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Nano Research 2015年第12期8卷 3972-3981页

作者： Giampiero Amato gianluca Milano Umberto Vignolo Ettore Vittone Quantum Research Laboratory INRIM Strada delle Cacce 91 Torino Italy Department of Physics NIS Research Center University of Torino via Pietro Giuria 1 10125 Torino Italy

The effect of laser irradiation on chemically vapor deposited （CVD） graphene was studied by analyzing the temporal evolution of Raman spectra acquired under various illumination conditions. The spectra showed that the normalized intensity of the defect-related peak increases with the square root of the exposure time and varies almost linearly with the laser power density. Furthermore, the hardness of graphene to radiation damage depends on its intrinsic structural quality. The results suggest that, contrary to the common belief, micro-Raman spectroscopy cannot be considered a noninvasive tool for the characterization of graphene. The experimental observations are compatible with a model that we derived from the interpretative approach of the Staebler-Wronski effect in hydrogenated amorphous silicon; this approach assumes that the recombination of photoexcited carriers induces the breaking of weak C-C bonds.

关键词： chemically vapor deposited (CVD) graphene Raman spectroscopy defect kinetics laser irradiation

Frailty in patients admitted to hospital for acute coronary syndrome: when, how and why?

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Journal of Geriatric Cardiology 2019年第2期16卷 129-137页

作者： Elisabetta Tonet Rita Pavasini Simone Biscaglia gianluca Campo Cardiovascular Institute Azienda Ospedaliero-Universitaria di FerraraConaItaly Maria Cecilia Hospital GVM Care&ResearchCotignolaItaly

Frailty is an issue of paramount importance for cardiologists,because of the aging of patients admitted to hospital for acute coronary syndrome(ACS)and the straight relationship between aging and *** tools have been provided in this setting,in order to objectively assess frailty status,but important questions are still *** are conflicting data about a unique definition of frailty in subjects with cardiovascular diseases,the timing to perform a frailty evaluation in the context of an acute myocardial infarction,the mean to assess frailty in these patients and the usefulness of the information derived from the frailty *** results from the analysis of several items and a multidomain evaluation including laboratory values,clinical data and physical performance assessment is required for a comprehensive frailty ***,regardless of the frailty tool,the prevalence of frailty in older ACS patients is high and it could add important information to the decision-making process about invasive strategy,the multivessel disease management,dual antiplatelet therapy and secondary prevention *** present overview tries to summarize the current knowledge about the definition and prevalence of frailty in older adults admitted to hospital for ACS,suggesting how frailty assessment may improve the management of older ACS patients.

关键词： Acute coronary syndrome Frailty The elderly

Radioembolization in the setting of liver transplantation: great expectations or hard times?

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Hepatobiliary Surgery and Nutrition 2018年第1期7卷 58-60页

作者： Quirino Lai gianluca Mennini Hepato-bilio-pancreatic and Liver Transplant Unit Department of SurgerySapienza University of RomeRomeItaly

Trans-arterial radio-embolization(TARE)with yttrium-90 represents one of the most efficacious approaches for the treatment of selected patients with advanced hepatocellular cancer(HCC)(1).

关键词： embolization arterial liver

Desertification risk,economic resilience and social issues:From theory to practice

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Chinese Journal of Population,Resources and Environment 2020年第2期18卷 155-163页

作者： gianluca Egidi Luca Salvati Department of Agricultural and Forestry Sciences(DAFNE) Tuscia UniversityVia San Camillo de LellisI-01100 ViterboItaly Department of Economics and Law University of MacerataVia Armaroli 43I-62100 MacerataItaly

Land degradation and early forms of desertification in both advanced economies and emerging countries reflect complex socio-environmental processes driven by multiple interactions between biophysical and socioeconomic forces across different spatial *** present study investigates desertification risk,land degradation,and socio-demographic dynamics through the lens of“resilience,”adopting complex adaptive systems(CAS)*** resilience of socio-environmental systems exposed to land degradation is defined as the capacity of a regional economy to respond to crises and reorganize by making changes to preserve functions,structure,and feedback,and to promote future development *** reviewing the socioeconomic resilience of local socio-ecological systems exposed to land degradation,this study achieves a better comprehension of the multifaceted processes that lead to a higher risk of desertification and the intimate relationship with underlying population trends and demographic dynamics.A comprehensive approach based on resilience thinking was formulated to review both environmental and socio-demographic issues at the landscape scale,and provide a suitable foundation for sustainability science and regional development policies.

关键词： Population dynamics Ecosystem functioning Socio-ecological resilience Complex adaptive systems Interpretative framework

ARBITRARILY HIGH-ORDER ENERGY-CONSERVING METHODS FOR HAMILTONIAN PROBLEMS WITH QUADRATIC HOLONOMIC CONSTRAINTS

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Journal of Computational Mathematics 2024年第4期42卷 1145-1171页

作者： Pierluigi Amodio Luigi Brugnano gianluca Frasca-Caccia Felice Iavernaro Dipartimento di Matematica Università di BariItaly Dipartimento di Matematica e Informatica"U.Dini" Università di FirenzeItaly Dipartimento di Matematica Università di SalernoItaly

In this paper,we define arbitrarily high-order energy-conserving methods for Hamilto-nian systems with quadratic holonomic *** derivation of the methods is made within the so-called line integral *** tests to illustra... 详细信息

关键词： Constrained Hamiltonian systems Quadratic holonomic constraints Energy-conserving methods Line integral methods Hamiltonian Boundary Value Methods HB-VMs

Tumor budding as a potential histopathological biomarker in colorectal cancer:Hype or hope?

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World Journal of Gastroenterology 2012年第45期18卷 6532-6536页

作者： Fabio Grizzi Giuseppe Celesti gianluca Basso Luigi Laghi Laboratories of Molecular Gastroenterology Humanitas Clinical and Research CenterRozzano20089 MilanItaly

Colorectal cancer （CRC）, the third most commonly di- agnosed type of cancer in men and women worldwide is recognized as a complex multi-pathway disease, an observation sustained by the fact that histologically identical tumors may have different outcome, including various response to therapy. Therefore, particularly in early and intermediate stage （stages Ⅱ and Ⅲ, respec- tively） CRC, there is a compelling need for biomarkers helpful of selecting patients with aggressive disease that might benefit from adjuvant and targeted therapy. Histopathological examination shows that likely other solid tumors the development and progression of hu- man CRC is not only determined by genetically abnor- mal cells, but also by intricate interactions between malignant cells and the surrounding microenvironment. This has led to reconsider the features of tumor mi- croenvironment as potential predictive and prognostic biomarkers. Among the histopathological biomarkers, tumor budding （i.e., the presence of individual cells and small clusters of tumor cells at the tumor invasive front）has received much recent attention, particularly in the setting of CRC. Although its acceptance as a reportable factor has been held back by a lack of uniformity with respect to qualitative and quantitative aspects, tumor budding is now considered as an independent adverse prognostic factor in CRC that may allow for stratifica- tion of patients into risk categories more meaningful than those defined by tumor-node-metastasis staging alone, and also potentially guide treatment decisions, especially in T2-T3 NO （stage Ⅱ） CRCs.

关键词： Colorectal cancer Tumor budding Bio-marker Histopathology

Enhanced activity of bimetallic Fe-Cu catalysts supported on ceria toward water gas shift reaction: synergistic effect

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Frontiers of Chemical Science and Engineering 2023年第12期17卷 1962-1972页

作者： gianluca Landi Giulia Sorbino Fortunato Migliardini Giovanna Ruoppolo Almerinda Di Benedetto Institute of Sciences and Technologies for Sustainable Energy and Mobility-CNR Naples 80125Italy Department of Chemical Materials and Production EngineeringUniversity of Naples Federico ⅡNaples 80125Italy

Within the“hydrogen chain”,the high-temperature water gas shift reaction represents a key step to improve the H2 yield and adjust the H2/COx ratio to fit the constraints of downstream *** the commercial application of the high-temperature water gas shift,novel catalysts characterized by higher intrinsic activity(especially at low temperatures),good thermal stability,and no chromium content are *** this work,we propose bimetallic iron-copper catalysts supported on ceria,characterized by low active phase content(iron oxide+copper oxide<5 wt%).Fresh and used samples were characterized by inductively coupled plasma mass spectrometry,X-ray diffraction,nitrogen physisorption,scanning electron microscopy coupled with energy-dispersive X-ray spectroscopy,and temperature programmed reduction in hydrogen to relate physicochemical features and catalytic *** sample with iron/copper≈1 and 4 wt%active phase content showed the best catalytic properties in terms of turnover frequency,no methane formation,and *** unique properties were due to both strong iron-copper interaction and strong metal-support interaction,leading to outstanding redox behavior.

关键词： water gas shift iron copper bimetallic catalysts ceria hydrogen

Ops!... Where is my left main？

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Journal of Geriatric Cardiology 2018年第9期15卷 609-610页

作者： gianluca Rigatelli Mario Lupia Marco Zuin Cardiovascular Diagnosis and Endoluminal hlterventions Unit Rovigo General Hospital Rovigo Italy Vascular Surgery Padua University School of Medicine. Padua Italy Section of Internal and Cardiopuhnonary Medicine Department of Medical Science University of Ferrara Ferrara Italy

Coronary artery anomalies can reach easily nowadays elderly age, causing troubles at both diagnostic and thera- peutic levels. A 80-year-old hypertensive man underwent coronary artery angiography because of a doubtful... 详细信息

关键词： Angiography Left main Right coronary artery

Biofabrication of nanocomposite-based scaffolds containing human bone extracellularmatrix for the differentiation of skeletal stem and progenitor cells

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Bio-Design and Manufacturing 2024年第2期7卷 121-136页

作者： Yang-Hee Kim Janos M.Kanczler Stuart Lanham Andrew Rawlings Marta Roldo gianluca Tozzi Jonathan I.Dawson gianluca Cidonio Richard O.C.Oreffo Faculty of Medicine Bone and Joint Research GroupCentre for Human DevelopmentStem Cells and RegenerationInstitute of Developmental SciencesUniversity of SouthamptonSouthampton SO166YDUK School of Pharmacy and Biomedical Science University of PortsmouthPortsmouth PO12DTUK School of Engineering Faculty of Engineering and ScienceUniversity of GreenwichGreenwich ME44TBUK Center for Life Nano-and Neuro-Science(CLN2S) Italian Institute of Technology00161 RomeItaly

Autograft or metal implants are routinely used in skeletal ***,they fail to provide long-term clinical resolution,necessitating a functional biomimetic tissue engineering *** use of native human bone tissue for synthesizing a biomimeticmaterial inkfor three-dimensional(3D)bioprintingof skeletal tissueis anattractivestrategyfor ***,human bone extracellular matrix(bone-ECM)offers an exciting potential for the development of an appropriate microenvironment for human bone marrow stromal cells(HBMSCs)to proliferate and differentiate along the osteogenic *** this study,we engineered a novel material ink(LAB)by blending human bone-ECM(B)with nanoclay(L,Laponite®)and alginate(A)polymers using extrusion-based *** inclusion of the nanoﬁller and polymeric material increased the rheology,printability,and drug retention properties and,critically,the preservation of HBMSCs viability upon *** composite of human bone-ECM-based 3D constructs containing vascular endothelial growth factor(VEGF)enhanced vascularization after implantation in an ex vivo chick chorioallantoic membrane(CAM)*** inclusion of bone morphogenetic protein-2(BMP-2)with the HBMSCs further enhanced vascularization and mineralization after only seven *** study demonstrates the synergistic combination of nanoclay with biomimetic materials(alginate and bone-ECM)to support the formation of osteogenic tissue both in vitro and ex vivo and offers a promising novel 3D bioprinting approach to personalized skeletal tissue repair.

关键词： Extracellular matrix Nanoclay Bone 3D bioprinting

Color variation in signal crayfish Pacifastacus leniusculus

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Current Zoology 2021年第1期67卷 35-43页

作者： Roberto SACCHI Stefania CANCIAN Daniela GHIA gianluca FEA Alan COLADONATO Dipartimento di Scienze della Terra e dell'Ambiente Universita degli Studi di PaviaViale Tarameli 24Pavia1-27100Italy

External coloration in animals depends on the interaction of several different factors including the genetics and epigenetics processes that underlie the color expression,the mechanisms of color perception,and the general mechanisms controlling color evolution and *** all,camouflages from predators and conspicuousness are of particular interest because pose animal to choose between opposite adjustment in *** external coloration of crustaceans is mainly due to the accumulation of carotenoids in the exoskeleton and the epidermal layer,and the trade-off between camouflage and communication had led to a variety of responses,involving signal partitioning,spectral sensibility,changing coloration,or signaling ***,we used digital images to explore intrapopulation variability of the external coloration of Pacifastacus leniusculus among body regions within an individual and between *** found that 1)ventral coloration of claws are more saturated and brilliant than upper parts,2)males express a more saturated and brightness coloration than females,especially on the lower portion of claws,3)color intensity and brightness increases with size differently in different body regions,and 4)brightness is more variable in males than in *** the above patterns support the hypothesis that color in this species could be the result of a compromise between camouflage from predators and conspicuousness for *** results of this study suggest that carotenoid might have something to do with intraspecific communication and perform more complex functions than that of a simple pigment.

关键词： crayfish external coloration HSV individual variation sexual dimorphism