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一个多中心城市的连续型预测动态用户最优模型

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一个多中心城市的连续型预测动态用户最优模型

Endoscopic en bloc resection of an exophytic gastrointestinal stromal tumor with suction excavation technique

中国力学大会-2015

作者：林志阳 wong S.C. 张鹏蒋艳群 choi K. 杜豫川上海大学上海市应用数学和力学研究所香港大学土木工程系西南科技大学数学系

使用有限体积方法求解模型的两个部分,使用自适应相继平均法求解不动点问题。给出一个有两个CBD的城市的数值算例验证模型和数值方法的有效性。

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World Journal of Gastroenterology 2016年第23期22卷 5454-5458页

作者： Hyuk Soon choi Hoon Jai Chun Kyoung-Oh Kim Eun Sun Kim Bora Keum Yoon-Tae Jeen Hong Sik Lee Chang Duck Kim Division of Gastroenterology and Hepatology Department of Internal MedicineInstitute of Gastrointestinal Medical Instrument ResearchKorea University College of MedicineKorea University Medical Center Department of Internal Medicine Gachon University Gil Medical CenterGachon University of Medicine and Science

Here, we report the first successful endoscopic resection of an exophytic gastrointestinal stromal tumor (GIST) using a novel perforation-free suction excavation technique. A 49-year-old woman presented for further management of a gastric subepithelial tumor on the lesser curvature of the lower body, originally detected via routine upper gastrointestinal endoscopy. Abdominal computed tomography and endoscopic ultrasound showed a 4-cm extraluminally protruding mass originating from the muscularis propria layer. The patient firmly refused surgical resection owing to potential cardiac problems, and informed consent was obtained for endoscopic removal. Careful dissection and suction of the tumor was repeated until successful extraction was achieved without serosal injury. We named this procedure the suction excavation technique. The tumor’s dimensions were 3.5 cm × 2.8 cm × 2.5 cm. The tumor was positive for C-KIT and CD34 by immunohistochemical staining. The mitotic count was 6/50 high-power fields. The patient was followed for 5 years without tumor recurrence. This case demonstrated the use of endoscopic resection of an exophytic GIST using the suction excavation technique as a potential therapy without surgical resection.

关键词： Gastrointestinal stromal tumor Endoscopic resection Submucosal tumor Subepithelial tumor En bloc resection

Antibiotic treatment for Helicobacter pylori : Is the end coming?

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2015年第4期6卷 183-198页

作者： Su Young Kim Duck Joo choi Jun-Won Chung Division of Gastroenterology Department of Internal Medicine Gachon University Gil Medical Center

Infection with the Gram-negative pathogen Helicobacter pylori(H. pylori) has been associated with gastroduodenal disease and the importance of H. pylori eradication is underscored by its designation as a groupI carcinogen. The standard triple therapy consists of a proton pump inhibitor, amoxicillin and clarithromycin, although many other regimens are used, including quadruple, sequential and concomitant therapy regimens supplemented with metronidazole, clarithromycin and levofloxacin. Despite these efforts, current therapeutic regimens lack efficacy in eradication due to antibiotic resistance, drug compliance and antibiotic degradation by the acidic stomach environment. Antibiotic resistance to clarithromycin and metronidazole is particularly problematic and several approaches have been proposed to overcome this issue, such as complementary probiotic therapy with Lactobacil us. Other studies have identified novel molecules with an anti-H. pylori effect, as well as tailored therapy and nanotechnology as viable alternative eradication strategies. This review discusses current antibiotic therapy for H. pylori infections, limitations of this type of therapy and predicts the availability of newly developed therapies for H. pylori eradication.

关键词： Helicobacter pylori Treatment Antibiotic resistanc

前列腺素類制劑與宮頸球囊促宮頸成熟的效果比較

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镜湖医学 2020年第2期20卷 24-27页

作者：何健菁黃淑健蔡嘉慧澳門鏡湖醫院婦產科中國

目的比較陰道用前列腺素類制劑(前列腺素E2栓劑,PGE2)與COOK宮頸擴張球囊促宮頸成熟及引產的效果。方法選擇2016年10月~2018年4月於本院引產的104例孕足月,但宮頸條件不成熟產婦為研究對象。採用隨機方式分為實驗組1和實驗組2,每組各52... 详细信息

目的比較陰道用前列腺素類制劑(前列腺素E2栓劑,PGE2)與COOK宮頸擴張球囊促宮頸成熟及引產的效果。方法選擇2016年10月~2018年4月於本院引產的104例孕足月,但宮頸條件不成熟產婦為研究對象。採用隨機方式分為實驗組1和實驗組2,每組各52例。實驗組1採用可控釋地諾前列酮栓進行引產,實驗組2採用COOK宮頸擴張球囊引產。比較兩組產婦促宮頸成熟效果、引產結果及相關併發症情況等。結果實驗組2引產處理後Bishop評分、促宮頸成熟總有效率均顯著高於實驗組1;實驗組2誘發臨床時間顯著短於實驗組1,陰道分娩率顯著高於實驗組1;兩組產後2小時出血量、新生兒窒息情況和不良反應率相似。結論與藥物前列腺素E2足月妊娠引產相比較,應用宮頸擴張球囊,能更有效促宮頸成熟,縮短引產時間和提高陰道分娩率,且不增加產婦和新生兒風險,是一種理想的引產方法。

关键词：足月妊娠引產宮頸擴張雙球囊前列腺素類制劑促宮頸成熟引產結果

8-Hydroxydeoxyguanosine:Not mere biomarker for oxidative stress,but remedy for oxidative stress-implicated gastrointestinal diseases

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World Journal of Gastroenterology 2012年第4期18卷 302-308页

作者： Chan-Young Ock Eun-Hee Kim Duck Joo choi Ho Jae Lee Ki-Baik Hahm Myung Hee Chung Lab of Translational Medicine Gachon University of Medicine and ScienceLee Gil Ya Cancer and Diabetes Institute Department of Gastroenterology Gachon Graduate School of MedicineGil Hospital Sungkyunkwan University Samsung Advanced Institute for Biomedical Research

Reactive oxygen species （ROS） attack guanine bases in DNA easily and form 8-hydroxydeoxyguanosine （8-OHdG）, which can bind to thymidine rather than cytosine, based on which, the level of 8-OHdG is gen- erally regarded as a biomarker of mutagenesis conse- quent to oxidative stress. For example, higher levels of 8-OHdG are noted in Helicobacter pylori-associated chronic atrophic gastritis as well as gastric cancer. However, we have found that exogenous 8-OHdG can paradoxically reduce ROS production, attenuate the nuclear factor-KB signaling pathway, and ameliorate the expression of proinflammatory mediators such as interleukin （IL）-I, IL-6, cyclo-oxygenase-2, and induc- ible nitric oxide synthase in addition to expression of nicotinamide adenine dinucleotide phosphate oxidase （NOX）-I, NOX organizer-1 and NOX activator-1 in vari- ous conditions of inflammation-based gastrointestinal （GI） diseases including gastritis, inflammatory bowel disease, pancreatitis, and even colitis-associated carci- nogenesis. Our recent finding that exogenous 8-OHdG was very effective in either inflammation-based or oxidative-stress-associated diseases of stress-related mucosal damage has inspired the hope that synthetic 8-OHdG can be a potential candidate for the treatment of inflammation-based GI diseases, as well as the pre- vention of inflammation-associated GI cancer. In this editorial review, the novel fact that exogenous 8-OHdG can be a functional molecule regulating oxidative- stress-induced gastritis through either antagonizing Rac-guanosine triphosphate binding or blocking the signals responsible for gastric inflammatory cascade is introduced.

关键词： 8-hydroxydeoxyguanosine Oxidative stress Inflammation Carcinogenesis Prevention

A feasible modified biopsy method for tissue diagnosis of gastric subepithelial tumors

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World Journal of Gastroenterology 2013年第29期19卷 4752-4757页

作者： Jung Ho Kim Jun-Won Chung Minsu Ha Min Young Rim Jong Joon Lee Jungsuk An Yoon Jae Kim Kyoung Oh Kim Kwang An Kwon Dong Kyun Park Yeon Suk Kim Duck Joo choi Department of Internal Medicine Gachon University Gil Medical Center Incheon 405-760 South Korea Department of Pathology Gachon University Gil Medical Center Incheon 405-760 South Korea

AIM: To evaluate the diagnostic yield and safety of a modified technique for the histological diagnosis of subepithelial tumors (SETs). METHODS: A retrospective review of patients who underwent a modified technique for the histological diagnosis of gastric SETs, consisting of a mucosal incision with a fixed flexible snare (MIF) and deep-tissue biopsy under conventional endoscopic view, from January 2012 to January 2013 was performed. Eleven patients with gastric SETs 10-30 mm in diameter and originating from the third or fourth layer on endoscopic ultrasonography were included. RESULTS: The mean age was 59.8 (range, 45-76) years, and 5 patients were male. The mean size of the SETs was 21.8 (range, 11-30) mm. The number of biopsy specimens was 6.3 (range 5-8). The mean procedure time was 9.0 min (range, 4-17 min). The diagnostic yield of MIF biopsies was 90.9% (10/11). The histological diagnoses were leiomyoma (4/11, 36.4%), aberrant pancreas (3/11, 27.3%), gastrointestinal stromal tumors (2/11, 18.2%), an inflammatory fibrinoid tumor (1/11, 9.1%); one result was non-diagnostic (1/11, 9.1%). There were six mesenchymal tumors; the specimens obtained in each case were sufficient for an immunohistochemical diagnosis. There was no major bleeding, but one perforation occurred that was successfully controlled by endoscopic clipping. CONCLUSION: The MIF biopsy was simple to perform, safe, and required a shorter procedure time, with a high diagnostic yield for small SETs.

关键词： Subepithelial tumors Stomach Biopsy Endoscopy Diagnostic techniques

孕婦B族鏈球菌感染與新生兒預後相關性的回顧性分析

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镜湖医学 2013年第2期13卷 9-11页

作者：波蒂鄧月愛黄照恒洪濱澳門鏡湖醫院婦產科中国

目的以澳門地區孕婦為研究對象,探討B族鏈球菌感染發病率,分娩方式與新生兒預後相關關係。方法採用2012年在本院分娩並在孕晚期感染GBS者171人為研究對象,於孕35~37週留取孕婦生殖道分泌物行細菌培養;所有入選病例生產的新生兒均行耳、... 详细信息

目的以澳門地區孕婦為研究對象,探討B族鏈球菌感染發病率,分娩方式與新生兒預後相關關係。方法採用2012年在本院分娩並在孕晚期感染GBS者171人為研究對象,於孕35~37週留取孕婦生殖道分泌物行細菌培養;所有入選病例生產的新生兒均行耳、咽、鼻拭子細菌培養,以體溫,胸片,CBC,CRP,NE%作為新生兒感染的觀察指標,同時採集孕婦的臨床特徵(包括孕週,胎次,年齡,分娩方式,破膜方式,羊水性狀等),進行卡方分析。結果陰道分娩及剖宮產分娩新生兒耳培養B族鏈球菌陽性率有差異(P<0.05),陰道分娩新生兒陽性率高於剖宮產新生兒,新生兒血白細胞總數間有差異(P<0.05),亦為陰道分娩新生兒相對較高。肺部感染、發熱等合併症發病率並無差異。破膜方式在新生兒感染相關指標無明顯差異。結論孕35~37週對孕婦常規進行直腸、陰道分泌物GBS培養篩查;對篩查結果陽性的孕婦產程中預防性使用抗生素,且在分娩前4h内用藥,如果剖宮產前胎膜未破則無需抗生素預防;在保證預防性使用抗生素的條件下,可根據產科指征實行人工破膜,並不會增加新生兒感染的幾率。

关键词： B族鏈球菌新生兒預後

Catalpa bignonioides extract improves exercise performance through regulation of growth and metabolism in skeletal muscles

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Asian Pacific Journal of Tropical Biomedicine 2024年第2期14卷 47-54页

作者： Hoibin Jeong Dong-joo Lee Sung-Pil Kwon SeonJu Park Song-Rae Kim Seung Hyun Kim Jae-Il Park Deug-chan Lee Kyung-Min choi WonWoo Lee Ji-Won Park Bohyun Yun Su-Hyeon Cho Kil-Nam Kim Seoul Center Korea Basic Science InstituteSeoul 02841Republic of Korea Chuncheon Center Korea Basic Science InstituteChuncheon 24341Republic of Korea Research&Development Center Chungdam CDC JNPharm LLC.Chuncheon 24341Republic of Korea Department of Biomedical Technology Kangwon National UniversityChuncheon 24341Republic of Korea Yonsei Institute of Pharmaceutical Sciences College of PharmacyYonsei UniversityIncheon 21983Republic of Korea Gwangju Center Korea Basic Science InstituteGwangju 61751Republic of Korea Honam National Institute of Biological Resources 99Gohadoan-gilMokpo-siJeollanam-do58762Republic of Korea Department of Bio-analysis Science University of Science&TechnologyDaejeon34113Republic of Korea

Objective:To evaluate the effects of Catalpa bignonioides fruit extract on the promotion of muscle growth and muscular capacity in vitro and in ***:Cell viability was measured using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide *** proliferation was assessed using a 5-bromo-2’-deoxyuridine(BrdU)assay *** blot analysis was performed to determine the protein expressions of related *** effects of Catalpa bignonioides extract were investigated in mice using the treadmill exhaustion test and whole-limb grip strength *** composition analysis was performed using high-performance liquid chromatography(HPLC).Results:Catalpa bignonioides extract increased the proliferation of C2C12 mouse myoblasts by activating the Akt/mTOR signaling *** also induced metabolic changes,increasing the number of mitochondria and glucose metabolism by phosphorylating adenosine monophosphate-activated protein *** an in vivo study,the extract-treated mice showed improved motor abilities,such as muscular endurance and grip ***,HPLC analysis showed that vanillic acid may be the main component of the Catalpa bignonioides extract that enhanced muscle ***:Catalpa bignonioides improves exercise performance through regulation of growth and metabolism in skeletal muscles,suggesting its potential as an effective natural agent for improving muscular strength.

关键词： Catalpa bignonioides Skeletal muscle Cell proliferation Mitochondria Energy metabolism C2C12

Immediate balloon deflation method in endoscopic papillary large balloon dilation for extraction of difficult bile duct stones

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Open Journal of Gastroenterology 2013年第2期3卷 142-147页

作者： Duk Joo choi Yeon Suk Kim Jung Ho Kim Yang Suh Ku Min Su Ha Ju Hyeon Kim Department of Internal Medicine Gachon University Gil Medical Center Incheon South Korea

Background/Aims: Recently, endoscopic papillary large balloon dilation (EPLBD) using a large balloon (12 - 20 mm) for extraction of difficult common bile duct (CBD) stones has been widely accepted with favorable outcomes. However, there is no consensus with regard to the ballooning time. The aim of our study was to evaluate the efficacy and safety of immediate balloon deflation in EPLBD for the treatment of difficult bile duct stone. Methods: This was a retrospective study of 80 consecutive patients with bile duct stones who were treated with an immediate balloon deflation method in EPLBD combined with endoscopic sphincterotomy (EST) between January 2010 and December 2012. Overall success rate, success rate at first ERCP, and the frequency of mechanical lithotripsy for complete stone removal were assessed for efficacy and safety was evaluated by assessing major complications. Results: Overall success rate for complete stone removal was high (78/80, 97.5%) and success rate for complete stone removal at first ERCP was 86.3% (69/80). The use of mechanical lithotripsy was 0% (0/80). The overall complication rate was favorable (5/80, 6.3%). PostERCP pancreatitis was observed in 3 patients (two: mild, one: moderate). In subgroup analysis, the presence of periampullary diverticulum was the only factor affecting the success rate at first ERCP. Conclusion: This study demonstrated the favorable outcome of immediate balloon deflation for treatment of difficult CBD stones and can be considered for clinical application.

关键词： Endoscopic Papillary Large Balloon Dilation Ballooning Time Immediate Balloon Deflation Difficult Bile Duct Stone