者： Safwat Mohd. El-Hoseny Pierre Basmaji Gabriel Molina de Olyveira Ligia Maria Manzine Costa Abdulwahid M. Alwahedi José Domingos da Costa Oliveira gino bruno francozo Al Qassimi Hospital Sharjah United Arab Emirates Innovatec’s-Biotechnology Research and Development S&atildeo Carlos Brazil Department of Physical Chemistry UNESP Araraquara Brazil Department of Chemistry USP FFCLRP Ribeir&atildeo Preto Brazil

Bacterial cellulose (BC) can be used in wide area of applied scientific, especially for tissue regeneration and regenerative medicine, lately, bacterial cellulose mats are used in the treatment of skin conditions such as burns and ulcers, because of the morphology of fibrous biopolymers serving as a support for cell proliferation, its pores allow gas exchange between the organism and the environment. Moreover, the nanostructure and morphological similarities with collagen make BC attractive for cell immobilization, cell support and Natural Extracellular Matrix (ECM) Scaffolds. In this scope, Natural ECM is the ideal biological scaffold since it contains all the components of the tissue. The development of mimicking biomaterials and hybrid biomaterial can further advance directed cellular differentiation without specific induction. The extracellular matrix (ECM) contains several signals that are received by cell surface receptors and contribute to cell adhesion and cell fate which control cellular activities such as proliferation, migration and differentiation. As such, regenerative medicine studies often rely on mimicking the natural ECM to promote the formation of new tissue by host cells, and characterization of natural ECM components is vital for the development of new biomimetic approaches. In this work, the bacterial cellulose fermentation process is modified by the addition of vegetal stem cell to the culture medium and natural materials before the bacteria are inoculated. In vivo behavior using natural ECM for regenerative medicine is presented.

关键词： Bacterial Cellulose (Nanoskin) Natural Nanocomposites Regenerative Medicine Stem Cells

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Special Nanoskin-ACT-Biological Membranes from Deep Wounds

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Journal of Biomaterials and Nanobiotechnology 2018年第1期9卷 79-88页

作者： Saqer Al Mualla Mashael Al Nabooda Noura Salim Salman Pierre Basmaji Gabriel Molina De Olyveira Ligia Maria Manzine Costa Jose Domingos Da Costa Oliveira gino bruno francozo Al Qassimi Hospital/Kuwait Hospital SharjahUnited Arab Emirates Biotechnology Research and Development Sao CarlosBrazil Department of Nanomedicine and Nanotoxicology IFSC-USPSao CarlosBrazil Materials Engineering Department Sao Carlos School of EngineeringUniversity of Sao PauloSao PauloBrazil

Bacterial cellulose (BC) is established as a newest biomaterial, and it can be used for medical and odontology applications. In addition, it has called attention for uses such as membrane for wound care and tissue engineering. In this work, the bacterial cellulose fermentation process is modified by the addition of natural materials before the bacteria are inoculated. In vivo behavior using natural ECM for regenerative medicine is presented and completed wound healing process is 3 months.

关键词： Bacterial Cellulose(Nanoskin^(█))&ACT(Advanced Cell Therapy) Natural Nanocomposites Tissue Engineering

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Covalent functionalization of decellularized tissues accelerates endothelialization

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Bioactive Materials 2021年第11期6卷 3851-3864页

作者： Eleonora Dal Sasso Annj Zamuner Andrea Filippi Filippo Romanato Tiziana Palmosi Luca Vedovelli Dario Gregori Jose Luís Gòmez Ribelles Teresa Russo Antonio Gloria Laura Iop gino Gerosa Monica Dettin Department of Cardiac Thoracic and Vascular Sciences and Venetian Institute of Molecular MedicinePaduaItaly Department of Industrial Engineering University of PaduaPaduaItaly LIFELAB Program Consorzio per la Ricerca SanitariaCORISVeneto RegionItaly Department of Physics and Astronomy“G.Galilei” University of PaduaPaduaItaly Fondazione bruno Kessler TrentoItaly Institute of Pediatric Research Citt`a della Speranza PaduaItaly Center for Biomaterials and Tissue Engineering CBITUniversitat Polit`ecnica de Val`enciaVal`enciaSpain Biomedical Research Networking Center on Bioengineering Biomaterials and Nanomedicine(CIBER-BBN)ValenciaSpain Institute of Polymers Composites and BiomaterialsNational Research Council of ItalyNaplesItaly

In the field of tissue regeneration,the lack of a stable endothelial lining may affect the hemocompatibility of both synthetic and biological *** drawbacks might be prevented by specific biomaterial functionalization to induce selective endothelial cell(EC)*** bovine pericardia and porcine aortas were selectively functionalized with a REDV tetrapeptide at 10^(-5)M and 10^(-6)M working *** scaffold-bound peptide was quantified and REDV potential EC adhesion enhancement was evaluated in vitro by static seeding of human umbilical vein *** viable cells and MTS production were statistically higher in functionalized tissues than in *** histoarchitecture,geometrical features,and mechanical properties were unaffected by peptide *** selective immobilization of REDV was effective in accelerating ECs adhesion while promoting proliferation in functionalized decellularized tissues intended for blood-contacting applications.

关键词： Decellularized pericardium Decellularized aorta Covalent functionalization Endothelialization REDV Mechanical analysis

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