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Renal transplants from older deceased donors: Is preimplantation biopsy useful? A monocentric observational clinical study

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World Journal of Transplantation 2018年第4期8卷 110-121页

作者： giacomo colussi Costanza Casati Valeriana Giuseppina Colombo Mario Livio Pietro Camozzi Fabio Rosario Salerno Division of Nephrology Dialysis and Renal Transplantatation ASST Grande Ospedale Territoriale Niguarda Division of Pathology ASST Grande Ospedale Territoriale Niguarda School of Nephrology Milano-Bicocca University

AIM To compare survival of kidney transplants from deceased extended criteria donors(ECD) according to:(1) donor graft histological score; and(2) allocation of high score grafts either to single(SKT) or dual(DKT) *** Renal biopsy was performed as part of either a newly adopted DKT protocol, or of surveillance protocol in the past. A total 185 ECD graft recipients were categorized according to pre-implantation graft biopsy into 3 groups: SKT with graft score 1 to 4 [SKT(1-4), n = 102]; SKT with donor graft score 5 to 8 [SKT(> 4), n = 30]; DKT with donor graft score 5 to 7(DKT, n = 53). Graft and patient survival were analyzed by Kaplan-Meier curves and compared by log-rank test. Mean number of functioning graft years by transplant reference, and mean number of dialysis-free life years by donor reference in recipients were also calculated at 1, 3 and 6 years from transplantation. RESULTS There were no statistically significant differences in graft and patient survival between SKT(1-4) and SKT(> 4), and between SKT(> 4) and DKT. Recipient renal function(plasma creatinine and creatinine clearance) at 1 years did not differ in SKT(1-4) and SKT(> 4)(plasma creatinine 1.71 ± 0.69 and 1.69 ± 0.63 mg/dL; creatinine clearance 49.6 + 18.5 and 52.6 + 18.8 m L/min, respectively); DKT showed statistically lower plasma creatinine(1.46 ± 0.57, P 4)]. CONCLUSION In transplan

关键词： Dual kidney transplant Extended criteria donor Graft survival Pre-implantation biopsy score Renal transplantation Single kidney transplant

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