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Edouard Manet

Edouard Manet

Building Transcription Factor Binding Site Models to Understand Gene Regulation in Plants

作者： gilles Ne?ret [translation Chris Miller].

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Molecular Plant 2019年第6期12卷 743-763页

作者： Xuelei Lai Arnaud Stigliani gilles Vachon Cristel Carles Cezary Smaczniak Chloe Zubieta Kerstin Kaufmann Francois Parcy CNRS Univ. Grenoble Alpes CEA INRA BIG-LPCV 38000 Grenoble France Department for Plant Cell and Molecular Biology Institute for Biology Humboldt-Universitat zu Berlin Berlin Germany

Transcription factors (TFs) are key cellular components that control gene expression. They recognize specific DNA sequences, the TF binding sites (TFBSs), and thus are targeted to specific regions of the genome where they can recruit transcriptional co-factors and/or chromatin regulators to fine-tune spatiotemporal gene regulation. Therefore, the identification of TFBSs in genomic sequences and their subsequent quantitative modeling is of crucial importance for understanding and predicting gene expression. Here, we review how TFBSs can be determined experimentally, how the TFBS models can be constructed in silico, and how they can be optimized by taking into account features such as position interdependence within TFBSs, DNA shape, and/or by introducing state-of-the-art computational algorithms such as deep learning methods. In addition, we discuss the integration of context variables into the TFBS modeling, including nucleosome positioning, chromatin states, methylation patterns, 3D genome architectures, and TF cooperative binding, in order to better predict TF binding under cellular contexts. Finally, we explore the possibilities of combining the optimized TFBS model with technological advances, such as targeted TFBS perturbation by CRISPR, to better understand gene regulation, evolution, and plant diversity.

关键词： Transcription factor binding site Gene regulation flower development

Semantics for linking data from 4D BIM to digital collaborative support

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Frontiers of Engineering Management 2022年第1期9卷 104-116页

作者： Calin BOJE Veronika BOLSHAKOVA Annie GUERRIERO Sylvain KUBICKI gilles HALIN Luxembourg Institute of Science and Technology(LIST) 5 Avenue des Hauts-ForneauxEsch-sur-AlzetteL-4362Luxemburg UMR n°3495 Modèles et Simulations pour l’Architecture et le Patrimoine Centre de Recherche en Architecture et Ingénierie(MAP-CRAI) 1 Rue Bastien LepageNancy54000France Universitéde Lorraine(UL) Nancy54000France

Synchronous collaboration sessions within the context of 4D BIM position construction professionals into a complex socio—technical *** system includes hardware,software,people,and broader community *** article strictly focuses on the ontology representation of synchronous collaboration sessions with collocated collective *** model is designed by considering various 4D BIM model uses while a digital multiuser touch table facilitates the collaboration between *** outlined ontological model aims to improve interoperability and to move toward a knowledge-driven,smart-built environment paradigm.A knowledge engineering methodology is outlined,by virtue of which the semantics of the presented model are defined and *** from nearby knowledge fields,especially from the Industry Foundation Classes,are *** examples on querying the knowledge base according to the project meeting requirements are outlined to demonstrate the benefits of using the *** 4D BIM model data can be imported by using standard formats,capturing data about the social context remains a challenge in the *** is expected to change the ontology model structure by considering user ergonomics,data modeling requirements,as well as technical implementation constraints.

关键词： 4D BIM ontology IFC decision-making linked data collaboration planning

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热塑性尼龙纤维烧结过程的建模及实验验证

高分子材料科学与工程 2013年第3期29卷 177-181页

作者：徐凡李昕 gilles Regnier Denis Defauchy Laboratoire Procedes et Ingenierie en Mecanique et Materiaux UMR CNRS 8006Arts et Metiers Paris TechPairs 75013France Laboratoire d'Etude des Microstructures et de Mecanique des Materiaux UMR CNRS 7239Universite de LorraineMetz 57045France 上海交通大学材料科学与工程学院上海200240

为了研究热塑性聚合物粉末的烧结合并过程,在Frenkel、Eshelby和Pokluda等人模型的基础上建立2D数学模型,同时用尼龙纤维(长度远大于直径,可视为无限长)进行烧结实验,观察其横截面的合并过程。将数学模型预测结果与实验结果以及Constrai... 详细信息

为了研究热塑性聚合物粉末的烧结合并过程,在Frenkel、Eshelby和Pokluda等人模型的基础上建立2D数学模型,同时用尼龙纤维(长度远大于直径,可视为无限长)进行烧结实验,观察其横截面的合并过程。将数学模型预测结果与实验结果以及Constrained Natural Element Method(C-NEM)数值模拟结果进行对比,其结果基本一致,所获得的数学模型和实验结果可为烧结合并过程的数值模拟和理论研究提供依据。

关键词：烧结热塑性纤维 2D模型合并过程表面张力粘滞力

Evidence-based approach to management of hepatic encephalopathy in adults

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World Journal of Hepatology 2022年第4期14卷 670-681页

作者： gilles Jadd Hoilat Fathima Keshia Suhail Talal Adhami Savio John Department of Medicine SUNY Upstate Medical UniversitySyracuseNY 13210United States Department of Gastroenterology Cleveland Clinic FoundationClevelandOH 44195United States Department of Gastroenterology SUNY Upstate Medical UniversitySyracuseNY 13210United States

Hepatic encephalopathy(HE)is a reversible syndrome of impaired brain function and represents one of the many complications of portal hypertension and decompensated liver *** ammonia is clearly implicated in the pathogenesis of HE,the pathogenesis of HE is multifactorial with numerous mechanisms that results in functional impairment of neuronal *** initial management of HE focuses on supportive care and stabilization which includes providing appropriate nutritional ***,focus should be on identifying and treating the precipitating *** are many therapeutic agents available for the management of HE,most of which are directed towards lowering the gut nitrogen load and thus the serum ammonia *** review aims to provide an update on the conventional and emerging treatment options for HE.

关键词： Hepatic encephalopathy Lactulose Rifaximin Fecal microbiota transplant Zinc L-ornithine L-aspartate

Ion stopping in dense plasmas: A basic physics approach

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Matter and Radiation at Extremes 2016年第6期1卷 277-307页

作者： Claude Deutsch gilles Maynard Laboratoire de Physique des Gaz et Plasmas CNRSUniv-Paris SudUniversite Paris-Saclay91405 OrsayFrance

We survey quite extensively the present research status of ion-stopping in dense plasmas of potential importance for initial confinement fusion(ICF)drivenby intense and heavy ion beams,and alsofor warm dense matter(WDM).First,we putemphasis on every possible mechanism involved in the shaping of the ion projectile effective charge,while losing energy in a target plasma with classical ions and partially degenerate ***,we switch to ion stopping by target bound electrons,taking detailed account of mean excitation *** electron stopping has already been given a lot of attention in former works[*** et al.,Recent *** 1(2000)1-23;Open Plasma Phys.J.3(2010)88-115].Then,we extend the usual standard stopping model(SSM)framework to nonlinear stopping including a treatment of the Z 3 Barkas effect and a confronting comparison of Bloch and Bohr Coulomb ***,we document low velocity ion slowing down(LVISD)in single ion plasmas as well as in binary ionic mixtures(BIM),in connection with specific ICF fuels.

关键词： Ion projectile effective charge Mean excited energies Nonlinear stopping Binary ionic mixture

Management of hepatocellular adenoma: Solitary-uncomplicated, multiple and ruptured tumors

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World Journal of Gastroenterology 2005年第36期11卷 5691-5695页

作者： Christian Toso Pietro Majno Axel Andres Laura Rubbia-Brandt Thierry Berney Leo Buhler Philippe Morel gilles Mentha Abdominal and Transplant Surgery University Hospital Geneva Switzerland Clinical Pathology University Hospital Geneva Switzerland

AIM： While hepatocellular adenomas （HAs） have often been studied as a unique entity, we aimed to better define current management of the various forms of HAs. METHODS： Twenty-five consecutive patients operated for solitary-uncomplicated （9）, multiple （6）, and ruptured （10） HAs were reviewed according to management strategies and outcomes. RESULTS： All solitary-uncomplicated HAs （ranged 2.2- 14 cm in size） were removed. Out of 25 HAs, 2 （8%） included loci of carcinoma. In the multiple HA group, previously undiagnosed tumors were identified during surgery in 5/6 cases. In three cases with multiple spread HA, several lesions had to be left unresected. They remained unmodified after 4-, 6-, and 6-year radiological follow-up. Patients with ruptured HA （ranged 1.7-10 cm in size） were initially managed with hemodynamic support and angiography, allowing the embolizaUon of actively bleeding tumors in two patients. All ruptured tumors were subsequently removed 5.5 d （range 4-70 d） after admission. CONCLUSION： Tumors suspected of HA, regardless of the size, should be resected, because of high chances of rupture causing bleeding, and/or containing malignant foci. Although it is desirable to remove all lesions of multiple HA, this may not be possible in some patients, for whom long-term radiological follow-up is advised. Ruptured HA can be managed by hemodynamic support and angiography, allowing scheduled surgery. 2005 The WJG Press and Elsevier Inc. All rights reserved

关键词： Liver Adenoma Management Surgery

Quasi-Networks in Social Relational Systems

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Systems Science and Systems Engineering 1992年第1期2卷 25-33页

作者： Robert P.gilles Pieter H.M.Ruys Department of Economies Virginia Polytechnic Institute & State UniversityDepartment of Econometrics Tilburg University Blacksburg Virginia USATilburgthe Netherlands

In social sciences it is more or less generally acknowledged that (social) networks seem to be the natural tool in the organization of social activity. In the liteature on the mathematical description of social phenomena the concept of a network is hardly *** this paper we focus on the development of a’possible mathematical formualtion of the properties of a social network and a minimal and nearly complete social relational subsystem as a quasi-network within the setting of an economic trade system.

关键词： social relational system quasi-network.

Preoperative rectosigmoid endoscopic ultrasonography predicts the need for bowel resection in endometriosis

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World Journal of Gastroenterology 2019年第6期25卷 696-706页

作者： Victor Desplats René-Louis Vitte Joseph du Cheyron gilles Roseau Arnaud Fauconnier Frédérick Moryoussef Department of Hepato-gastroenterology Centre Hospitalier Intercommunal Poissy Saint Germain Department of Statistics Centre Hospitalier Intercommunal Poissy Saint Germain Department of Gastroenterology H?pital Cochin Department of Obstetrics and Gynecology Centre Hospitalier Intercommunal Poissy Saint Germain University of Saint Quentin en Yvelines

BACKGROUND Rectosigmoid endometriosis is an underdiagnosed disease responsible for abdominal pain, transit disorders and rectal bleeding. Two surgical approaches,rectosigmoid bowel resection(segmental or patch) or intramuscular layer dissection(shaving), are *** To assess whether the lesion features observed via preoperative rectosigmoid endoscopic ultrasonography(RS-EUS) might predict the need for bowel *** This multicentric retrospective study was conducted on patients with rectosigmoid endometriosis who underwent a curative surgical procedure,evaluated by RS-EUS performed by two trained operators, between January 2012 and March 2018. A univariate statistical analysis was performed on nodules' RSEUS features(thickness, width, infiltration of the submucosae, presence of a bump into the digestive lumen and presence of multiple rectosigmoid localizations). A multivariate logistic regression was then performed on the significant *** Of the 367 patients, 73 patients with rectosigmoid endometriosis were evaluated by RS-EUS and underwent rectosigmoid surgery. After the univariate analysis was completed, thickness, width and infiltration of the submucosae were identified as potential predictive factors for bowel resection. In a multivariate logistic regression model, only thickness appeared to be a significant [odds ratio(OR) = 1.49, 95% confidence interval(CI): 1.04-2.12, P = 0.028] predictive factor for bowel resection. Receiver operating characteristic analysis performed showed that a thickness over 5.20 mm might be used as cut-off with a sensitivity of 76%, a specificity of 81%, and an area under carve = 0.82. The cut-off values for 100%sensitivity and 100% specificity were 0.90 mm and 10.00 mm, respectively. A trend concerning width to predict the need for resection was also observed(OR1.12, 95%CI: 1.00-1.26, P = 0.054)CONCLUSION The presence of a rectosigmoid nodule of endometriosis greater than 5.20 mm thick on RS-EUS might predi

关键词： Endometriosis Surgery Endoscopy Ultrasound Bowel disease Rectum and sigmoid