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Investigation of cell mechanics using single-beam acoustic tweezers as a versatile tool for the diagnosis and treatment of highly invasive breast cancer cell lines: an in vitro study

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Microsystems & Nanoengineering 2020年第1期6卷 927-938页

作者： Hae Gyun lim Hsiao-Chuan Liu Chi Woo yoon Hayong Jung Min Gon Kim Changhan yoon Hyung Ham Kim KKirk Shung Department of Creative IT Engineering Pohang University of Science and TechnologyPohang 37673Republic of Korea NIH Resource Center for Medical Ultrasonic Transducer Technology and Department of Biomedical Engineering University of Southern CaliforniaLos AngelesCA 90089USA Department of Biomedical Engineering Inje UniversityGimhaeGyeongnam 50834Republic of Korea

Advancements in diagnostic systems for metastatic cancer over the last few decades have played a significant role in providing patients with effective treatment by evaluating the characteristics of cancer *** the progress made in cancer prognosis,we still rely on the visual analysis of tissues or cells from histopathologists,where the subjectivity of traditional manual interpretation *** paper presents the development of a dual diagnosis and treatment tool using an in vitro acoustic tweezers platform with a 50MHz ultrasonic transducer for label-free trapping and bursting of human breast cancer *** cancer cell detection and classification,the mechanical properties of a single cancer cell were quantified by single-beam acoustic tweezers(SBAT),a noncontact assessment tool using a focused acoustic ***-mimicking phantoms and agarose hydrogel spheres(AHSs)served to standardize the biomechanical characteristics of the *** on the analytical comparison of deformability levels between the cells and the AHSs,the mechanical properties of the cells could be indirectly measured by interpolating the Young’s moduli of the *** a result,the calculated Young’s moduli,i.e.,1.527kPa for MDA-MB-231(highly invasive breast cancer cells),2.650kPa for MCF-7(weakly invasive breast cancer cells),and 2.772 kPa for SKBR-3(weakly invasive breast cancer cells),indicate that highly invasive cancer cells exhibited a lower Young’s moduli than weakly invasive cells,which indicates a higher deformability of highly invasive cancer cells,leading to a higher metastasis ***-cell treatment may also be carried out by bursting a highly invasive cell with high-intensity,focused ultrasound.

关键词： diagnosis treatment weakly

Recurred forehead osteoma disseminated after previous osteoma excision:A case report

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World Journal of Clinical Cases 2023年第31期11卷 7684-7689页

作者： Dong Yun Lee SooA lim Jung Soo yoon SuRak Eo Plastic and Reconstructive Surgery DongGuk University Medical CenterGoYang 10326South Korea

BACKGROUND Forehead osteoma is a commonly encountered benign facial bone *** excision of benign forehead masses is widely ***,we report a rare case of recurrent forehead osteoma that disseminated after a previous osteoma *** SUMMARY A 54-year-old female patient had previously undergone endoscopic removal of a single forehead osteoma at 30 years of ***,she had a recurrent osteoma around the same site and underwent another endoscopic resection at 40 years of *** her first visit to our outpatient clinic,she presented with a cobblestone-like irregular surface on the forehead and a 3D facial bone computed tomography scan revealed a widely ragged surface of the inoculated osteoma on the outer table of the frontal *** general anesthesia,we performed a radical complete excision of the disseminated osteoma through a bicoronal incision using an osteotome,chisel,mallet,and *** hypothesized that the recurrence may have been caused by the inoculation of residual osteoma remnants from the previous *** surgeons should be cautious when removing osteoma particles,particularly when using an endoscopic *** To prevent recurrence,it is essential to conduct additional meticulous burring and a thorough inspection of the surface after copious irrigation.

关键词： Recurred osteoma Inoculation Dissemination Bicoronal approach Craniofacial Case report

Green synthesis,characterization and antimicrobial activity of silver nanoparticles using methanolic root extracts of Diospyros sylvatica

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Journal of Environmental Sciences 2017年第5期29卷 157-163页

作者： Lakshmi Pethakamsetty Kalyani Kothapenta Hanumanta Rao Nammi Lakshmi Kalyani Ruddaraju Pratap Kollu Soon gil yoon Sri Venkata Narayana Pammi Department of Microbiology College of Science and Technology Andhra University Visakhapatnam 530003 India DST-PURSE Programme Advanced Analytical Laboratory Andhra University Visakhapatnam 530003 India Sri Vishnu College of Pharmacy Department of Pharmaceutical Technology Vishnupur Bhimavaram A.P. 530041 India DST-INSPIRE Faculty Department of Metallurgical Engineering & Materials Science Indian Institute of Technology Bombay Mumbai 400076 India Department of Materials Science and Engineering Chungnam National University Daeduk Science Town 305-764 Daejeon South Korea

The current research study focuses to formulate the biosynthesized silver nanoparticles for the first time from silver acetate using methanolic root extracts of Diospyros sylvatica,a member of family Ebenaceae. TEM analysis revealed the average diameter of Ag NPs around 8 nm which is in good agreement with the average crystallite size（10 nm）calculated from X-ray Diffraction（XRD）analysis. Further the study has been extended to the antimicrobial activity against test pathogenic Gram（＋）ve,Gram（-）ve bacterial and fungal strains. The bioinspired Ag-NP showed promising activity against all the tested bacterial strains and the activity was enhanced with increased dosage levels

关键词： Root extract Silver nanoparticles Antimicrobial properties

Confluence of ZnO and PTFE Binder for Enhancing Performance of Thin-Film Lithium-Ion Batteries

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Energy & Environmental Materials 2024年第5期7卷 48-56页

作者： Subhashree Behera Swathi Ippili Venkatraju Jella Na-Yeong Kim Seong Cheol Jang Ji-Won Jung Soon-gil yoon Hyun-Suk Kim Department of Materials Science and Engineering Chungnam National UniversityDaejeon 34134South Korea School of Materials Science and Engineering University of UlsanUlsan 44776South Korea Department of Energy and Materials Engineering Dongguk UniversitySeoul 04620South Korea

Developing anode materials with high specific capacity and cycling stability is vital for improving thin-film lithium-ion ***-film zinc oxide(ZnO)holds promise due to its high specific capacity,but it suffers from volume changes and structural stress during cycling,leading to poor battery *** this research,we ingeniously combined polytetrafluoroethylene(PTFE)with ZnO using a radio frequency(RF)magnetron co-sputtering method,ensuring a strong bond in the thin-film composite *** effectively reduced stress on the active material and mitigated volume change effects during Li^(+)ion intercalation and *** composite thin films are thoroughly characterized using advanced techniques such as X-ray diffraction,scanning electron microscopy,and X-ray photoelectron spectroscopy for investigating correlations between material properties and electrochemical ***,the ZnO/PTFE thin-film electrode demonstrated an impressive specific capacity of 1305 mAh g^(-1)(=7116 mAh cm^(-3))at a 0.5C rate and a remarkable capacity retention of 82%from the 1st to the 100th cycle,surpassing the bare ZnO thin film(50%).This study provides valuable insights into using binders to stabilize active materials in thin-film batteries,enhancing battery performance.

关键词： li-ion batteries metal oxides anodes polytetrafluoroethylene(PTFE) thin films

Tribological properties of short carbon fibers reinforced epoxy composites

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Friction 2014年第3期2卷 226-239页

作者： Nay Win KHUN He ZHANG Lee Hoon lim Chee yoon YUE Xiao HU Jinglei YANG School of Mechanical and Aerospace Engineering 2School of Materials Science and EngineeringNanyang Technological University50 Nanyang AvenueSingapore 639798Singapore

Short carbon fiber(SCF)reinforced epoxy composites with different SCF contents were developed to investigate their tribological *** friction coefficient and wear of the epoxy composites slid in a circular path against a steel pin inclined at 45°to a vertical axis and a steel ball significantly decreased with increased SCF content due to the solid lubricating effect of SCFs along with the improved mechanical strength of the *** scanning electron microscope(SEM)observation showed that the epoxy composites had less sensitive to surface fatigue caused by the repeated sliding of the counterparts than the *** tribological results clearly showed that the incorporation of SCFs was an effective way to improve the tribological properties of the epoxy composites.

关键词： epoxy composite short carbon fiber friction wear

High prevalence of osteoporosis in patients with gastric adenocarcinoma following gastrectomy

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World Journal of Gastroenterology 2007年第48期13卷 6492-6497页

作者： Jung Sub lim Sang Bum Kim Ho-yoon Bang Gi Jeong Cheon Jong-Inn Lee Department of Pediatrics Korea Cancer Center Hospital Department of Surgery Korea Cancer Center Hospital Department of Nuclear Medicine Korea Cancer Center Hospital

AIM： To evaluate the prevalence and predictive factors of osteoporosis in patients with gastric adenocarcinoma alter gastrectomy.METHODS： The study included 133 patients diagnosed with gastric adenocarcinoma but who did not undergo prior diagnostic work-up for osteoporosis. Bone mineral density （BMD） was measured by dual-energy X-ray absorptiometry （DXA） and vertebral deformity was assessed by plain X-rays. We evaluated the effects of age, sex, body mass index （BMI）, anemia, back pain, vertebral deformity, tumor staging, reconstruction type, and past medical history to determine predictive factors of osteoporosis in these patients.RESULTS： The prevalence of osteoporosis in the lumbar spine was 38.3% （male, 28.9%; female, 54.0%）, and 15.0% in the femoral neck （male, 10.8%; female, 22.0%）. The vertebral deformity rate was 46.6% （male, 43.4%; female, 52.0%）. Age, BMI and hemoglobin correlated with BMD （P 〈 0.01）. In males, anemia and age 〉 64 years were independent predictive factors of osteoporosis in multivariate analysis. In females, back pain was an independent factor for osteoporosis.CONCLUSION： The results of this study revealed that prevalence of osteoporosis and vertebral bone deformity rate were high in gastric cancer patients, regardless of post-gastrectomy duration and operation type. Early diagnosis and a proper management plan must be established in these patients.

关键词： Gastric adenocarcinoma Gastrectomy Bone mineral density Osteoporosis Vertebral deformity Anemia Back pain

ESR2–HDA6 complex negatively regulates auxin biosynthesis to delay callus initiation in Arabidopsis leaf explants during tissue culture

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Plant Communications 2024年第7期5卷 200-214页

作者： Kyounghee Lee Hobin yoon Ok-Sun Park Jongbu lim Sang-Gyu Kim Pil Joon Seo Department of Chemistry Seoul National UniversitySeoul 08826Korea Research Institute of Basic Sciences Seoul National UniversitySeoul 08826Korea Interdisciplinary Program in Agricultural Biotechnology Seoul National UniversitySeoul 08826Korea Plant Genomics and Breeding Institute Seoul National UniversitySeoul 08826Korea Department of Biological Sciences KAISTDaejeon 34141Korea

Plants exhibit an astonishing ability to regulate organ regeneration upon *** of leaf explants promotes the biosynthesis of indole-3-acetic acid(IAA),which is polar-transported to excised regions,where cell fate transition leads to root founder cell specification to induce de novo root *** regeneration capacity of plants has been utilized to develop in vitro tissue culture ***,we report that IAA accumulation near the wounded site of leaf explants is essential for callus formation on 2,4-dichlorophenoxyacetic acid(2,4-D)-rich callus-inducing medium(CIM).Notably,a high concentration of 2,4-D does not compensate for the action of IAA because of its limited efflux;rather,it lowers IAA biosynthesis via a negative feedback mechanism at an early stage of in vitro tissue culture,delaying callus *** auxin negative feedback loop in CIM-cultured leaf explants is mediated by an auxin-inducible APETALA2 transcription factor,ENHANCER OF SHOOT REGENERATION 2(ESR2),along with its interacting partner HISTONE DEACETYLASE 6(HDA6).The ESR2–HDA6 complex binds directly to,and removes the H3ac mark from,the YUCCA1(YUC1),YUC7,and YUC9 loci,consequently repressing auxin biosynthesis and inhibiting cell fate transition on 2,4-D-rich *** findings indicate that negative feedback regulation of auxin biosynthesis by ESR2 and HDA6 interferes with proper cell fate transition and callus initiation.

关键词： auxin biosynthesis negative feedback loop ESR2 HDA6 YUCCA chromatin modification

Long Short-Term Memory Recurrent Neural Network-Based Acoustic Model Using Connectionist Temporal Classification on a Large-Scale Training Corpus

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China Communications 2017年第9期14卷 23-31页

作者： Donghyun Lee Minkyu lim Hosung Park Yoseb Kang Jeong-Sik Park gil-Jin Jang Ji-Hwan Kim Department of Computer Science and Engineering Sogang University Department of Information and Communication Engineering Yeungnam University School of Electronics Engineering Kyungpook National University

A Long Short-Term Memory(LSTM) Recurrent Neural Network(RNN) has driven tremendous improvements on an acoustic model based on Gaussian Mixture Model(GMM). However, these models based on a hybrid method require a forced aligned Hidden Markov Model(HMM) state sequence obtained from the GMM-based acoustic model. Therefore, it requires a long computation time for training both the GMM-based acoustic model and a deep learning-based acoustic model. In order to solve this problem, an acoustic model using CTC algorithm is proposed. CTC algorithm does not require the GMM-based acoustic model because it does not use the forced aligned HMM state sequence. However, previous works on a LSTM RNN-based acoustic model using CTC used a small-scale training corpus. In this paper, the LSTM RNN-based acoustic model using CTC is trained on a large-scale training corpus and its performance is evaluated. The implemented acoustic model has a performance of 6.18% and 15.01% in terms of Word Error Rate(WER) for clean speech and noisy speech, respectively. This is similar to a performance of the acoustic model based on the hybrid method.

关键词： acoustic model connectionisttemporal classification large-scale trainingcorpus long short-term memory recurrentneural network

Gouty tenosynovitis with compartment syndrome in the hand: A case report

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World Journal of Clinical Cases 2023年第30期11卷 7492-7496页

作者： Dong Yun Lee SuRak Eo SooA lim Jung Soo yoon Department of Plastic and Reconstructive Surgery DongGuk University Medical CenterGoYang 10326South Korea

BACKGROUND Gout is a common type of inflammatory arthritis caused by the deposition of monosodium urate crystals in the joints and surrounding *** typically appears with abrupt and intense pain,redness,and swelling in the affected *** frequently targets the lower extremities,such as the big ***,rarely,gout can manifest in atypical locations,including the hands,leading to an uncommon presentation known as gouty ***,it can result in significant morbidity owing to the potential for severe complications,such as myonecrosis and compartment *** SUMMARY An 82-year-old male patient with a history of hypertension,cerebral infarction,Parkinson's disease,and recurrent gout attacks sought medical attention because of progressive pain and swelling in the right *** findings revealed forearm swelling,raising concerns of possible tenosynovitis,bursitis,septic arthritis,and compartment syndrome.A fasciotomy was performed to decompress the patient’s hands and *** procedure revealed diffuse tenosynovitis,tophi with a pus-like discharge surrounding the carpal tunnel,and involvement of the flexor and extensor tendon ***,microbiological investigations,including Gram staining,acid-fast bacilli,tuberculosis,and nontuberculous mycobacteria,yielded negative *** patient was ultimately diagnosed with a severe gouty attack with compartment syndrome and *** arthritis and infectious flexor tenosynovitis were ruled *** debridement and inflammation control were initiated,followed by staged closure with a skin *** Septic-like complications can occur in the absence of infection in severe gout attacks with pus-like discharges due to compartment syndrome and *** can be used to differentiate between gouty attacks,septic arthritis,and infectious *** of the flexor and extensor muscles,as in this case,is *** study contributes to the literature

关键词： Compartment syndrome Extensor compartment Gout Tenosynovitis Case report