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Increased cD4/cD8 Lymphocyte ratio predicts favourable neoadjuvant treatment response in gastric cancer:A prospective pilot study

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World Journal of Gastrointestinal Oncology 2023年第2期15卷 303-317页

作者： Daniel Skubleny Andrea Lin Saurabh Garg Ross McLean Michael Mccall Sunita Ghosh Jennifer L Spratlin Daniel Schiller gina Rayat Department of Surgery University of AlbertaEdmonton T6G 2R3ABCanada Department of Surgery University of AlbertaEdmonton T6G 2R3AlbertaCanada Department of Laboratory Medicine and Pathology University of AlbertaEdmonton T6G 2R3AlbertaCanada Department of Oncology University of AlbertaEdmonton T6G 2R3AlbertaCanada Department of Oncology Cross Cancer InstituteUniversity of AlbertaEdmonton T5G 1Z2ABCanada

BAcKGROUND Despite optimal neoadjuvant chemotherapy only 40%of gastric cancer tumours achieve complete or partial treatment *** the absence of treatment response,neoadjuvant chemotherapy in gastric cancer contributes to adverse events without additional survival benefit compared to adjuvant treatment or surgery *** strategies and methods are required to optimize the allocation of existing treatment regimens such as FLOT chemotherapy(5-Fluorouracil,Leucovorin,Oxaliplatin and Docetaxel).Predictive biomarkers detected using immunohistochemistry(IHc)methods may provide useful data regarding treatment *** To investigate the utility of cD4,cD8,Galectin-3 and E-cadherin in predicting neoadjuvant FLOT chemotherapy tumour response in gastric *** Forty-three adult patients with gastric adenocarcinoma,of which 18 underwent neoadjuvant chemotherapy,were included in a prospective clinical *** biopsies were obtained from gastric cancer and normal adjacent gastric *** in expression of Galectin-3,Ecadherin,cD4^(+)and cD8^(+)molecules between tumours with and without treatment response to neoadjuvant chemotherapy were assessed with *** response was graded by clinical pathologists using the Tumour Regression Score according to the college of American Pathologists *** response was defined as complete or near complete tumour response,whereas partial or poor/no response was defined as *** IHc images were annotated and quantitatively assessed using QuPath *** expression between responsive and incomplete response tumours was assessed using a two-sided Wilcoxon *** expression was also compared between normal and cancer tissue and between 15 paired tumour samples before and after *** performed a preliminary multivariate analysis and power analysis to guide future *** analyses were completed using R *** The ratio betw

关键词： cD4 cD8 Galectin-3 Neoadjuvant chemotherapy Treatment response Gastric cancer

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Drawing Inspiration from Yan Fu and Lu Xun:Self-Analysis and critique of the National character in the 21st century

Drawing Inspiration from Yan Fu and Lu Xun:Self-Analysis and...

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北京论坛（2011）文明的和谐与共同繁荣--传统与现代、变革与转型

作者： gina chen US Fulbright Scholar Yale University Sichuan University

From the end of the 19th century to the beginning of the 20th century,china under the Qing dynasty was undermined simultaneously on nearly every *** suffered through numerous defeats,humiliations,and unequal treaties ... 详细信息

关键词： century Drawing Inspiration from Yan Fu and Lu Xun:Self-Analysis and critique of the National character in the 21

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Whither (or Wither) chinese Women’s Films? Baober in love and The Jade Goddess of Mercy

Whither (or Wither) Chinese Women’s Films? Baober in love a...

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“全球化语境中电影美学与理论新趋势”国际学术研讨会

作者： gina Marchetti

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Deciphering the Stigmatic Transcriptional Landscape of compatible and Self-Incompatible Pollinations in Brassica napus Reveals a Rapid Stigma Senescence Response Following compatible Pollination

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Molecular Plant 2013年第6期6卷 1988-1991页

作者： Subramanian Sankaranarayanan Muhammad Jamshed Srijani Deb Kate chatfield-Reed Eun-Joo gina Kwon Gordon chua Marcus A. Samuel Department of Biological Sciences University of Calgary 2500 University Drive NW Calgary AB T2N 1N4 Canada Institute of Biocomplexity and Informatics Department of Biological Sciences University of Calgary Calgary AB Canada

Dear Editor, Self-incompatibility （SI） is a genetic mechanism through which flowering plants prevent self-pollination to ensure out- crossing and genetic diversity. In Brassica sp., this mechanism is controlled by the self-incompatibility （S） locus, in which, the stigmatic ＇S-locus receptor kinase （SRK）＇ recognizes the ＇S-locus cysteine rich protein （ScR）＇ from the self-pollen to elicit an active rejection response. This results in blocking of compatibil- ity factors from being delivered to the site of pollen attachment leading to self-pollen rejection （chapman and Goring, 2010）. In contrast, following recognition of compatible signals from the cross-pollen or compatible pollen （cP）, the stigma releases its resources such as water and nutrients to the dry pollen so that the pollen tube can germinate and penetrate the stigmatic cuticle leading to successful fertilization. Thus, an incompatible or self-pollen is fully capable of eliciting a compatible response, but is actively rejected before compatible responses can occur.

关键词： Self-incompatibility (SI) Brassica napus

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Defining response to radiotherapy in rectal cancer using magnetic resonance imaging and histopathological scales

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World Journal of Gastroenterology 2016年第37期22卷 8414-8434页

作者： Muhammed RS Siddiqui Jemma Bhoday Nicholas J Battersby Manish chand Nicholas P West Al-Mutaz Abulafi Paris P Tekkis gina Brown Department of colorectal Surgery Croydon University Hospital Croydon London CR7 7YE United Kingdom Department of Radiology Royal Marsden Hospital Sutton SM2 5PT United Kingdom Pathology and Tumour Biology Leeds Institute of Cancer and Pathology St. James's University Hospital Leeds LS9 7TF United Kingdom Department of Surgery Royal Marsden Hospital Fulham Rd London SM2 5PT United Kingdom

AIM To define good and poor regression using pathology and magnetic resonance imaging(MRI) regression scales after neo-adjuvant chemotherapy for rectal *** A systematic review was performed on all studies up to December 2015, without language restriction, t h a t w e r e i d e n t i f i e d f r o m M E D L I N E, c o c h r a n e controlled Trials Register(1960-2015), and EMBASE(1991-2015). Searches were performed of article bibliographies and conference abstracts. MeS H and text words used included "tumour regression", "mr TRG", "poor response" and "colorectal cancers". clinical studies using either MRI or histopathological tumour regression grade(TRG) scales to define good and poor responders were included in relation to outcomes [local recurrence(LR), distant recurrence(DR), disease-free survival(DFS), and overall survival(OS)]. There was no age restriction or stage of cancer restriction for patient inclusion. Data were extracted by two authors working independently and using pre-defined outcome *** Quantitative data(prevalence) were extracted and analysed according to meta-analytical techniques using comprehensive meta-analysis. Qualitative data(LR, DR, DFS and OS) were presented as ranges. The overall proportion of poor responders after neo-adjuvant chemoradiotherapy(cRT) was 37.7%(95%cI: 30.1-45.8). There were 19 different reported histopathological scales and one MRI regression scale(mrT RG). clinical studies used nine and six histopathological scales for poor and good responders, respectively. All studies using MRI to define good and poor response used one scale. The most common histopathological definition for good response was the Mandard grades 1 and 2 or Dworak grades 3 and 4; Mandard 3, 4 and 5 and Dworak 0, 1 and 2 were used for poor response. For histopathological grades, the 5-year outcomes for poor responders were LR 3.4%-4.3%, DR 14.3%-20.3%, DFS 61.7%-68.1% and OS 60.7-69.1. Good pathological response 5-year outcomes were LR

关键词： Tumour regression mrT RG Poor response Neo-adjuvant therapy Rectal cancer

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An Optimal Lifetime Utility Routing for 5G and Energy-Harvesting Wireless Networks

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ZTE communications 2015年第1期13卷 35-42页

作者： gina Martinez Shufang Li chi Zhou Department of Electrical and computer Engineering Illinois Institute of Technology Telecommunication Engineering Institute Beijing University of Posts and Telecommunication

Harvesting energy from environmental sources such as solar and wind can mitigate or solve the limited-energy problem in wireless sensor networks. In this paper, we propose an energy-harvest-aware route-selection method that incorporates harvest availability properties and energy storage capacity limits into the routing decisions. The harvest-aware routing problem is formulated as a lin- ear program with a utility-based objective function that balances the two conflicting routing objectives of maximum total and maxi- mum minimum residual network energy. The simulation results show that doing so achieves a longer network lifetime, defined as the time-to-first-node-death in the network. Additionally, most existing energy-harvesting routing algorithms route each traffic flow independently from each other. The LP formulation allows for a joint optimization of multiple trafic flows. Better residual energy statistics are also achieved by such joint consideration compared to independent optimization of each commodity.

关键词： routing 5G energy-harvesting wireless sensor networks

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Religious and cultural Significance of the citron （citrus medica L. ＇Diamante＇） from calabria （South Italy）： A Biblical Fruit of the Mediterranean Land

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Journal of Environmental Science and Engineering(A) 2015年第4期4卷 203-209页

作者： gina Maruca Gaetano Laghetti Karl Hammer Institute of Bioresources and Bioscience National Council of Research Bari 70126 Italy Former Institute of crop Science University of Kassel Witzenhausen D-37213 Germany

The history and geographical origin of citron （citrus medica L.） is still unknown but most of authors agree that it originated in Southeast Asia. There are different opinions about the exact period and the steps by which it was brought from its country of origin to the Mediterranean basin where it is cultivated in corsica, crete and in southern Italy （calabria region）. In particulary, citrus medica ＇Diamante＇ grows, almost exclusively, in a restricted area of the Tyrrhenian cost of the region calabria, called ＂Riviera dei cedri＂, a relevant local economic district. This citron has been and is, still being used by Jews for worship during the Feast of Tabernacles, a very important religious ritual, where it plays a prominent part; in fact, for this holiday of Sukkot, the use of the authentic citron that grows in calabria region is recommended, because it is not grafted. In this paper, the fascinating history of c. medica and its spread from the centers of origin to the Mediterranean is reported with the aim to investigate the religious and cultural significance of the c. medica ＇Diamante＇, an exclusive and historical heritage of the calabria region.

关键词： citron (citrus medica L.) sukkot Hebrew.

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Maternal Mortality Interventions: A Systematic Review

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Open Journal of Preventive Medicine 2014年第9期4卷 699-707页

作者： gina Marie Piane Eliva Ambugo clinton community Health Department National University Costa Mesa CA USA

Background: In order to achieve the World Health Organization’s Millennium Development Goal of reducing maternal mortality by three quarters by 2015, a strong global commitment is needed to address this issue in low-income nations where the risk to women is greatest. A comprehensive international effort must include provision of obstetric and general medical care as well as community-based interventions, with an emphasis on the latter in nations where the majority of women deliver babies at home without a trained attendant. Methods: This systematic analysis evaluates interventions published in Medline and cINAHL whose outcome measure is maternal mortality. Analysis includes components of the intervention, nation and maternal death rates. Results: Nine studies documented the effectiveness of various clinical and community-based interventions, including specific drug regimens and procedures, in reducing the risk of maternal death. Six studies reported interventions that did not significantly alter maternal mortality outcomes, and the intervention in one study demonstrated increased risk of maternal death. conclusion: The dearth of evidence highlights the need for increased focus on translational research that bridges the gap between medical advances and community-based interventions that are feasible in low-income nations. This cannot be accomplished without a stronger commitment to reducing maternal mortality by global health practitioners and researchers.

关键词： Maternal Mortality Systematic Review Women’s Health

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关于罗令源部分作品中跨文化相遇情境里的身体的跨文化分析

关于罗令源部分作品中跨文化相遇情境里的身体的跨文化分析

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作者： gina Zieaell 北京外国语大学

学位级别：硕士

这篇论文从中德跨文化日耳曼学角度出发,选取作为跨文化文学代表作家的旅德华裔罗令源部分作品为研究对象,如短篇小说《夜游莱茵河》(2008)与《留洋肚子静悄悄》(2009),对其中的身体和空间方面进行分析。跨文化文学中研究文化主题的一... 详细信息

这篇论文从中德跨文化日耳曼学角度出发,选取作为跨文化文学代表作家的旅德华裔罗令源部分作品为研究对象,如短篇小说《夜游莱茵河》(2008)与《留洋肚子静悄悄》(2009),对其中的身体和空间方面进行分析。跨文化文学中研究文化主题的一个卓有成就的方面即是审视一部作品中"内容"与"语言表达"之间的关系。本文以乌尔索拉·胡森-魏德曼于2003年提出的"身体"这一文化主题为基础,这一主题在既定的文化语境中具有秩序的功能和交流功能,这些功能使身体这一文化主题具有代表性,对科学性分析极其重要。在罗令源的作品中,"身体"在德国男性和中国女性的跨文化交遇情境中发挥着主要媒介的作用,他们的身体在具有象征性的一定"空间"内活动,划定界限或超越界限。这篇论文基本概念包括文化、跨文化与跨文化文学。跨文化日耳曼学使用的文化概念特点是具有开放性、变化性和依关性。这种文化概念认为,每个人都必然参与集体的实践性活动,参与象征性的实践活动,这些实践活动也是会变化的,因此这些活动使每个人都与他人相联系。不同文化圈的成员相遇时,一方可能会认为对方一些行为举止陌生。他们互动交流中产生的差异也处于不断的变化中,这就是跨文化概念。跨文化文学的基本出发点是,文学作品中也出现这种互动,这些文学中的陌生感也会同时促成学习效应,增强人们在应对文化陌异感时的宽容性。因此跨文化文学的主要研究对象是关注陌异性、迁移、跨文化相遇、权力关系等的语篇。本论文分析罗令源作品如何借助身体与空间来表达上述跨文化文学所研究的主要主题,所以有必要仔细探讨目前关于身体方面已有的研究成果。这部分包括"身体"这一概念的辞源和及对其研究的历史沿革,从而令人便于理解研究者为何对"身体"这一主题越来越多给予关注。自20世纪80年代以来,"身体"和"身体性"成为热点研究课题。每个关于身体研究的学科都有不同的传统和参量,会映射出不同的研究侧重点,这些各不相同的侧重点不乏矛盾之处。本论文以前述跨文化日耳曼学的基本概念以及跨文化文学在相关方面的论述为理论框架,试图在此基础上从文化、语言的和文学及三者相互联系的语境角度来分析"身体"这一文化主题这一主题也与对"空间"的概念阐释密切相关,两者的联结点是身份认同。。在一定社会背景中,谁可以进入某个空间,该如何表现,通常与身体的特征相关。因此,这里的"空间"不仅是地点意义上的概念,同时也是具有象征意义的区域,这个区域会体现人们的行为所带来的结果。本论文的分析部分围绕"身体"和"空间"主题研究小说如何描述跨文化相遇情境,及跨文化日耳曼学其他重要主题。在选取的罗令源作品中,身体的亲密接触始终作为情节中一个重要要素出现,体现着某种关系的状况:如果两人争吵时或他们关系罩上阴影,性交就停止,而变成单方的行为或暴力行为。反之,和谐的性生活也表达关系的亲密。因此,跨文化的相遇也总是个人身体的接触。身体的亲近便意味着允许对方越过有形的的身体界限进入私人空间,这或许是受到欢迎的亲密行为,但也可能是不受欢迎的暴力行为。如果把罗令源作品里描写的身体亲密行为与性交看做跨文化相遇的典型代表,那么可以说这种暗示着在空间里发生的动态变化就是罗令源使用的最重要表达手段。界限不但能被越过,而且会成为相会和相遇之地这种观念被是罗令源展现为,身体亲近是一种触及界限的活动。与此密切相关的,是罗令源笔下的主人公的活动空间及归属空间,以及身体互动和对身体施加某种行为所体现的权力关系。由这篇论文可见,"身体"概念是一个很好的切入点,能够将跨文化日耳曼学涵括的陌异性、空间和边界问题的研究联结在一起。但是,这种研究方法也一定存在着风险,即:罗令源作品中描写的身体交遇被单纯从字面角度去理解为跨文化相遇,而不是从隐喻的角度去理解。实际上,在跨文化日耳曼学和跨文化文学框架下把跨文化相遇的情境复杂化,以此去解读罗令源的文学作品,这一点很重要,就会发现这种解读方法与罗令源的作品分不开,就不会将其作品中的主人公看做静止的A文化和B文化的代表人物,从而避免一种本质主义的解读方法。她的作品中的角色在交遇中总是变动不居,体现为文化方面与个体的发展变化。罗令源冷静而中立的语言表述令读者拥有充足的阐释空间,而小说中那些突出身体的具体场景不禁令读者移情于主人公,仿佛感同身受。跨文化日耳曼学和跨文化文学领域中今后在"身体"主题方面可以继续研究的,也许主要是继续探讨身体、空间、界限隐喻的关系,其中特别要关注两个领域中的关键概念,如跨文化性或陌异性。与此相关的一个可以联结的角度是在空间视角下研究移民文学中的隐喻。如前所述,亦可从性别角度进行延展,或结合用以评判身体陌异性的、关于身体和种族主义已有的研究。就如本论文多次强调的,身体这一研究对象具有多义性,因此可以进行结合和延展的研究方面也是多样的,但是需要准确给予研究以定位。但是,由于"身体"具有普遍的代表性,

关键词：跨文化文学罗令源身体空间

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Lactic Acid Is Not Muscles’Foe,It’s Fuel

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当代外语研究 2006年第7期 4-6页

作者： gina Kolata 李海龙

长期以来,人们一直认为乳酸会在运动过程中导致肌肉组织疲劳。然而,加州大学伯克利分校的教授通过研究否定了这一观点,并且确认乳酸是肌肉组织的能量来源。肌细胞将葡萄糖转化成乳酸,而乳酸则成为制造能量的线粒体的燃料。这不但纠正了... 详细信息

长期以来,人们一直认为乳酸会在运动过程中导致肌肉组织疲劳。然而,加州大学伯克利分校的教授通过研究否定了这一观点,并且确认乳酸是肌肉组织的能量来源。肌细胞将葡萄糖转化成乳酸,而乳酸则成为制造能量的线粒体的燃料。这不但纠正了“科学史上的经典错误之一”,也为如何培训更出色的运动员提供了新的理念。

关键词：乳酸肌肉组织线粒体葡萄糖伯克利分校运动过程能量来源加州大学肌细胞科学史

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