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Mechanistic action of the acute toxicity of Bajitian(Morinda officinalis)in zebrafish embryos

Journal of Traditional chinese Medical Sciences 2020年第3期7卷 308-315页

作者： Lirong Tan Min Cheng gigi chi ting auyeung Oscar Yu Suen Chan Xueping Chen Infinitus(china)Company Ltd. Guangzhou529100China Vitargent(International)Biotechnology Limited. Hong Kong SAR999077China College of Veterinary Medicine and Life Science City University of Hong KongHong Kong SAR999077China

Objectives:To investigate acute toxicity of Bajitian(Morinda officinalis)in zebrafish ***:Zebrafish embryos at 48-h post fertilization(hpf)were exposed to Bajitian ethanol extract for72 *** causative action of a delay in yolk sac absorption by Bajitian was investigated by RT-PCR analysis of lipid metabolism-related microsomal triglyceride transfer protein(MTP),apolipoprotein CII(ApoC2)and lipogenesis-related liver x receptor(LXR)*** effect of Bajitian eliciting an inflammatory response was studied by exposing 72 hpf myeloperoxidase(MPO):GFP transgenic zebrafish embryos to Bajitian extract for 4 *** was done by TUNEL,caspase-3/7,and RT-PCR analysis of the apoptosis related pathway B-cell lymphoma 2 associated X protein(Bax),Nuclear factor kappa-lightchain-enhancer of activated B cells(NF-k B)genes,neutrophil development-related stem cell leukaemia(SCL)and transcription factor PU.1 genes,to reveal the causative action of Bajitian reducing ***:RT-PCR analysis found that Bajitian extract had no effect on the expression of MTP or ApoC2 genes,but upregulated LXR gene,which might explain the delay in yolk sac *** of the inflammatory response showed that compared with negative controls,Bajitian extract significantly(P<.05)reduced the number of neutrophils in MPO:GFP ***,caspase-3/7,and RT-PCR analysis of Bax and NF-k B genes found that Bajitian extract did not trigger the cell *** RT-PCR analysis found that Bajitian extract did not affect SCL expression,but did lead to down-regulation of *** inhibition of neutrophil development/differentiation may explain the decline in the total number of neutrophils following Bajitian treatment,which could be attributed to the anti-inflammatory effects found clinically for this ***:This study demonstrated that Bajitian caused a delay in yolk sac absorption and a decrease neutrophil in zebrafish embryos,which may be related to the inhibit

关键词： Bajitian Morinda officinalis Neutrophil Zebrafish PU.1 Liver x receptor(LXR) Anti-inflammation

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Solid Phase Extraction Chemiluminescence Determination of Methamidaphos on Vegetables

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Chemical Research in chinese Universities 2006年第1期22卷 21-24页

作者： LI Xiao-zhou GUAN ting-ting ZHOU chi YIN Ji-qiu ZHANG Yi-hua College of Chemistry Jilin University Changchun 130012 P.R. China College of lnspection Dalian Medical University Dalian 116031 P.R. China

The determination of the methamidaphos pesticide residue on vegetables with a simple solid phase extract（SPE） flow injection（FI） -chemiluminescence（CL） method is described. The method is based on the enhancing effect of methamidaphos on the CL reaction of luminol with hydrogen peroxide in an alkaline solution. Under the optimal conditions, the CL intensity is linear to the methamidaphos mass concentration in a range of 0. 2-13μg/mL （ r= 0. 9992）. The detection limit（3σ） is 0. 047μg/mL. The relative standard deviations for the analysis of three samples are 1.8%, 2.5% and 3.7% （ n = 5 ）, respectively. The recovery is in a range of 90%-109% by the method. In this work, this method was successfully applied to the determination of the methamidaphos residue on some vegetable samples.

关键词： Chemiluminescence Flow injection Solid phase extraction Methamidaphos

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Corrosion assessment for spent nuclear fuel disposal in crystalline rock,using variant cases of hydrogeological modeling

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Nuclear Science and Techniques 2020年第12期31卷 20-31页

作者： chi-Che Hung Fraser King Yun-Chen Yu chi-Jen Chen Yuan-chieh Wu Wei-ting Lin 机构不详

This paper presents a corrosion assessment of copper spent nuclear fuel disposal canisters in crystalline rock,using hydrogeological modeling.A simplified approach is considered,to avoid complex and time-consuming computer *** simplified case is presented as a base case,with changes in the hydrogeological parameters presented as variant *** results show that in Taiwan’s base case,decreasing the hydraulic conductivity of the rock or decreasing the hydraulic conductivity of dikes results in a shorter transport path for sulfide and an increase in corrosion ***,the estimated canister failure time is still over one million years in the variant cases.

关键词： Spent nuclear fuel disposal Corrosion assessment Hydrogeological modeling

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Design of Semipersistent Resource Allocation in LTE-V Network

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Computer Systems Science & Engineering 2023年第4期45卷 131-147页

作者： Yi-ting Mai chi-En Li Department of Sport Management National Taiwan University of SportTaichung City40404TaiwanChina Department of Computer Science and Information Engineering National Chi Nan UniversityNantou County54561TaiwanChina

Radio network access technology currently used in 4G/5G is Long Term Evolution-Advanced(LTE-A),which was developed by 3rd Generation Partnership Project(3GPP).Device-to-device(D2D)communication is a technology enabling direct communications among wireless devices without forwarding through an evolved Node B(eNB).Moreover,D2D transmission can support vehicles as a vehicle-to-vehicle(V2V)*** is possible to avoid accidents via exchanging movement-related information among vehicles and effectively increase driving safety(and efficiency).However,radio resources are limited in radio networks.A vehicle transmits through D2D in Long Term Evolution-Vehicle(LTE-V)mode-3 standard,and an eNB can allocate the same spectrum radio resources for cellular and V2V links *** using the same radio resources,the probability of interference may *** study designed a semipersistent resource allocation algorithm based on different cycles in an LTE-V ***,resource allocation under different cycles was analyzed,and a scheme for resource selection is proposed based on cycle *** proposed Semi Persistent Gain Aware Resource Allocation(SP-GARA)scheme selects resources based on the expected sum rate of the cycle size and analyzes and discusses the results of the total sum rate at different cycles and speeds for an improved performance.

关键词： 4G/5G LTE-V D2D C-V2X resource allocation semipersistent

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Energetic processes regulating the strength of MJO circulation over the Maritime Continent during two types of El Ni?o

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Atmospheric and Oceanic Science Letters 2018年第2期11卷 112-119页

作者： HSU Pang-chi FU Zhen XIAO ting Key Laboratory of Meteorological Disaster of Ministry of Education Nanjing University of Information Science & Technology Nanjing China Joint International Research Laboratory of Climate and Environment Change Nanjing University of information Science &Technology Nanjing China Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of information Science & Technology Nanjing China Guangzhou Meteorological Observatory GuangzhouChina

The zonal shift of SST warming patterns associated with the eastern Pacific （EP） and central Pacific （CP） El Ni（n）o leads to a significant contrast in MJO strength over the Maritime *** MJO circulation tends to be stronger over the Maritime Continent during the mature phase （autumnwinter） of CP El Ni（n）o than of EP El Ni（n）*** on a new MJO kinetic energy （KE） budget equation,in which the effects of mean flow and high-frequency disturbances on the MJO are separated,we found that the low-level MJO gains more KE from the background mean flow during CP El Ni（n）o events,although at the same time the enhanced MJO transfers more KE to high-frequency *** the three-dimensional circulation anomalies,the low-level convergence and cyclonic anomalies associated with upward anomalies of the Walker circulation over the Maritime Continent play leading roles in inducing the enhanced barotropic energy conversion from mean flow to MJO during CP El Ni（n）o events relative to EP El Ni（n）o *** more vigorous MJO with strengthened vertical motion and heating anomalies at the upper troposphere can maintain its amplitude through the baroclinic energy conversion from the MJO available potential energy to *** the low-tomid tropospheric barotropic energy conversion from mean flow to MJO and upper-level baroclinic energy conversion contribute positively to the enhanced MJO over the Maritime Continent during CP El Ni（n）o years compared to during EP El Ni（n）o years.

关键词： MJO kinetic energy budget central Pacific and eastern Pacific El Ni(n)oscale interaction

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Fabrication method of ultra-small gradient-index fiber probe

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Advances in Manufacturing 2014年第4期2卷 327-332页

作者： chi Wang Fang Zhang Shu-Bo Bi Xue-Qin Xia ting-ting Xu Department of Precision Mechanical Engineering Shanghai University

Fabrication method and device of ultra-small gradient-index （GRIN） fiber probe were investigated in order to explore the development of ultra-small probes for optical coherence tomography （OCT） imaging. The beam- expanding effect of no-core fiber （NCF） and the focusing properties of the GRIN fiber lens were analyzed based on the model of GRIN fiber probe consisting of single-mode fiber （SMF）, NCF and GRIN fiber lens. A stereo micro- scope based system was developed to fabricate the GRIN fiber probe. A fiber fusion splicer and an ultrasonic cleaver were used to weld and cut the fiber respectively. A con- focal microscopy was used to measure the dimensions of probe components. The results show that the sizes of probe components developed are at the level of millimeter. Therefore, the proposed experimental system meets the fabrication requirements of an ultra-small self-focusing GRIN fiber probe. This shows that this fabrication device and method can be employed in the fabrication of ultra- small self-focusing GRIN fiber probe and applied in the study of miniaturized optical probes and OCT systems.

关键词： Optical coherence tomography (OCT) Gradient-index (GRIN) fiber probe GRIN fiber lens No-core fiber (NCF)

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Povacoat affecting solid-state polymorphic changes of indomethacin after co-evaporation from different types of solvents via conventional and microwave drying techniques

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Asian Journal of Pharmaceutical Sciences 2016年第3期11卷 376-384页

作者： Shan-Yang Lin Hong-Liang Lin Ying-ting chi Ru-Ying Hung Yu-ting Huang chi-Yu Kao Wei-Hsien Hsieh Department of Biotechnology and Pharmaceutical Technology Yuanpei University of Medical Technology

The effect of Povacoat on the solid state characteristics and polymorphic transformation of γ-form of indomethacin(γ-IMC) after solvent co-evaporation via two drying methods was investigated by thermoanalytical and FTIR spectroscopic studies. The types of solvents(water,ethanol, and water:ethanol(1:9 ～ 2:8, v/v)), weight ratios of Povacoat:IMC(4:1 ～ 4:10, w/w),and drying methods(air-drying and microwave-drying) were selected as variables in this study. A physical mixture of Povacoat and γ-IMC was also carried out by neat grinding *** results indicate that there was no interaction between Povacoat and γ-IMC or no polymorphic change of γ-IMC after the neat co-grinding process. Since Povacoat was only soluble in water or <30% ethanol aqueous solution but γ-IMC was only soluble in organic solvents,different solvents and drying methods might significantly influence the solid-state characteristics of IMC formed in the presence of Povacoat. It was found that the amorphous IMC was formed in the Povacoat/IMC evaporates after dissolving both Povacoat and γ-IMC in water:ethanol(mixed ratio=1:9 and 2:8, v/v) and co-evaporation via microwave-drying, whereas the α-IMC was formed in the Povacoat/IMC evaporates via the air-drying method. In addition, the predominate α-IMC formation was only found in all the Povacoat/IMC evaporates with different weight ratios prepared by previously dissolving in water:ethanol(1:9, v/v) and co-evaporation via air-drying, but the amorphous IMC formation after co-evaporation via microwave-drying was obtained except the 4:10(w/w) weight ratio. The thermal effect of microwave irradiation and the presence of Povacoat might be responsible for the amorphous IMC formation in the Povacoat/IMC evaporates.

关键词： Povacoat Indomethacin (IMC) Air-drying Microwave-drying α-IMC Amorphous IMC

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Cenozoic stratigraphy of Taiwan:Window into rifting,stratigraphy and paleoceanography of South china Sea

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chinese Science Bulletin 2012年第24期57卷 3130-3149页

作者： HUANG chi-Yue YEN Yi ZHAO QuanHong LIN chiou-ting Key Laboratory of Marginal Sea Geology Guangzhou Institute of Geochemistry Chinese Academy of Sciences Guangzhou 510640 China State Key Laboratory of Marine Geology School of Ocean and Earth Sciences Tongji University Shanghai 200092 China

Shallow marine sequences of the northern South china Sea (SCS) are uplifted and exposed by plate convergence in the Taiwan mountain belt. These deposits provide detailed geological information about the rifting event, stratigraphy, sedimentology, paleoclimate and paleoceanography of the shallow SCS to compare with what are recorded in the ODP 1148 deep-sea core. Seismic surveys and marine micropalentological studies show that Eocene sequences in the offshore Taiwan Strait and onland Taiwan mountain belt are all deposited in rifting basins and are covered unconformably by the Late Oligocene-Neogene post-rifting strata. Between syn-rifting and post-rifting sequences, there is a regional break-up unconformity throughout the island. Early Oligocene and Late Eocene strata are missing along the break-up unconformity equivalent to the T7 unconformity in the Pearl River Mouth Basin off south china. This may suggest that the SCS oceanic crust could have initiated between 33 and 39 Ma. Neither obvious stratigraphic gap nor slumping features are found in the Oligocene-Miocene transition interval of Taiwan. This observation highly contrasts with what has been documented from the ODP 1148 deep-sea core. This suggests that the stratigraphic gap and slumping features could only be recorded in the SCS deep sea region, but not in the shallow shelf near Taiwan. Compared to the Middle Miocene paleoceanographic re-organization events in the SCS deep sea, the geological history of the Taiwan shallow sequence shows changes of in sedimentation and faunal composition. Due to the Antarctic glacial expansion at^14 Ma, Middle to late Miocene strata of the Western Foothills show progressive regression sedimentations associated with a decrease of benthic foraminif-eral abundance and a sharp faunal turnover event. Many Early-Middle Miocene endemic benthic foraminifers were extinct in 14-13 Ma and new benthic foraminifers of the Kuroshio Current fauna appeared from 10.2 Ma, comparable with new oc

关键词：新生代地层中国南海台湾海峡古海洋学地层学裂谷底栖有孔虫中中新世

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Sulfite as the substrate of C-sulfonate metabolism ofα,β-unsaturated carbonyl containing andrographolide:analysis of sulfite in rats'intestinal tract and the reaction kinetics of andrographolide with sulfite

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chinese Journal of Natural Medicines 2021年第9期19卷 706-712页

作者： HUO Zhi-Peng FENG Xin-chi WANG Yu TIAN Yu-ting QIU Feng School of chinese Materia Medica and State Key Laboratory of Component-based Chinese MedicineTianjin University of Traditional Chinese MedicineTianjin 301617China ~TCM Research Center Tasly AcademyTasly Holding Group Co.Ltd.Tianjin 300402China State Key Laboratory of Critical Technology in Innovative chinese Medicine Tasly Pharmaceutical Co.Ltd.Tianjin 300402China Institute of Pharmacy China Pharmaceutical UniversityNanjing 210009China Institute of Pharmaceutical Science and Technology Tianjin UniversityTianjin 300072China

One-sixth of the currently known natural products containα,β-unsaturated carbonyl *** previous studies reported a rare C-sulfonate metabolic *** groups were linked to theβ-carbon ofα,β-unsaturated carbonyl-based natural compounds through this ***,the mechanism of this type of metabolism is still not fully understood,especially whether it is formed through enzyme-mediated biotransformation or direct sulfite *** this work,the enzyme-mediated and non-enzymatic pathways were ***,the sulfite content in rat intestine was determined by LC-MS/*** results showed that the amount of sulfite in rat intestinal contents was from 41.5 to 383μg·g^(-1),whereas the amount of sulfite in rat feed was lower than the lower limit of quantitation(20μg·g^(-1)).Second,the reaction kinetics of sulfite-andrographolide reactions in phosphate buffer solutions(pH 6-8)was *** half-lives of andrographolide ranged from minutes to *** was suggested that the C-sulfonate reaction of andrographolide was very ***,the C-sulfonate metabolites of andrographolide were both detected when andrographolide and L-cysteine-S-conjugate andrographolide were incubated with the rat small intestine contents or sulfite,indicating that the sulfite amount in rat intestine contents was high enough to react with andrographolide,which assisted a significant portion of andrographolide ***,the comparison of andrographolide metabolite profiles among liver homogenate(with NADPH),liver S9(with NADPH),small intestine contents homogenate(with no NADPH),and sulfite solution incubations showed that the C-sulfonate metabolites were predominantly generated in the intestinal tract by non-enzymatic *** summary,sulfite can serve as a substrate for C-sulfonate metabolism,and these results identified non-enzymatically nucleophilic addition as the potential mechanism for C-sulfonate metabolism of compounds containingα,β-unsaturated carbonyl moie

关键词： Sulfite C-Sulfonate metabolites α,β-Unsaturated carbonyl Reaction kinetics Andrographolide Non-enzymatic

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Wave Scattering by Twin Surface-Piercing Plates Over A Stepped Bottom:Trapped Wave Energy and Energy Loss

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china Ocean Engineering 2019年第4期33卷 398-411页

作者： DENG Zheng-zhi WANG Chen WANG chi YAO Yu OU Ze-ting WANG Li-xian Institute of Port Coastal and Offshore Engineering Zhejiang University Zhoushan 316021 China Nanjing Hydraulic Research Institute Nanjing 210029 China School of Hydraulic Engineering Changsha University of Science and Technology Changsha 410114 China Departments of Naval Architecture Ocean and Structural Engineering School of Transportation Wuhan University of Technology Wuhan 430063 China

To evaluate the trapped wave energy and energy loss, the problem of wave scattering by twin fixed vertical surface- piercing plates over a stepped bottom is numerically simulated using the open source package OpenFOAM and the associated toolbox waves2Foam. The volume of fluid (VOF) method was employed to capture the free surface in the time domain. The validation of the present numerical model was performed by comparing with both the analytical and experimental results. The effects of the spacing between two plates and the configuration of stepped bottom on the hydrodynamic characteristics, such as reflection and transmission coefficients, viscous dissipation ratio, and relative wave height between the plates (termed as trapped wave energy), were examined. Moreover, the nonlinear effects of the incident wave height on the hydrodynamic characteristics were addressed as well. The results show that the step configuration can be tuned for efficient-performance of wave damping, and the optimum configurations of the step length B, the step height h1 and the spacing b, separately equaling λ/4, 3h/4, and 0.05h (λ and h are the wavelength and the water depth, respectively), are recommended for the trapping of wave energy.

关键词： OpenFOAM twin surface-piercing plates viscous dissipation wave nonlinearity trapped wave energy

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