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Management of perianal fistulas in Crohn's disease:An upto-date review

World Journal of Gastroenterology 2015年第5期21卷 1394-1403页

作者： Manuela Marzo Carla Felice Daniela Pugliese gianluca andrisani Giammarco Mocci Alessandro Armuzzi Luisa Guidi IBD Unit Complesso Integrato ColumbusUniversità Cattolica del Sacro Cuore00168 RomeItaly

Perianal disease is one of the most disabling manifestations of Crohn's disease.A multidisciplinary approach of gastroenterologist,colorectal surgeon and radiologist is necessary for its management.A correct diagnosis,based on endoscopy,magnetic resonance imaging,endoanal ultrasound and examination under anesthesia,is crucial for perianal fistula *** medical and surgical therapies are discussedin this review,including new local treatment modalities that are under investigation.

关键词： Crohn’s disease Perianal fistula Surgery Drug ther

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Colon capsule endoscopy:What we know and what we would like to know

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World Journal of Gastroenterology 2014年第45期20卷 16948-16955页

作者： Cristiano Spada Federico Barbaro gianluca andrisani Leonardo Minelli Grazioli Cesare Hassan Isabella Costamagna Mariachiara Campanale Guido Costamagna Department of General Surgery Digestive Endoscopy Unit Catholic University

Colonoscopy is usually perceived as an invasive and potentially painful procedure, being also affected by a small, but definite, risk of major complications (cardiopulmonary complications, perforation, hemorrhage) and even mortality. To improve both acceptability and safety, PillCam Colon Capsule Endoscopy (CCE) (Given Imaging Ltd, Yoqneam, Israel) has been developed. CCE represents a non-invasive technique that is able to explore the colon without sedation and air insufflation. The Second Generation of Colon Capsule Endoscopy (PillCam Colon 2) (CCE-2) was proven to be an accurate tool to detect colonic neoplastic lesions when used in average risk individuals. To date, the evidence supports the use of CCE-2 in case of colonoscopy failure, in patients unwilling to perform colonoscopy and when colonoscopy is contraindicated. Other potential applications, such as colorectal cancer screening or diagnostic surveillance of inflammatory bowel disease need to be clarified. In this paper, the current “state of the art”, potential application of CCE and future needs are evaluated.

关键词： Colon capsule endoscopy Incomplete colonoscopy Regimen of preparation Accuracy Fields of application

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What is the best way to manage screening for infections and vaccination of inflammatory bowel disease patients?

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2016年第3期7卷 387-396页

作者： gianluca andrisani Alessandro Armuzzi Manuela Marzo Carla Felice Daniela Pugliese Alfredo Papa Luisa Guidi IBD Unit Complesso Integrato Columbus Università Cattolica del Sacro Cuore

The use of biological agents and immunomodulators for inflammatory bowel disease(IBD) is associated with an increased risk of opportunistic infections, in particular of viral or bacterial etiology. Despite the existence of international guidelines, many gastroenterologists have not adopted routine screening and vaccination in those patients with IBD, which are candidate for biologic therapy. Available strategies to screen, diagnose and prevent bacterial and viral infections in patients with IBD prior to start biological therapy are discussed in this review.

关键词： Inflammatory bowel disease Opportunistic infections Immunomodulators Corticosteroids Anti-tumor necrosis factor agents

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