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Five-year clinical outcomes of first-generation versus second-generation drug-eluting stents following coronary chronic total occlusion intervention

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Journal of Geriatric Cardiology 2019年第8期16卷 639-647页

作者： Yong Hoon Kim Ae-Young Her Seung-Woon Rha Byoung Geol Choi Se Yeon Choi Jae Kyeong Byun Yoonjee park Dong Oh Kang Won Young Jang Woohyeun Kim Ju Yeol Baek Woong gil Choi Tae Soo Kang Jihun Ahn Sang-Ho park Ji Young park Min-Ho Lee Cheol Ung Choi Chang Gyu park Hong Seog Seo Division of Cardiology Department of Internal MedicineKangwon National University School of MedicineChuncheonSouth Korea Department of Cardiology Soonchunhyang University College of MedicineSeoulSouth Korea Cardiovascular Center Korea University Guro HospitalSeoulSouth Korea Department of Medicine Korea University Graduate SchoolSeoulSouth Korea Cardiovascular Center Seoul St. Mary’s Hospitalthe Catholic University of KoreaSeoulSouth Korea Cardiology Department Konkuk University Chungju HospitalChungjuSouth Korea Department of Internal Medicine Cardiovascular DivisionDankook University HospitalCheonanSouth Korea Department of Cardiology Soonchunhyang University Gumi HospitalGumiSouth Korea Cardiology Department Soonchunhyang University Cheonan HospitalCheonanSouth Korea Division of Cardiology Department of Internal MedicineCardiovascular CenterNowon Eulji Medical CenterEulji UniversitySeoulSouth Korea

Background There are limited data comparing long-term clinical outcomes between first-generation (1G) and second-generation (2G) drug-eluting stents (DESs) in patients who underwent successful percutaneous coronary intervention (PCI) for coronary chronic total occlusion (CTO) lesion. Methods A total of 840 consecutive patients who underwent PCI with DESs for CTO lesion from January 2004 to November 2015 were enrolled. Finally, a total of 324 eligible CTO patients received 1G-DES (Paclitaxel-eluting stent or Sirolimus-eluting stent, n = 157) or 2G-DES (Zotarolimus-eluting stent or Everolimus-eluting stent, n = 167) were enrolled. The clinical endpoint was the occurrence of major adverse cardiac events (MACE) defined as all-cause death, recurrent myocardial infarction (re-MI), total repeat revascularization [target lesion revascularization (TLR), target vessel revascularization (TVR), and non-TVR]. We investigated the 5-year major clinical outcomes between 1G-DES and 2G-DES in patient who underwent successful CTO PCI. Results After propensity score matched (PSM) analysis, two well-balanced groups (111 pairs, n = 222, C-statistic = 0.718) were generated. Up to the 5-year follow-up period, the cumulative incidence of all-cause death, re-MI, TLR, TVR and non-TVR were not significantly different between the two groups. Finally, MACE was also similar between the two groups (HR = 1.557, 95% CI: 0.820–2.959, P = 0.176) after PSM. Conclusions In this study, 2G-DES was not associated with reduced long-term MACE compared with 1G-DES following successful CTO revascularization up to five years.

关键词： Chronic total occlusion Drug-eluting stent Outcomes

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Risk of inflammatory bowel disease in patients with chronic obstructive pulmonary disease: A nationwide, population-based study

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World Journal of Gastroenterology 2019年第42期25卷 6354-6364页

作者： Jooyoung Lee Jong Pil Im Kyungdo Han Seona park Hosim Soh Kukhwan Choi Jihye Kim Jaeyoung chun Joo Sung Kim Department of Internal Medicine and Healthcare Research Institute Healthcare System Gangnam CenterSeoul National University HospitalSeoul 06236South Korea Department of Internal Medicine and Liver Research Institute Seoul National University College of MedicineSeoul 03080South Korea Department of Biostatics College of MedicineCatholic University of KoreaSeoul 06591South Korea Department of Internal Medicine CHA Gangnam Medical CenterCHA UniversitySeoul 06135South Korea Department of Internal Medicine Gangnam Severance HospitalYonsei University College of MedicineSeoul 06273South Korea

BACKGROUND There is a growing evidence regarding an increased risk of inflammatory bowel disease(IBD)among patients with airway *** To investigate the influence of chronic obstructive pulmonary disease(COPD)on the risk of *** A nationwide,population-based study was conducted using data from the National Health Insurance Service database.A total of 1303021 patients with COPD and 6515105 non-COPD controls were *** COPD group was divided into the severe and the mild COPD group according to diagnostic *** risk of IBD in patients with COPD compared to controls was analyzed by Cox proportional hazard regression *** cumulative incidences of IBD were compared between the *** The COPD group had higher incidences of IBD compared to non-COPD controls(incidence rate,9.98 vs 7.18 per 100000 person-years,P<0.001).The risk of IBD in the COPD group was increased by 1.38(adjusted hazard ratio(HR);95%CI:1.25-1.52).The incidence rate of IBD was higher in the severe COPD group than in the mild COPD group(12.39 vs 9.77 per 100000 person-year,P<0.001).The severity of COPD was associated with an increased risk of IBD(adjusted HR 1.70 in severe COPD,95%CI:1.27-2.21 and adjusted HR 1.35 in mild COPD,95%CI:1.22-1.49)CONCLUSION The incidences of IBD were significantly increased in COPD patients in South Korea and the risk of developing IBD also increased as the severity of COPD increased.

关键词： Claim data Inflammatory bowel disease Chronic obstructive pulmonary disease Crohn’s disease Ulcerative colitis

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COVID-19-activated SREBP2 disturbs cholesterol biosynthesis and leads to cytokine storm

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Signal Transduction and Targeted Therapy 2020年第1期5卷 910-920页

作者： Wonhwa Lee June Hong Ahn Hee Ho park Hong Nam Kim Hyelim Kim Youngbum Yoo Hyosoo Shin Kyung Soo Hong Jong Geol Jang chun Gwon park Eun Young Choi Jong-Sup Bae Young-Kyo Seo Aging Research Center Korea Research Institute of Bioscience and BiotechnologyDaejeon 34141Republic of Korea Division of Pulmonology and Allergy Department of Internal MedicineCollege of MedicineYeungnam University and Regional Center for Respiratory DiseasesYeungnam University Medical CenterDaegu 42415Republic of Korea Department of Biotechnology and Bioengineering Kangwon National UniversityChuncheonGangwon-do 24341Republic of Korea Center for BioMicrosystems Brain Science InstituteKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Division of Bio-Medical Science and Technology KIST SchoolKorea University of Science and TechnologySeoul 02792Republic of Korea College of Pharmacy Chungnam National UniversityDaejeon 34134Republic of Korea Department of Biomedical Engineering SKKU Institute for ConvergenceSungkyunkwan University(SKKU)SuwonRepublic of Korea Biomedical Institute for Convergence at SKKU(BICS) Sungkyunkwan University2066 Seobu-roJangan-guSuwon 16419Republic of Korea College of Pharmacy CMRIResearch Institute of Pharmaceutical SciencesBK21 Plus KNU Multi-Omics based Creative Drug Research TeamKyungpook National UniversityDaegu 41566Republic of Korea

Sterol regulatory element binding protein-2(SREBP-2)is activated by cytokines or pathogen,such as virus or bacteria,but its association with diminished cholesterol levels in COVID-19 patients is ***,we evaluated SREBP-2 activation in peripheral blood mononuclear cells of COVID-19 patients and verified the function of SREBP-2 in ***,we report the first observation of SREBP-2 C-terminal fragment in COVID-19 patients’blood and propose SREBP-2 C-terminal fragment as an indicator for determining *** confirmed that SREBP-2-induced cholesterol biosynthesis was suppressed by Sestrin-1 and PCSK9 expression,while the SREBP-2-induced inflammatory responses was upregulated in COVID-19 ICU *** an infectious disease mouse model,inhibitors of SREBP-2 and NF-κB suppressed cytokine storms caused by viral infection and prevented pulmonary *** results collectively suggest that SREBP-2 can serve as an indicator for severity diagnosis and therapeutic target for preventing cytokine storm and lung damage in severe COVID-19 patients.

关键词： cytokine diagnosis damage

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Preparation of chitosan–TPP nanoparticles and their physical and biological properties

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Asian Journal of Pharmaceutical Sciences 2016年第1期11卷 166-167页

作者： Eunsun Lee Sang Jun park Jae Ho Lee Min Sup Kim chun-Ho Kim Laboratory of Tissue Engineering Korea Institute of Radiological and Medical ScienceSeoul 139-706Republic of Korea Laboratory of Molecular Medicine College of MedicineDankook UniversitySeoul 100-380Republic of Korea

Over the last few decades,several polymeric nanoparticles using biomaterials have been extensively developed for use as drug delivery systems(DDS)and for other medical *** nanoparticles have the advantage of controlled drug-targeting delivery and release,which improves the stability,enhances the efficiency and reduces the side effects of the drug[1].Chitosan is a versatile polymer that has been used in drug delivery system as nanoparticles because of biodegradable,biocompatible,and low toxicity[2].

关键词： Chitosan Tripolyphosphate Nanoparticles DDS

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Development of Building Maintenance System for Monitoring Repair and Replacement Histories of Public Facilities

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Journal of Civil Engineering and Architecture 2012年第11期6卷 1464-1472页

作者： chun-Kyong Lee Tae-Keun park Technical Institute LCCKOREA Co. Ltd Seou1317-909 Korea Department of Architecture Engineering Mokwon University Daejeon 302-318 Korea

The Korea Water Resources Corporation （K-Water） has encountered four problems during the management of water resources of approximately 1,300 buildings spread throughout the country-degradation, budget constraints, lack of standards, and lack of planning. In this study, we have developed a mechanism for collecting, maintaining, and analyzing ground data for repair and replacement works. Our BMS （building maintenance system） uses the recorded repair and replacement work histories and calculates the life cycle costs of the related items. Further, it enables the performance of repair and replacement tasks through an integrated approach aimed at preventive maintenance. In this manner, the BMS is expected to maximize the efficiency of the formulation of prevention and maintenance work plans, monitoring of work histories, predictions of future tasks from the analyses of repair and replacement histories, and performance of LCC （life cycle cost） calculations. Reliable maintenance of national properties can thus be achieved by using the BMS, which promotes reasonable and efficient repair and replacement activities.

关键词： Maintenance system priority determination repair and replacement public facilities

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Helicobacter pylori infection following partial gastrectomy for gastric cancer

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World Journal of Gastroenterology 2014年第11期20卷 2765-2770页

作者： Sanghoon park Hoon Jai chun Department of Internal Medicine KEPCO Medical CenterSeoul 132-703South Korea Division of Gastroenterology and Hepatology Department of Internal MedicineInstitute of Digestive Disease and NutritionKorea University College of Medicine Korea University Medical Center Seoul 136-705South Korea

Gastric remnants are an inevitable consequence of partial gastrectomy following resection for gastric *** presence of gastric stumps is itself a risk factor for redevelopment of gastric *** pylori(***)infection is also a well-known characteristic of gastric *** colonization in the remnant stomach therefore draws special interest from clinicians in terms of stomach cancer development and pathogenesis;however,the ***-infected gastric remnant is quite different from the intact organ in several aspects and researchers have expressed conflicting opinions with respect to its role in *** instance,*** infection of the gastric stump produced controversial results in several recent *** prevalence of *** infection in the gastric stump has varied among recent *** developing in the remnant stomach presents with a unique pattern of inflammation that is different from the pattern seen in ordinary gastritis of the intact *** also has a significant influence on the colonization of the stomach stump,with several studies reporting mixed results as *** contrast,the elimination of *** from the gastric stump has shown a dramatic impact on eradication *** elimination is recognized to be important for cancer prevention and considerable agreement of opinion is seen among *** overcome the current discrepancies in the literature regarding the role of *** in the gastric stump,further research is required.

关键词： Helicobacter pylori Gastrectomy Gastric cancer

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Prevention and management of non-steroidal anti-inflammatory drugs-induced small intestinal injury

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World Journal of Gastroenterology 2011年第42期17卷 4647-4653页

作者： Sung Chul park Hoon Jai chun Chang Don Kang Donggeun Sul Division of Gastroenterology and Hepatology Department of Internal MedicineKangwon National University School of Medicine Division of Gastroenterology and Hepatology Department of Internal MedicineKorea University Anam Hospital Korea University College of Medicine Graduate School of Medicine Korea University

Non-steroidal anti-inflammatory drug （NSAID）-induced small bowel injury is a topic that deserves attention since the advent of capsule endoscopy and balloon enteroscopy. NSAID enteropathy is common and is mostly asymptomatic. However, massive bleeding, stricture, or perforation may occur. The pathogenesis of small intestine injury by NSAIDs is complex and different from that of the upper gastrointestinal tract. No drug has yet been developed that can completely prevent or treat NSAID enteropathy. Therefore, a long-term randomized study in chronic NSAID users is needed.

关键词： Non-steroidal anti-inflammatory drugs Small intestinal injury Prevention Treatment

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Recent progress in studies of factors that elicil pancreatic β-cell expansion

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Protein & Cell 2015年第2期6卷 81-87页

作者： Qiu Li Zhi-chun Lai Shandong Provincial Hospital Affiliated to Shandong University Jinan 250021 ChinaA Department of Biology The Pennsylvania State University University Park PA 16802 USA Department of Biochemistry and Molecular Biology The Pennsylvania State University University Park PA 16802 USA

The loss of or decreased functional pancreatic β-cell is a major cause of type 1 and type 2 diabetes. Previous studies have shown that adult β-cells can maintain their ability for a low level of turnover through replication and neogenesis. Thus, a strategy to prevent and treat dia- betes would be to enhance the ability of β-cells to increase the mass of functionalβ-cells. Consequently, much effort has been devoted to identify factors that can effectively induce β-cell expansion. This review focuses on recent reports on small molecules and protein fac- tors that have been shown to promote β-cell expansion.

关键词： pancreatic islet β-cell cell proliferation/replication/expansion cell signaling

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Mutual regulation between Hippo signaling and actin cytoskeleton

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Protein & Cell 2013年第12期4卷 904-910页

作者： Yurika Matsui Zhi-chun Lai I ntercollege Graduate Degree Program in Cell and Developmental Biology The Pennsylvania State UniversityUniversity ParkPA 16802USA Department of Biology The Pennsylvania State UniversityUniversity ParkPA 16802USA Department of Biochemistry and Molecular Biology The Pennsylvania State UniversityUniversity ParkPA 16802USA

Hippo signaling plays a crucial role in growth control and tumor suppression by regulating cell proliferation,apoptosis,and *** Hippo signaling is regulated has been under extensive *** the past three years,an increasing amount of data have supported a model of actin cytoskeleton blocking Hippo signaling activity to allow nuclear accumulation of a downstream effector,Yki/Yap/*** the other hand,Hippo signaling negatively regulates actin cytoskeleton *** review p rovides insight on the mutual regulatory mechanisms between Hippo signaling and actin cytoskeleton for a tight control of cell behaviors during animal development,and points out outstanding questions for further investigations.

关键词： Hippo signaling actin cytoskeleton negative feedback growth control development

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Predictive value of ^(18)F-fluorodeoxyglucose PET/CT for transarterial chemolipiodolization of hepatocellular carcinoma

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World Journal of Gastroenterology 2012年第25期18卷 3215-3222页

作者： Myeong Jun Song Si Hyun Bae Ie Ryung Yoo chung-Hwa park Jeong Won Jang Ho Jong chun Byung gil Choi Hae Giu Lee Jong Young Choi Seung Kew Yoon Department of Internal Medicine College of MedicineThe Catholic University of KoreaSeoul 137-040South Korea Department of Nuclear Medicine College of MedicineThe Catholic University of KoreaSeoul 137-040South Korea Department of Radiology College of MedicineThe Catholic University of KoreaSeoul 137-040South Korea

AIM： To investigate the correlation of 18F-fluorodeoxy- glucose （18F-FDG） positron emission tomography （PET） with clinical features and the prediction of treatment response. METHODS： A total of 83 hepatocellular carcinoma （HCC） patients undergoing 18F-FDG PET before transar- terial chemolipiodolization with systemic chemo-infusion between October, 2006 and May, 2009 were retrospec-tively enrolled. The patients included 68 men and 15 women （mean age, 60 ~ 10.7 years）. The effect of 18F- FDG-monitored PET uptake on clinical features and on the evaluated treatment response was ascertained with modified Response Evaluation Criteria in Solid Tumors. The PET parameters of maximal standardized uptake value of the tumor （Tsuvmax）, the ratio of the tumor maximal standardized uptake value （SUV） to the liver maximal SUV （Tsuvmax/Lsuwax） and the ratio of tumor maximal SUV to the liver mean SUV （msuvmax/LSUVrnean） were tested as predictive factors. RESULTS： Among the 3 SUV parameters, the TSUV- =maxdLsuvmean ratio （cutoff value of 1.90） was significantly associated with tumor burden including tumor size, tu- mor number, α-fetoprotein levels and tumor stage （P 〈 0.001, P = 0.008, P = 0.011, P 〈 0.001, respectively）. The objective response rates in patients with a high SUV ratio （≥ 1.90） were significantly better than those with a low SUV ratio （〈 1.90）（P = 0.020）. The overall survival rates of patients exhibiting a low Tsuvmax/Lsu- Vmean ratio （〈 1.90） and those with a high SUV ratio （≥1.90） was 38.2 and 10.3 mo, respectively （P 〈 0.01）. However, the time to progression showed no significant difference between the groups （P = 0.15）. CONCLUSION： 18F-FDG PET can be an important predictor of HCC treatment. In particular, the Tsuvmax/ Lsuwean ratio （cutoff value of 1.90） can provide useful information in treatment prognosis for HCC patients treated with Iocoregional therapy.

关键词： 18F-fluorodeoxyglucose positron emissiontomography Transarterial chemolipiodolization withsystemic chemo-infusion Treatment response Predic-tive factor, Overall survival

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