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Journal of Modern Power Systems and Clean Energy 2016年第4期4卷 542-553页

作者： Aagje J.h.van MEERWIJK RenéM.J.BENDERS Alejandro DAVILA-MARTINEZ gideon a.h.laugs IVEM(ESRIG) University of GroningenGroningenThe Netherlands

In order to cut greenhouse-gas emissions and increase energy security,the European Commission stimulates the deployment of intermittent renewable energy sources(IRES) towards *** an electricity system with high shares of IRES implemented in the network,energy balancing like storage is needed to secure grid stability and smooth demand *** hydro storage(PhS) is at this moment the best option for large scale *** has strong ambitions to further develop their PhS sector and become the battery of *** this research,the potential of the Swiss PSh plants is explored,whilst taking inflow into the upper reservoirs of the PhS plants into *** simulate electricity imbalance,Germany is used as a case *** already has a high penetration of IRES and has plans to increase installed IRES *** using an energy planning model(Power Plan),three future scenarios of the German electricity system were designed,each with a different set of IRES installed(solar,mixed and wind).Results show that the Swiss battery ambition offers most benefits to a wind-oriented scenario,reducing both shortages as well as *** inflow in Swiss PhS-reservoirs is of minor importance when looking at security of supply,although it was shown that the solarscenario profits more from inflow in terms of system ***,a potential conflict was observed in the solar-scenario between the need for electricity storage and the storage of natural inflow,resulting in more surpluses in the system when inflow was taken into account.

关键词： Pumped hydro storage(PhS) Local hydrology Germany Switzerland Intermittent renewable energy sources(IRES) Scenarios

Antigen presentation,autoantibody production,and therapeutic targets in autoimmune liver disease

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Cellular & Molecular Immunology 2021年第1期18卷 92-111页

作者： Andrea Kristina horst Kingsley gideon Kumashie Katrin Neumann Linda Diehl Gisa Tiegs Institute of Experimental Immunology and hepatology University Medical Center Hamburg-EppendorfMartinistraBe 52D-20251 HamburgGermany hamburg Center for Translational Immunology University Medical Center Hamburg-EppendorfMartinistraBe 52D-20251 HamburgGermany

The liver is an important immunological organ that controls systemic *** liver harbors professional and unconventional antigen-presenting cells that are crucial for tolerance induction and *** the immune response in homeostasis depends on a healthy and well-toned immunological liver microenvironment,which Is maintained by the crosstalk of liver-resident antigen-presenting cells and intrahepatic and liver-infiltrating *** response to pathogens or autoantigens,tolerance is disrupted by unknown *** parenchymal and nonparenchymal cells exhibit unique antigen-presenting *** presentation of microbial and endogenous lipid-,metabolite-and peptide-derived antigens from the gut via conventional and nonconventional mechanisms can educate intrahepatic immune cells and elicit effector responses or *** of this balance results in autoimmune liver diseases,such as autoimmune hepatitis,primary biliary cholangitis,and primary sclerosing *** the exact etiologies of these autoimmune liver diseases are unknown,it is thought that the disruption of tolerance towards self-antigens and microbial metabolites and lipids,as well as alterations in bile acid composition,may result in changes in effector cell activation and polarization and may reduce or impair protective antiinflammatory regulatory T and B cell ***,the canonical and noncanonical transmission of antigens and antigen:MhC complexes via trogocytosis or extracellular vesicles between different(non)immune cells in the liver may play a role in the induction of hepatic inflammation and ***,we summarize emerging aspects of antigen presentation,autoantibody production,and the application of novel therapeutic approaches in the characterization and treatment of autoimmune liver diseases.

关键词： liver tolerance autoimmune liver disease antigen presentating cell

Development of a Test Program for Assessing the SCC, Pitting and Crevice Corrosion Behaviour of Selected Corrosion Resistant Alloy Liner Materials for Clad Pipe for Offshore Applications

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Journal of Mechanics Engineering and Automation 2013年第12期3卷 778-784页

作者： Barry gideon Liam Ward Corrmet Limited Perth 6000 Western Australia Australia Environmental and Chemical Engineering RMIT University Melbourne 3001 Australia

The development of an offshore gas field involves production of oil and gas from subsea wells. Design considerations for a particular subsea system have identified the maximum temperature for operations which is greater than 130 ~C. Consequently, for large diameter flowlines, this precludes the use of duplex stainless steels as CRA＇s （corrosion resistant alloys） for service under the expected operating conditions. Attention has therefore focused on alternative CRA＇s such as austenitic stainless steels and Ni based alloys as mechanically clad or lined clad pipe for carbon steel subsea gas flowlines. One design concern is the recognized temperature limit for CRA materials, such as 316L stainless steel and similar alloys in production fluids is taken to be 120 ~C. This then raises concerns surrounding their suitability for providing sufficient corrosion resistance/stress corrosion cracking resistance in gas environments containing COz and h2S at temperatures higher than 130 ~C. It was recommended that specific testing should be completed at temperatures greater than 133 ~C to establish that candidate materials are still corrosion resistant. The focus of this study was to develop, implement and assess a testing program that would predict the suitability of a series of CPA＇s alloys for use in mechanical clad/lined subsea gas flowlines, with respect to pitting corrosion, crevice corrosion and stress corrosion cracking. This paper will present the rationale adopted for this testing program to simulate the stringent operating conditions, the results from these findings and the overall assessment/integrity of the candidate alloys selected.

关键词： Stress corrosion cracking crevice corrosion pitting corrosion corrosion resistant alloy.

Forensic isoscapes based on intra-individual temporal variation of δ^(18)O and ^(206)Pb/^(207)Pb in human teeth

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Forensic Sciences Research 2021年第1期6卷 42-52页

作者： Laura A.Regan Nathan W.Bower Samuel J.Brown Craig C.Lundstrom gideon Bartov Matthew D.Cooney Office of Net Assessment Department of DefenseWashingtonDCUSA Chemistry and Biochemistry Department Colorado CollegeColorado SpringsCOUSA Geology Department University of IllinoisUrbanaILUSA Information Technology Services Colorado CollegeColorado SpringsCOUSA

Isotopic signatures used in the georeferencing of human remains are largely fixed by spatially distinct geologic and environmental ***,location-dependent temporal changes in these isotope ratios should also be considered when determining an individual’s provenance and/or *** of the relevant isotopes can be impacted by predictable external factors such as climate change,delocalisation of food and water sources and changes in sources and uses of *** Multi-Collector Inductively-Coupled Plasma Mass Spectrometer(MC-ICP-MS)analyses of ^(206)Pb/^(207)Pb in tooth enamel and dentin from a population of 21±1-year-old individuals born circa 1984 and isotope ratio mass spectrometry(IRMS)of δ^(18)O in their enamel,we examined the expected influence of some of these *** resulting adjustments to the geographic distribution of isotope ratios(isoscapes)found in tooth enamel and dentin may contain additional useful information for forensic identification,but the shifts in values can also impact the uncertainty and usefulness of identifications if they are not taken into account.

关键词： Forensic sciences dentin enamel environmental geolocation isoscape radiogenic and stable isotopes

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妊娠期水痘感染的处理

中国产前诊断杂志（电子版） 2012年第2期4卷 37-41页

作者： Alon Shrim gideon Koren Mark h. Yudin Dan Farine 李焱焱 SOGC

目的回顾妊娠期水痘带状疱疹病毒感染(水痘)减少产妇并发症和胎儿感染的干预措施以及产前和围产期管理的现有数据。方法回顾水痘带状疱疹病毒感染的母婴结局。比较不同治疗方式对改善母婴后遗症的效果。证据来源在Medline上检索了1970年... 详细信息

目的回顾妊娠期水痘带状疱疹病毒感染(水痘)减少产妇并发症和胎儿感染的干预措施以及产前和围产期管理的现有数据。方法回顾水痘带状疱疹病毒感染的母婴结局。比较不同治疗方式对改善母婴后遗症的效果。证据来源在Medline上检索了1970年1月至2010年11月期间在英国发表的文献和临床指南。价值根据加拿大预防保健专责小组报告(Report of the Canadian Task Force on Preventive health Care)的标准评定证据质量等级。根据该报告中描述的方法(见表)依次列出临床实践中的以下建议。

关键词：水痘疫苗妊娠期水痘带状疱疹病毒干预措施免疫球蛋白阿昔洛韦感染症胎儿感染预防保健孕妇

Evading the host response:Staphylococcus“hiding”in cortical bone canalicular system causes increased bacterial burden

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Bone Research 2020年第4期8卷 447-457页

作者： Stephen D.Zoller Vishal hegde Zachary D.C.Burke howard Y.Park Chad R.Ishmael gideon W.Blumstein William Sheppard Christopher hamad Amanda h.Loftin Daniel O.Johansen Ryan A.Smith Marina M.Sprague Kellyn R.hori Samuel J.Clarkson Rachel Borthwell Scott I.Simon Jeff F.Miller Scott D.Nelson Nicholas M.Bernthal Department of Orthopedic Surgery University of CaliforniaLos Angeles125016th St Suite 2100Santa MonicaCA 90404USA David Geffen School of Medicine University of CaliforniaLos Angeles10833 Le Conte AveLos AngelesCA 90095USA Department of Internal Medicine University of CaliforniaLos Angeles757 Westwood PlazaSuite 7501Los AngelesCA 90095USA Department of Biomedical Engineering University of CaliforniaDavisDavisCA 95616USA California NanoSystems Institute University of CaliforniaLos Angeles570 Westwood PlazaLos AngelesCA 90095USA Department of Microbiology Immunologyand Molecular GeneticsDavid Geffen School of MedicineUniversity of CaliforniaLos Angeles 90095USA Department of Pathology University of CaliforniaLos Angeles125016th St Suite 3450Santa MonicaCA 90404USA

Extremity reconstruction surgery is increasingly performed rather than amputation for patients with large-segment pathologic bone *** persists as to the optimal void filler for this“limb salvage”surgery,whether metal or allograft *** focus on optimizing important functional gains for patients,and the risk of devastating implant infection has been thought to be similar regardless of implant *** insights into infection pathophysiology are challenging this equipoise,however,with both basic science data suggesting a novel mechanism of infection of Staphylococcus aureus(the most common infecting agent)into the host lacunar–canaliculi network,and also clinical data revealing a higher rate of infection of allograft over *** current translational study was therefore developed to bridge the gap between these insights in a longitudinal murine model of infection of allograft bone and ***-time Staphylococci infection characteristics were quantified in cortical bone vs metal,and both microarchitecture of host implant and presence of host immune response were *** orders-of-magnitude higher bacterial burden was established in cortical allograft bone over both metal and cancellous *** establishment of immune-evading microabscesses was confirmed in both cortical allograft haversian canal and the submicron canaliculi network in an additional model of mouse femur bone *** study results reveal a mechanism by which Staphylococci evasion of host immunity is possible,contributing to elevated risks of infection in cortical *** presence of this local infection reservoir imparts massive clinical implications that may alter the current paradigm of osteomyelitis and bulk allograft infection treatment.

关键词： immunity insight reservoir

Risk factors for impaired glucose tolerance in obese children and adolescents

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World Journal of Diabetes 2010年第4期1卷 129-134页

作者： Michaela Kleber gideon de Sousa Sophie Papcke Thomas Reinehr Vestische hospital for Children and Adolescents University of Witten/Herdecke hospital for Children and Adolescents

AIM:To investigate which obese children have an increased risk for impaired glucose tolerance(IGT),a risk factor for later ***:We studied 169 European untreated obese children and adolescents with normal glucose tolerance at *** circumference,fasting glucose,lipids,blood pressure,pubertal stage,2 h glucose in oral glucose tolerance test(oGTT),and hbA1c were deter mined at baseline and 1 year ***:One year after baseline,19(11.2) children demonstrated IGT,4(2.4) children had impaired fas ting glucose,no(0) child suffered from diabetes,and 146(86) children still showed normal glucose *** baseline,the children with IGT and with normal glucose tolerance in a one-year follow-up did not differ significantly in respect of any analyzed parameter,apart from pubertal *** children developing IGT entered puberty significantly more frequently(37 vs 3,P he childr en with IGT demonstrated significantly increased waist circumference,blood pressure values,insulin and triglyceride concentrations,and insulin resistance index *** children remaining in the normal glucose tolerance status 1 year after baseline did not demonstrate any significant ***:During the study period of 1 year,more than 10 of the obese children with normal glucose tolerance converted to *** screening with oGTT seems meaningful in obese children entering puberty or demonstrating increased insulin resistance,waist circumference,blood pressure,or triglyceride concen trations.

关键词： Impaired glucose tolerance Risk factors Lipids Blood pressure Pubertal stage Waist circumference

Assessment of d ifferent f ormalin c oncentrations on the h istochemical s taining of l iver,k idneys and l ungs of Wistar r ats

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Toxicology Advances 2023年第3期5卷 22-27页

作者： gideon Taiwo Oluwaloye Ochuko Fortunate Jenakevwe Kenneth Chukwudi Onyegbula Julius Kayode Bankole Seyi Samson Enitan Department of Medical Laboratory Science Babcock UniversityIlisan-Remo121103Ogun StateNigeria Department of Biomedical Laboratory Science University of IbadanIbadan200005Oyo StateNigeria Department of Medical Laboratory Science Ambrose Alli UniversityEkpoma310006Edo StateNigeria

Background:Formaldehyde is a chemical substance used to preserve the biochemical and physiological components of a tissue by preventing autolysis and putrefaction,leaving the tissue in a life-like ***:This study aims to assess the effect of formalin concentrations on the histochemical staining in liver,kidneys and lungs of Wistar ***:A total of ten(10)Wistar rats were purchased and allowed to acclimatize for a period of 2 weeks in plastic cages with iron netting at the Animal house facility,Babcock *** animals were placed on standard rat feeds and water *** rats were randomly sacrificed by cervical dislocation,following mild anaesthesia using chloroform *** histological examination,the liver,lungs,and kidneys of Wistar rats were removed and preserved in neutral buffered formalin at 2%,4%,6%,8%,and 10%*** were stained in haematoxylin and Eosin(Vector Laboratories,***,US).The quality of the nuclei,cytoplasm and cell membrane were graded on a scale of 1(poor)to 5(excellent).Results:Six percent(6%)formalin was observed to produce excellent results in liver tissues with a total grade of sixteen(16).10%formalin produced excellent results in lung tissues with a total grade or nineteen(19).Interestingly,2%,6%and 10%formalin concentrations produced excellently results in kidney tissues with the highest total grade fourteen(14).Conclusion:This study concludes that 6%formalin produced better section and staining qualities more than the commonly used 10%formalin according to the observations from the stained *** implies that the concentration of formalin affects the histochemical staining in liver,kidneys and lungs of Wistar rats.

关键词： fixation kidney liver lungs neutral buffered formalin Wistar rats

2015年辽宁省阜新蒙古族自治县贾家沟西遗址试掘报告

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边疆考古研究 2019年第1期 53-76页

作者：吉迪滕铭予 Yonaton GOLDSMITh 苏军强 Ofer MARDER 涂栋栋 Roi ShAVIT 向明文 Keren NEBENhAUS 马志坤陈秋荷杨晓燕 Chris J.Stevens Dorian Q.Fuller 耶路撒冷希伯来大学耶路撒冷91000 吉林大学长春130012 加州理工学院帕萨迪纳10-90 辽宁省文物考古研究所沈阳110003 本·古里安大学贝尔谢巴84001 西北大学文化遗产学院文化遗产研究与保护技术教育部重点实验室西安710069 中国科学院地理科学与资源研究所中国科学院陆地表层格局与模拟院重点实验室北京100101 中国科学院大学北京100049 中国科学院青藏高原研究所中国科学院高寒生态重点实验室北京100101 中国科学院青藏高原地球科学卓越创新中心北京100101 伦敦大学院大学考古研究所伦敦WC1H0AL

农业与定居生活方式的起源和发展不仅彻底改变了人类的生存策略、饮食方式和生活条件,而且加速了社会复杂化的进程。研究这一过程,对于理解世界范围内人类社会的发展具有非常重要的意义。作为世界上农业独立起源与发展的中心之一,中国... 详细信息

农业与定居生活方式的起源和发展不仅彻底改变了人类的生存策略、饮食方式和生活条件,而且加速了社会复杂化的进程。研究这一过程,对于理解世界范围内人类社会的发展具有非常重要的意义。作为世界上农业独立起源与发展的中心之一,中国尚不能建立从狩猎采集社会到农业社会的详细轨迹。自2012年起,吉林大学和辽宁省文物考古研究所合作开展了"中国东北地区农业与定居的起源"项目。项目组以查海遗址为基点,在其东部进行了两个季度的区域性田野考古调查工作,调查面积为104.46平方千米,不仅初步勾勒出该地区从新石器时代早期至汉代的聚落形态变化,还采集到大量的细石器和早期陶片,为探讨该地区农业起源问题提供了丰富的资料[1]。

关键词：小河西文化石磨棒植硅体淀粉粒分析阜新蒙古族自治县

2015年辽宁省阜新蒙古族自治县塔尺营子遗址试掘报告

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边疆考古研究 2019年第1期 1-52页

作者：滕铭予吉迪苏军强 Ido WAChTEL Ahiad OVADIA Ofer MARDER 涂栋栋 Roi ShAVIT 马志坤陈秋荷杨晓燕 Chris J.Stevens Dorian Q.Fuller 王震王争王欢向明文崔嵩姚崇 hagit PRIGOJIN Tiki STEINER Keren NEBENhAUS 刘西平吉林大学长春130012 耶路撒冷希伯来大学耶路撒冷91000 辽宁省文物考古研究所沈阳110003 本·古里安大学贝尔谢巴84001 西北大学文化遗产学院文化遗产研究与保护技术教育部重点实验室西安710069 中国科学院地理科学与资源研究所中国科学院陆地表层格局与模拟院重点实验室北京100101 中国科学院大学北京100049 中国科学院青藏高原研究所中国科学院高寒生态重点实验室北京100101 中国科学院青藏高原地球科学卓越创新中心北京100101 英国伦敦大学院大学考古研究所伦敦WC1H0AL 阜新市文物管理办公室阜蒙县博物馆美国匹兹堡大学

自2012年起,吉林大学和辽宁省文物考古研究所合作开展了"中国东北地区农业与定居的起源"项目,在阜新查海遗址的东部地区进行了区域性田野考古调查[1]。2015年,为了进一步了解阜新地区新石器时代不同阶段古代居民的经济生活,在前期进行... 详细信息

自2012年起,吉林大学和辽宁省文物考古研究所合作开展了"中国东北地区农业与定居的起源"项目,在阜新查海遗址的东部地区进行了区域性田野考古调查[1]。2015年,为了进一步了解阜新地区新石器时代不同阶段古代居民的经济生活,在前期进行的区域性田野考古调查工作的基础上,选择了贾家沟西遗址(田野调查时遗址编号为12D56)和塔尺营子遗址(田野调查时遗址编号为12D16)进行了试掘。本文是塔尺营子遗址的试掘报告。

关键词：兴隆洼文化植硅体分析附加堆纹阜新蒙古族自治县