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Multidisciplinary approach to suspected sudden unexpected infant death caused by milk-aspiration:A case report

World Journal of Clinical Cases 2020年第18期8卷 4128-4134页

作者： Aniello Maiese Raffaele La Russa Mauro Arcangeli gianpietro volonnino Alessandra De Matteis Paola Frati Vittorio Fineschi Department of Surgical Pathology MedicalMolecular and Critical AreaInstitute of Legal MedicineUniversity of PisaPisa 56126Italy Department of Anatomy HistologyForensic Medicine and OrthopedicsSapienza University of RomaRoma 00185Italy Department of Life Health and Environmental SciencesUniversity of L'AquilaL'Aquila 67100Italy Department SAIMLAL Sapienza University of RomaRoma 00185Italy

BACKGROUND The term sudden unexpected infant death(SUID)is not always properly *** refers to a broad range of conditions that sometimes defy *** is not only a strong emotional impact on the family,but such cases are also quite *** causes may be multiple,not always readily apparent,and have potential repercussions,especially in terms of *** SUMMARY A 5-month-old male baby was pronounced dead following acute lung failure and cardiopulmonary *** parents had immediately rushed their child to the hospital,stating the baby was found prone and not ***-body postmortem computed tomography(PMCT)was performed,revealing a hypodense material of indeterminate nature within the main airways and areas of ground-glass parenchymal *** autopsy,the respiratory tract mucosa appeared edematous and was coated with a whitish stringy *** was widespread airspace reduction due to parenchymal *** sacs and bronchial openings contained abundant amorphous material admixed with white blood *** studies were performed,targeting CD15,CD68,and ***,the focus was on alpha-lactalbumin(milk protein),which showed marked immunopositivity within alveolar *** staining of macrophages was also particularly *** Postmortem investigations are thus essential to identify causes of death and surrounding *** is a useful tool in this setting,given the frequent dearth of autopsy findings and ambiguity as to cause of death in SUID *** findings,later confirmed by immunohistochemical investigations,were indicative of active pneumonia due to aspirated *** present account illustrates the importance a broad diagnostic approach to SUID in cases of forensic *** is a very valuable aid in cases of forensic interest,as it can provide useful information in all those situations in which the cause of death is uncertain or

关键词： Sudden unexpected infant death Aspiration pneumonia Postmortem computed tomography Case report Diagnosis Immunohistochemistry

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The role of SARS-COV-2 infection in promoting abnormal immune response and sepsis:A comparison between SARS-COV-2-related sepsis and sepsis from other causes

Infectious Medicine

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Infectious Medicine 2023年第3期2卷 202-211页

作者： Andrea Piccioni Laura Franza Federico Rosa Marcello Candelli Marcello Covino Michela Ferrara gianpietrovolonnino Giuseppe Bertozzi Maria Vittoria Zamponi Aniello Maiese Gabriele Savioli Francesco Franceschi Raffaele La Russa Department of Emergency Medicine Fondazione Policlinico Universitario A.Gemelli IRCCS1-00168 RomeItaly UniversitàCattolica del Sacro Cuore 1-00168 RomeItaly Department of Anatomical HistologicalForensic and Orthopedic SciencesSapienza University of Rome00186 RomeItaly Department of Clinical and Experimental Medicine Institute of Legal MedicineUniversity of Foggia71100 FoggiaItaly Department of Surgical Medicaland Molecular Pathology and Critical Care MedicineUniversity of Pisavia Roma 5556126 PisaItaly Emergency Department IRCCS Policlinico San Matteo27100 PaviaItaly Department of Clinical-Surgical Diagnostic and Pediatric SciencesUniversity of Pavia27100 PaviaItaly

Background:COVID-19 caused by SARS-CoV-2 virus is characterized by respiratory compromise and immune system involvement,even leading to serious disorders,such as cytokine ***:We then conducted a literature review on the topic of sepsis and covid-19,and in parallel conducted an experimental study on the histological finding of patients who died from SARS-Covid 19 infection and a control ***:Sepsis associated with covid-19 infection has some similarities and differences from that from other ***:In this paper the complex interplay between the 2 disorders was discussed,focusing on the similarities and on the effect that one could have on the other.A preliminary experimental section that demonstrates the multisystemic involvement in subjects who die from SARS-CoV-2 is also proposed.

关键词： SARS-COV-2 Cytokine storm SARS-CoV-2 Septic shock Sepsis

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