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Liquid biopsy in colorectal cancer:No longer young,but not yet old

World Journal of Gastroenterology 2022年第15期28卷 1503-1507页

作者： giandomenico roviello Daniele Lavacchi Lorenzo Antonuzzo Martina Catalano Enrico Mini Department of Health Sciences Section of Clinical Pharmacology and OncologyUniversity of FlorenceFirenze 50139Italy Clinical Oncology Unit AOU CareggiFirenze 50134Italy Department of Experimental and Clinical Medicine University of FirenzeFirenze 50134Italy School of Human Health Sciences University of FlorenceFlorence 50134Italy

Colorectal cancer(CRC)is one of the most prevalent cancers and the second leading cause of cancer-related deaths worldwide.The treatment strategy employed in CRC patients is becoming highly dependent on molecular characteristics present at diagnosis and during treatment.Liquid biopsy is an emerging field in the management of this cancer,and its relevance as a potential diagnostic,prognostic,monitoring,and therapeutic tool makes it a viable strategy in the clinical management of CRC patients.Liquid biopsy also has certain limitations,but these limitations seem to be at the reach of near-future technological development.In this letter,we focus on the clinical perspectives of liquid biopsy in CRC with particular regard to the various biomarkers recently identified that have been shown to be potentially useful in multiple aspects of early stage or metastatic CRC.

关键词： Colorectal cancer Liquid biopsy Circulating tumor DNA Diagnosis Prognosis Targeted therapy

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Is there still a place for docetaxel rechallenge in prostate cancer?

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World Journal of Clinical Oncology 2015年第5期6卷 99-103页

作者： Roberto Petrioli Edoardo Francini giandomenico roviello Medical Oncology Unit Department of MedicineSurgery and NeurosciencesUniversity of Siena Medical Oncology Unit Policlinico Umberto Ⅰ HospitalUniversity of Rome

Three-weekly docetaxel plus prednisone is the standard first-line cytotoxic treatment for patients with metastatic castrate-resistant prostate cancer(m CRPC). Today, several new treatment options are available for patients with tumor progression after first-line docetaxel: Abiraterone, enzalutamide, cabazitaxel, sipuleucel-T immunotherapy, and the radionuclide radium-223. However, despite the evolving scenario in CRPC treatment, the optimal sequencing of the innovative therapies remains unclear. The reintroduction of docetaxel at the occurrence of disease progression after a drug holiday(docetaxel rechallenge) was often proposed, and this chemotherapeutic agent showed to maintain antitumor activity in m CRPC patients. Docetaxel rechallenge may still constitute a valid treatment option mainly for patients with favorable response to first-line docetaxel, at least > 3 mo progression-free interval, age less than 75 years, good performance status, and acceptable docetaxel toxicity. The risk of cumulative toxicity must be evaluated, since sensory neuropathy, nail disorders and fatigue might occur on docetaxel rechallenge.

关键词： Abiraterone acetate Docetaxel Prostate cancer Prostate-specific antigen Rechallenge

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Robotic approach with neoadjuvant chemotherapy in adult Wilms’ tumor: A feasibility study report and a systematic review of the literature

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Asian Journal of Urology 2023年第2期10卷 128-136页

作者： Simone Sforza Valeria Emma Palmieri Maria Rosaria Raspollini giandomenico roviello Alberto Mantovani Umberto Basso Maria Carmen Affinita Alberto D’Angelo Lorenzo Antonuzzo Marco Carini Andrea Minervini Lorenzo Masieri Department of Oncologic Minimally-Invasive Urology and AndrologyCareggi HospitalUniversity of FlorenceFlorenceItaly Department of Pediatric Urology Meyer Children HospitalUniversity of FlorenceFlorenceItaly Clinical Oncologic Unit Careggi HospitalUniversity of FlorenceFlorenceItaly Histopathology and Molecular Diagnostics Careggi HospitalUniversity of FlorenceFlorenceItaly Medical Oncology Unit 1 Istituto Oncologico Veneto IOV IRCCSPaduaItaly Hematology Oncology Division Department of Women’s and Children’s HealthPadova University HospitalPaduaItaly Department of Biology and Biochemistry University of BathBathUK

Objective:The incidence of Wilms’tumor(WT)among adult individuals accounts for less than 1%of kidney cancer cases,with a prognosis usually less favorable when compared to younger individuals and an overall survival rate of 70%for the adult patients versus 90%for the pediatric cases.The diagnosis and treatment of WT are complex in the preoperative setting;neoadjuvant chemotherapy(NAC)or robotic surgery has rarely been described.This study aimed to review the literature of robotic surgery in WT and report the first adult WT management using both NAC and robotic strategy.Methods:We reported a case of WT managed in a multidisciplinary setting.Furthermore,according to Preferred Reporting Items for Systematic reviews and Meta-Analyses recommendations,a systematic review of the literature until August 2020 of WT treated with a robotic approach was carried out.Results:A 33-year-old female had a diagnosis of WT.She was scheduled to NAC,and according to the clinical and radiological response to a robotic radical nephrectomy with aortic lymph nodes dissection,she was managed with no intraoperative rupture,a favorable surgical outcome,and a follow-up of 25 months,which did not show any recurrence.The systematic review identified a total number of 230 cases of minimally invasive surgery reported in the literature for WT.Of these,approximately 15 patients were carried out using robotic surgery in adolescents while none in adults.Moreover,NAC has not been administered before minimally invasive surgery in adults up until now.Conclusion:WT is a rare condition in adults with only a few cases treated with either NAC or minimally invasive approach so far.The advantage of NAC followed by the robotic approach could lead to favorable outcomes in this complex scenario.Notwithstanding,additional cases of adult WT need to be identified and investigated to improve the oncological outcome.

关键词： Nephroblastoma Nephrectomy Renal neoplasm Minimally invasive surgery Rare tumor

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