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Functional role of circRNA CHRC through miR-431-5p/KLF15 signaling axis in the progression of heart failure

Journal of Genetics and Genomics 2024年第8期51卷 844-854页

作者： yi Hu Huaming Cao Jie Sheng yizhuo Sun Yuping Zhu Qin Lin Na yi Siyu He Luying Peng Li Li State Key Laboratory of Cardiology and medical Innovation Center Shanghai East HospitalTongji University School of MedicineShanghai 200120China Shanghai Arrhythmias Research Center Shanghai East HospitalTongji University School of MedicineShanghai 200120China Laboratory of molecular Genetics and Stem Cell Differentiation Tongji University School of MedicineShanghai 200120China Department of Cardiology Shanghai Shibei HospitalShanghai 200435China Research Units of Origin and Regulation of Heart Rhythm Chinese Academy of Medical SciencesShanghai 200120China

Pathological myocardial hypertrophy is a common early clinical manifestation of heart failure,with noncoding RNAs exerting regulatory ***,the molecular function of circular RNAs(circRNAs)in the progression from cardiac hypertrophy to heart failure remains *** uncover functional circRNAs and identify the core circRNA signaling pathway in heart failure,we construct a global triple network(microRNA,circRNA,and mRNA)based on the competitive endogenous RNA(ceRNA)*** observe that cardiac hypertrophy-related circRNA(circRNA CHRC),within the ceRNA network,is down-regulated in both transverse aortic constriction mice and Ang-II--treated primary mouse *** circRNA CHRC increases cross-sectional cell area,atrial natriuretic peptide,andβ-myosin heavy chain levels in primary mouse *** screening shows that circRNA CHRC targets the miR-431-5p/KLF15 axis implicated in heart failure progression in vivo and in *** with anti-Ago2-RNA confirms the interaction between circRNA CHRC and miR-431-5p,while miR-431-5p mimics reverse Klf15 activation caused by circRNA CHRC *** summary,circRNA CHRC attenuates cardiac hypertrophy via sponging miR-431-5p to maintain the normal level of Klf15 expression.

关键词： circRNA CHRC Heart failure CeRNA miR-431-4p KIf15

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Grain boundary engineering for enhancing intergranular damage resistance of ferritic/martensitic steel P92

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Nuclear Science and Techniques 2024年第5期35卷 186-199页

作者： Lei Peng Shang-ming Chen Jing-yi Shi Yong-Jie Sun yi-Fei Liu yin-Zhong Shen Hong-Ya He Hui-Juan Wang Jie Tian State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China School of materials Engineering Shanghai University of Engineering Science333 Long Teng RoadShanghai 201620China Experimental Center of Engineering and material Science University of Science and Technology of ChinaHefei 230026China

Ferritic/martensitic(F/m)steel is widely used as a structural material in thermal and nuclear power ***,it is susceptible to intergranular damage,which is a critical issue,under service *** this study,to improve the resistance to intergranular damage of F/m steel,a thermomechanical process(TmP)was employed to achieve a grain boundary engineering(GBE)microstructure in F/m steel *** TmP,including cold-rolling thickness reduction of 6%,9%,and 12%,followed by austenitization at 1323 K for 40 min and tempering at 1053 K for 45 min,was applied to the as-received(AR)P92 *** prior austenite grain(PAG)size,prior austenite grain boundary character distribution(GBCD),and connectivity of prior austenite grain boundaries(PAGBs)were *** to the AR specimen,the PAG size did not change *** fraction of coincident site lattice boundaries(CSLBs,3≤Σ≤29)and Σ3^(n) boundaries along PAGBs decreased with increasing reduction ratio because the recrystallization fraction increased with increasing reduction *** PAGB connectivity of the 6%deformed specimen slightly deteriorated compared with that of the AR ***,potentiodynamic polarization studies revealed that the intergranular damage resistance of the studied steel could be improved by increasing the fraction of CSLBs along the PAGBs,indicating that the TmP,which involves low deformation,could enhance the intergranular damage resistance.

关键词： Grain boundary engineering Ferritic/martensitic steel Prior austenite grain boundary character distribution Grain boundary connectivity Intergranular damage resistance

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Persistent organic pollutants and chemicals of emerging Arctic concern in the Arctic environment

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Environmental Science and Ecotechnology 2024年第2期18卷 1-3页

作者： yi-Fan Li Roland Kallenborn Zifeng Zhang International Joint Research Center for Persistent Toxic Substances(IJRC-PTS) State Key Laboratory of Urban Water Resource and EnvironmentHarbin Institute of TechnologyHarbin 150090China International Joint Research Center for Arctic Environment and Ecosystem(IJRC-AEE) Polar AcademyHarbin Institute of Technology(PA-HIT)Harbin 150090China Heilongjiang Provincial Key Laboratory of Polar Environment and Ecosystem(HPKL-PEE) Harbin 150090China IJRC-PTS-NA TorontoONM2J 3N8Canada Faculty of Chemistry Biotechnology and Food Sciences(KBM)Norwegian University of Life Sciences(NMBU)NOe1433 AsNorway

Environmental pollutants,such as persistent organic pollutants(POPs),enter the Arctic mainly via long-range transport(LRT)through atmospheric and ocean/river *** the other hand,chemicals of emerging Arctic concern(CEACs)are often introduced as local contaminants from industrial,municipal,or infrastructure-related *** of their origins,all these contaminants negatively impact the health of the environment and the indigenous ***,in recent decades,the Arctic has been experiencing unprecedented climate *** combination of Arctic environmental changes and the introduction of new anthropogenic contaminants as chemical aids for exploiting Arctic resources led to a severe imbalance in the Arctic ***,an international consortium of Arctic experts asked for internationally coordinated actions to mitigate the serious problems that environmental pollution causes on Arctic ecosystems and people,according to the Berlin statement[1].

关键词： Arctic statement pollution

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Dynamic control of district heating networks with integrated emission modelling:A dynamic knowledge graph approach

Energy and AI

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Energy and AI 2024年第3期17卷 29-47页

作者： markus Hofmeister Kok Foong Lee yi-Kai Tsai magnus müller Karthik Nagarajan Sebastian mosbach Jethro Akroyd markus Kraft Department of Chemical Engineering and Biotechnology University of CambridgePhilippa Fawcett DriveCambridgeCB30ASUnited Kingdom Cambridge Centre for Advanced Research and Education in Singapore CARES Ltd.1 Create WayCREATE Tower#05-05138602Singapore CmCL Innovations Sheraton HouseCambridgeCB30AXUnited Kingdom The Alan Turing Institute 96 Euston RoadLondonNW12DBUnited Kingdom

This paper presents a knowledge graph-based approach for the dynamic control of a district heating network with integrated emission dispersion modelling. We propose an interoperable and extensible implementation to forecast the anticipated heat demand of a municipal heating network, minimise associated total generation cost based on a previously devised methodology, and couple it with dispersion simulations for induced airborne pollutants to provide automatic insights into air quality implications of various heat sourcing strategies. We create cross-domain interoperability in the nexus of energy and air quality via newly developed ontologies and semantic software agents, which can be chained together via The World Avatar dynamic knowledge graph to resemble the behaviour of complex systems. Furthermore, we integrate the City Energy Analyst into this ecosystem to provide building-level insights into energy demand and renewable generation potential to foster strategic analyses and scenario planning. Underlying calculations use building and weather data from the knowledge graph in place of inherent assumptions in the official software release, facilitating a more data-driven approach. All use cases are implemented for a mid-size town in Germany as a proof-of-concept, and a unified visualisation interface is provided, allowing for the examination of 3D buildings alongside their corresponding energy demand and supply time series, as well as emission dispersion data. With this work, we outline the potential of Semantic Web technologies to connect digital twins for holistic energy modelling in smart cities, thereby addressing the increasing complexity of interconnected energy systems.

关键词： Knowledge graph Digital twin Inter operability Energy modelling Emi ssion dispersi on

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Exercise-induced adaptation of neurons in the vertebrate locomotor system

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Journal of Sport and Health Science 2024年第2期13卷 160-171页

作者： Yue Dai yi Cheng Renkai Ge Ke Chen Liming Yang Key Lab of Adolescent Health Assessment and Exercise Intervention of ministry of Education College of Physical Education and Health CareEast China Normal UniversityShanghai 200241China Shanghai Key Laboratory of multidimensional Information Processing School of Communication and Electronic EngineeringEast China Normal UniversityShanghai 200241China School of Physical Education and Health Care East China Jiaotong UniversityNanchang 330013China Key Laboratory of High Confidence Software Technologies of ministry of Education School of Computer SciencePeking UniversityBeijing 100871China

Vertebrate neurons are highly dynamic cells that undergo several alterations in their functioning and physiologies in adaptation to various external *** particular,how these neurons respond to physical exercise has long been an area of active *** of the vertebrate locomotor system’s adaptability suggest multiple mechanisms are involved in the regulation of neuronal activity and properties during *** this brief review,we highlight recent results and insights from the field with a focus on the following mechanisms:(a)alterations in neuronal excitability during acute exercise;(b)alterations in neuronal excitability after chronic exercise;(c)exercise-induced changes in neuronal membrane properties via modulation of ion channel activity;(d)exercise-enhanced dendritic plasticity;and(e)exercise-induced alterations in neuronal gene expression and protein *** hope is to update the community with a cellular and molecular understanding of the recent mechanisms underlying the adaptability of the vertebrate locomotor system in response to both acute and chronic physical exercise.

关键词： Dendritic plasticity Excitability Exercise Ion channel modulation Neuron adaptation

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Ignition and Lean Blowout Characteristics of a Reverse-Flow Combustor for an Ultra-Compact Gas Turbine Engine

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Journal of Thermal Science 2024年第5期33卷 1897-1906页

作者： JIN yi HUANG Yakun YAO Kanghong ZHANG Kai WANG Yunbiao WANG Donghao College of Energy and Power Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China National Key Laboratory of Transient Physics Nanjing University of Science and TechnologyNanjing 210094China Low-carbon Aerospace Power Engineering Research Center of ministry of Education Nanjing 210016China

The flame stability limit and propagation characteristics of a reverse-flow combustor without any flame-stabilized device were experimentally investigated under room temperature and *** results indicate that it is feasible to stabilize the flame in the recirculation zones constructed by the impact jet flow from the primary holes and dilution *** flame projected area is mainly distributed in the recirculation zone upstream of the primary holes,whose presence and absence mark the ignition and *** the ignition process,the growth rate and value of the flame projected area first increase and then decrease with the inlet velocity increasing from 9.4 m/s to 42.1 m/s.A rapid reduction followed by a slow reduction of ignition and lean blowout equivalence ratios is achieved by the increased inlet *** the non-reacting fluid structure in three sections was measured,and detailed velocity profiles were analyzed to improve the understanding of the flame stabilization *** results are conducive to the design of an ultra-compact combustor.

关键词： ultra-compact combustor gas turbine reverse-flow combustor ignition lean blowout

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Visualisation and Heat Transfer Performance of mini-Channel Flat Heat Pipe with a Binary mixture

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Journal of Thermal Science 2024年第5期33卷 1712-1725页

作者： FAN Gaoting TANG Aikun CAI Tao SHAN Chunxian PAN Jun JIN yi School of Energy and Power Engineering Jiangsu UniversityZhenjiang 212013China Jiangsu Jinhe Energy Technology Co.Ltd Zhenjiang 212400China

To unravel the intricacies of two-phase gas-liquid flow characteristics and heat transfer behavior,an array mini-channel gravity plate heat pipe(AmGPHP)is proposed in this work,which allows for observing the internal changes in the state of the working *** flow patterns such as pool flow,columnar flow,and slug flow,are experimentally explored and analyzed in *** is found that the optimal volume fill ratio is 20%by utilizing start-up time and thermal resistance as performance evaluation *** this fill ratio,a medium optimization strategy by blending ethanol within R141b is proposed and *** comparison to pure working fluids,the heat transfer performance of AmGFHP in the binary fluid has been significantly augmented due to temperature and concentration shifts resulting from disparate boiling *** the 10%volume fraction ethanol blending condition,the equivalent thermal conductivity of the heat pipe is dramatically elevated,with a value of 3110 W/(m·℃),along with the reduction of the minimum start-up power to 4 *** general,applying such a medium to heat pipes has considerable potential in practical applications.

关键词： flat heat pipe mini-channel visualisation two-phase flow binary mixtures thermal performance

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Conceptual design of a 714-mHz RFQ for compact proton injectors and development of a new tuning algorithm on its aluminium prototype

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Nuclear Science and Techniques 2024年第1期35卷 45-58页

作者： yi-Xing Lu Wen-Cheng Fang Yu-Sen Guo Zhen-Tang Zhao Shanghai Institute of Applied Physics Chinese Academy of Sciences Shanghai 201800China University of Chinese Academy of Sciences Beijing 101408China Shanghai Advanced Research Institute Chinese Academy of Sciences Shanghai 201204China Shanghai Key Laboratory of Cryogenics&Superconducting RF Technology Shanghai 201800China ShanghaiTech University Shanghai 201210China

Radio frequency quadrupoles(RFQs),which are crucial components of proton injectors,significantly affect the performance of proton accelerator *** RFQ with a high frequency of 714 mHz dedicated to compact proton injectors for medi-cal applications is designed in this *** RFQ is designed to accelerate proton beams from 50 keV to 4 meV within a short length of 2 m and can be matched closely with the downstream drift tube linac to capture more particles through a preliminary *** develop an advanced RFQ,challenging techniques,including fabrication and tuning method,must be evaluated and verified using a *** aluminium prototype is derived from the conceptual design of the RFQ and then redesigned to confirm the radio frequency performance,fabrication procedure,and feasibility of the tuning ***,a new tuning algorithm based on the response matrix and least-squares method is developed,which yields favorable results based on the prototype,i.e.,the errors of the dipole and quadrupole components reduced to a low level after several tuning *** from the conceptual design and techniques obtained from the prototype,the formal mechanical design of the 2-m RFQ is ready for the next manufacturing step.

关键词： Compact proton injector RFQ IH-DTL High gradient Tuning

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Heteroatom anchors Fe-mn dual-atom catalysts with bi-functional oxygen catalytic activity for low-temperature rechargeable flexible Zn-air batteries

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Journal of Energy Chemistry 2024年第3期90卷 610-620,I0014页

作者： Yuting He Hongtao Li yi Wang Yufei Jia Yongning Liu Qiang Tan State Key Laboratory for mechanical Behaviour of materials School of Materials Science&EngineeringXi’an Jiaotong UniversityXi’an 710049ShaanxiChina

m-N-C(m=Fe,Co,Ni,etc.) catalyst owns high catalytic activity in the oxygen catalytic reaction which is the most likely to replace the Pt-based *** it is still a challenge to further increase the active site *** article constructs the high-efficiency Femn-N/S-C-1000 catalyst to realize ORR/OER bifunctional catalysis by hetero-atom,bimetal(Fe,mn) doped simultaneously *** evaluated it as bi-functional electro-catalysts,Femn-N/S-C-1000 exhibits excellent catalytic activity(E_(1/2)=0.924 V,E_(j=10)=1.617 V) in alkaline media,outperforms conventional Pt/C,RuO_(2) and most non-precious-metal catalysts reported recently,Such outstanding performance is owing to N,S co-coordinated with metal to form multi-types of single atom,dual atom active sites to carry out ***,nitrite poison test provides the proof that the active sites of Femn-N/S-C are more than that of single-atom catalysts to promote catalytic reactions *** better understand the local structure of Fe and mn active sites,XAS and DFT were employed to reveal that Femn-N_5/S-C site plays the key role during ***,the Femn-N/S-C-1000 based low-temperature rechargeable flexible Zn-air also exhibits superior discharge performance and extraordinary durability at-40℃.This work will provide a new idea to design diatomic catalysts applied in low-temperature rechargeable batteries.

关键词： Fe mn-N/S-C-1000 ORR OER Rechargeable flexible Zn-air batteries

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Tribological and Corrosion Properties of the CoCrAlYTaSiC-xCNTs Coatings Deposited by Laser Cladding

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Acta metallurgica Sinica(English Letters) 2024年第4期37卷 726-738页

作者： Hai Zhao yi Ding Wei Gao Bo Yu Jinghui Li mingya Zhang School of material Science and Engineering Anhui University of TechnologyMaanshan243002China maanshan Iron&Steel Co. LtdMaanshan243000China Applied Technology Research Institute Jiujiang Vocational UniversityJiujiang332000China School of metallurgical Engineering Anhui University of TechnologyMaanshan243002China

The mCrAlY coating has been potential candidate for the parts applied in friction and corrosion conditions, and CNTs (carbon nanotubes) are expected to improve the service performance of coatings owing to high lubrication and low chemical reactivity. In this work, a systematic investigation on the tribological and corrosion properties of CoCrAlYTaSiC-xCNTs coatings deposited by laser melting was analyzed. Results showed that the coatings had good-quality without typical metallurgical defects. The CNTs addition homogenized and refined the microstructure of coating, and also improved the tribological and corrosion properties. As the CNTs content changed from 0 to 4 wt%, the wear rate of coating decreased from 16.23 × 10^(-3) to 7.58 × 10^(-3) mg m^(−1), the jcorr of coating decreased from 4.13 × 10^(-4) to 1.23 × 10^(-4) A cm^(−2), and the Rct values increased from 12.69 to 25.07 Ω cm2.

关键词： mCrAlY coating Laser melting deposition Friction Electrochemical corrosion

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