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A human translational model based on neuroplasticity for pharmacological agents potentially effective in Treatment-Resistant Depression: focus on dopaminergic system

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Neural Regeneration Research 2020年第6期15卷 1027-1029页

作者： Ginetta Collo Emilio Merlo Pich Department of Molecular and Translational Medicine Section of PharmacologyUniversity of BresciaBresciaItaly Department of Biomedicine University of BaselBaselSwitzerland(Collo G)Neuroscience Therapeutic Area UnitTakeda Pharmaceuticals InternationalZurichSwitzerland Division of Brain Science Imperial CollegeLondonUK(Merlo Pich E

Major depressive disorder(MDD)is a common psychiatric condition characterized by two main symptoms,low mood and anhedonia.About 15–30%of people suffering from MDD do not respond to standard-of-care antidepressants,e.g.,the serotonin re-uptake inhibitors(SSRI),and are considered affected by Treatment-Resistant Depression(TRD).The neurobiology of this condition is presently unknown.Recent attempts of developing novel treatments for TRD have been driven by four major breakthroughs:(1)Increasing dopaminergic neurotransmission improves TRD symptoms;(2)Anhedonia occurs when central dopaminergic neurotransmission is low;(3)Enhanced neuroplasticity is critical for the action of antidepressants;(4)Ketamine shows antidepressant properties in TRD patients and triggers neuroplasticity in preclinical animal models.These breakthroughs are at the basis of a putative human translational cellular model for antidepressant agents that we are proposing in this article.The rationale is briefly described here.

关键词： breakthrough plasticity translational

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Ketamine enhances structural plasticity in human dopaminergic neurons:possible relevance for treatment-resistant depression

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Neural Regeneration Research 2018年第4期13卷 645-646页

作者： Ginetta Collo Emilio Merlo Pich Department of Molecular and Translational Medicine Section of PharmacologyUniversity of Brescia Department of Biomedicine University of Basel Neuroscience Therapeutic Area Unit Takeda Pharmaceuticals International Division of Brain Science Imperial College

Depression refers to a series of mental health issues characterized by loss of interest and enjoyment in everyday life,low mood and selected emotional,cognitive,physical and behavioral symptoms.Depression is a common disorder,affecting 5–15%of the general population.When diagnosed as major depressive disorder（MDD）,patients are currentlytreated with pharmacological agents such as serotonin or noradren- aline uptake inhibitors （SSRI or SNRI） or tricyclics.

关键词： MEK ERK Ketamine enhances structural plasticity in human dopaminergic neurons:possible relevance for treatment-resistant depression TRD MDD

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