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Red wine and green tea reduce H pylori- or VacA-induced gastritis in a mouse model

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World Journal of Gastroenterology 2007年第3期13卷 349-354页

作者： Paolo Ruggiero Giacomo Rossi Francesco Tombola Laura Pancotto Laura Lauretti Giuseppe Del Giudice Mario Zoratti Novartis Vaccines & Diagnostics s.r.l. Research Center SienaItaly Department of Veterinary Science University of Camerino Matelica Italy Department of Biomedical Sciences University of PadovaItaly CNR Institute of Neuroscience Section for Biomembranes Padova Italy CNR Institute of Neuroscience Section for Biomembranes Padova Italy

AIM: To investigate whether red wine and green tea could exert anti-H pylori or anti-VacA activity in vivo in a mouse model of experimental infection.METHODS: Ethanol-free red wine and green tea concentrates were administered orally as a mixture of the two beverages to H pylori infected mice, or separately to VacA-treated mice. Gastric colonization and gastric in? ammation were quantifi ed by microbiological, histopathological, and immunohistochemical analyses. RESULTS: In H pylori -infected mice, the red wine and green tea mixture significantly prevented gastritis and limited the localization of bacteria and VacA to the surface of the gastric epithelium. Similarly, both beverages significantly prevented gastric epithelium damage in VacA-treated mice; green tea, but not red wine, also altered the VacA localization in the gastric epithelium. CONCLUSION: Red wine and green tea are able to prevent H pylori -induced gastric epithelium damage, possibly involving VacA inhibition. This observation supports the possible relevance of diet on the pathological outcome of H pylori infection.

关键词：红葡萄酒绿茶幽门活性饮料组织病理学

Lipoprotein-associated phospholipase A2 prognostic role in atherosclerotic complications

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World Journal of Cardiology 2015年第10期7卷 609-620页

作者： Giuseppe Maiolino Valeria Bisogni Giacomo Rossitto Gian Paolo rossi Department of Medicine - DIMED Hypertension Clinic University of Padua

Atherosclerosis manifests itself clinically at advanced stages when plaques undergo hemorrhage and/or rupture with superimposed thrombosis, thus abruptly stopping blood supply. Identification of markers of plaque destabilization at a pre-clinical stage is, therefore, a major goal of cardiovascular research. Promising results along this line were provided by studies investigating the lipoprotein-associated phospholipase A2(Lp-PLA2), a member of phospholipase A2 proteins family that plays a key role in the metabolism of pro-inflammatory phospholipids, as oxidized low-density lipoproteins, and in the generation of pro-atherogenic metabolites, including lysophosphatidylcholine and oxidized free fatty acids. We herein review the experimental and clinical studies supporting use of Lp-PLA2 activity for predicting cardiovascular events. To his end we considered not only Lp-PLA2 activity and mass, but also Lp-PLA2 gene variations and their association with incident coronary artery disease, stroke, and cardiovascular mortality. Based on these evidences the major scientific societies have included in their guidelines the measurement of Lp-PLA2 activity among the biomarkers that are useful in risk stratification of adult asymptomatic patients at intermediate cardiovascular risk. The results of two recently published major clinical trials with the LpPLA2 inhibitor darapladib, which seem to challenge the pathogenic role of Lp-PLA2, will also be discussed.

关键词： Lipoprotein-associated phospholipase A2 Atheroscle

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米兰TENOHA多功能休闲餐厅

现代装饰 2019年第3期 44-51页

作者： Filippo Pagliani Michele rossi Andrea Dalpasso Alexia Caccavella Alice Cuteri giacomo Geroldi Andrea Manfredini Mario Frusca Andrea Martiradonna 范嘉苑意大利Park Associati

本案位于米兰的ViaVigevano区,与Navigli区接壤,四周商铺林立,各种餐厅、酒吧及夜店都伫立于此。作为一个改造项目,该空间前身是一家墙纸研究工作室,所在建筑是一座建于1931年的工业大楼。Tenoha是一个来自日本的品牌,此次的设计任务是... 详细信息

本案位于米兰的ViaVigevano区,与Navigli区接壤,四周商铺林立,各种餐厅、酒吧及夜店都伫立于此。作为一个改造项目,该空间前身是一家墙纸研究工作室,所在建筑是一座建于1931年的工业大楼。Tenoha是一个来自日本的品牌,此次的设计任务是打造出一个集典型餐饮、日式料理以及家居用品零售于一体的复合式休闲餐饮空间。面向街道一侧的零售空间采用了大面的玻璃门窗,街道上的行人路过时能瞥见里面琳琅满目的商品。内里的空间则涵盖餐厅、多功能区与活动区。中央的庭院是整个空间的中心位置,在这里可以举办各种活动,是最易聚集人群的区域。

关键词： TENOHA

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粘结复合树脂嵌体的3年纵向临床观察

中国口腔医学继续教育杂志 2009年第6期12卷 51-54页

作者： Antonio Barone giacomo Derchi Angelo rossi Simone Marconcini Ugo Covani 孙东涛（译）梁宇红（译）岳林（审）不详北京大学口腔医学院牙体牙髓科 100081

目的：①评价signum复合树脂嵌体的3年临床表现：②比较前磨牙和磨牙树脂嵌体修复的临床效果；③评价单、双面及多面嵌体的差异。材料与方法：30名患者的113个嵌体入选本研究．临床上由一名医师设计戴入，所有嵌体由同一名技师使用同一... 详细信息

目的：①评价signum复合树脂嵌体的3年临床表现：②比较前磨牙和磨牙树脂嵌体修复的临床效果；③评价单、双面及多面嵌体的差异。材料与方法：30名患者的113个嵌体入选本研究．临床上由一名医师设计戴入，所有嵌体由同一名技师使用同一种复合树脂材料（signum．Heraeus Kulzer）制作完成．采用三步粘结系统和同一种树脂粘结水门汀进行粘结。嵌体戴入后，由另一名不知情的医师按照改良美国公共卫生服务标准（USPHS）对修复体进行评估。结果：3年后．113个嵌体中有3个进行了重新修复．总失败率为26％。基线时，各项评价指标中被评为完好（A）的嵌体有88．5％～100％．3年后，嵌体的表面粗糙度、边缘解剖形态、边缘完整性和嵌体完整性与基线比较均存在显著的统计学差异（P〈0.05）。除了边缘解剖形态和边缘完整性以外，前磨牙与磨牙，单、双面与多面嵌体的临床效果比较无显著差异。结论：复合树脂嵌体的3年成功率很高（97．4％）．修复体的大小和牙位对其临床修复效果均无显著影响。

关键词：复合树脂嵌体复合树脂间接修复后牙