检索结果-南通市图书馆

Microscopic colitis in patients with mild duodenal damage:A new clinical and pathological entity(“lymphocytic enterocolitis”)?

引用

World Journal of Gastrointestinal Pathophysiology 2016年第4期7卷 307-313页

作者： Gabriele Antonio Bonagura Davide Giuseppe Ribaldone Sharmila Fagoonee Nicoletta Sapone gian paolo caviglia Giorgio Maria Saracco Marco Astegiano Rinaldo Pellicano Unit of Gastroenterology and Hepatology Molinette Hospital Institute for Biostructures and Bioimages-CNR c/o Molecular Biotechnology Center University of Torino Department of Medical Sciences University of Turin Department of Oncology University of Torino

AIM To evaluate the potential association between mild duodenal damage and microscopic colitis(MC).METHODS We retrospectively included 105 consecutive patients with type I Marsh-Oberhuber duodenal damage and negativity for immunoglobulin A anti-endomysium and anti-tissue transglutaminase.The following parameters were analyzed:Sex,age at execution of esophagogastroduodenoscopy,duodenal damage,and number of intraepithelial lymphocytes at biopsies,prevalenceof Helicobacter pylori infection,age at execution of colonoscopy,macroscopic and microscopic features of colonoscopy,family history of gastrointestinal and autoimmune diseases,smoking habits,biochemical parameters of inflammation and autoimmunity,use of proton pump inhibitors or nonsteroidal anti-inflammatory drugs,adverse reactions to drugs or foods,pathologies known to be associated with celiac disease or MC,living on a gluten-free diet or on a gluten-low diet for at least 1 mo.RESULTS Colonoscopy was performed in 59 patients,but only in 48 of them biopsies were taken in the entire colon.Considering the latter cohort,the diagnosis of MC was met in 25(52.1%) patients while in 18 patients other pathologic findings were reported:13(27%) cases of nonspecific inflammatory bowel disease,2(4.2%) cases of Crohn's disease,2(4.2%) cases of eosinophilic gastroenteritis,and 1(2.1%) case of autoimmune enteritis.Five(10.4%) patients had a normal colonoscopic result.Matching the groups by age,and considering only patients who underwent colonoscopy(42.7 ± 15.5 years) vs those who did not undergo colonoscopy(36.9 ± 10.6 years),a statistical difference was found(P = 0.039).Focusing on symptoms,diarrhea was statistically more prevalent in MC group than in patients who did not undergo colonoscopy(P = 0.03).CONCLUSION Mild duodenal damage is associated with MC in more than half of the cases.This association supports the hypothesis of a link between these two entities.

关键词： Autoimmune diseases Celiac disease Helicobacter pylori Intraepithelial lymphocytes Lymphocytic colitis Lymphocytic enterocolitis Microscopic colitis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Etiology of chronic liver diseases in the Northwest of Italy, 1998 through 2014

引用

World Journal of Gastroenterology 2016年第36期22卷 8187-8193页

作者： Giorgio Maria Saracco Andrea Evangelista Sharmila Fagoonee Giovannino Ciccone Elisabetta Bugianesi gian paolo caviglia Maria Lorena Abate Mario Rizzetto Rinaldo Pellicano Antonina Smedile Department of Oncology University of Turin10123 Turin Italy Unit of Cancer Epidemiology (CPO Piemonte) University of Turin10123 Turin Italy Institute for Biostructures and Bioimages-CNR c/o Molecular Biotechnology Center University of Turin10126 Turin Italy Department of Medical Sciences University of Turin10123 Turin Italy Unit of Gastroenterology Molinette Hospital10123 Turin Italy

AIM To assess the etiology of chronic liver diseases(CLD) from 1998 to 2014 at the outpatient clinic of Gastroenterology of the main hospital in Northwest of Italy among those dedicated to hepatology.METHODS A random sample of charts of patients referred to for increased liver enzymes between January 1998 and December 2006, and between January 2012 and December 2014 were reviewed. Etiology search included testing for hepatitis B virus(HBV), hepatitis C virus(HCV), autoimmune hepatitis, primary biliary cirrhosis, Wilson's disease and hereditary hemocromatosis. A risky alcohol consumption was also considered. Nonalcoholic fatty liver disease(NAFLD) was diagnosed in patients with histological and/or ultrasound evidence of steatosis/steatohepatitis, and without other causes of CLD.RESULTS The number of patients included was 1163. Of them, 528(45%) had positivity for HCV and 85(7%) for HBV. Among the virus-free patients, 417(36%) had metabolic disorders whereas the remaining had history of alcohol abuse, less prevalent causes of CLD or concomitant conditions. In comparison to 1998-2000(41%), a reduction of HCV alone-related cases was detected during the periods 2001-2003(35%, OR = 0.75, 95%CI: 0.53-1.06), 2004-2006(33%, OR = 0.70, 95%CI: 0.50-0.97) and 2012-2014(31%, OR = 0.64, 95%CI: 0.46-0.91). On the contrary, in comparison to 1998-2000(31%), metabolic-alone disorders increased in the period 2004-2006(39%, OR = 1.37, 95%CI: 0.99-1.91) and 2012-2014(41%, OR = 1.53, 95%CI: 1.09-2.16). The other etiologies remained stable. The increase of incidence of metabolic-alone etiology during the period 2004-2006 and 2012-2014 tended to be higher in older patients(≥ 50 years) compared to younger(P = 0.058).CONCLUSION In the Northwest of Italy, during this study period, the prevalence of HCV infection decreased notably whereas that of NAFLD increased.

关键词： Chronic liver diseases Cirrhosis Hepatitis C virus Hepatitis B virus Nonalcoholic steatohepatitis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

IL28B polymorphism genotyping as predictor of rapid virologic response during interferon plus ribavirin treatment in hepatitis C virus genotype 1 patients

引用

World Journal of Gastroenterology 2014年第36期20卷 13146-13152页

作者： Chiara Rosso Maria Lorena Abate Alessia Ciancio Silvia Strona gian paolo caviglia Antonella Olivero Giovanni Antonio Touscoz Mario Rizzetto Rinaldo Pellicano Antonina Smedile Department of Medical Science University of Turin 10123 Turin Italy Department of Gastroenterology and Hepatology Molinette Hospital 10126 Turin Italy

AIM: To clarify the association of interleukin-28B(IL28B) single nucleotide polymorphisms(SNPs) with hepatitis C virus(HCV) viremia changes for assessment of interferon(IFN) response. METHODS: A cohort of 118 Caucasian treatment-nave HCV-G1 infected patients, treated with pegylated-IFN alpha 2a or 2b associated with ribavirin(53 responders, 65 non-responders) during the period 2010-2012, were genotyped for IL28 B SNPs rs12979860 C>T and rs8099917 T>G. Genotyping was performed by realtime allelic discrimination assay. Serum HCV RNA levels were assayed at 2, 4, 12, 24 and 48 wk during therapy.Correlation between IL28 B genotypes and serum HCV RNA kinetics was investigated. Multivariable logistic regression analysis was performed to identify predictors of null-response.RESULTS: Twenty-six out of 118 patients(22%) had no HCV RNA decline ≥ 1 log IU/mL at therapy week 4(null-responders). IL28 B genotype was rs8099917(G*)/rs1297860(**) in 21/26(80%) of null-responder patients. Using multivariate analysis, it was shown that the presence of the rs8099917 G allele was the best predictor of null-response(OR = 7.9, 95%CI: 1.99-31.18). The presence of at least one favorable genotype showed a positive predictive value of above 90% for HCV RNA reduction ≥ log at week 4. Analysis of the HCV RNA kinetics during 12 wk of therapy in patients with IL28 B rs12979860 CT heterozygosis(n = 73), according to their rs8099917 status, showed that the viremia reduction was significantly different in patients carrying the rs8099917 G allele compared to those with favorable homozygosis.CONCLUSION: Our findings emphasize the association of the IL28 B rs8099917 G allele with HCV. Genotyping for both IL28 B SNPs is useful in clinical practice for thorough patient risk stratification based on IFN responsiveness.

关键词： Hepatitis C virus-G1 Interleukin-28B rs12 979860 I

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Laser-optimized Pt-Y alloy nanoparticles embedded in Pt-Y oxide matrix for high stability and ORR electrocatalytic activity

引用

Journal of Energy Chemistry 2024年第5期92卷 508-520页

作者： Riccardo Brandiele Andrea Guadagnini Mattia Parnigotto Federico Pini Vito Coviello Denis Badocco paolo Pastore gian Andrea Rizzi Andrea Vittadini Daniel Forrer Vincenzo Amendola Christian Durante Department of Chemical Sciences University of PaduaVia Marzolo 135131 PadovaItaly Istituto di Chimica della Materia Condensata e di Tecnologie per l’Energia ICMATE-CNR via Marzolo 1 I-35131 PadovaItaly

The development of active yet stable catalysts for oxygen reduction reaction(ORR)is still a major issue for the extensive permeation of fuel cells into everyday technology.While nanostructured Pt catalysts are to date the best available systems in terms of activity,the same is not true for stability,particularly under operating conditions.In this work,Pt_(Х)Y alloy nanoparticles are proposed as active and durable electrocatalysts for ORR.Pt_(Х)Y nanoalloys are synthesized and further optimized by laser ablation in liquid followed by laser fragmentation in liquid.The novel integrated laser-assisted methodology succeeded in producing Pt_(Х)Y nanoparticles with the ideal size(1000 A g^(-1).At the same time,the nanoalloys are embedded in a fine Pt oxide matrix,which allows a greater stability of the catalyst than the commercial Pt reference,as directly verified on a gas diffusion electrode.

关键词： Electrocatalysis GDE ORR Pt_(2)Y Pt_(3)Y LAL LFL Oxide support Pto Nanoalloys

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nutrient restriction-activated Fra-2 promotes tumor progression via IGF1R in miR-15a downmodulated pancreatic ductal adenocarcinoma

引用

Signal Transduction and Targeted Therapy 2024年第3期9卷 1132-1146页

作者： gian Luca Rampioni Vinciguerra Marina Capece Luca Reggiani Bonetti Giovanni Nigita Federica Calore Sydney Rentsch paolo Magistri Roberto Ballarin Fabrizio Di Benedetto Rosario Distefano Roberto Cirombella Andrea Vecchione Barbara Belletti Gustavo Baldassarre Francesca Lovat Carlo M.Croce Department of Cancer Biology and Genetics and Comprehensive Cancer Center The Ohio State UniversityColumbus 43210 OHUSA Department of Clinical and Molecular Medicine Faculty of Medicine and PsychologySant’Andrea HospitalUniversity of Rome“Sapienza”Rome 00189Italy Department of Diagnostic Clinic and Public Health MedicineUniversity of Modena and Reggio EmiliaModena 41100Italy Hepato-pancreato-biliary Surgery and Liver Transplantation Unit University of Modena and Reggio EmiliaModena 41100Italy Division of Molecular Oncology Centro di Riferimento Oncologico di Aviano(CRO)Istituto di Ricovero e Cura a Carattere Scientifico(IRCCS)National Cancer InstituteAviano 33081Italy

Pancreatic ductal adenocarcinoma(PDAC)is a lethal disease,characterized by an intense desmoplastic reaction that compresses blood vessels and limits nutrient supplies.PDAC aggressiveness largely relies on its extraordinary capability to thrive and progress in a challenging tumor microenvironment.Dysregulation of the onco-suppressor miR-15a has been extensively documented in PDAC.Here,we identified the transcription factor Fos-related antigen-2(Fra-2)as a miR-15a target mediating the adaptive mechanism of PDAC to nutrient deprivation.We report that the IGF1 signaling pathway was enhanced in nutrient deprived PDAC cells and that Fra-2 and IGF1R were significantly overexpressed in miR-15a downmodulated PDAC patients.Mechanistically,we discovered that miR-15a repressed IGF1R expression via Fra-2 targeting.In miR-15a-low context,IGF1R hyperactivated mTOR,modulated the autophagic flux and sustained PDAC growth in nutrient deprivation.In a genetic mouse model,Mir15aKO PDAC showed Fra-2 and Igf1r upregulation and mTOR activation in response to diet restriction.Consistently,nutrient restriction improved the efficacy of IGF1R inhibition in a Fra-2 dependent manner.Overall,our results point to a crucial role of Fra-2 in the cellular stress response due to nutrient restriction typical of pancreatic cancer and support IGF1R as a promising and vulnerable target in miR-15a downmodulated PDAC.

关键词： IGF1R Fra miR

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Modern surgical approach to hepatocellular carcinoma

引用

Hepatobiliary Surgery and Nutrition 2023年第6期12卷 953-955页

作者： paolo Magistri gian Piero Guerrini Stefano Di Sandro Fabrizio Di Benedetto Hepato-Pancreato-Biliary Surgery and Liver Transplantation Unit University Hospital of Modena“Policlinico”University of Modena and Reggio EmiliaModenaItaly

We are glad to contribute with an editorial on the important topic of therapeutic opportunities for hepatocellular carcinoma(HCC).The increasing diffusion of minimally invasive approaches to the liver and the growing experience worldwide have progressively changed our curative strategies for patients affected by primary and metastatic liver tumors(1).

关键词： Robotic surgery minimally invasive liver surgery(MILS) surgical oncology liver transplant living donor liver transplantation(LDLT)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Optimal weakening and damping using polynomial control for seismically excited nonlinear structures

引用

Earthquake Engineering and Engineering Vibration 2009年第4期8卷 607-616页

作者： gian paolo Cimellaro Department of Structural & Geotechnical Engineering(DISTR)

This paper presents an approach for the optimal design of a new retrofit technique called weakening and damping that is valid for civil engineering inelastic structures. An alternative design methodology is developed with respect to the existing ones that is able to determine the locations and the magnitude of weakening and/or softening of structural elements and adding damping while insuring structural stability. An optimal polynomial controller that is a summation of polynomials in nonlinear states is used in Phase I of the method to reduce the peak response quantities of seismically excited nonlinear or hysteretic systems. The main advantage of the optimal polynomial controller is that it is able to automatically stabilize the structural system. The optimal design of a shear-type structure is used as an example to illustrate the feasibility of the proposed approach, which leads to a reduction of both peak inter-story drifts and peak total accelerations.

关键词： weakening and damping optimal design optimal polynomial controller inter-story drift acceleration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Spectral and fragility evaluations of retrofitted structures through strength reduction and enhanced damping

引用

Earthquake Engineering and Engineering Vibration 2009年第1期8卷 115-125页

作者： gian paolo Cimellaro Hwasung Roh Alessandro De Stefano Department of Structural & Geotechnical Engineering (DISTR) Polytechnic of Turin Turin Italy Department of Civil Structural & Environmental Engineering University at Buffalo The State University of New York Buffalo USA

A retrofit procedure for existing buildings called the ＂weakening and damping technique＂（WED） is presented in this paper. Weakening of structures can limit the maximum response accelerations during severe ground motions, but leads to an increase in the displacements or inter-story drifts. Added damping by using viscous dampers, on the other hand, reduces the inter-story drifts and has no significant effect on total accelerations, when structures behave inelastically. The weakening and damping technique addresses the two main causes for both structural and nonstructural damage in structures. The weakening retrofit is particularly suitable for structures that have overstressed components and weak brittle components. In this paper, the advantages of the WeD are verified by nonlinear dynamic analysis and simplified spectral approach that has been modified to fit structures with additional damping devices. A hospital structure located in the San Fernando Valley in California is selected as a case study. The results from both analyses show that the retrofit solution is feasible to reduce both structural acceleration and displacement. A sensitivity analysis is also carried out to evaluate the effectiveness of the retrofitting method using different combinations of performance thresholds in accelerations and displacements through fragility analysis.

关键词： weakening damping retrofit inelastic spectral response fragility analysis nonlinear dynamic analysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Discovery of an unknown conduction mechanism in insulating polymers

引用

High Voltage 2020年第4期5卷 403-408页

作者： gian Carlo Montanari paolo Seri Leonard A.Dissado Center for Advanced Power Systems Florida State University2000 Levy AvenueFL 32310USA DEI University of BolognaViale del Risorgimento2–40136BolognaItaly Department of Engineering University of LeicesterUniversity RoadLeicesterLE17RHUK

Polymer dielectrics are widely used in electrical and electronic apparatus and devices because of their capability to insulate conductors,withstand high fields and suffer negligible conductive losses.Their near-to-zero conductivity has been explained in terms of long-accepted theories of electronic and ionic transport that lead to the accumulation of local net charge regions at high electric fields.Here the authors describe a previously unknown conduction mechanism consisting of small bipolar ultra-fast charge pulses crossing the polymer with the mobility,as large as,4 to 5 orders of magnitude greater than that of the previously known.The authors show that this motion is a consequence of molecular relaxation processes triggered by the electric field locally enhanced by the pulses themselves.Pulse accumulation at the electrodes increases interface field and thus contributes substantially towards premature failure in insulating dielectrics in DC fields.

关键词： conduction mechanism negligible

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Introspection on improper seismic retrofit of Basilica Santa Maria di Collemaggio after 2009 Italian earthquake

引用

Earthquake Engineering and Engineering Vibration 2011年第1期10卷 153-161页

作者： gian paolo Cimellaro Andrei M. Reinhorn Alessandro De Stefano Department of Structural & Geotechnical Engineering (DISTR) Politecnico di Torino Department of Civil Structural & Environmental Engineering University at Buffalo The State University of New York

The 2009 L’Aquila, Italy earthquake highlighted the seismic vulnerability of historic masonry building structures due to improper ＂strengthening＂ retrofit work that has been done in the last 50 years. Italian seismic standards recommend the use of traditional reinforcement techniques such as replacing the original wooden roof structure with new reinforced concrete （RC） or steel elements, inserting RC tie-beams in the masonry and new RC floors, and using RC jacketing on the shear walls. The L’Aquila earthquake revealed the numerous limitations of these interventions, because they led to increased seismic forces （due to greater additional weight） and to deformation incompatibilities of the incorporated elements with the existing masonry walls. This paper provides a discussion of technical issues pertaining to the seismic retrofit of the Santa Maria di Collemaggio Basilica and in particular, the limitations of the last （2000） retrofit intervention. Considerable damage was caused to the church because of questionable actions and incorrect and improper technical choices.

关键词： seismic vulnerability historic masonry building wooden roof structure seismic retrofit L’Aquila earthquake

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：