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Association between fundamental motor skills and physical activity in the early years:A systematic review and meta-analysis

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Journal of Sport and Health Science 2020年第6期9卷 542-552页

作者： Dan Jones Alison Innerd Emma L.giles Liane b.Azevedo School of Health and Life Sciences Teesside UniversityMiddlesbrough TS13BXUK

background:Physical activity(PA)in the early years is associated with a range of positive health *** motor skill(FMS)competence is associated with PA and is theorized to be driven by PA in the early years and vice versa in mid to late ***,to date,no studies have meta-analyzed the association between PA and FMS in the early ***:Six electronic databases were searched for articles published up to April ***-sectional and longitudinal studies were included if they targeted children(ages 3-6 year)as the population of the study and assessed the association between objectively measured PA and *** FMS,total physical activity(TPA),and moderate-to-vigorous physical activity(MVPA)data were meta-analyzed using a random effects ***:We identified 24,815 titles and *** total,19 studies met the inclusion criteria,including 14 cross-sectional and 4 longitudinal studies,as well as 1 study with cross-sectional and longitudinal *** was a significant but small positive association between FMS and MVPA(r=0.20,95%confidence interval(CI):0.13-0.26)and TPA(r=0.20,95%CI:0.12-0.28).Findings from longitudinal studies revealed that PA drives FMS in early *** was explored in 1 study,which found that perceived motor competence did not mediate the association between FMS and ***:Using a meta-analysis,this study is the first to show a positive association between FMS,MVPA,and TPA in the early years of childhood,suggesting that the association begins at an early *** evidence from longitudinal studies supports the theory that PA drives FMS in the early years of *** evidence is needed from large studies to track PA and FMS until mid to late childhood and to explore the mediators of this association.

关键词： Early years Fundamental motor skills Physical activity

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Targeting chronic lymphocytic leukemia cells in the tumor microenviroment: A review of the in vitro and clinical trials to date

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World Journal of Clinical Cases 2015年第8期3卷 694-704页

作者： Kyle Crassini Stephen P Mulligan O giles best Northern blood Research Centre and CLL Australian Research Consortium Kolling Institute of Medical Research Royal North Shore Hospital

Chronic lymphocytic leukemia(CLL) is the most common leukemia in the western world. Despite significantadvances in therapy over the last decade CLL remains incurable. Current front-line therapy often consists of chemoimmunotherapy-based regimens, most commonly the fludarabine, cyclophosphamide plus rituximab combination, but rates of relapse and refractory disease are high among these patients. Several key signaling pathways are now known to mediate the survival and proliferation of CLL cells in vivo, the most notable of which are the pathways mediated by the b-cell receptor(bCR) and cytokine receptors. A better understanding of the pathogenesis of the disease, the underlying biology of the CLL-cell and the roles of the tumour microenvironment has provided the rationale for trials of a range of novel, more targeted therapeutic agents. In particular, clinical trials of ibrutinib and idelalisib, which target the brutons tyrosine kinase and the delta isoform of phosphoinositol-3 kinase components of the bCR signaling pathway respectively, have shown extremely promising results. Here we review the current literature on the key signaling pathways and interactions of CLL cells that mediate the survival and proliferation of the leukemic cells. For each we describe the results of the recent clinical trials and in vitro studies of novel therapeutic agents.

关键词： Chronic lymphocytic leukemia Therapy Microenvironment Leukemia Novel

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绘制网格数据的等值图

微型计算机 1995年第3期15卷 80-81,F004页

作者： giles,b 李宗杰

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西澳大利亚斯帕戈维利太古宙火山喷气金矿化

国外前寒武纪地质 1985年第2期 72-83页

作者： b.FEHLbERG C.W.giles 骆辉

序言斯帕戈维利(Spargoville)金矿床位于西澳大利亚太古宙伊尔冈地块东部金矿田省卡尔古利(Kalgoorlic)南55公里,产于较大的绿岩带。绿岩带是本世纪初加强金矿勘探和开采的集中区。然而,可能部分由于金的细粒度和缺乏任何石英脉或剪切... 详细信息

序言斯帕戈维利(Spargoville)金矿床位于西澳大利亚太古宙伊尔冈地块东部金矿田省卡尔古利(Kalgoorlic)南55公里,产于较大的绿岩带。绿岩带是本世纪初加强金矿勘探和开采的集中区。然而,可能部分由于金的细粒度和缺乏任何石英脉或剪切系统这些前人所常用于找金的特征,斯帕戈维利矿床直到1934年才被发现。第二次世界大战期间,由于当时劳力缺乏,该矿床的有成效工作进行到1942年被迫关闭。这期间从107088吨矿石中生产了818克金。

关键词：金矿化碳酸盐阳起石碳化合物角闪石火山黄铁矿带火成岩火山岩喷出岩杂砂岩硫化矿物毒砂砷黄铁矿碎屑沉积物前寒武纪太古宙太古代西澳大利亚

Electrically-pumped compact topological bulk lasers driven by band-inverted bound states in the continuum

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Light(Science & Applications) 2023年第7期12卷 1337-1345页

作者： Song Han Jieyuan Cui Yunda Chua Yongquan Zeng Liangxing Hu Mingjin Dai Fakun Wang Fangyuan Sun Song Zhu Lianhe Li Alexander giles Davies Edmund Harold Linfield Chuan Seng Tan Yuri kivshar Qi Jie Wang Centre for Optoelectronics and biophotonics School of Electrical and Electronic Engineering&The Photonics InstituteNanyang Technological UniversitySingaporeSingapore Electronic Information School Wuhan UniversityWuhanChina school of Electronic and Electrical Engineering University of LeedsLeedsUK Nonlinear Physics Center Research School of PhysicsAustralian National UniversityCanberraACT 2601Australia Division of Physics and Applied Physics School of Physical and Mathematical SciencesNanyang Technological UniversitySingaporeSingapore

One of the most exciting breakthroughs in physics is the concept of topology that was recently introduced to photonics,achieving robust functionalities,as manifested in the recently demonstrated topological ***,so far almost all attention was focused on lasing from topological edge *** bands that reflect the topological bulk-edge correspondence have been largely ***,we demonstrate an electrically pumped topological bulk quantum cascade laser(QCL)operating in the terahertz(THz)frequency *** addition to the band-inversion induced in-plane reflection due to topological nontrivial cavity surrounded by a trivial domain,we further illustrate the band edges of such topological bulk lasers are recognized as the bound states in the continuum(biCs)due to their nonradiative characteristics and robust topological polarization charges in the momentum ***,the lasing modes show both in-plane and out-of-plane tight confinements in a compact laser cavity(lateral size~3λ_(laser)).Experimentally,we realize a miniaturized THz QCL that shows single-mode lasing with a side-mode suppression ratio(SMSR)around 20 *** also observe a cylindrical vector beam for the far-field emission,which is evidence for topological bulk bIC *** demonstration on miniaturization of single-mode beam-engineered THz lasers is promising for many applications including imaging,sensing,and communications.

关键词： pumped polarization lasing

A complete compilation of matrix metalloproteinase expression in human malignant gliomas

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World Journal of Clinical Oncology 2012年第5期3卷 67-79页

作者： Carsten Hagemann Jelena Anacker Ralf-Ingo Ernestus giles H Vince Department of Neurosurgery Tumorbiology Laboratory University of Würzburg Josef-Schneider-Str. 11 D-97080 Würzburg Germany Department of Obstetrics and Gynaecology University of Würzburg Josef-Schneider-Str. 4 D-97080 Würzburg Germany

Glioblastomas are characterized by an aggressive local growth pattern, a marked degree of invasiveness and poor prognosis. Tumor invasiveness is facilitated by the increased activity of proteolytic enzymes which are involved in destruction of the extracellular matrix of the surrounding healthy brain tissue. Elevated levels of matrix metalloproteinases(MMPs) were found in glioblastoma(GbM) cell-lines, as well as in GbM biopsies as compared with low-grade astrocytoma(LGA) and normal brain samples, indicating a role in malignant progression. A careful review of the available literature revealed that both the expression and role of several of the 23 human MMP proteins is controversely discussed and for some there are no data available at all. We therefore screened a panel of 15 LGA and 15 GbM biopsy samples for those MMPs for which there is either no, very limited or even contradictory dataavailable. Hence, this is the first complete compilation of the expression pattern of all 23 human MMPs in astrocytic tumors. This study will support a better understanding of the specific expression patterns and interaction of proteolytic enzymes in malignant human glioma and may provide additional starting points for targeted patient therapy.

关键词： Astrocytic tumor Expression pattern Glioblastoma cell-lines Glioblastoma multiforme Matrix metalloproteinase

Therapeutic approaches and drug-resistance in chronic lymphocytic leukaemia

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Cancer Drug Resistance 2020年第3期3卷 532-549页

作者： Narjis Fatima Kyle R.Crassini Lauren Thurgood Yandong Shen Richard I.Christopherson bryone Kuss Stephen P.Mulligan Oliver giles best Kolling Institute of Medical Research University of SydneyRoyal North Shore HospitalSydneyNSW 2065Australia. School of Life and Environmental Sciences University of SydneySydney NSW 2008Australia. College of Medicine and Public Health Flinders UniversityBedford ParkAdelaideSA 5042Australia.

The treatment of chronic lymphocytic leukaemia has been revolutionised in recent years,first by the introduction of chemoimmunotherapy regimens and subsequently by the development of drugs,including ibrutinib,idelalisib and venetoclax,that target components of the b-cell receptor signalling pathway or b-cell lymphoma 2 family of *** high initial response rates in patients treated with chemoimmunotherapy or targeted agents,a significant proportion of patients relapse with progressive and refractory *** a subset of these patients,drug resistance has been associated with specific genetic lesions or activation of alternate pro-survival ***,the mechanisms that confer drug resistance in the remainder of the patients with refractory disease have yet to be fully *** this review,we discuss our current understanding of the mechanics of drug resistance in chronic lymphocytic leukaemia and describe how this knowledge may aid in rationalising future treatment strategies to prevent the development of refractory or aggressive transformation of the disease.

关键词： Chronic lymphocytic leukaemia drug resistance targeted cancer therapy

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前上颌区种植的可控性辅助牙槽嵴扩增技术

中国口腔医学继续教育杂志 2011年第3期14卷 174-178页

作者： giles b.Horrocks 蒋建晖（译）吴东（审）陈江（审）不详福建医科大学附属口腔医学院福建省福州市鼓楼区杨桥中路246号 350002

本文主要介绍一种简单而又有效的前上颔美学区的可控性辅助牙槽嵴扩增技术（***）。牙槽骨萎缩及牙槽嵴狭窄导致了种植窝制备的困难．CARE外科技术有效地利用了骨膜保护结构和骨膜下嵴顶部松弛切口．具备高度的可预见性，可以用于无牙... 详细信息

本文主要介绍一种简单而又有效的前上颔美学区的可控性辅助牙槽嵴扩增技术（***）。牙槽骨萎缩及牙槽嵴狭窄导致了种植窝制备的困难．CARE外科技术有效地利用了骨膜保护结构和骨膜下嵴顶部松弛切口．具备高度的可预见性，可以用于无牙颌的狭窄牙槽嵴的扩增。压电外科技术的精确应用及萎缩牙槽骨水平推开器和循环骨冷却系统的辅助应用．使种植外科过程具备了高度的可预见性．它可以实现即刻种植．不但减少了患者的治疗时间、并发症发病率、种植体功能丧失率及总体费用，同时也增大了萎缩上牙槽嵴的自体骨量。

关键词：扩增技术牙槽嵴可控性种植窝牙槽骨萎缩电外科技术上颌辅助应用

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光纤陀螺

导弹与航天运载技术(中英文) 1985年第10期 31-40页

作者： b. Culshaw I. P. giles 余显昭

本文论述光纤陀螺原理,讨论了限制这种测量装置性能的各种因素。在仔细研究萨纳克干涉仪基础上,提出一种高性能光纤陀螺。最后,在介绍光纤陀螺的运用时,还谈及这种测量装置生产时的技术问题。

关键词：光纤陀螺光纤环单模光纤光导纤维光纤干涉仪互易性多模半导体激光器陀螺漂移输出光强光纤长度光源调制