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Spatiotemporal oxygen dynamics in young leaves reveal cyclic hypoxia in plants

Molecular Plant 2024年第3期17卷 377-394页

作者： Paolo M.Triozzi Luca Brunello Giacomo Novi gianmarco Ferri Francesco Cardarelli Elena Loreti Mariano Perales Pierdomenico Perata PlantLab Center of Plant SciencesSant'Anna School of Advanced Studies56010 PisaItaly Centro de Biotecnologia y Genomica de Plantas Universidad Politecnica de Madrid(UPM)-Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria(INIA-CSIC)Campus de Montegancedo UPMPozuelo de Alarcon28223 MadridSpain Fondazione Pisana per la Scienza 56017 PisaItaly Laboratorio NEST Scuola Normale SuperioreIstituto Nanoscienze-CNRPiazza S.Silvestro1256127 PisaItaly institute of Agricultural Biology and Biotechnology National Research Council56124 PisaItaly Departamento de Biotecnologia-Biologia Vegetal Escuela Tecnica Superior de Ingenieria AgronomicaAlimentaria y de BiosistemasUniversidad Politecnica de Madrid(UPM)28040 Madrid.Spain

Oxygen is essential for plant growth and development.Hypoxia occurs in plants due to limited oxygen avail-abilityfollowing adverse environmental conditions as well inhypoxic niches in otherwisenormoxic environ-ments.However,the existence and functional integration of spatiotemporal oxygen dynamics with plant development remains unknown.In animal systems dynamic fluctuations in oxygen availability are known as cyclic hypoxia.In this study,we demonstrate that cyclic fluctuations in internal oxygen levels occur in young emerging leaves of Arabidopsis plants.Cyclic hypoxia in plants is based on a mechanism requiring the ETHYLENE RESPONSE FACTORS type VII(ERFVII)that are central components of the oxygen-sensing machinery in plants.The ERFVll-dependent mechanism allows precise adjustment of leaf growth in response to carbon status and oxygen availability within plant cells.This study thus establishes a functional connection between internal spatiotemporal oxygen dynamics and developmental processes of plants.

关键词： Arabidopsis hypoxia cyclic hypoxia leaf development oxygen-sensing mechanism ERFVII

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Type-B monoamine oxidase inhibitors in neurological diseases:clinical applications based on preclinical findings

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Neural Regeneration Research 2024年第1期19卷 16-21页

作者： Marika Alborghetti Edoardo Bianchini Lanfranco De Carolis Silvia Galli Francesco E.Pontieri Domiziana rinaldi Neurology Unit NESMOS DepartmentFaculty of Medicine&PsychologySapienza-University of RomeSant’Andrea University HospitalRomeItaly Department of Clinical and Behavioral Neurology IRCCS-Fondazione Santa LuciaRomeItaly

Type-B monoamine oxidase inhibitors,encompassing selegiline,rasagiline,and safinamide,are available to treat Parkinson's disease.These drugs ameliorate motor symptoms and improve motor fluctuation in the advanced stages of the disease.There is also evidence suppo rting the benefit of type-B monoamine oxidase inhibitors on non-motor symptoms of Parkinson's disease,such as mood deflection,cognitive impairment,sleep disturbances,and fatigue.Preclinical studies indicate that type-B monoamine oxidase inhibitors hold a strong neuroprotective potential in Parkinson's disease and other neurodegenerative diseases for reducing oxidative stress and stimulating the production and release of neurotrophic factors,particularly glial cell line-derived neurotrophic factor,which suppo rt dopaminergic neurons.Besides,safinamide may interfere with neurodegenerative mechanisms,countera cting excessive glutamate overdrive in basal ganglia motor circuit and reducing death from excitotoxicity.Due to the dual mechanism of action,the new generation of type-B monoamine oxidase inhibitors,including safinamide,is gaining interest in other neurological pathologies,and many supporting preclinical studies are now available.The potential fields of application concern epilepsy,Duchenne muscular dystrophy,multiple scle rosis,and above all,ischemic brain injury.The purpose of this review is to investigate the preclinical and clinical pharmacology of selegiline,rasagiline,and safinamide in Parkinson's disease and beyond,focusing on possible future therapeutic applications.

关键词： glial cell line-derived neurotrophic factor(GDNF) glutamate neurological disorders neuroprotection Parkinson's disease preclinical studies rasagiline safinamide selegiline type-B monoamine oxidase(MAO_(B))inhibitors

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Corneal collagen cross-linking in patients with keratoconus from the Dresden protocol to customized solutions:theoretical basis

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 951-962页

作者： Ciro Caruso Luca D’Andrea Mario Troisi Michele rinaldi Raffaele Piscopo Salvatore Troisi Ciro Costagliola Corneal Transplant Center Pellegrini HospitalVia Portamedina alla Pignasecca 41Napoli 80127Italy Eye Clinic Department of NeurosciencesReproductive and Odontostomatological SciencesUniversity of Naples Federico IINaples 80131Italy Public Health Department University of Naples Federico IINaples 80131Italy Salerno Hospital University Ophthalmologic UnitBaronissiCampania 84131Italy

Keratoconus is an ectatic condition characterized by gradual corneal thinning,corneal protrusion,progressive irregular astigmatism,corneal fibrosis,and visual impairment.The therapeutic options regarding improvement of visual function include glasses or soft contact lenses correction for initial stages,gas-permeable rigid contact lenses,scleral lenses,implantation of intrastromal corneal ring or corneal transplants for most advanced stages.In keratoconus cases showing disease progression corneal collagen crosslinking(CXL)has been proven to be an effective,minimally invasive and safe procedure.CXL consists of a photochemical reaction of corneal collagen by riboflavin stimulation with ultraviolet A radiation,resulting in stromal crosslinks formation.The aim of this review is to carry out an examination of CXL methods based on theoretical basis and mathematical models,from the original Dresden protocol to the most recent developments in the technique,reporting the changes proposed in the last 15y and examining the advantages and disadvantages of the various treatment protocols.Finally,the limits of non-standardized methods and the perspectives offered by a customization of the treatment are highlighted.

关键词： corneal collagen cross linking keratoconus custom fast protocol Dresden protocol lambert-beer law Bunsen-roscoe law

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Two big orifices in the second duodenal portion:A case of an atypical double papilla

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 83-85页

作者： Salvatore Francesco Vadalàdi Prampero Nikola Panic Marco Massidda Chiara Rocchi Pierluigi Maria rinaldi Ana Malenkovic Milutin Bulajic Gastroenterology and GI Endoscopy Department Mater Olbia HospitalOlbia 07026Italy Digestive Endoscopy Unit University Clinic"Dr Dragisa Misovic-Dedinje"Belgrade 11000Serbia Radiology Department Mater Olbia HospitalOlbia 07026Italy

With the advent of endoscopic retrograde cholangiopancreatography(ERCP)in the early 1970s,anatomic anomalies of the Vaterian system were described endoscopically[1].Although the occurrence is rare,the common bile duct(CBD)and the pancreatic duct may fail to coalesce during embryologic development.This leads to double major papilla because both ducts open into the duodenum separately[1].In this way the cranial duct communicates with the CBD,while the caudal orifice communicates with the pancreatic duct[2].

关键词： orifice Vater atypical

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The Arabidopsis COP9 SIGNALOSOME INTERACTING F-BOX KELCH 1 Protein Forms an SCF Ubiquitin Ligase and Regulates Hypocotyl Elongation

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Molecular Plant 2013年第5期6卷 1616-1629页

作者： Anna Franciosini Benedetta Lombardi Silvia lafrate Valeria.Pecce Giovanni Mele Leonardo Lupacchini gianmarco rinaldi Youichi Kondou Giuliana Gusmaroli Shiori Aki Tomohiko Tsuge Xing-Wang Deng Minami Matsui Paola Vittorioso Paolo Costantin Giovanna Serino Dipartimento di Biologia e Biotecnologie Sapienza Universita di Roma Italy Istituto di Biologia e Biotecnologia Agraria Consiglio Nazionale delle Ricerche Italy RIKEN Plant Science Center Yokohama Japan Department of Molecular Cellular and Development Biology Yale University New Haven CT USA Present address: Department of Biology University of South Carolina Beaufort Bluff'ton AC USA Molecular Biology Laboratory Institute for Chemical Research Kyoto University Japan The New York Botanical Garden Bronx NY USA

The regulation of protein turnover by the ubiquitin proteasome system （UPS） is a major posttranslational mechanism in eukaryotes. One of the key components of the UPS, the COP9 signalosome （CSN）, regulates ＇cullin-ring＇ E3 ubiquitin ligases. In plants, CSN participates in diverse cellular and developmental processes, ranging from light signaling to cell cycle control. In this work, we isolated a new plant-specific CSN-interacting F-box protein, which we denominated CFK1 （COP9 INTERACTING F-BOX KELCH 1）. We show that, in Arabidopsis thaliana, CFK1 is a component of a functional ubiquitin ligase complex. We also show that CFK1 stability is regulated by CSN and by proteasome-dependent proteoly- sis, and that light induces accumulation of the CFK1 transcript in the hypocotyl. Analysis of CFK1 knockdown, mutant, and overexpressing seedlings indicates that CFK1 promotes hypocotyl elongation by increasing cell size. Reduction of CSN levels enhances the short hypocotyl phenotype of CFKl-depleted seedlings, while complete loss of CSN activity sup- presses the Iong-hypocotyl phenotype of CFKl-overexpressing seedlings. We propose that CFK1 （and its regulation by CSN） is a novel component of the cellular mechanisms controlling hypocotyl elongation.

关键词： Arabidopsis thaliana ubiquitin COP9 signalosome proteasome F-box protein hypocotyl elongation seed-ling development.

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Endoscopic ultrasound-guided portal pressure gradient measurement in managing portal hypertension

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World Journal of Gastrointestinal Surgery 2023年第6期15卷 1033-1039页

作者： Cosmas rinaldi Adithya Lesmana Internal Medicine Hepatobiliary DivisionDr.Cipto Mangunkusumo National General HospitalUniversitas IndonesiaJakarta 10430DKIIndonesia Digestive Disease&GI Oncology Center Medistra HospitalJakarta 12950DKIIndonesia Gastrointestinal Cancer Center MRCCC Siloam Semanggi HospitalJakarta 12930DKIIndonesia

Portal hypertension(PH)is still a challenging clinical condition due to its silent manifestations in the early stage and needs to be measured accurately for early detection.Hepatic vein pressure gradient measurement has been considered as the gold standard measurement for PH;however,it needs special skill,experience,and high expertise.Recently,there has been an innovative development in using endoscopic ultrasound(EUS)for the diagnosis and management of liver diseases,including portal pressure measurement,which is commonly known as EUS-guided portal pressure gradient(EUS-PPG)mea-surement.EUS-PPG measurement can be performed concomitantly with EUS evaluation for deep esophageal varices,EUS-guided liver biopsy,and EUS-guided cyanoacrylate injection.However,there are still major issues,such as different etiologies of liver disease,procedural training,expertise,availability,and cost-effectiveness in several situations with regard to the standard management.

关键词： Portal hypertension Hepatic vein Endoscopic ultrasound Portal pressure

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交代作用是火星上甲烷的来源之一

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矿物岩石地球化学通报 2024年第3期 592-592页

作者： rinaldi Michele Sami Mikhail Dimitri A.Sveqensky 夏群科

解释火星早期气候更温暖的关键之一是火星大气中存在的还原性温室气体(如甲烷和氢气)。甲烷在地球与火星大气中的形成机制,及其对其它类地行星或系外行星气候的潜在长期影响尚未明确,需要深入研究。为了研究火星壳-幔边界岩浆流体的碳...

解释火星早期气候更温暖的关键之一是火星大气中存在的还原性温室气体(如甲烷和氢气)。甲烷在地球与火星大气中的形成机制,及其对其它类地行星或系外行星气候的潜在长期影响尚未明确,需要深入研究。为了研究火星壳-幔边界岩浆流体的碳化学种型的生成规律,美国圣安德鲁斯大学地球与环境学院和约翰斯霍普金大学地球与行星科学系的研究人员合作,使用了一种热力学模型—深地球水模型(Deep Earth Water model)来预测流体-岩石交代变质过程中的碳元素分配。这项研究实验条件的温度范围是300～800℃,压强为0.5 GPa,并同时结合了不同的氧逸度情况进行了模拟。

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Impact of endoscopic ultrasound-guided radiofrequency ablation in managing pancreatic malignancy

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World Journal of Gastrointestinal Surgery 2023年第2期15卷 163-168页

作者： Cosmas rinaldi Adithya Lesmana Hepatobiliary Division Internal Medicine DepartmentDr.Cipto Mangunkusumo National General HospitalUniversitas IndonesiaJakarta 10430Indonesia Digestive Disease and Gastrointestinal Oncology Center Medistra HospitalJakarta 12950Indonesia Gastrointestinal Cancer Center MRCCC Siloam Semanggi HospitalJakarta 12930Indonesia

Pancreatic malignancy is still the most lethal gastrointestinal malignancy.It has a very poor prognosis with low survival rate.Surgery is still the main treatment option for pancreatic malignancy.Most patients already have locally advanced and even late stage disease due to non-specific abdominal symptoms.Even though some cases are still suitable for surgical treatment,due to its aggressiveness adjuvant chemotherapy is becoming the standard treatment for controlling the disease.Radiofrequency ablation(RFA)is a thermal therapy that has been used as one of the standard treatments for liver malignancy.It can also be performed intraoperatively.There are several reports on percutaneous RFA treatment for pancreatic malignancy using transabdominal ultrasound and guided by computed tomography scan.However,due to its anatomical location and the risk of high radiation exposure,these methods seem to be very limited.Endoscopic ultrasound(EUS)has been widely used for pancreatic abnormality evaluation due to its ability to detect more accurately,especially small pancreatic lesions,compared to other imaging modalities.By the EUS approach,it is easier to achieve good visualization of tumor ablation and necrosis as the echoendoscope position is closer to the tumor area.Based on studies and a recent meta-analysis,EUS-guided RFA is a promising treatment approach for most pancreatic malignancy cases,but most studies only collected data from a small sample size.Larger studies are needed before clinical recommendations can be made.

关键词： Endoscopic ultrasound Radio frequency ablation Percutaneous Surgery Pancreatic malignancy

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Damage detection with image processing: a comparative study

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Earthquake Engineering and Engineering Vibration 2023年第2期22卷 333-345页

作者： Marianna Crognale Melissa De Iuliis Cecilia rinaldi Vincenzo Gattulli Department of Structural and Geotechnical Engineering Sapienza University of Romevia Eudossiana 18Rome 00167Italy

Large structures,such as bridges,highways,etc.,need to be inspected to evaluate their actual physical and functional condition,to predict future conditions,and to help decision makers allocating maintenance and rehabilitation resources.The assessment of civil infrastructure condition is carried out through information obtained by inspection and/or monitoring operations.Traditional techniques in structural health monitoring(SHM)involve visual inspection related to inspection standards that can be time-consuming data collection,expensive,labor intensive,and dangerous.To address these limitations,machine vision-based inspection procedures have increasingly been investigated within the research community.In this context,this paper proposes and compares four different computer vision procedures to identify damage by image processing:Otsu method thresholding,Markov random fields segmentation,RGB color detection technique,and K-means clustering algorithm.The first method is based on segmentation by thresholding that returns a binary image from a grayscale image.The Markov random fields technique uses a probabilistic approach to assign labels to model the spatial dependencies in image pixels.The RGB technique uses color detection to evaluate the defect extensions.Finally,K-means algorithm is based on Euclidean distance for clustering of the images.The benefits and limitations of each technique are discussed,and the challenges of using the techniques are highlighted.To show the effectiveness of the described techniques in damage detection of civil infrastructures,a case study is presented.Results show that various types of corrosion and cracks can be detected by image processing techniques making the proposed techniques a suitable tool for the prediction of the damage evolution in civil infrastructures.

关键词： damage detection image processing image classification civil infrastructure inspection structural health monitoring analysis

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Portal Hypertension in Nonalcoholic Fatty Liver Disease:From Pathogenesis to Clinical Practice

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Journal of Clinical and Translational Hepatology 2022年第5期10卷 979-985页

作者： Saut Horas H.Nababan Cosmas rinaldi Adithya Lesmana Hepatobiliary Division Department of Internal MedicineDr Cipto Mangunkusumo National General HospitalMedical Faculty Universitas IndonesiaJakartaIndonesia Gastrointestinal Cancer Center MRCCC Siloam Semanggi HospitalJakartaIndonesia Digestive Disease&GI Oncology Center Medistra HospitalJakartaIndonesia

Portal hypertension in nonalcoholic fatty liver disease(NAFLD)mostly occur in cirrhotic stage.However,several experimental and clinical studies showed evidence of portal hypertension in NAFLD without significant or advance fibrosis.This early development of portal hypertension in NAFLD is associated with liver sinusoidal contraction by hepatocellular lipid accumulation and ballooning,which is also accompanied by capillarization and dysfunction of liver sinusoidal endothelial cells.Both of these impaired mechanical and molecular components can cause an increase in intrahepatic vascular resistance which lead to the increase of portal pressure in the absence of significant liver fibrosis.Extrahepatic factors such as insulin resistance and gut dysbiosis may also contribute to liver sinusoidal endothelial dysfunction and early portal hypertension in NAFLD.The clinical impact of early portal hypertension in NAFLD is still unclear.However,clinical tools for diagnosis and monitoring of portal hypertension in NAFLD are being investigated to predict high-risk patients and to guide therapy.

关键词： Portal hypertension NAFLD NASH Metabolic

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