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Cytomegalovirus frequency in neonatal intrahepatic cholestasis determined by serology, histology, immunohistochemistry and PCR

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World Journal of Gastroenterology 2009年第27期15卷 3411-3416页

作者： Maria Angela Bellomo-Brandao Paula D Andrade Sandra CB Costa Cecilia AF Escanhoela Jose Vassallo gilda porta Adriana MA De Tommaso Gabriel Hessel Department of Pediatrics Faculty of Medical Sciences State University of Campinas (UNICAMP)Campinas-SP 13083-970 Brazil Department of Internal Medicine Faculty of Medical Sciences State University of Campinas (UNICAMP)Campinas-SP 13083-970 Brazil Department of Pathology Faculty of Medical Sciences State University of Campinas (UNICAMP) Campinas-SP 13083-970 Brazil Department of Pediatrics Children's Institute of Medical School of the University of So Paulo (USP) So Paulo-SP 05403-000 Brazil

AIM: To determine cytomegalovirus (CMV) frequency in neonatal intrahepatic cholestasis by serology, histological revision (searching for cytomegalic cells), immunohistochemistry, and polymerase chain reaction (PCR), and to verify the relationships among these ***: The study comprised 101 non-consecutive infants submitted for hepatic biopsy between March 1982 and December 2005. Serological results were obtained from the patient's f iles and the other methods were performed on paraffin-embedded liver samples from hepatic biopsies. The following statistical measures were calculated: frequency, sensibility, specif ic positive predictive value, negative predictive value, and ***: The frequencies of positive results were as follows: serology, 7/64 (11%); histological revision, 0/84; immunohistochemistry, 1/44 (2%), and PCR, 6/77 (8%). Only one patient had positive immunohistochemical fi ndings and a positive PCR. The following statistical measures were calculated between PCR and serology: sensitivity, 33.3%; specificity, 88.89%; positive predictive value, 28.57%; negative predictive value, 90.91%; and accuracy, 82.35%. CONCLUSION: The frequency of positive CMV varied among the tests. Serology presented the highest positive frequency. When compared to PCR, the sensitivity and positive predictive value of serology were low.

关键词： Cytomegalovirus Hepatitis Neonatal Cholestasis Liver Children Immunohistochemistry Polymerase chain reaction

Image grid display:A study on automatic scrolling presentation

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Visual Informatics 2017年第1期1卷 16-24页

作者： Marco porta Stefania Ricotti Department of Electrical Computer and Biomedical EngineeringUniversity of PaviaPaviaItaly

In this paper we describe a study on image grid display with automatic vertical *** scroll operations are normally carried out manually by the user,in the context of RSVP(Rapid Serial Visual Presentation)techniques this work considers a presentation mode in which the image grid is automati-cally *** experiments carried out with 50 testers,we have investigated user performance while looking for specific target subjects within large collections of *** numbers of columns and scrolling speeds have been *** search task implied both clicking on the identified target pictures and simply vocally stating their visual *** this purpose,and to identify possible specific gaze behaviours,eye tracking technology has been *** obtained results show that number of columns and scroll speed do affect search ***,the user’s gaze tends to focus on different screen areas depending on the values of these two *** it is not possible to definitely find an optimal columns-speed combination that is valid in all cases,the particular context of use can suggest feasible solutions according to one’s *** the best of our knowledge,image grid display with automatic scrolling has never been studied to date.

关键词： Image griddisplay Automatic scrolling Image presentationmodes Image collections Rapid serialvisual presentation

Recent advances in the frontline treatment of metastatic renal cell carcinoma

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Journal of Cancer Metastasis and Treatment 2021年第1期7卷 695-706页

作者： Camillo porta Mimma Rizzo Department of Biomedical Sciences and Human Oncology University of Bari‘A.Moro’Bari 70124Italy Division of Medical Oncology A.O.U.Consorziale Policlinico di BariBari 70124Italy Division of Translational Oncology I.R.C.C.S.Istituti Clinici Scientifici MaugeriPavia 27100Italy

We aim to describe the most recent advances in the upfront treatment of metastatic renal cell carcinoma,and to provide criteria-though often subjective-which could be used for treatment selection,by means of a critical review of the results of novel trials of immune-based combinations,coupled with personal considerations and *** date,5 immune-based combinations have been tested within large phase III trials;four of them yielded a significant overall survival benefit(Ipilimumab+Nivolumab,Pembrolizumab+Axitinib,Nivolumab+Cabozantinib and Pembrolizumab+Lenvatinib),while the combination of Avelumab+Axitinib,although reaching study primary endpoint,determined just a significant progression-free survival *** terms of safety,the excess of adverse events is overall counterbalanced to the higher activity of the ***,all the discussed immune-based combinations were ultimately approved by different regulatory authorities,and are indeed included in the most important international *** for longer follow-ups and more mature trial data,as well as for real-world experiences,in the absence of validated biomarkers,our 1st line treatment choice cannot but rely on methodologically incorrect treatment comparisons,personal preferences,and experience.

关键词： Renal cell carcinoma immune checkpoint inhibitors antiangiogenics survival

Medical treatment of unresectable hepatocellular carcinoma: Going beyond sorafenib

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World Journal of Hepatology 2010年第3期2卷 103-113页

作者： Camillo porta Chiara Paglino Medical Oncology and Laboratory of Preclinical Oncology and Experimental Therapies IRCCS San Matteo University Hospital Foundation Medical Oncology Interior Radiation Control Coating Systems. San Matteo University Hospital Foundation

Even though Sorafenib has radically changed the natural history of those hepatocellular carcinoma patients who are not amenable for curative treatments, further therapeutic improvements are badly needed. As it was for Sorafenib, our increasingly refined understanding of the complex mechanisms underlying HCC carcinogenesis are the starting point for the future development of such treatments. Presently, a number of molecularly targeted agents are in different stages of development for this once orphan cancer. Indeed, several pathways are presently being explored to identify potentially active drugs, including epidermal growth factor receptor, vascular endothelial growth factor/vascular endothelial growth factor receptors, mammalian target of rapamycin, phosphatidyl-inositol-3-kinase/Akt, insulin growth factor, Aurora kinase, Wnt/β-catenin, retinoic acid receptor and hepatocyte growth factor/C-Met. This review is aimed at addressing the results obtained so far with these newer drugs, also considering the challenges we shall face in the near future, including the issue of response evaluation and identification of predictive/ prognostic biomarkers.

关键词： Hepatocellular carcinoma Molecularly targeted agents Molecular pathways

Mixed neuroendocrine non-neuroendocrine tumors:The quest for evidence

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World Journal of Gastrointestinal Oncology 2024年第12期16卷 4532-4536页

作者： Mauro Cives Camillo porta Raffaele Palmirotta Interdisciplinary Department of Medicine University of Bari“Aldo Moro”Bari 70124Italy Department of Medical Oncology AOU Consorziale Policlinico di BariBari 70124Italy

Mixed neuroendocrine non-neuroendocrine neoplasms(MiNENs)are rare mixed tumors containing both neuroendocrine and non-neuroendocrine components that occupy at least 30%of the whole ***,both components appear to derive from an identical cellular precursor undergoing early dual differentiation or late *** our understanding of MiNENs has improved in recent years,many areas of uncertainty *** this context,setting diagnostic criteria capable of capturing the continuum of disease biology while providing clinically meaningful information in terms of prognosis and response to treatments appears vital to advance the field and improve patients’*** is needed to generate robust classification schemes,and multi-institutional cooperation will likely play a crucial role in building adequately powered cohorts to address some of the most pressing questions discussed in this *** is the minimum representation for each component needed to define MiNENs?How can the epidemiology of MiNENs change according to different diagnostic definitions?How can we generate the clinical evidence nee-ded to optimize the management of MiNENs?

关键词： Mixed neuroendocrine non-neuroendocrine neoplasms Neuroendocrine neoplasm Neuroendocrine carcinoma Mixed tumors Digestive Gastroenteropancreatic

Yield performance estimation of corn hybrids using machine learning algorithms

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Artificial Intelligence in Agriculture 2021年第1期5卷 82-89页

作者： Farnaz Babaie Sarijaloo Michele porta Bijan Taslimi Panos M.Pardalos Department of Industrial and Systems Engineering University of FloridaGainesvilleFLUSA Department of Computer Engineering University of ParmaParmaItaly

Estimation of yield performance for crop products is a topic of interest in *** breeding programs,we cannot test all possible hybrids created by crossing two parents(inbred and tester)since it would be too time consuming and *** this paper,we exploit different machine learning algorithms including decision tree,gradient boosting machine,random forest,adaptive boosting,XGBoost and neural network to predict the yield of corn hybrids using data provided in the 2020 Syngenta Crop *** participants were asked to predict the yield of missing hybrids which were not tested *** results show that the prediction obtained by XGBoost is more accurate than other models with a root mean square error equal to ***,we use XGBoost model to estimate the yield performance for untested combinations of inbreds and *** this approach,we identify hybrids with high predicted yield that can be bred to increase corn production.

关键词： Yield prediction Data analysis Corn hybrids Machine learning Agricultural data

Newborn screening for galactosemia:a 30-year single center experience

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World Journal of Pediatrics 2015年第2期11卷 160-164页

作者： Francesco porta Severo Pagliardini Veronica Pagliardini Alberto Ponzone Marco Spada Department of Pediatrics University of TorinoTorinoItaly

Background:Galactosemia due to complete or near-complete galactose-l-phosphate uridyltransferase(GALT)deficiency was the first disorder added to the pioneering newborn screening panel besides *** the last 50 years,many criticisms have been focused on the opportunity of its ***,long-term single center experiences with this issue are generally ***:We reviewed the outcome of newborn screening for hypergalactosemia performed at our department since 1982 and the correspondent long-term clinical ***:Among 1123909 newborns screened for hypergalactosemia,33 showed abnormal results confirmed at second tier *** patients were affected with classic galactosemia,8 partial GALT deficiency,3 severe galactokinase deficiency,7 transient galactosemia,one congenital porto-systemic shunt,and one glucose transporter 2 *** neonatal liver failure in the late first week of life(5.8±1.1 days)unavoidably complicated the clinical course of classic galactosemia,unless in three second-born siblings treated on the basis of presumptive diagnosis immediately after newborn screening sample collection on day *** early treatment and longterm steadily normal peripheral blood galactose,77%of patients with severe GALT deficiency present mild to severe intellectual *** patients with partial GALT deficiency showed normal intellectual development on a regular diet,as well as patients with galactokinase deficiency under ***:Availability of screening results within the fifth day after birth would allow the prevention of acute decompensation in classic galactosemia.A systematic diagnostic work-up in all positive newborns is essential to unravel the etiology of hypergalactosemia.

关键词： galactose galactosemia liver failure mental retardation newborn screening

Renal cell carcinoma and viral infections:A dangerous relationship?

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World Journal of Nephrology 2022年第1期11卷 1-12页

作者： Melissa Bersanelli Chiara Casartelli Sebastiano Buti Camillo porta Medical Oncology Unit University Hospital of ParmaParma 43126Italy Department of Medicine and Surgery University of ParmaParma 43126Italy Department of Biomedical Sciences and Human Oncology University of Bari‘A.Moro’Bari 70121Italy Department of Medical Oncology Policlinico ConsorzialeBari 70124Italy

Virus-related cancers in humans are widely recognized,but in the case of renal cancer,the link with the world of viruses is not clearly established in humans,despite being known in animal *** the present review,we aimed to explore the literature on renal cell carcinoma(RCC)for a possible role of viruses in human RCC tumorigenesis and immune homeostasis,hypothesizing the contribution of viruses to the immunogenicity of this tumor.A scientific literature search was conducted using the PubMed,Web of Science,and Google Scholar databases with the keywords“virus”or“viruses”or“viral infection”matched with(“AND”)“renal cell carcinoma”or“kidney cancer”or“renal cancer”or“renal carcinoma”or“renal tumor”or“RCC”.The retrieved findings evidenced two main aspects testifying to the relationship between RCC and viruses:The presence of viruses within the tumor,especially in non-clear cell RCC cases,and RCC occurrence in cases with pre-existing chronic viral *** retrieved translational and clinical data suggest the possible contribution of viruses,particularly Epstein-Barr virus,to the marked immunogenicity of sarcomatoid *** addition,it was revealed the possible role of endogenous retrovirus reactivation in RCC oncogenesis,introducing new fascinating hypotheses about this tumor’s immunogenicity and likeliness of response to immune checkpoint inhibitors.

关键词： Renal cell carcinoma Renal cancer Kidney cancer Viruses Viral infections Retrotransposons

Subcapsular hepatic haematoma of the right lobe following endoscopic retrograde cholangiopancreatography: Case report and literature review

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World Journal of Gastroenterology 2016年第17期22卷 4411-4415页

作者： Marco Antonio Zappa Alberto Aiolfi Ilaria Antonini Cinzia Domenica Musolino Andrea porta Department of General and Emergency surgery Ospedale S Famiglia Fatabenefratelli 22036 Erba Italy

Sub capsular hepatic haematoma is a rare complication after endoscopic retrograde cholangiopancreatography (ERCP). Exact pathological mechanism is still unclear and few reports are nowadays available in literature. We report the case of a 58-year-old woman with recurrent episodes of upper abdominal pain, nausea and vomiting. On the basis of laboratory exams, abdomen ultrasound and magnetic resonance imaging she was diagnosed with a common bile duct stone. Endoscopic biliary sphincterotomy was performed. On the following day the patient complaint severe abdominal pain with rebound and hemodynamic instability. A computed tomography scan reveal a 14 cm × 6 cm × 19 cm sub-capsular hepatic haematoma on the right lobe that was successfully managed via percutaneous embolization. Sub capsular liver haematoma is a rare life threatening complication after ERCP that should be managed according to patients’ haemodynamic and clinic.

关键词： Endoscopic guidewire Endoscopic retrograde cholangiopancreatography Abdominal pain Subcapsular hepatic hematoma Embolization