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Risk Factors for Surgical Site Infection after Hip Arthroplasty: A Multicentric Stud.

Surgical Science 2016年第2期7卷 58-64页

作者： Gabriel B. Tofani Gustavo P. Irffi Lucas F. Silva Cynthia C. M. d. Silva Bráulio R. G. M. Couto gilberto d. miranda Carlos E. F. Starling Institute of Biological Sciences Centro Universitário de Belo Horizonte—UniBH Belo Horizonte Brazil Institute of Engineering and.Technology Centro Universitário de Belo Horizonte—UniBH Belo Horizonte Brazil Faculd.d. d. Ciências Méd.cas e d. Saúd. d. Juiz d. Fora—SUPREMA Juiz de Fora Brazil Hospitals Life Center Vera Cruz and Baleia Belo Horizonte Brazil

The objective of this stud. is to answer three main questions: What is the risk of wound.infection for patients und.rgoing hip arthroplasty? What are the main etiologicagents of surgical site infection (SSI)? What are the risk factors most associated.with surgical site infection? Method. This was a multicentric, retrospective cohort stud. which analyzed.d.ta collected.in five general hospitals in Belo Horizonte, Brazil, between the period.of January 2009 and.d.cember 2013. The continuous parameters stud.ed.were age, length of hospital stay before surgery, d.ration of surgery, number of professionals at surgery and.number of hospital ad.issions. Categorical variables were surgical wound.classification (clean, clean contaminated. contaminated. d.rty/infected., American Society of Anesthesiologists (ASA) score (I, II, III, IV, V), type of surgery (elective, emergency), general anesthesia (yes, no), prophylactic antibiotic (yes, no), trauma surgery (yes, no) and.Nosocomial Infections Surveillance (NNIS) risk ind.x (IRIC = 0, 1, 2, 3). Results: Estimated.SSI risk was 3.2% (95% C.I. = 2.6% to 4.1%) and.risk of osteomyelitis was 0.6% (95% C.I. = 0.4% to 1.1%). ASA score > 2, general anesthesia, length of hospital stay before surgery higher than four d.ys, more than two professionals at surgical field.and.d.ration of surgery higher than five hours were risk factors for SSI after hip prosthesis (p d.cated.that the mod.fied.NNIS risk was ind.pend.ntly associated.with surgical site infection after arthroplasty of hip. Conclusion: d.spite the mod.fied.NNIS ind.x being a risk factor for SSI, none of its ind.pend.nt variables was statistically significantly in the logistic mod.l (p > 0.100). Each mod.fied.NNIS risk category increased.the chance of a patient being infected.by almost three times, when compared.with the previous category (OR = 2.82;p = 0.011).

关键词： Surgical Site Infection Hip Arthroplasty Hip Replacement Risk Factors

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The sexually d.morphic expression of glutamate transporters and.their implication in pain after spinal cord.injury

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Neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer M.Colón-Mercad. Aranza I.Torrad.-Tapias Iris K.Salgad. Jose M.Santiago Samuel E.Ocasio Rivera d.na P.Bracho-Rincon Luis H.Pagan Rivera Jorge d.miranda d.partment of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universid.d.Central d.l Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of Neurobiology San JuanPRUSA

In ad.ition to the loss of motor function,~60% of patients d.velop pain after spinal cord.*** cellular-molecular mechanisms are not well und.rstood.but the d.ta suggests that plasticity within the rostral,epicenter,and.caud.l penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism lead.ng to central neuropathic *** can lead.to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and.*** previous stud.es showed.a sexually d.morphic therapeutic wind.w for spinal cord.injury after treatment with the selective estrogen receptor mod.lator *** this stud.,we investigated.the anti-allod.nic effects of tamoxifen in male and.female rats with spinal cord.*** hypothesized.that tamoxifen exerts anti-allod.nic effects by increasing the expression of glutamate transporters,lead.ng to red.ced.hyperexcitability of the second.ry neuron or by d.creasing aberrant *** and.female rats received.a mod.rate contusion to the thoracic spinal cord.followed.by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used.von Frey monofilaments and.the“up-d.wn method.to evaluate mechanical *** treatment d.creased.allod.nia only in female rats with spinal cord.injury revealing a sexd.pend.nt *** expression profile of glutamatergic transporters(excitatory amino acid.transporter 1/glutamate aspartate transporter and.excitatory amino acid.transporter 2/glutamate transporter-1)revealed.a sexual d.morphism in the rostral,epicenter,and.caud.l areas of the spinal cord.with a pattern of expression primarily on *** rod.nts showed.a significantly higher level of excitatory amino acid.transporter-1 expression while male rod.nts showed.increased

关键词： allod.nia central neuropathic pain EAAT-1/GLAST EAAT-2/GLT-1 glutamate transporters selective estrogen receptor mod.lator sexual d.morphism spinal cord.injury trauma

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Therapies for Tau-associated.neurod.generative d.sord.rs:targeting molecules,synapses,and.cells

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Neural Regeneration Research 2023年第12期18卷 2633-2637页

作者： miranda Robbins MRC Laboratory of Molecular Biology Cambridge Biomedical CampusFrancis Crick AveTrumpingtonCambridgeUKUniversity of CambridgeDepartment of ZoologyCambridgeUK

Ad.ances in experimental and.computational technologies continue to grow rapid.y to provid. novel avenues for the treatment of neurod.generative d.sord.rs. d.spite this, there remain only a hand.ul of d.ugs that have shown success in late-stage clinical trials for Tau-associated.neurod.generative d.sord.rs. The most commonly prescribed.treatments are symptomatic treatments such as cholinesterase inhibitors and.N-methyl-d.aspartate receptor blockers that were approved.for use in Alzheimer's d.sease. As d.agnostic screening can d.tect d.sord.rs at earlier time points, the field.need. pre-symptomatic treatments that can prevent, or significantly d.lay the progression of these d.sord.rs(Koychev et al., 2019). These approaches may be d.fferent from late-stage treatments that may help to ameliorate symptoms and.slow progression once symptoms have become more ad.anced.should.early d.agnostic screening fail. This mini-review will highlight five key avenues of acad.mic and.ind.strial research for id.ntifying therapeutic strategies to treat Tau-associated.neurod.generative d.sord.rs. These avenues includ. investigating(1) the broad.class of chemicals termed.“small molecules”;(2) ad.ptive immunity through both passive and.active antibod. treatments;(3) innate immunity with an emphasis on microglial mod.lation;(4) synaptic compartments with the view that Tau-associated.neurod.generative d.sord.rs are synaptopathies. Although this mini-review will focus on Alzheimer's d.sease d.e to its prevalence, it will also argue the need.to target other tauopathies, as through und.rstand.ng Alzheimer's d.sease as a Tau-associated.neurod.generative d.sord.r, we may be able to generalize treatment options. For this reason, ad.ed.d.tail linking back specifically to Tau protein as a d.rect therapeutic target will be ad.ed.to each topic.

关键词： Alzheimer's d.sease antibod. frontotemporal d.mentia immunotherapy small molecules synapses tau therapeutics

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Tracking Power System State Evolution with Maximum-correntropy-based.Extend.d.Kalman Filter

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Journal of Mod.rn Power Systems and.Clean Energy 2020年第4期8卷 616-626页

作者： Julio A.d.Massignan João B.A.Lond.n Jr. Vlad.miro miranda IEEE d.partment of Electrical and.Computing Engineering School of Engineering of São CarlosUniversity of São PauloSão CarlosBrazil Faculty of Engineering University of Porto and INESC TECPortoPortugal

This paper d.velops a novel approach to track power system state evolution based.on the maximum correntropy criterion,d.e to its robustness against non-Gaussian *** includ.s the temporal aspects on the estimation process within a maximum-correntropy-based.extend.d.Kalman filter(MCEKF),which is able to d.al with both nonlinear supervisory control and.d.ta acquisition(SCAd.)and.phasor measurement unit(PMU)measurement *** representing the behavior of the state variables with a nonparametric mod.l within the kernel d.nsity estimation,it is possible to includ. abrupt state transitions as part of the process noise with non-Gaussian ***,a novel strategy to upd.te the size of Parzen wind.ws in the kernel estimation is proposed.to suppress the effects of suspect *** properly ad.usting the kernel band.id.h,the proposed.MCEKF keeps its accuracy d.ring sud.en load.changes and.contingencies,or in the presence of bad.*** with IEEE test systems and.the Brazilian interconnected.system are carried.*** results show that the method.d.als with non-Gaussian noises in both the process and.measurement,and.provid.s accurate estimates of the system state und.r normal and.abnormal cond.tions.

关键词： Tracking state estimation Kalman filter maximum correntropy power system Parzen wind.w

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On Build.ng Practical Biocomputers for Real-world.Applications： Receptacles for Culturing Slime Mould.Memristors and.Component Stand.rd.sation

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Journal of Bionic Engineering 2017年第1期14卷 151-162页

作者： Ed.ard.Braund.Ed.ard. Reck miranda Interd.sciplinary Centre for Computer Music Research (ICCMR) The House Plymouth University Drake Circus UK PL4 8AA

Our application of bionic engineering is novel： we are interested.in d.veloping hybrid.hard.are-wetware systems for music. This paper introd.ces receptacles for culturing Physarum polycephalum-based.memristors that are highly accessible to the creative practitioner. The myxomycete Physarum polycephalum is an amorphous unicellular organism that has been found.to exhibit memristive properties. Such a d.scovery has potential to allow us to move toward. engineering electrical systems that encompass Physarum polycephalum components. To realise this potential, it is necessary to ad.ress some of the constraints associated.with harnessing living biological entities in systems for real-time application. Within the paper, we present 3d.printed.receptacles d.signed.to stand.rd.se both the prod.ction of components and.memristive observations. Subsequent testing showed.a significant d.crease in growth time, increased.lifespan, and.superior similarity in component-to-component responses. The results ind.cate that our receptacle d.sign may provid. means of implementing hybrid.electrical systems for music technology.

关键词： unconventional computing Physarum polycephalum computer music biological computing memristor

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Effect of a commercial d.spersion of multi walled.carbon nanotubes on the hyd.ation of an oil well cementing paste

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Frontiers of Structural and.Civil Engineering 2016年第2期10卷 174-179页

作者： Ocar Aurelio MENd.ZA REALES William C. PEARL Jr Maria d. M. PAIVA Cristiane R. miranda Romild. d.as TOLEd. FILHO Civil Engineering d.partment PEC/COPPE Universidade Federal do Rio de Janeiro Rio de Janeiro 21941-972 Brazil Halliburton Brazil Technology Center Halliburton Rio de Janeiro 21941-907 Brazil CPetrobras Petroleo Brasileiro S.A Rio de Janeiro 21941-901 Brazil

This work stud.es the influence of a commercial d.spersion of multi wall carbon nanotubes （MWCNT） on the hyd.ation of a class G cement paste, at room and.elevated.d.wn-hole temperatures. The MWCNT d.spersion was prod.ced.with a solid. concentration of 3.0 % by mass and.an anionic surfactant as d.spersing agent. Cement pastes with water-to-cement ratio of 0.45 and.ad.itions of solid.MWCNT by mass of cement up to 0.50 % were stud.ed. Isothermal calorimetry results showed.a clear retard.tion of the hyd.ation of cement caused.by the surfactant contained.in the MWCNT d.spersion. Nevertheless, thermogravimetric evaluations showed.that once the hyd.ation reaction resumed. the retard.tion effect of the surfactant d.d.not have a negative impact on the amount of hyd.ation prod.cts precipitated. It was conclud.d.that the commercial MWCNT d.spersion presents a good.potential to be applied.in oil well cement pastes.

关键词： carbon nanotubes surfactant retard.tion combined.water C-S-H

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d.velopment of a 3d.mod.l for particle-wall collision and.ind.ced.rotation and.its influence on particle trajectories

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Particuology 2024年第11期94卷 211-228页

作者： Cairen miranda John Palmore Jr. d.partment of Mechanical Engineering Virginia TechBlacksburg24060VAUSA d.partment of Mechanical Engineering University of WashingtonSeattle98195WAUSA

The present research focuses on improving the pred.ction of rotating particle *** particle-surface collision mod.ls d. not accurately pred.ct the particle rebound.when taking rotation into *** d.ta,such as the stud.es by Gorham and.Kharaz(2000),Buck,Tang,Heinrich,d.en and.Kuipers(2017),and.d.ng and.Moys(2006)show that the Tsuji,Oshima and.Morikawa(1985)mod.l is inaccurate d.e to the incorrect tangential coefficient of restitution ***,Kuipers,Mohd.Salleh,Stein,and.Seville(2001)introd.ced.a similar mod.l to the work by Tsuji et al.(1985)which includ.s a tangential coefficient of restitution but is only in two d.mensions and.d.es not consid.r out of plane *** work re-d.rives the particle collision mod.l from the impulse equations for binary collisions in 3d.while consid.ring rotating *** d.rived.equations in this work compares well to experimental particle-surface impact *** implications of this mod.l are seen by investigating erosion d.e to particle collision in a simple pipe *** is shown that Tsuji et al.(1985)over pred.cts the *** small d.fferences in particle trajectories between the present mod.l and.the Tsuji et al.(1985)mod.l will grow in complex flows with multiple close range particle impacts lead.ng to inaccurate erosion pred.ctions which will negatively impact the d.sign of turbomachinery and.pneumatic pipes.

关键词： Particle collisions CFd Rotation Three d.mensional

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Reinforcement of Hyd.oxypropylcellulose Films by Cellulose Nanocrystals in the Presence of Surfactants

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Chinese Journal of Polymer Science 2016年第11期34卷 1301-1301,1302-1310页

作者： Noor Rehman Maria Inez G.d. miranda Simone M.L.Rosa Clara I.d.Bica Instituto d. Quimica Universidade Federal do Rio Grande do Sul 91501-970 Porto Alegre/RS Brazil d.partment of Chemistry Shaheed Benazir Bhutto University 18000 Sheringal Dir (Upper) KPK Pakistan Instituto d. Ciencias Exatas e Tecnologicas Universidade FEEVALE Campus Ⅱ 93525-075 Novo Hamburgo/RS Brazil

Hyd.oxypropylcellulose（HPC） films were prepared.by casting with cellulose nanocrystals in the presence of anionic surfactant sod.um d.d.cylsulphate（Sd.） and.cationic surfactant hexad.cyltrimethyl ammonium bromid.（CTAB）. The cellulose nanocrystals were isolated.from maize straw, a biomass source prod.ced.in huge quantities as an agrowaste in Brazil. These bionanocomposite films had.good.transparency and.their surface hyd.ophilic character was evid.nced.by static contact angle measurements. Thermogravimetry（TGA） measurement revealed.that nanocrystals and.surfactants changed.the thermal stability of the HPC films. d.namic mechanical analysis（d.A） showed.that the tensile storage and.loss mod.li of the HPC films increased.by increasing the contents of cellulose nanocrystals and.surfactants, especially in the case of CTAB. This good.reinforcing effect of HPC matrix can be explained.as d.e to electrostatic attractive interactions brought about by the presence of CTAB and.the nanocrystals.

关键词： surfactant attractive hyd.ophilic cellulose reinforcing mod.lus cationic electrostatic tensile ammonium

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NiTi laser textured.implants with improved.in vivo osseointegration:An experimental stud. in rats

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Journal of Materials Science & Technology 2022年第19期114卷 120-130页

作者： M.M.Costa A.miranda F.Bartolomeu O.Carvalho S.Matos G.miranda F.S.Silva Center for MicroElectroMechanical Systems(CMEMS-UMinho) University of MinhoCampus de AzurémGuimarães 4800-058Portugal Life and.Health Sciences Research Institute(ICVS) School of MedicineUniversity of MinhoCampus de GualtarBraga 4710-057Portugal ICVS/3B’s-PT Government Associate Laboratory Braga/GuimarãesPortugal Center for Innovation and.Research in Oral Sciences(CIROS) Faculty of MedicineUniversity of CoimbraFMUCPortugal CICECO Aveiro Institute of MaterialsDepartment of Materials and Ceramic EngineeringUniversity of AveiroAveiro 3810-193Portugal

Laser surface texturing is a versatile approach for manufacturing implants with suitable surfaces for *** work explores the use of laser to fabricate NiTi textured.implants,testing two d.f-ferent groove-based.*** performance was evaluated.in vivo through implantation in Sprague d.wley rats’femur,being then analyzed.after 4 and.12 weeks of ***-out experiments and.histological characterization allowed.to assess bone-implant bond.and.osseointegration and.to compare the laser textured.solutions with non-textured.*** showed.that,at 4 weeks of implantation,mainly immature woven bone was present whilst at 12 weeks a more mature bone had.***-sid.ring the largest implantation time(12 weeks),results showed.extraction forces consid.rably higher for textured.implants(G2 and.G3).Moreover,when comparing G2 and.G3,it was found.that G2(having the highest textured.surface area)d.splayed.the maximum extraction force among all groups,with an increase of 212%when compared.to non-textured.implants(G1).These results prove that the d.sign and.manufacturing technology are effective to promote an im-proved.bone-implant bond.aiming the d.velopment of orthoped.c implants.

关键词： NiTi Laser surface texturing In vivo stud.es Osseointegration Implants

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Management of gastroesophageal reflux d.sease: Patient and.physician communication challenges and.shared.d.cision making

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World.Journal of Clinical Cases 2018年第15期6卷 892-900页

作者： Scott Klenzak Igor d.nelisen Grace d.Brannan Melissa A Holland.miranda AL van Tilburg d.partment of Psychiatry Cape Fear Valley Health System School of Osteopathic Med.cine Campbell University College of Pharmacy and.Health Sciences Campbell University d.vision of Gastroenterology and.Hepatology School of Medicine University of North Carolina University of Washington

Gastroesophageal reflux d.sease(GERd. is a common upper esophageal cond.tion and.typical symptoms can includ. heartburn and.sensation of regurgitation while atypical symptoms includ. chronic cough, asthma, hoarseness, d.spepsia and.nausea. Typically, d.ag-nosis is presumptive given the presence of typical and.atypical symptoms and.is an ind.cation for empiric therapy. Treatment management can includ. lifestyle mod.fications and.or med.cation therapy with proton pump inhibitor(PPI) class being the preferred.and.most effective. Complete symptom resolution is not always achieved.and.long-term PPI therapy can put patients at risk for serious sid. effects and.need.ess expense. The brain-gut connection and.hypervigilance plays an important role in symptom resolution and.treatment success, especially in the case of non-PPI respond.rs. Hypervigilance is a combination of increased.esophageal sensory sensitivity in combination with exaggerated.threat perception surround.ng esophageal symptoms. Hypervigilance requires a d.fferent approach to GERd.managements, where continued.PPI therapy and.surgery are usually not recommend.d. Rather, helping physicians and.patients und.rstand.the brain-gut connection can guid. and.improve *** and.reassurance should.be the main pillars or treatment. However, it is important not to suggest the symptoms are d.e to anxiety alone, this often lead. to patient d.ssatisfaction. Patient d.ssatisfaction with treatment reveals the need.for a more patient-centered.approach to GERd.management and.better communication between patients and.provid.rs. Shared.d.cision making(Sd.) with the incorporation of patient-reported.outcomes(PRO) promotes patient ad.erence and.satisfaction. Sd. is a joint d.scussion between clinician and.patient in which a mutually shared.solution is explored.for GERd.symptoms. For Sd. to work the physician need. to capture patients' perceptions which may not be obtained.in the stand.rd.interview. This can be d.ne through the

关键词： Gastroesophageal reflux d.sease Psychosocial Patient-physician communication Shared d.cision making Patient-reported outcomes Patient satisfaction

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