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Impact of the timing of capsule endoscopy in overt obscure gastrointestinal bleeding on yield and rebleeding rate-is sooner than 14 d advisable?

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World Journal of Gastrointestinal Endoscopy 2018年第4期10卷 74-82页

作者： Catarina Gomes Rolando Pinho Adélia Rodrigues Ana Ponte Joana Silva Jaime pereira Rodrigues Mafalda Sousa Joao Carlos Silva Joao carvalho Department of Gastroenterology Centro Hospitalar Vila Nova de Gaia/EspinhoPorto 4434502Portugal

AIM To evaluate the impact of the timing of capsule endoscopy(CE) in overt-obscure gastrointestinal bleeding(OGIB). METHODS Retrospective, single-center study, including patients submitted to CE in the setting of overt-OGIB between January 2005 and August 2017. Patients were divided into 3 groups according to the timing of CE(≤ 48 h; 48 h-14 d; ≥ 14 d). The diagnostic and therapeutic yield(DY and TY), the rebleeding rate and the time to rebleed were calculated and compared between groups. The outcomes of patients in whom CE was performed before(≤ 48 h) and after 48 h(> 48 h), and before( 48 h groups(P = 0.03).CONCLUSION Performing CE within 48 h from overt-OGIB is associated to a higher TY and a lower rebleeding rate and longer time to rebleed.

关键词： Overt-obscure gastrointestinal bleeding Capsule endoscopy Timing Diagnosis Therapeutic Rebleeding

Accessory Placental Structures—A Review

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Open Journal of Animal Sciences 2014年第5期4卷 305-312页

作者： Rennan Lopes Olio Luis Miguel Lobo Márcio Aparecido pereira Amilton Cesar Santos Diego carvalho Viana Phelipe Oliveira Favaron Maria Angelica Miglino Department of Surgery School of Veterinary Medicine and Animal Science University of Sao Paulo Sao Paulo Brazil

Many studies have reported on the different types of placenta in different species, but accessory or paraplacental structures are mentioned only in species that have such a nutrient-exchanging mechanism. Hystricomorph rodents possess a subplacenta, swine and equines have the placental areola, equines have the chorionic girdle, and carnivores have hemophagous organs that are equivalent to the placental hematoma in ruminants. These accessory structures are specialized tissues for specific nutrient exchanges in different species, and they are adaptive modifications exhibited by domestic and wild species to remedy the nutritional deficiencies that are related to permeability of the main placenta to important nutrients for the growth and development of the fetus during the gestation.

关键词： Placental Areola Chorionic Girdle Placental Hematoma Hemophagous Organs Subplacenta

Self-reported participation restrictions in normal hearing individuals in thyroid ontogeny: Evidence of subclinical changes

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Journal of Otology 2019年第1期14卷 6-11页

作者： Caio Le?nidas Oliveira de Andrade Gabriela carvalho Machado Luan Paulo Franco Magalh?es Elen pereira de Jesus Elaine Alves Matias Taíse Lima de Oliveira Cerqueira Hélida Braga de Oliveira Luciene da Cruz Fernandes Helton Estrela Ramos Crésio de Arag?o Dantas Alves Postgraduate Program in Interactive Processes of Organs and Systems Institute of Health Science–Federal University of Bahia Department of Life Sciences University of the State of Bahia Social Services Sister Dulce Institute of Health Science–Federal University of Bahia Department of Speech Therapy Institute of Health Science–Federal University of Bahia Department of Bioregulation Health & Sciences Institute Federal University Bahia (UFBA) Medical School Institute of Health Science–Federal University of Bahia

Purpose: To verify evidence of subclinical alterations through self-reported participation restrictions in normal hearing individuals and congenital hypothyroidism ***: An analytical, quantitative, cross-sectional exploratory study with a 1:1 ratio, consisting of a convenience sample of 86 normal hearing individuals with(n = 42) and without(n = 44) congenital hypothyroidism diagnosis. All participants underwent tonal and speech audiometry, immitance and distortion product otoacoustic emissions. The researchers excluded people with hearing loss, genetic syndromes and metabolic diseases. The instrument used for evaluate of self-reported participation restrictions was the HHIE-adapted questionnaire, composed of 25 questions, 12 of which were social domain and 13 emotional domain. Student's ttest and chi-square test were used for statistical analysis at a significance level of 5%.Results: There was a significant(p < 0.001) self-reported participation restrictions in CH(61.9%), with a greater relevance for the social domain(p = 0.002). There was a greater frequency of mild/moderate(40.5%)and higher prevalence of association with clinical factors and adherence to ***: The findings indicate that self-reported participation restrictions in normal hearing individuals with congenital hypothyroidism was more significant than in the non-exposed group, suggesting evidence of subclinical auditory abnormalities in this population.

关键词： Hearing Hearing loss Auditory perception Congenital hypothyroidism Surveys and questionnaires

Coffee and Caffeine Intake among Students of the Brazilian Northeast

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Food and Nutrition Sciences 2016年第1期7卷 30-36页

作者： Andreza Gomes Penafort Isabella Barbosa pereira Carneiro Antônio Augusto Ferreira Carioca Maria Olganê Dantas Sabry Francisco José Maia Pinto Helena Alves de carvalho Sampaio University of Fortaleza Fortaleza Brazil State University of Ceara Fortaleza Brazil

The purpose of this study was to evaluate the pattern of intake of coffee and caffeine-containing food among students in a post-secondary institution in northeastern Brazil. We interviewed 498 students. Among these students, 72.3% (n = 360) reported to consume coffee, with a higher pre- valence among women (68.3%) and students aged between 18 and 25 years (82.8%). The student’s residence itself was the top location for taking coffee (90.6%) and the most widely used method of preparation was brewing coffee using a cloth filter (82.5%). The average intake of coffee was 199.0 ± 230.6 ml/day, with a frequency of 1.6 ± 1.4 times a day and concentration between 4% - 12%. Coffee was the main source of caffeine and the average daily intake of 147.3 ± 141.2 mg of caffeine was low. The data showed that the intake of coffee and caffeine does not represent a risk factor for the population studied. On the other hand, the scarcity of national studies on the subject points to the need of similar research about customer profile and pattern of consumption of coffee and caffeine, especially regarding the preparation technique of coffee, featuring benefits or risks for the development of chronic diseases.

关键词： Coffee Caffeine Chronic Disease

Sensory Profile of Fermented Arabica Coffee in the Perception of American Cupping Tasters

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Agricultural Sciences 2019年第3期10卷 321-329页

作者： Lucas Louzada pereira Rogério carvalho Guarconi Tais Rizzo Moreira Dério Brioschi Jr. Joao Paulo pereira Marcate Luiz Henrique Bozzi Pimenta de Sousa Aldemar Polonini Moreli Danieli Grancieri Debona Carla Schwengber Ten Caten Federal Institute of Education Science and Technology of Espírito Santo Venda Nova do Imigrante CampusFood Science and Technology ProgramRua Elizabeth Minete PerimVitóriaBrazil Capixaba Institute for Technical Assistance Research and ExtensionINCAPERDepartment of StatisticsDomingos MartinsBrazil Department of Forest Sciences and Wood Federal University of Espirito SantoCenter for Agrarian Sciences and EngineeringJeronimo MonteiroBrazil Department of Production and Transportation Engineering Federal University of Rio Grande do SulPorto AlegreBrazil

The consumption of specialty coffees has been growing year after year, indicating that several niches and market forms according to the sensorial orientation of the consumers, as well as the cupping tasters and agents are responsible for the composition of blends, and for the physical and sensory classification of the coffees in the industry. This study presented 5 methods of spontaneous and induced fermentation to different North American cupping tasters, in order to evaluate coffee quality potential, based on the Specialty Coffee Association (SCA) protocol. During the months of May to July of 2017, 150 coffee samples were evaluated. Initial results indicate that North American cupping tasters evaluated dry fermented coffees using yeast culture as superiors, in the sensorial aspect, than the more conventional methods in Brazil. Such indication opens new discussions on the acceptance of a determined product, followed by the potential for modification of the sensory route as of the fermentation that will affect the attributes.

关键词： Arabica Coffee Fermentation Acceptance Cupping Tasters

Rice and Bean:Glycemic Index and Glycemic Load of the“Baiao de Dois”

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Agricultural Sciences 2014年第9期5卷 770-775页

作者： Tatiana Uchoa Passos Helena Alves de carvalho Sampaio Soraia Pinheiro Machado Arruda Maria Luisa pereira de Melo Jose Wellington de Oliveira Lima Daianne Cristina Rocha Public Health State University of CearaFortalezaBrazil Pharmacology State University of CearaFortalezaBrazil

The “bai?o de dois” is a typical Brazilian dish and a rich combination of rice and beans. This preparation has a high nutritional value but its effect on glycemic response is not yet studied. To determine the glycemic index and glycemic load of foods can help prescribing diets and as a result, improving the treatment and prevention of chronic diseases. This study aimed to access the glycemic index (GI) and glycemic load (GL) of “bai?o de dois”. Following the protocol recommended by the Food and Agriculture Organization, 6 volunteers were recruited to perform blood glucose tests. Each volunteer performed three glucose tolerance tests and a test with “bai?o de dois”. All tests were undertaken in separate weeks. Through the calculation of the areas under each of the curves, it was possible to access the GI of “bai?o de dois” by the average values of six GIs found for each volunteer. It was calculated that the GL of each portion tested and recommended servings per capita. It was found that “bai?o de dois” had low GI (44) and GL (6) at the recommended per capita, but high GL (22) at the portion tested (bigger than the recommended). The “bai?o de dois” do not present a potential risk for developing chronic diseases, but it is recommended consumption to be monitored.

关键词： Glycemic Index Glycemic Load Regional Food Baiao de Dois Chronic Disease

Oral Cancer:Health Promotion and Visual Screening—A Study Report

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Journal of Cancer Therapy 2013年第8期4卷 1313-1320页

作者： Augusta P.Silveira Augusta Marques Miguel Pavao Eurico Monteiro Gabriela pereira Joaquim Goncalves Luís Castro Maria Ines Guimaraes Bernardete carvalho Claudia Ribeiro Teresa Sequeira Faculty of Heath Sciences Fernando Pessoa UniversityPortoPortugal Centre of Health Studies and Research Coimbra UniversityCoimbraPortugal Non-Governmental Organization(NGO):Mundo A Sorrir PortoPortugal Portuguese Institute for Oncology PortoPortugal Instituto Politecnico do Cavado e do Ave BarcelosPortugal Porto Portugal Well Medical Spa PortoPortugal Health Sciences Department Portuguese Catholic UniversityViseuPortugal

Background: Oral cancer presents a heterogeneous geographic incidence. Annually, more than 275,000 new cases are diagnosed worldwide. In spite of the easy accessibility of oral cavity during physical examination, most malignancies are not diagnosed until late stages of disease. Methods: Oral health promotion was our main objective, risk factors were identified and oral cavity self-examination was promoted. The population considered (n = 1117) was divided in two main age groups—a youngest (individuals under 25 years old) mostly targeted for oral cancer awareness and oral cavity self examination promotion, and an older group having accumulated potential risk exposure. Results: The results obtained revealed smoking habits and fruits-vegetables consumption deficit as the highest risks factors found. Considering a Risk Factor Exposure Index analysis, individuals with secondary level of instruction and living in sub-urban areas assumed the highest risk exposure. Alcohol consumption had also contributed as a significant risk exposure. Conclusions: Some of these risk factors work as biological reward of quality of life deficit. A wide comprehension of the problem requires a multidisciplinary approach necessarily involving Health and Social Sciences in order to target the core of oral cancer health promotion. An effective epidemiological strategy must thus support three major aspects: population knowledge, sensitization and visual screening.

关键词： Oral Cancer Visual Screening Oral Health Promotion Epidemiological Strategies

Multi-omics Analysis of Young Portulaca oleracea ***’Responses to High NaCl Doses Reveals Insights into Pathways and Genes Responsive to Salinity Stress in this Halophyte Species

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Phenomics 2023年第1期3卷 1-21页

作者： Vivianny Nayse Belo Silva Thalliton Luiz carvalho da Silva Thalita Massaro Malheiros Ferreira Jorge Candido Rodrigues Neto Andrépereira Leão JoséAntônio de Aquino Ribeiro Patrícia Verardi Abdelnur Leonardo Fonseca Valadares Carlos Antônio Ferreira de Sousa Manoel Teixeira Souza Júnior Graduate Program of Plant Biotechnology Federal University of LavrasCP 3037LavrasMG 37200-000Brazil Institute of Chemistry Federal University of GoiásCampus SamambaiaGoiâniaGO 74690‐900Brazil Brazilian Agricultural Research Corporation Embrapa Mid-NorthTeresinaPI 64008-780Brazil Brazilian Agricultural Research Corporation Embrapa AgroenergyBrasíliaDF 70770‐901Brazil

Soil salinity is among the abiotic stressors that threaten agriculture the most,and purslane(Portulaca oleracea L.)is a dicot species adapted to inland salt desert and saline habitats that hyper accumulates salt and has high phytoremediation *** researchers consider purslane a suitable model species to study the mechanisms of plant tolerance to drought and salt ***,a robust salinity stress protocol was developed and used to characterize the morphophysiological responses of young purslane plants to salinity stress;then,leaf tissue underwent characterization by distinct omics platforms to gain further insights into its response to very high salinity *** salinity stress protocol did generate different levels of stress by gradients of electrical conductivity at field capacity and water potential in the saturation extract of the substrate,and the morphological parameters indicated three distinct stress *** expected from a halophyte species,these plants remained alive under very high levels of salinity stress,showing salt crystal-like structures constituted mainly by Na^(+),Cl^(−),and K^(+)on and around closed stomata.A comprehensive and large-scale metabolome and transcriptome single and integrated analyses were then employed using leaf *** multi-omics integration(MOI)system analysis led to a data-set of 51 metabolic pathways with at least one enzyme and one metabolite differentially expressed due to salinity *** data sets(of genes and metabolites)are valuable for future studies aimed to deepen our knowledge on the mechanisms behind the high tolerance of this species to salinity *** conclusion,besides showing that this species applies salt exclusion already in young plants to support very high levels of salinity stress,the initial analysis of metabolites and transcripts data sets already give some insights into other salt tolerance mechanisms used by this species to support high levels of salinity stress.

关键词： Purslane RNA-Seq Chemometrics High-resolution mass spectrometry Abiotic stress Multi-omics integration

Liver Histology after Chronic Use of Alcohol and Exercise Training in Rats

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Journal of Pharmacy and Pharmacology 2018年第1期6卷 52-60页

作者： Marina Silva de Lucca Eveline Tortes pereira Thamires Righi Camilo Amaro de carvalho Clayton Israel Nogueira Daise Nunes Queiroz da Cunha Antonio Jose Natali Luciana Moreira Lima Department of Medicine and Nursing Federal University of Vigosa MG CEP 36. 570-900 Brazil Postgraduate Program in Physical Education Federal University of Vigosa MG CEP 36. 5 70-900 Brazil Department of Biochemistry and Molecular Biology Federal University of Vicosa MG CEP 36. 570-900 Brazil Department of Veterinary Medicine Federal University of Vigosa MG CEP 36.570-900 Brazil

Objectives： To investigate the effects of physical training on the liver morphology and morphometry after chronic use of alcohol in rats. Methods： Twenty-four Wistar rats were housed in cages with controlled environment and randomly divided into four groups according to treatment received. In the initial treatment, alcohol was administered to SA （sedentary alcohol） and EA （exercise alcohol） groups. After four weeks, physical training program was held on a treadmill with EA and EC （exercise control） groups. Area, perimeter, maximum and minimum diameter and form factor of nucleus and cytoplasm of hepatocytes were analyzed. Key findings： Micro-vesicular fatty degeneration, predominantly pericentrolobular, of mild to moderate intensity, was found especially in animals treated with alcohol. EC group showed nucleus area greater than the nucleus area of EA and SA groups. The form factor was lower in the EC group than in the EA group. EA group showed maximum cytoplasm diameter is smaller than in SC （sedentary control） group. Conclusions： Physical training for two weeks was not enough to suppress histopathologic changes in the liver caused by chronic use of alcohol in rats. Chronic use of alcohol seems to have minimized the beneficial effect of physical training in the nucleus area of hepatocytes.

关键词： Alcohol exercise steatosis alcoholic liver disease animal model.