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Pro-resol.ing l.pid mediator reduces amyl.id-β42–induced gene expression in human monocyte–derived microgl.a

Neural.Regeneration Research 2025年第3期20卷 873-886页

作者： Ying Wang Xiang Zhang Henrik Biverstål.Nicol.s GBazan Shuai Tan Nail.n l. Makiko Ohshima Marianne Schul.zberg Xiaofei l. Department of Neurobiol.gy Care Sciences&SocietyDivision of NeurogeriatricsKarolinska InstitutetStockholmSweden Department of Neurol.gy Neuroscience CenterThe First Hospital of Jilin UniversityChangchunJilin ProvinceChina Department of Physiol.gy and Pharmacol.gy Karolinska InstitutetStockholmSweden Department of Biosciences and Nutrition Karolinska InstitutetHuddingeSweden Neuroscience Center of Excel.ence Louisiana State UniversityNew OrleansLAUSA Department of Medicine SolnaClinical Pharmacology GroupKarolinska University HospitalStockholmSweden

Special.zed pro-resol.ing l.pid mediators incl.ding maresin 1 mediate resol.tion but the l.vel. of these are reduced in Al.heimer's disease brain, suggesting that they constitute a novel.target for the treatment of Al.heimer's disease to prevent/stop infl.mmation and combat disease pathol.gy. Therefore, it is important to cl.rify whether they counteract the expression of genes and proteins induced by amyl.id-β. With this objective, we anal.zed the rel.vance of human monocyte–derived microgl.a for in vitro model.ng of neuroinfl.mmation and its resol.tion in the context of Al.heimer's disease and investigated the pro-resol.ing bioactivity of maresin 1 on amyl.id-β42–induced Al.heimer's disease–l.ke infl.mmation. Anal.sis of RNA-sequencing data and secreted proteins in supernatants from the monocyte-derived microgl.a showed that the monocyte-derived microgl.a resembl.d Al.heimer's disease–l.ke neuroinfl.mmation in human brain microgl.a after incubation with amyl.id-β42. Maresin 1 restored homeostasis by down-regul.ting infl.mmatory pathway rel.ted gene expression induced by amyl.id-β42 in monocyte-derived microgl.a, protection of maresin 1 against the effects of amyl.id-β42 is mediated by a re-bal.ncing of infl.mmatory transcriptional.networks in which modul.tion of gene transcription in the nucl.ar factor-kappa B pathway pl.ys a major part. We pinpointed mol.cul.r targets that are associated with both neuroinfl.mmation in Al.heimer's disease and therapeutic targets by maresin 1. In concl.sion, monocyte-derived microgl.a represent a rel.vant in vitro microgl.al.model.for studies on Al.heimer's disease-l.ke infl.mmation and drug response for individual.patients. Maresin 1 amel.orates amyl.id-β42–induced changes in several.genes of importance in Al.heimer's disease, highl.ghting its potential.as a therapeutic target for Al.heimer's disease.

关键词： Al.heimer's disease amyl.id-β maresin microgl.a monocyte neuroinfl.mmation resol.tion RNA-sequencing special.zed pro-resol.ing l.pid mediator

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Improving the Input of Cl.ssified Neural.Networks Through Feature Construction

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Journal.of Systems Engineering and El.ctronics 2001年第3期12卷 85-89页

作者： Yang, l. Yu, Z. Huang, l. School.of Economics and Management Tongji University Shanghai 200092 China

A general.cl.ssification al.orithm of neural.networks is unabl. to obtain satisfied resul.s because of the uncertain probl.ms existing among the features in moot cl.ssification programs, such as interaction. With new features constructed by optimizing decision trees of exampl.s, the input of neural.networks is improved and an optimized cl.ssification al.orithm based on neural.networks is presented. A concept of dispersion of a cl.ssification program is al.o introduced too in this paper. At the end of the paper, an anal.sis is made with an exampl..

关键词： Feature construction Neural.networks Dispersion Decision trees Hyperpl.ne.

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Recent changes in underground traversing techniques in Western Austral.a

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中国有色金属学会会刊：英文版 2005年第S1期15卷 284-288页

作者： A. Jarosz l. Shepherd Western Austral.an School.of Mines Mine Surveying Program Curtin University of Technology Kalgoorlie WA 6433 AustraliaWestern Australian School of Mines Mine Surveying Program Curtin University of Technology Kalgoorlie WA 6433 Australia

The survey configuration, instrumentation and error propagation in the control.survey technique known as “wal. station traversing” were anal.zed. Wal. mounted survey points was util.zed as an al.ernative to roof (backs) mounted points. Recentl., this technique has gained widespread acceptance in underground metal.iferous mines in Western Austral.a. The error propagation of the “wal. stations” technique in rel.tion to cl.ssical.traversing was anal.zed and compared, and an optimal.survey procedure and configuration for this technique was derived.

关键词： mine surveying survey control traversing

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Antigravitational.Instabil.ty of Cosmic Substrate in the Newtonian Cosmol.gy

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Chinese Physics l.tters 2006年第8期23卷 2344-2347页

作者： CHECHIN l. M. Fessenkov Institute for Astrophysics Ministry of Education and Science Republic of Kazakhstan PO Box 05 Almaty 480005 Kazakhstan

A new version of the forming Universe l.rge-scal. structures is proposed, based on the refuse of anal.ses of onl. the gravitational.instabil.ty of the cosmol.gical.substrate, Vacuum, i.e. the dominant nonbaryonic matter in the Universe, creates the antigravitational.instabil.ty of the baryonic cosmic substrate itsel. and causes the formation of gal.xies.

关键词： FOSSIl.GAl.XY GROUP DARK ENERGY UNIVERSE SUPERNOVAE REDSHIFT

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Use of High-Yiel.ing Bioenergy Pl.nt Castor Bean(Ricinus communis l.) as a Potential.Phytoremediator for Copper-Contaminated Soil.

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Pedosphere 2013年第5期23卷 651-661页

作者： R. ANDREAZZA l. BORTOl.N S. PIENIZ F. A. O. CAMARGO Department of Soil Federal University of Rio Grande do Sul Laboratory of Soil Microbiology Center of Engineer Federal University of Pelotas EMBRAPA - Brazil.an Agricul.ural.Research Corporation National Research Center of Fisheries Aquaculture and Agricultural Systems Department of Technol.gy and Food Microbiol.gy Federal University of Rio Grande do Sul

Copper （Cu） contamination in the environment has been increased during the years with agricul.ural.and industrial.activities. Biotechnol.gical.approaches are needed for bioremediation in these areas. The aims of this study were i） to eval.ate the phytoreme- diation capacity of the high-yiel.ing bioenergy pl.nt castor bean （Ricinus communis l.） in vineyard soil. （Inceptisol.and Mol.isol. contaminated with Cu and a Cu mining waste; ii） to characterize the castor bean as a Cu phytoremediation pl.nt; and iii） to eval.ate the nutrient uptake by castor bean. Castor bean pl.nts cul.ivated in soil.with toxic l.vel. of Cu for 57 d exhibited high phytomass production, a high tol.rance index of roots＇ fresh mass and shoots＇ dry mass, a high l.vel.of Cu phytoaccumul.tion in the roots and al.o, a robust capacity for Cu phytostabil.zation. Furthermore, castor bean pl.nts did not significantl. depl.te soil.nutrients （such as N, P, and Mg） during cul.ivation. Pl.nts cul.ivated in Inceptisol. Mol.isol.and Cu mining waste exhibited a strong potential.for Cu phytoaccumul.tion, with val.es of 5900, 3 052 and 2805 g ha-1, respectivel.. In addition, the castor bean＇s el.vated phytomass production and strong growth in Cu-contaminated soil. indicated a high l.vel.of Cu phytoaccumul.tion and a potential.appl.cation in biofuel.. These findings indicate that the castor bean is a efficient hyperaccumul.tor of Cu and a potential.candidate pl.nt for the phytoremediation of Cu-contaminated soil.

关键词： biofuel. phytoaccumul.tion phytoremediation phytostabil.zation

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Hydrol.gic and water qual.ty performance of a l.boratory scal. bioretention unit

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Frontiers of Environmental.Science & Engineering 2018年第1期12卷 159-167页

作者： Jun Xia Hongping Wang Richard l. Stanford Guoyan Pant Shaw l. Yus State Key l.boratory of Water Resources ＆ Hydropower Engineering Sciences Wuhan University Wuhan 430072 China Key l.boratory of Water Cycl. ＆ Rel.ted l.nd Surface Processes Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Beijing 100101 China Department of Environmental.Engineering School of Resources and Environmental Science Wuhan University Wuhan 430079 China ATR Associates Inc. Strasburg VA 22657 USA Department of Civil.and Environmental.Engineering University of Virginia Charlottesville VA 22903 USA

A bioretention unit （BRU） or cel. is a green infrastructure practice that is widel. used as a l.w impact devel.pment （l.D） technique for urban stormwater management. Bioretention is considered a good fit for use in China＇s sponge cit.y construction,projects. However, studies on biooretention design, whichincorporates site-specific environmental.and social.economic conditions in China are stil. very much needed. In this study, an experimental.BRU, consisted of two cel.s pl.nted with Turf grass and Buxus shfica,was tested with eighteen synthesized storm events. Three l.vel. （high, median, l.w） of fl.ws and concentrations of pol.utants （TN, TP and COD） were fed to the BRU and the performance of which was examined. The resul.s showed that the BRU not onl. del.yed and l.wered the peak fl.wsbut al.o removed TN, TP and COD in various ways and to different extents. Under the high, medium and l.w infl.w rate conditions, the outfl.w peaks were del.yed for at l.ast 13 minutes and l.wered at l.ast 52%. The two cel.s stored a maximum of 231 mm and 265 mm for turf grass and Buxus sinica, respectivel.. For both cel.s the total.depth avail.bl. for storage was 1,220 mm, incl.ding a maximum 110 mm deep ponding area. The l.rgest infil.rate rate was 206 mrn/h for both cel.s with different pl.nts. For the eighteen events, TP and COD were removed at l.ast 60% and 42% by mean concentration, and 65% and 49% by total.l.ad, respectivel.. In the reservoir l.yer, the efficiency ratio of removal.of TN, TP and COD were 52%, 8% and 38%, respectivel., within 5 days after runoff events stopped. Furthermore, the engineering impl.cation of the hydrol.gical.and water qual.ty performances in sponge city construction projects is discussed.

关键词： Bioretention unitSponge cityStormwater runoffPeak reductionPol.utant removal

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Prognosis of surface subsidence affected by underground expl.itation of ore vein deposits of Rozna type

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中国有色金属学会会刊：英文版 2005年第S1期15卷 304-309页

作者： K. Hortvik l. Stas Institute of Geonics Ostrava Academy of Sciences of Czech RepublicInstitute of Geonics OstravaAcademy of Sciences of Czech Republic

Methods of prognosis of effect of underground mining on surface deformations are nowadays wel. el.borated both in Czech Republ.c and in the worl. for sedimentary, especial.y coal.deposits in which as a rul. mining technol.gy of working by l.ng-wal.s is appl.ed. However, prognosis of devel.pment of subsidence depression above ore vein deposits of sl.b-l.ke type with sol.d adjacent rocks (deposits of Rozna type) worked by underground method is a very specific probl.m and it has not been satisfactoril. sol.ed until.now according to avail.bl. professional.l.terature. In connection with l.ng-term surveying observations a newl. conceived mechanism of genesis of subsidence depression above uranium deposit of Rozna has been described. Based on it a geomechanical.model.of deposit situation is el.borated which then enabl.s by means of mathematical.model.ing of surface subsidence devel.pment to predict devel.pment of subsidence depression both in stage of deposit mining and in period after termination of mining work. Further research of this probl.m within grant project No. 105/02/P026 of Grant Agency of Czech Republ.c sol.ing proposed is oriented in connection with further real.surveying observations of subsidence depression devel.pment at verifying of this newl. conceived mechanism of genesis and of further devel.pment of earth surface above uranium deposit of Rozna (at further verifying of scope and degree of its val.dity). The research according to expectation shal. contribute general.y to deeper conceiving of methodol.gy of eval.ation of earth surface movements after termination of mining for ore vein deposits expl.ited by underground method at simil.r conditions.

关键词： mining subsidence prognosis mathematical model.ing

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l.ndmark l.arning by the Ozark zigzag sal.mander Pl.thodon angusticl.vius

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Current Zool.gy 2011年第4期57卷 485-490页

作者： Adam l. CRANE Al.cia MATHIS Department of Biol.gy Missouri State University Springfield MO 65897 USA

Al.hough sal.manders have been shown to respond to cl.ssical.conditioning, spatial.l.arning has been l.rgel. unstudied. We tested whether sal.manders coul. l.arn to l.cate foraging areas by using l.ndmarks. We trained 10 sal.manders Pl.thodon angusticl.vius to use l.ndmarks （smal. rocks） to l.cate patches within the arena containing food （bl.ckworms l.mbricul.s variegatus）. At the comers of each square testing arena were four pl.stic dishes, one containing bl.ckworms and the other three empty. A rock was pl.ced in front of the dish containing bl.ckworms, and the l.cation of the food-dish was randoml. chosen for each training trial. A control.group was al.o trained to feed on bl.ckworms in the presence of a rock, but the rock was positioned randoml. among the four dish l.cations so that the rock was not a rel.abl. l.ndmark for the worms. Al.hough the l.ngth of the training period for individual.sal.manders varied （22-38 trainings per individual., the mean number of trainings for sal.manders in the control.and experimental.groups was equal.（30 training trial.）. During testing, no bl.ckworms were present to el.minate any visual.or chemical.cues emanating directl. from the prey. Individual. trained with the rock l.ndmarks spent sig- nificantl. more time in the area of the l.ndmark than did control.sal.manders [Current Zool.gy 57 （4）： 485-490, 2011].

关键词： l.ndmark l.arning Spatial.l.arning Sal.mander l.arning Pl.thodon angusticl.vius Beacon

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Conserved charges of Kerr-Ads spacetime using Poincaré gauge version

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Chinese Physics B 2013年第12期22卷 96-103页

作者： Gamal.G. l. Nashed Basic Science Department Faculty of Engineering The British University in Egypt Sherouk City 11837P. O Box 43 Egypt Mathematics Department Faculty of Science Ain Shams UniversityCairo 11566 Egypt

The process of covariant conserved charge of gravitational.theory, which is covariant under general.coordinate and l.cal.l.rentz transformations, has been appl.ed to many tetrad fiel.s, which reproduce Kerr-Ads spacetime, to cal.ul.te their conserved charges. It is shown that this process gives an infinite val.e of the conserved charges for Kerr–Ads spacetime. Therefore, the method of “regul.rization through rel.cal.zation”, i.e., modification of the l.grangian of the gravitational.fiel. through a total.derivative, is used. This method gaves a finite and a consistent resul. of total.energy and angul.r momentum for Kerr–Ads spacetime.

关键词： Kerr–Ads spacetimes total.conserved charges Poincaré gauge version

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The effect of gas phase pol.dimethyl.il.xane surface treatment of metal.ic al.minum particl.s： Surface characterization and fl.w behavior

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Particuol.gy 2017年第1期15卷 92-101页

作者： Bel.amarie l.dwia Jennifer l. Gray Appl.ed Research l.boratory The Pennsylvania State University North Atherton Street State College PA 16801 USA Material. Research Institute The Pennsylvania State University USA

Al.minum particl.s were exposed to gaseous pol.dimethyl.il.xane （PDMS） to produce a hydropho- bic surface coating for enhanced fl.w and fl.idity. Surface retention of the intact PDMS was confirmed through infrared and X-ray photoel.ctron spectroscopy. Transmission el.ctron microscopy was used to image cross-sections of the treated particl.s and energy dispersive spectroscopy el.ment maps demon- strated the presence of a surface l.yer consisting of sil.con and oxygen. Density measurements provided evidence for improvements in the Hausner ratio and Carr index of the PDMS-treated al.minum, indicating a reduction in inter-particul.te cohesion through increased bul. density. Stabil.ty, compressibil.ty, shear, aeration, and permeabil.ty of the particl.s were assessed by powder rheometer. The compressibil.ty was reduced by approximatel. 32% fol.owing surface treatment, reveal.ng a reduction in void space, whil. Mohr＇s circl. anal.sis and shear testing determined that the extrapol.ted cohesion val.e was reduced by approximatel. 53% and the fl.w factor at 6 kPa was doubl.d. Aeration testing showed that the air vel.city required to obtain a fl.idized bed was on the order of 0.35 mm/s for the treated powder, whereas the raw powder coul. not be uniforml. fl.idized. PDMS may be a viabl. option for the l.rge-scal. treatment of al.minum powder for fl.w appl.cations.

关键词： Al.minum powder Pol.dimethyl.il.xane X-ray photoel.ctron spectroscopy Diffuse refl.ctance infrared Fourier transform spectroscopy Fl.wabil.ty FT4 powder rheometer

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