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International NeuroAIDS: prospects of HIV-1 associated neurological com-plications

Cell Research 2005年第Z1期15卷 962-969页

作者： J Roberto TRUJILLO gilberto jaramillo-rangel Marta ORTEGA-MARTINEZ Augusto C PENALVA de OLIVEIRA Jose E VIDAL Joseph BRYANT Robert C GALLO Institute of Human Virology University of Maryland Biotechnology Institute 725 W Lombard Street Baltimore MD 21201 USA Institute of Infectious Diseases Emilio Ribas Sao Paulo 01246 Brazil Clinical Research Unit in Human Retrovirology University of CampinasSao Paulo 01246 Brazil. Institute of Infectious Diseases Emilio Ribas Sao Paulo 01246 Brazil

Neurological complications associated with HIV-1/AIDS are being recognized with a high frequency that parallels the increased number of AIDS cases. The early infiltration by HIV-1 into the nervous system can cause primary and/or secondary neurological complications. The most common neurocognitive disorder is AIDS Dementia Complex (ADC). In developing countries of Asia the three most opportunistic infections are tuberculosis (TB), cryptococcosis, and Pneumocystis carinii pneumonia. Therefore, it is expected that secondary neurological complications due to TB and cryptococcosis will be the most common cause of morbility and mortality in HIV-1/AIDS cases in China. Research of NeuroAIDS in China is necessary to understand the impact and the biology of HIV-1 in the nervous system. Future studies would include, the molecular epidemiology and the description of opportunistic infections associated to HIV-1; the neuropathological description of primary and secondary HIV-1 complications in different groups; the HIV-1 neurot- ropism and immune response studies for China’s unique HIV-1 strains and recombinant forms derived from the nervous system, including experimental models such as the use of transgenic rats; and the study of potential resistant virus, primarily when the anti-retroviral therapy (ART) has not full access in the brain.

关键词： NeuroAIDS HIV-1 neurotropism AIDS dementia complex.

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Mental health in organizations from a healthcare analytics framework:taxonomic model,trends,and impact of COVID-19

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Journal of Management Analytics 2024年第1期11卷 62-86页

作者： Jorge Iván Pérez Rave Carlos Mario Zapata jaramillo Gloria Patricia jaramillo Álvarez IDINNOV research group IDINNOV S.A.SMedellínColombia Department of Computing and Decision Sciences Universidad Nacional de ColombiaMedellínColombia

Mental disorders negatively affect employee well-being and organizational *** face a challenge in terms of how to manage mental *** paper clarifies three issues(underlying patterns,trends,and impact of COVID-19)regarding the scientific study of mental health in organizations from a healthcare analytics *** framework comprises eight stages considering a text-driven approach with scientific corpora assisted by linguistic/computational and statistical *** study discovers a new taxonomic model comprising five patterns in the scientific discourse on the *** analyses reveal imbalances and concerns regarding the interests associated with the patterns,which is reinforced by examining patterns“before”and“during”*** paper complements psychological/epidemiological studies on mental health in organizations from a healthcare analytics perspective.

关键词： Healthcare analytics healthcare management analytics mental health scientific discourse text analytics taxonomy COVID-19 management analytics

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Learning from the COVID-19 pandemic:A systematic review of mathematical vaccine prioritization models

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Infectious Disease Modelling 2024年第4期9卷 1057-1080页

作者： gilberto Gonzalez-Parra Md Shahriar Mahmud Claus Kadelka Instituto de Matematica Multidisciplinar Universitat Politecnica de ValenciaValenciaSpain Department of Mathematics New Mexico Tech801 Leroy PlaceSocorro87801NMUSA Department of Mathematics Iowa State University411 Morrill RdAmes50011IAUSA

As the world becomes ever more connected,the chance of pandemics increases as *** recent COVID-19 pandemic and the concurrent global mass vaccine roll-out provides an ideal setting to learn from and refine our understanding of infectious disease models for better future *** this review,we systematically analyze and categorize mathematical models that have been developed to design optimal vaccine prioritization strategies of an initially limited *** older individuals are disproportionately affected by COVID-19,the focus is on models that take age explicitly into *** lower mobility and activity level of older individuals gives rise to non-trivial *** research questions concern the optimal time interval between vaccine doses and spatial vaccine *** review showcases the effect of various modeling assumptions on model outcomes.A solid understanding of these relationships yields better infectious disease models and thus public health decisions during the next pandemic.

关键词： Review Mathematical model Age COVID-19 Vaccine allocation Vaccine roll-out

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Mathematical modeling for estimating influenza vaccine efficacy:A case study of the Valencian Community,Spain.

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Infectious Disease Modelling 2024年第3期9卷 744-762页

作者： Carlos Andreu-Vilarroig Rafael J.Villanueva gilberto González-Parra Instituto de Matemática Multidisciplinar Universitat Politècnica de ValènciaValenciaSpain Department of Mathematics New Mexico TechSocorroNMUSA

Vaccine efficacy and its quantification is a crucial concept for the proper design of public health vaccination *** this work we proposed a mathematical model to estimate the efficacy of the influenza vaccine in a real-word *** particular,our model is a SEIR-type epidemiological model,which distinguishes vaccinated and unvaccinated ***,its dynamics is governed by a nonlinear system of ordinary differential equations,where the non-linearity arises from the effective contacts between susceptible and infected *** key aspects of this study is that we use a vaccine distribution over time that is based on real data specific to the elderly people in the Valencian Community and the calibration process takes into account that over one influenza season a specific proportion of the population becomes infected with *** consider the effectiveness of the vaccine,the model incorporates a parameter,the vaccine attenuation factor,which is related with the vaccine efficacy against the influenza *** this framework,in order to calibrate the model parameters and to obtain an influenza vaccine efficacy estimation,we considered the 2016–2017 influenza season in the Valencian Community,Spain,using the influenza reported cases of vaccinated and *** order to ensure the model identifiability,we choose to deterministically calibrate the parameters for different scenarios and we find the one with the minimum error in order to determine the vaccine *** calibration results suggest that the influenza vaccine developed for 2016–2017 influenza season has an efficacy of approximately 76.7%,and that the risk of becoming infected is five times higher for an unvaccinated individual in comparison with a vaccinated *** estimation partially agrees with some previous studies related to the influenza *** study presents a new integrated mathematical approach to study the influenza vaccine efficacy and gives f

关键词： Mathematical modeling Epidemiology SEIR Vaccine efficacy Influenza Valencian community

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Chitosan Nanoparticles as Biostimulant in Lettuce (Lactuca sativa L.) Plants

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Phyton-International Journal of Experimental Botany 2024年第4期93卷 777-787页

作者： Silvia C.Ramírez-Rodríguez Pablo Preciado-rangel Marcelino Cabrera-De La Fuente Susana González-Morales Hortensia Ortega-Ortiz Tecnológico Nacional de México Instituto Tecnológico de TorreónEjido AnaTorreónCoahuila27170México Departamento de Horticultura Universidad Autónoma Agraria Antonio NarroSaltillo25315México Departamento de Materiales Avanzados Centro de Investigación en Química AplicadaSaltilloCoahuila25294México

Biodegradable nanoparticles such as chitosan nanoparticles (CSNPs) are used in sustainable agriculture since theyavoid damage to the environment;CSNPs have positive effects such as the accumulation of bioactive compoundsand increased productivity in plants. This study aimed to investigate the impact of applying CSNPs on lettuce,specifically focusing on enzymatic activity, bioactive compounds, and yield. The trial was conducted using a completelyrandomized design, incorporating CSNPs: 0, 0.05, 0.1, 0.2, 0.4, and 0.8 mg mL−1. The doses of 0.4 mg mL−1improve yields up to 24.6% increases and 0.1 mg mL−1 of CSNPs increases total phenols by 31.2% and antioxidantcapacity by 34.6%. In addition, when low concentrations of CSNPs (0.05 and 0.1 mg L−1) were applied, anincrease in catalase was determined. The CSNPs represent a good alternative to be used as a biostimulant in sustainableagriculture because they improve the yield and quality of lettuce by increasing the bioactive compounds.

关键词： Biostimulant bioactive compounds enzymatic activity

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Robotic Surgery: An Effective Treatment Option for Epiphrenic Diverticulum Associated with Nutcracker Esophagus

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Surgical Science 2024年第1期15卷 1-6页

作者： Augusto Tinoco gilberto Carvalho Leonardo Tinoco Ana Paula Quintão Department of Digestive Surgery Hospital S&#227o Jos&#233 do Ava&#237 Itaperuna Brazil

Background: Epiphrenic Diverticulum is frequently associated with esophageal motility disorders, such as nutcrackers esophagus. The diagnosis is usually made using imaging studies such as a Barium esophagogram, and esophageal manometry. Surgical treatment options for epiphrenic diverticulum and EN include diverticulectomy and wide myotomy. Aim: The resection of three epiphrenic diverticula and extensive myotomy were performed by robotic thoracoscopy uneventfully. Case presentation: A 65-year-old female complaining of dysphagia for solid foods, Chest pain and regurgitation. Esophagogastroduodenoscopy (EDG) with difficulty in advancing the endoscope at 25 cm and demonstrating an ED, no hiatal hernia and normal stomach and duodenum. Barium Esophagogram showed multiple diverticula and tortuosity throughout the esophagus. Conclusion: With robotic surgery, surgeons can perform highly precise operations with enhanced 3D vision and control. Through this cutting-edge approach, the treatment of ED associated with EN can be drastically changed, promising better outcomes for patients.

关键词： Robotic Surgery Myotomy Nutcracker Esophagus Epiphrenic Diverticulum

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Antioxidant Activity and Phytochemical Screening in Acacia rigidula Benth. Leaves

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Advances in Bioscience and Biotechnology 2024年第1期15卷 15-38页

作者： Aneth Ochoa-Negrete Rene rangel Marcus Antonius Ynalvez Ruby A. Ynalvez Department of Biology and Chemistry Texas A&M International University Laredo TX USA Department of Social Sciences Texas A&M International University Laredo TX USA

This study aimed to compare the total phenolic content (TPC) and antioxidant activities of A. rigidula extracts. It also aimed to identify phenolic acids present in the extracts. The 2,2-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP), and ferric thiocyanate lipid peroxidation antioxidant assays were performed. High performance liquid chromatography was used to identify phenolic acids. There was no solvent effect on TPC nor on scavenging activities, and inhibition of lipid peroxidation (p > 0.05) among solvent extracts. On the other hand, 1:1:3 water: acetone: methanol extract (10.22 mg GAE/g sample) had significantly higher reducing potential than 50% ethanol extract (EE) (9.259 mg GAE/g sample) (p 0.05). Phenolic fraction designated as fraction 4 had the highest antioxidant activity (p < 0.05) with 69.49% ABTS scavenging activity and FRAP reducing potential, 22.26 mg of GAE/g sample. DPPH scavenging activities of fractions 4 (55.59%) and 5 (55.64%) were significantly higher than the other fractions (p A. rigidula extracts contain gallic, caffeic, vanillic, p-coumaric, salicylic acids and vanillin.

关键词： Acacia Plant Extract Antioxidant Activity Total Phenolic Acid HPLC Gallic Acid

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Quantification of the Vertical Load Applied to the Pavement during Cornering Maneuver of a Battery Electric Commercial Vehicle

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Journal of Traffic and Transportation Engineering 2024年第5期12卷 207-213页

作者： Pablo Kubo Ney Siqueira gilberto Grossl Luis Welin Mairon Dobicz Marcio Andrade Department of Complete Vehicle Volvo Group North AmericaGreensboro 27409USA Department of Complete Vehicle Volvo Trucks BrazilCuritiba 81260-900Brazil

The wheel loads of heavy trucks are the major source of pavement damage,given the repeated loadings imposed by them due to transient events and surface *** related studies focus on steady-state context regarding simplified vehicle’s parameters and ideal pavement conditions,this paper aims to analyze the vertical load applied to the pavement by considering cornering maneuver as a transient event,on a battery electric vehicle *** this concern,measurements were performed on a rigid truck,with two steering front axles,in a closed course proving *** relationship has been presented between vehicle’s speed,lateral acceleration and transferred vertical load for a given curve radius of 85.6 m and 3.7°of transversal *** measurements results indicated that for every 10 km/h increasing on the vehicle’s speed,additional 110 kgf will be transferred to the pavement on the outer side of the cornering *** value itself could not be considered high,but it will be also added to the static load,or overload in some truck applications.

关键词： Load transfer durability vehicle dynamics

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Impact of seismic design on tunnels in rock-Case histories

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Underground Space 2017年第2期2卷 106-114页

作者： Carlos A.jaramillo COWI North America 1300 Clay Street7th FloorOaklandCA 94612USA

The tunnel industry has considered that tunnels,especially tunnels in rock,are naturally resistant to earthquake action,including faulting,shaking,deflection and ground *** the number of case histories of tunnels subject to earthquake action has increased,the industry has started to recognize that,although tunnels in rock have good resistance against earthquakes generating peak ground accelerations(PGA)lower than 0.5 g,it is important to include the dynamic forces and displacements generated by seismic ground motions in the design process to obtain a more reliable *** additional earthquake forces impact the final design,potentially requiring changes to the ground support and additional reinforcement of the concrete lining,as illustrated by case histories presented in this paper.

关键词： Tunnel Tunnels Seismic design Earthquake impact Tunnel lining Ground support

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Need for a comprehensive medical approach to the neuroimmuno-gastroenterology of irritable bowel syndrome

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World Journal of Gastroenterology 2011年第23期17卷 2791-2800页

作者： Pejman Katiraei gilberto Bultron Department of Pediatrics Loma Linda University11175 Campus StreetColeman Pavilion A1121Loma LindaCA 92350United States

Irritable bowel syndrome （IBS） is defined by the Rome ]I[ criteria as symptoms of recurrent abdominal pain or discomfort with the onset of a marked change in bowel habits with no evidence of an inflammatory, anatomic, metabolic, or neoplastic process. As such, many clinicians regard IBS as a central nervous system problem of altered pain perception. Here, we review the recent literature and discuss the evidence that supports an organic based model, which views IBS as a complex, heterogeneous, inter-dependent, and multi-variable inflammatory process along the neuronal-gut axis. We delineate the organic pathophysiology of IBS, demonstrate the role of inflammation in IBS, review the possible differences between adult and pediatric IBS, discuss the merits of a comprehensive treatment model as taught by the Institute of Functional Medicine, and describe the potential for future research for this syndrome.

关键词： Irritable bowel syndrome Abdominal pain Inflammation Probiotics Stress

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