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Cyclosporine-Associated Nephrotoxicity

Open Journal of Nephrology 2013年第3期3卷 168-180页

作者： Maria Delia Colombo Renata Perego gilberto bellia Department of Dermatology Marchesi Hospital Inzago (MI) Italy Novartis Farma S.p.A. Origgio (VA) Italy

Cyclosporine (CsA) has revolutionized transplant medicine and is currently one of the most important immunosuppressive agents for a wide range of organ transplantations and of autoimmune and inflammatory diseases, such as rheumatoid arthritis, uveitis, psoriasis, and atopic dermatitis. Renal impairment represents the main limitation to CsA long-term continuous therapy. However, it has been shown that nephrotoxicity is associated with longer treatment duration, larger cumulative doses and higher daily dose of CsA. With low dose regimens (<5 mg/kg/day), stable serum creatinine levels have been observed up to 15-20 years after kidney transplantation. Intermittent therapy may offer a good therapeutic strategy to limit long-term renal dysfunction, given the fact that renal structural changes are dose- and time-dependent. The best predictor of permanent renal damage is a persistent increase in serum creatinine level one month after treatment withdrawal. In patients with autoimmune diseases, the percentage increase in serum creatinine above baseline value during CsA therapy has been shown to predict CsA-induced nephropathy. Before CsA therapy initiation, patients should undergo a thorough baseline evaluation including laboratory assessments, in particular electrolytes, serum creatinine, and urea levels. Furthermore, patients should be evaluated for factors that might increase the risk of nephrotoxicity, such as obesity, older age, hypertension, concomitant use of nephrotoxic drugs, and pre-existing renal conditions. In the present paper, CsA-induced nephropathy will be reviewed in terms of pathophysiology, pathologic and clinical findings, and strategies for prevention and management.

关键词： Cyclosporine Nephrotoxicity Immunosuppression Transplant Creatinine

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Gender medicine and psoriasis

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World Journal of Dermatology 2014年第3期3卷 36-44页

作者： Delia Colombo Nicoletta Cassano gilberto bellia Gino A Vena Novartis Farma Sp A 21040 Origgio Italy Dermatology and Venereology Private Practice Bari and Barletta Italy

The study of specific differences between women and men is arousing huge interests in various fields of medicine, including dermatology. The available data on gender medicine applied to common skin diseases are unfortunately still scanty. Psoriasis is a chronic immunemediated skin disease which affects 1%-3% of most populations worldwide and can involve also the joints and entheses. The pathogenesis of the disease is very complex, resulting from the interaction between genetic predisposition and several environmental triggers. The pathogenic role of sex hormones has also been hypothesized. The analysis of gender-specific differences in psoriasis seems to suggest some interesting findings, such as an earlier age of disease onset in females, a higher probability of severe disease in men, or different tendencies in care utilization, adherence to treatment, development of psychological distress, and coping strategies. Moreover, sex-related differences have been recently described in some epidemiological and clinical features among patients with psoriatic arthritis. The objective of this article is to review briefly the available evidence regarding gender differences in various aspects of psoriasis, such as epidemiology, genetics, risk factors, associated conditions, quality of life, clinical and therapeutic aspects.

关键词： Psoriasis Psoriatic arthritis Gender medicine Sex differences Epidemiology Risk factors Clinical aspects Comorbidities Quality of life Therapeutic management

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Metallocene Catalysts Technology,Academic Aspects,Industrial Challenges, Environmental Implication

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石油化工 2004年第z1期33卷 -页

作者： Abbas Razavi Vincenzo bellia Didier Baekelmans Sabine Sirol Martine Slawinsky Liliane Peters Margo Lopez Vladimir Marin Atofiina Research Centre de Recherche du Groupe Total Fina ElfZone industrielle CB - 1718 Feluy (Senefe)Belgium Atofina Research &Technology Center 1700 Battleground RoadLa PorteTX 77571 Atofiina ResearchCentre de Recherche du Groupe Total Fina ElfZone industrielle CB - 1718 Feluy (Senefe)Belgium Atofiina ResearchCentre de Recherche du Groupe Total Fina ElfZone industrielle CB - 1718 Feluy (Senefe)Belgium Atofiina ResearchCentre de Recherche du Groupe Total Fina ElfZone industrielle CB - 1718 Feluy (Senefe)Belgium Atofiina ResearchCentre de Recherche du Groupe Total Fina ElfZone industrielle CB - 1718 Feluy (Senefe)Belgium Atofiina ResearchCentre de Recherche du Groupe Total Fina ElfZone industrielle CB - 1718 Feluy (Senefe)Belgium Atofina Research &Technology Center 1700 Battleground RoadLa PorteTX 77571 Atofina Research &Technology Center 1700 Battleground RoadLa PorteTX 77571

　　Single site catalysts related polypropylene exhibit large diversity in their polymer chain microstructures far exceeding the tactic varieties observed with the polypropylene obtained with native, multiple site,het...

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质量数A≈125的热核GDR特性的研究

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原子核物理评论 2004年第3期21卷 207-209页

作者：范红梅 D.Santonocito Y.Blumenfeld P.Piattelli C.Agodi R.Alba G.bellia R.Coniglione F.Delaunay A.Del Zoppo P.Finocchiaro N.Frascaria V.Lima C.Maiolino E.Migneco P.Sapienza 中国科学院近代物理研究所甘肃兰州 730000 INFN-LNS 44 Via S.Sofia I-95123 Catania Italy Institute de Physique Nucleaire N2P3-CNRS-F-91046 Orsay France Dipartimento di Fisica dell'Università di Catania Italy INFN-LNS 44 Via S.Sofia I-95123 Catania ItalyDipartimento di Fisica dell'Università di Catania Italy

简单介绍了利用LNS的回旋加速器产生的116Sn束轰击12C和24Mg靶的实验装置以及实验过程.该实验通过MEDEA探测器测量了由全熔合与非全熔合反应产生的较低激发能区(160—300MeV)质量数A≈125的热核的巨偶极共振特性,比较了不同靶子、不同... 详细信息

简单介绍了利用LNS的回旋加速器产生的116Sn束轰击12C和24Mg靶的实验装置以及实验过程.该实验通过MEDEA探测器测量了由全熔合与非全熔合反应产生的较低激发能区(160—300MeV)质量数A≈125的热核的巨偶极共振特性,比较了不同靶子、不同束流能量时巨偶极共振的γ产额的变化.

关键词：熔合反应巨偶极共振γ产额氟化钡晶体 MEDEA探测器原子核物理

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