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Embedded fuzzing:a review of challenges,tools,and solutions

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Cybersecurity 2022年第4期5卷 1-18页

作者： Max Eisele Marcello Maugeri Rachna Shriwas Christopher Huth giampaolo Bella Safety Security and PrivacyRobert Bosch GmbHRenningenGermany Dept.of Math and Computer Science Universita degli Studi di CataniaCataniaItaly RBEl Robert Bosch GmbHBangaloreIndia.

Fuzzing has become one of the best-established methods to uncover software ***,the market of embedded systems,which binds the software execution tightly to the very hardware architecture,has grown at a steady pace,and that pace is anticipated to become yet more sustained in the near *** systems also beneft from fuzzing,but the innumerable existing architectures and hardware peripherals complicate the development of general and usable approaches,hence a plethora of tools have recently *** comes a stringent need for a systematic review in the area of fuzzing approaches for embedded systems,which we term'embedded fuzzing"for *** inclusion criteria chosen in this article are semi-objective in their coverage of the most relevant publication venues as well as of our personal *** review rests on a formal definition we develop to represent the realm of embedded *** continues by discussing the approaches that satisfy the inclusion criteria,then defines the relevant elements of comparison and groups the approaches according to how the execution environment is served to the system under *** resulting review produces a table with 42 entries,which in turn supports discussion suggesting vast room for future research due to the limitations noted.

关键词： Embedded systems Dynamic analysis Vulnerability mining Embedded security Software security

The “mitochondrial stress responses”: the “Dr. Jekyll and Mr. Hyde” of neuronal disorders

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Neural Regeneration Research 2022年第12期17卷 2563-2575页

作者： Simone Patergnani giampaolo morcian. Marianna Carinci Sara Leo Paolo Pinton Alessandro Rimessi Department of Medical Sciences Section of Experimental MedicineLaboratory for Technologies of Advanced TherapiesUniversity of FerraraFerraraItaly Center of Research for Innovative Therapies in Cystic Fibrosis University of FerraraFerraraItaly

Neuronal disorders are associated with a profound loss of mitochondrial functions caused by various stress conditions,such as oxidative and metabolic stress,protein folding or import defects,and mitochondrial DNA *** engage in different coordinated responses to safeguard mitochondrial *** this review,we will explore the contribution of mitochondrial stress responses that are activated by the organelle to perceive these dangerous conditions,keep them under control and rescue the physiological condition of nervous *** the sections to come,particular attention will be dedicated to analyzing how compensatory mitochondrial hyperfusion,mitophagy,mitochondrial unfolding protein response,and apoptosis impact human neuronal ***,we will discuss the relevance of the new concept:the“mito-inflammation”,a mitochondria-mediated inflammatory response that is recently found to cover a relevant role in the pathogenesis of diverse inflammatory-related diseases,including neuronal disorders.

关键词： Alzheimer’s disease apoptosis mitochondrial dynamics mito-inflammation mitophagy multiple sclerosis neurodegeneration Parkinson’s disease UPRmt

Morbidity and psychological impact of prostate biopsy： the future calls for a change

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Asian Journal of Andrology 2014年第3期16卷 415-417页

作者： Andrea Minervini Gianni Vittori giampaolo Siena Marco Carini Department of Urology University of FlorenceCareggi Hospital Florence Italy.

Currently transrectal ultrasound-guided prostate biopsy （TRUS-Bx） is one of the most common urological procedures, with more than 1 million performed per year in Europe and the United States. Among patients undergoing TRUS-Bx, approximately one-third will receive a diagnosis of prostate cancer （PCa）, while two-thirds receive a negative result on initial biopsy. Negative biopsy patients maintain an estimated risk of repeated biopsy of 12% at I year and 38% at 5 years. 2 Standard TRUS-Bx is likely to systematically miss significant tumors, particularly in the anterior and apical parts of the gland.3 A crucial aim of urologists in the next decade is to increase the accuracy of the procedure and avoid the use of inappropriate biopsies.

关键词： Morbidity psychological impact prostate biopsy

Management of single pulmonary metastases from colorectal cancer:State of the art

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World Journal of Gastrointestinal Oncology 2022年第4期14卷 820-832页

作者： Marco Chiappetta Lisa Salvatore Maria Teresa Congedo Maria Bensi Viola De Luca Leonardo PetraccaCiavarella Floriana Camarda Jessica Evangelista Vincenzo Valentini giampaolo Tortora StefanoMargaritora Filippo Lococo Department of Thoracic Surgery Fondazione Policlinico Universitario Agostino Gemelli IRCCS-UniversitàCattolica del Sacro CuoreRome 00168Italy Oncologia Medica Comprehensive Cancer Center Fondazione Policlinico Universitario Agostino Gemelli IRCCS-UniversitàCattolica del Sacro CuoreRome 00168Italy Department of Radiation Therapy Fondazione Policlinico Universitario Agostino Gemelli IRCCS-UniversitàCattolica del Sacro CuoreRome 00168Italy

Colorectal cancer(CRC)is one of the most common causes of death from *** seeding occurs in approximately 10%of patients surgically treated for primary CRC with radical intent:the lung is the most common site of metastases after the *** surgical treatment of liver metastases is widely accepted to affect long-term outcomes,more controversial and not standardized is the therapy for CRC patients developing lung *** suggests the potential curative role of pulmonary metastasectomy,especially in oligometastatic ***,the optimal strategy of care and the definition of prognostic factors after treatment still need to be *** review focused on the uncommon scenario of single pulmonary metastases from *** explored pertinent literature and provide an overview of the epidemiology,clinical characteristics and imaging of single pulmonary metastases from ***,we identified the best available evidence for overall *** particular,we analyzed the role and results of locoregional approaches(surgery,radiotherapy or ablative procedures)and their integration with systemic therapy.

关键词： Colorectal cancer Pulmonary metastases Oligometastases Chemotherapy Surgery Radiotherapy

Environmental benefits for a geothermal power plant with CO_(2) reinjection:case study of the Kizildere 3 U1 geothermal power plant

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Energy Storage and Saving 2023年第4期2卷 631-638页

作者： María Dolores Mainar-Toledo Ural Halaçoglu Hakan Alp Sahiller Tugrul Hazar Claudio Zuffi Maryori Díaz-Ramírez giampaolo Manfrida Research Centre for Energy Resources and Consumption(CIRCE) Zaragoza50018Spain CIRCE Institute University of ZaragozaZaragoza50009Spain Zorlu Enerji Istanbul34394Türkiye Department of Industrial Engineering University of FlorenceFirenze50134Italy

Geothermal power plants(GPP)with high non condensable gases(NCG)content geothermal fluid have shown to be environmental impacting relating to their energy production,which could be critical if no corrective actions are *** GPP of Kizildere 3 U1,located in Türkiye(Denizli),in where the geothermal fluid contains high percentage of CO_(2),99%of the NCG fraction,which represents the 3%of the geothermal fluid mass,is taken as a relevant case study to implement a new innovation consisting of NCG reinjection to reduce the amount of NCGs released to the *** order to calculate the present environmental impacts which the plant is causing(baseline);and the potential reduction of environmental impacts which can be achieved with the innovation(reinjection),a life cycle assessment(LCA)calculation were *** data were collected for all the relevant stages of the energy conversion cycle and complemented where necessary with secondary data from other geothermal power plants *** main results of the baseline environmental assessment show that the construction phase is the most impacting phase due to the materials used in the power plant building construction,electrical generation equipment and distributed machinery and infrastructures;the effects in the operation phase are dominated by the geothermal fluid *** this sense,the application of CO_(2) reinjection at the Turkish site into the reservoir will prevent the emission of 1,700 tons⋅year􀀀1 in the pilot site and 10%of the total emissions released along the life span of the GPP.

关键词： Life cycle assessment Geothermal energy Non-condensable gases Reinjection CO_(2)emissions avoided

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不平衡电网下变流器多机系统的稳定性分析

电力自动化设备 2023年第10期43卷 176-183页

作者：张益邹志翔杨佳俊陈武王政 giampaolo Buticchi 程明东南大学电气工程学院江苏南京210096 宁波诺丁汉大学理工学院浙江宁波315100

基于不平衡电网条件下的并网交互系统,研究了电压源型变流器(VSC)的稳定性问题。首先提出了不平衡电网下带双二阶广义积分器锁相环(DSOGI-PLL)的变流器导纳模型。分析总结了带不同类型锁相环的VSC系统导纳特性。基于导纳模型研究了配置... 详细信息

基于不平衡电网条件下的并网交互系统,研究了电压源型变流器(VSC)的稳定性问题。首先提出了不平衡电网下带双二阶广义积分器锁相环(DSOGI-PLL)的变流器导纳模型。分析总结了带不同类型锁相环的VSC系统导纳特性。基于导纳模型研究了配置不同类型锁相环的多VSC系统稳定性问题,指出了多VSC系统稳定性的改善方向。进一步提出,带DSOGI-PLL变流器的并入可以在增加并网系统输出功率的同时有效改善变流器的稳定裕度。同时,研究了公共耦合点处负序电压改变时VSC与电网阻抗的交互机理。最后,对理论分析进行了实验验证。

关键词：不对称电网多VSC系统稳定性分析三相并网变流器 DSOGI-PLL

B cell development is critically dependent on NFATc1 activity

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Cellular & Molecular Immunology 2019年第5期16卷 508-520页

作者： Sabrina giampaolo Gabriela Wojcik Stefan Klein-Hessling Edgar Serfling Amiya K.Patra Department of Molecular Pathology Institute of PathologyUniversity of WürzburgJosef Schneider-Str.297080 WürzburgGermany Institute of Translational and Stratified Medicine Faculty of Medicine and DentistryUniversity of PlymouthPlymouth PL68BUUK Comprehensive Cancer Center Mainfranken University of WürzburgJosef Schneider-Str.697080 WürzburgGermany

B cell development in bone marrow is a precisely regulated complex *** successive stages of differentiation,which are regulated by a multitude of signaling pathways and an array of lineage-specific transcription factors,the common lymphoid progenitors ultimately give rise to mature B *** to early thymocyte development in the thymus,early B cell development in bone marrow is critically dependent on IL-7 *** this IL-7-dependent stage of differentiation,several transcription factors,such as E2A,EBF1,and Pax5,among others,play indispensable roles in B lineage specification and *** recent studies have implicated several other transcription factors in B cell development,the role of NFATc1 in early B cell developmental stages is not ***,using multiple gene-manipulated mouse models and applying various experimental methods,we show that NFATc1 activity is vital for early B cell *** of NFATc1 activity in pro-B cells suppresses EBF1 expression,impairs immunoglobulin gene rearrangement,and thereby preBCR formation,resulting in defective B cell ***,deficiency in NFATc1 activity arrested the pro-B cell transition to the pre-B cell stage,leading to severe B cell *** findings suggest that,along with other transcription factors,NFATc1 is a critical component of the signaling mechanism that facilitates early B cell differentiation.

关键词： Differentiation EBF1 NFATc1 Pro-B Pre-B

The reuse of abandoned Acquaresi mine voids for storage of the Masua flotation tailings

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International Journal of Coal Science & Technology 2014年第2期1卷 213-220页

作者： Pier Paolo Manca Paolo Desogus giampaolo Orru DICAAR Department of Civil EngineeringEnvironmental and ArchitectureUniversity of CagliariCagliariItaly

Often in abandoned mine sites are present both underground voids produced by mining and the tailings of treatment *** interesting solution for the rehabilitation of the sites would be to place the tailings of the process in the underground mining voids,thus obtaining the reclamation of surface areas and the stabilization of abandoned voids to prevent the dangerous phenomena of ***,these operations require inert waste,which must not be source of pollution,and the choice of a water/solid optimum to ensure good conditions of pumpability.

关键词： Acquaresi mine Mine voids Masua Flotation tailings

Predictive factors of clinical response in steroid-refractory ulcerative colitis treated with granulocyte-monocyte apheresis

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World Journal of Gastroenterology 2011年第14期17卷 1831-1835页

作者： Valeria D'Ovidio Donatella Meo Angelo Viscido giampaolo Bresci Piero Vernia Renzo Caprilli Department of Clinical Sciences Gastrointestinal UnitPoliclinico Umberto IUniversity of Rome"La Sapienza"Viale del Policlinico 155Rome 00161Italy Gastrointestinal Unit Azienda Ospedaliera-Universitaria PisanaPisa 56100Italy

AIM:To identify factors predicting the clinical response of ulcerative colitis patients to granulocyte-monocyte apheresis (GMA). METHODS:Sixty-nine ulcerative colitis patients (39 F,30 M) dependent upon/refractory to steroids were treated with GMA. Steroid dependency,clinical activity index (CAI),C reactive protein (CRP) level,erythrocyte sedimentation rate (ESR),values at baseline,use of immunosuppressant,duration of disease,and age and extent of disease were considered for statistical analysis as predictive factors of clinical response. Univariate and multivariate logistic regression models were used. RESULTS:In the univariate analysis,CAI (P = 0.039) and ESR (P = 0.017) levels at baseline were singled out as predictive of clinical remission. In the multivariate analysis steroid dependency [Odds ratio (OR) = 0.390,95% Confidence interval (CI):0.176-0.865,Wald 5.361,P = 0.0160] and low CAI levels at baseline (4 < CAI <7) (OR = 0.770,95% CI:0.425-1.394,Wald 3.747,P = 0.028) proved to be effective as factors predicting clinical response. CONCLUSION:GMA may be a valid therapeutic option for steroid-dependent ulcerative colitis patients with mild-moderate disease and its clinical efficacy seems to persist for 12 mo.

关键词：溃疡性结肠炎临床反应单核细胞粒细胞预测治疗 logistic回归模型激素