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CD5 expression promotes IL-10 production through activation of the MAPK/Erk pathway and upregulation of TRPC1 channels in B lymphocytes

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Cellular & Molecular Immunology 2018年第2期15卷 158-170页

作者： Soizic Garaud Taher E Taher Marjolaine Debant Miguel Burgos Sarra Melayah Christian Berthou Kaushal Parikh Jacques-Olivier Pers Damien Luque-Paz gilles chiocchia Maikel Peppelenbosch David A Isenberg Pierre Youinou Olivier Mignen Yves Renaudineau Rizgar A Mageed INSERM ERI29/EA2216 réseau epigenetique and réseau canaux ioniques du Cancéropôle Grand OuestBrest University Medical SchoolBrest29609France Centre for Experimental Medicine and Rheumatology William Harvey Research InstituteBarts and the London School of Medicine and DentistryQueen Mary University of LondonLondonEC1M 6BQUK Canalopathy and Calcium Signaling INSERM UMR1078Brest29238France Centre for Experimental and Molecular Medicine Academic Medical CenterMeibergdreef 9Amsterdam1105 AZThe Netherlands Laboratory of Immunology and Immunotherapy CHU MorvanBrest29609France Institut Cochin INSERM U567Paris75014France Department of Gastroenterology and Hepatology Erasmus MCGravendijkwal 230Rotterdam015 CERotterdamThe Netherlands Centre for Rheumatology University College LondonLondonWC1E 6JFUK

CD5 is constitutively expressed on T cells and a subset of mature normal and leukemic B cells in patients with chronic lymphocytic leukemia(CLL).Important functional properties are associated with CD5 expression in B cells,including signal transducer and activator of transcription 3 activation,IL-10 production and the promotion of B-lymphocyte survival and ***,the pathway(s)by which CD5 influences the biology of B cells and its dependence on B-cell receptor(BCR)co-signaling remain *** this study,we show that CD5 expression activates a number of important signaling pathways,including Erk1/2,leading to IL-10 production through a novel pathway independent of BCR *** pathway is dependent on extracellular calcium(Ca2+)entry facilitated by upregulation of the transient receptor potential channel 1(TRPC1)*** also show that Erk1/2 activation in a subgroup of CLL patients is associated with TRPC1 *** this subgroup of CLL patients,small inhibitory RNA(siRNA)for CD5 reduces TRPC1 ***,siRNAs for CD5 or for TRPC1 inhibit IL-10 *** findings provide new insights into the role of CD5 in B-cell biology in health and disease and could pave the way for new treatment strategies for patients with B-CLL.

关键词： B cells calcium CD5 MAPK/Erk TRPC1

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Towards an enhanced interpretation of δ18O changes during the past 300 kyr over Asia

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National Science Review 2022年第11期9卷 63-64页

作者： gilles Ramstein Laboratoire des Sciences du Climat et de l’Environnement LSCE/IPSL CEA-CNRS-UVSQUniversite Paris-Saclay

For many decades, the impact of orbital forcing on monsoon systems has been intensively studied. Rapidly, attention has been drawn to the Mid-Holocene due to the ’Green Sahara’, which was depicted, using many different proxies, as much more humid than the present-day desert. It also corresponds to enhanced Asian monsoons [1]. Climate models have been used to simulate this period.

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SEEMINGLY INJECTIVE VON NEUMANN ALGEBRAS

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Acta Mathematica Scientia 2021年第6期41卷 2055-2085页

作者： gilles PISIER Department of Mathematics Texas A&M UniversityCollege StationTX77843-3368USA

We show that a QWEP von Neumann algebra has the weak* positive approximation property if and only if it is seemingly injective in the following sense: there is a factorization of the identity of Id_(M)= vu : M→uB(H)→vM with u normal, unital, positive and v completely contractive. As a corollary, if M has a separable predual, M is isomorphic(as a Banach space) to B(l2). For instance this applies(rather surprisingly) to the von Neumann algebra of any free group. Nevertheless, since B(H) fails the approximation property(due to Szankowski) there are M ’s(namely B(H)^(**) and certain finite examples defined using ultraproducts) that are not seemingly ***, for M to be seemingly injective it suffices to have the above factorization of I dM through B(H) with u, v positive(and u still normal).

关键词： von Neumann algebra injectivity positive approximation property

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Combining data envelopment analysis and Random Forest for selectingoptimal locations of solar PV plants

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Energy and AI 2023年第1期11卷 129-137页

作者： gilles Cattani GSEM University of Geneva Geneva1213Switzerland

Solar photovoltaic (PV) energy has emerged as a potential alternative to carbon-based energies to meet theParis agreement commitment. This study investigates the effect of environmental variables on the efficiencyof solar PV panels. Data Envelopment Analysis (DEA) is used to estimate efficiencies of 91 solar PV panelslocated in Australia during the time period 2010–2020. The effects of environmental variables on the estimatedefficiencies are quantified using the truncated regression model. Random forest is then used to predict efficiencyof solar PV panel in every city of Australia. The results allow to determine the most suitable location and regions for solar PV energy production in Australia. This study provides an interesting and easily interpretabletool for policy decision makers.

关键词： Solar energy Location selection Australia Data envelopment analysis

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PM_(2.5) source apportionment in a French urban coastal site under steelworks emission influences using constrained non-negative matrix factorization receptor model

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Journal of Environmental Sciences 2016年第2期28卷 114-128页

作者： Adib Kfoury Frederic Ledoux Cloe Roche gilles Delmaire gilles Roussel Dominique Courcot Unite de Chimie Environnementale et Interactions sur le Vivant (UCEIV) EA4492 Universite du Littoral Cote d'Opale F-59140 Dunkerque France Laboratoire d'Informatique Signal et Image de la Cote d'Opale (LISIC) EA4491 Universite du Littoral Cote d'Opale F-52228 Calais France

The constrained weighted-non-negative matrix factorization（CW-NMF） hybrid receptor model was applied to study the influence of steelmaking activities on PM_（2.5）（particulate matter with equivalent aerodynamic diameter less than 2.5 μm） composition in Dunkerque,Northern France. Semi-diurnal PM_（2.5）samples were collected using a high volume sampler in winter 2010 and spring 2011 and were analyzed for trace metals, water-soluble ions, and total carbon using inductively coupled plasma – atomic emission spectrometry（ICP-AES）,ICP- mass spectrometry（ICP-MS）, ionic chromatography and micro elemental carbon analyzer. The elemental composition shows that NO_3^-, SO_4^（2-）, NH_4~＋and total carbon are the main PM_（2.5）constituents. Trace metals data were interpreted using concentration roses and both influences of integrated steelworks and electric steel plant were evidenced. The distinction between the two sources is made possible by the use Zn/Fe and Zn/Mn diagnostic ratios. Moreover Rb/Cr, Pb/Cr and Cu/Cd combination ratio are proposed to distinguish the ISW-sintering stack from the ISW-fugitive emissions. The a priori knowledge on the influencing source was introduced in the CW-NMF to guide the calculation. Eleven source profiles with various contributions were identified： 8 are characteristics of coastal urban background site profiles and 3 are related to the steelmaking activities. Between them,secondary nitrates, secondary sulfates and combustion profiles give the highest contributions and account for 93% of the PM_（2.5）concentration. The steelwork facilities contribute in about 2%of the total PM_（2.5）concentration and appear to be the main source of Cr, Cu, Fe, Mn, Zn.

关键词： PM_(2.5) Receptor modeling Non-negative matrix factorization Source apportionment Steelworks

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Very Regular Solutions for the Landau-Lifschitz Equation with Electric Current

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Chinese Annals of Mathematics,Series B 2018年第5期39卷 889-916页

作者： gilles CARBOU Rida JIZZINI Laboratoire de Mathématiques Appliquées de Pau UMR CNRS 5142 Université de Pau et des Pays de l'Adour Institut de Mathématiques de Bordeaux UMR CNRS 5251 Université de Bordeaux 351 cours de la Libération

The authors consider a model of ferromagnetic material subject to an electric current, and prove the local in time existence of very regular solutions for this model in the scale of H^k spaces. In particular, they des... 详细信息

关键词： Ferromagnetic materials Compatibility conditions Existence result

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Cell culture systems for the hepatitis C virus

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World Journal of Gastroenterology 2007年第17期13卷 2442-2445页

作者： gilles Duverlie Czeslaw Wychowski Virology Laboratory Amiens University Hospital Amiens F-80054 Amiens cedex 1 France and Hepatitis C Unit Institut de Biologie de Lille 1 rue du Pr Calmette BP 447 F-59021 Lille cedex France Hepatitis C Unit Institut de Biologie de Lille 1 rue du Pr Calmette BP 447 F-59021 Lille cedex France

Since the discovery of HCV in 1989, the lack of a cell culture system has hampered research progress on this important human pathogen. No robust system has been obtained by empiric approaches, and HCV cell culture remained hypothetical until 2005. The construction of functional molecular clones has served as a starting point to reconstitute a consensus infectious cDNA that was able to transcribe infectious HCV RNAs as shown by intrahepatic inoculation in a chimpanzee. Other consen- sus clones have been selected and established in a hu- man hepatoma cell line as replicons, i.e. self-replicating subgenomic or genomic viral RNAs. However, these repli- cons did not support production of infectious virus. Inter- estingly, some full-length replicons could be established without adaptive mutations and one of them was able to replicate at very high levels and to release virus particles that are infectious in cell culture and in vivo. This new cell culture system represents a major breakthrough in the HCV field and should enable a broad range of basic and applied studies to be achieved.

关键词： Hepatitis C virus Biology Cell CultureSystem In vitro models

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The Role of a Vanishing Interfacial Layer in Perfect Elasto-Plasticity

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Chinese Annals of Mathematics,Series B 2015年第5期36卷 813-828页

作者： gilles A.FRANCFORT Alessandro GIACOMINI LAGA Université Paris-Nord and Institut Universitaire de France DICATAM Sezione di Matematica Universita degli Studi di Brescia

A two-phase elasto-plastic material is investigated. It is shown that, if the interface is modeled as the limit of a vanishing layer of a third material, then the resulting two-phase material will exhibit a smaller in... 详细信息

关键词： Plasticity Variational Evolutions Interfaces Functions of bounded deformation

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A Numerical Analysis of Turbulent Compressible Radial Channel Flow with Particular Reference to Pneumatic Controllers

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Journal of Thermal Science 2004年第1期13卷 24-29页

作者： gilles Roy Dinh Vo-Ngoc Vadim Bravine Faculty of Engineering Université de MonctonMonctonNBCanadaE1A 3E9Faculty of EngineeringUniversité de MonctonMonctonNBCanadaE1A 3E9Faculty of EngineeringUniversité de MonctonMonctonNBCanadaE1A 3E9

A numerical analysis of turbulent axisymmetric radial compressible channel flow between a nozzle and a flat plate is presented in this paper. In particular, the application of this type of flow situation in pneumatic dimensional control systems is considered. The Spalart-Allmaras one-equation turbulence model is used. The resulting highly coupled PDE system has been solved using the control volume based numerical approach where the power-law scheme was used extensively to compute the diffusive and convective fluxes of momentum. Results show that local Mach numbers can easily achieve and surpass unity for typical industrial configurations. Also, in the case of a standard industrial nozzle geometry, the presence of a toroidal recirculation zone that moves radially outward is clearly identified in most cases. Separated flow areas are of particular concern as it has been shown previously that they can cause nozzle fouling in industrial applications. It has been shown that the size of this region is dependant on feed pressure. Considerable differences between results obtained using the Spalart-Allmaras and standard k- εturbulence models have also been noticed.

关键词： compressible radial flow numerical simulation pneumatic controllers impinging jet with confinement.

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CONCEPTUAL INTEGRATION

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外国语 2003年第2期26卷 2-7页

作者： gilles Fauconnier The University of California

Cognitive science research in the last twenty-five years has provided considerable evidence that reason is embodied. The neural architectures that evolved to produce perception, sensation, and bodily movement are at t... 详细信息

关键词：概念一体化认知语言学复杂性物质基础独立结构

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