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Identification of Aristolactam Derivatives That Act as Inhibitors of Human Immunodeficiency Virus Type 1 Infection and Replication by Targeting Tat-Mediated Viral Transcription

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Virologica Sinica 2021年第2期36卷 254-263页

作者： Young Hyun Shin Chul Min Park Hong gi kim Dong-Eun kim Min Suk Choi Jeong-ah kim Byeong-Sun Choi Cheol-Hee Yoon Division of Viral Disease Research Center for Infectious Disease ResearchKorea National Institute of HealthHeungdeok-guCheongju-siShungbuk 28159Republic of Korea Center for Convergent Research of Emerging Virus Infection Korea Research Institute of Chemical TechnologyYuseong-guDaejeon 34114Republic of Korea

Despite the success of antiretroviral therapy(ART),efforts to develop new classes of antiviral agents have been hampered by the emergence of drug ***-indole-bearing aristolactams are compounds that have been isolated from various plants species and which show several clinically relevant effects,including anti-inflammatory,antiplatelet,and antimycobacterial ***,the effect of these compounds on human immunodeficiency virus type 1(HIV-1)infection has not yet been *** this study,we discovered an aristolactam derivative bearing dibenzo[cd,f]indol-4(5 H)-one that had a potent anti-HIV-1 effect.A structure-activity relationship(SAR)study using nine synthetic derivatives of aristolactam identified the differing effects of residue substitutions on the inhibition of HIV-1 infection and cell *** the compounds tested,1,2,8,9-tetramethoxy-5-(2-(piperidin-1-yl)ethyl)-dibenzo[cd,f]indol-4(5 H)-one(Compound 2)exhibited the most potent activity by inhibiting HIV-1 infection with a half-maximal inhibitory concentration(IC50)of 1.03 lmol/L and a half-maximal cytotoxic concentration(CC50)of 16.91 lmol/L(selectivity index,16.45).The inhibitory effect of the compounds on HIV-1 infection was linked to inhibition of the viral replication ***-of-action studies showed that the aristolactam derivatives did not affect reverse transcription or integration;instead,they specifically inhibited Tat-mediated viral *** together,these findings show that several aristolactam derivatives impaired HIV-1 infection by inhibiting the activity of Tat-mediated viral transcription,and suggest that these derivatives could be antiviral drug candidates.

关键词： Human immunodeficiency virus type 1(HIV-1) Aristolactam Antiviral activity HIV-1 transcription

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Surface characteristics of HA coated Ti-Hf binary alloys after nanotube formation

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中国有色金属学会会刊：英文版 2009年第4期19卷 852-856页

作者： Yong-Hoon JEONG Won-gi kim Geun-Hyeong PARK Han-Cheol CHOE Yeong-Mu KO Department of Dental Materials & Research Center of Nano-Interface Activation for Biomaterials College of DentistryChosun University Research Center for Oral Disease Regulation of the Aged College of DentistryChosun University

Ti-Hf binary alloys contained 10%,20%,30% and 40%(mass fraction)Hf were manufactured in the vacuum furnace *** then,specimens were homogenized for 24 h at 1 000 ℃ in argon *** formation of oxide nanotubes was conducted by anodic oxidation on the Ti-Hf alloy in 1 mol/L H3PO4 electrolytes containing small amounts of NaF at room *** hydroxyapatite(HA) coating made of tooth ash prepared by electron-beam physical vapor deposition(EB-PVD) *** corrosion behaviors of the specimens were examined through potentiodynamic test in 0.9% NaCl solution by *** microstructures of the alloys were examined by field emission scanning electron microscopy(FE-SEM) and x-ray diffractometer(XRD).It was observed that the lamellar structure translated to needle-like structure with Hf *** formed and HA coated Ti-xHf alloys had a good corrosion resistance.

关键词：二元合金 HA涂层纳米管表面特性管形 0.9%NaCl溶液物理气相沉积铪

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Multi-millijoule terahertz emission from laser- wakefield-accelerated electrons

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Light(Science & Applications) 2023年第2期12卷 248-258页

作者： Taegyu Pak Mohammad Rezaei-Pandari Sang beom kim Geonwoo Lee Dae Hee Wi Calin loan Hojbota Mohammad Mirzaie Hyeongmun kim Jae Hee Sung Seong Ku Lee Chul Kang Ki-Yong kim Center for Relativistic Laser Science Institute for Basic ScienceGwangju 61005Korea Department of Physics and Photon Science Gwangju Institute of Science and Technology(GIST)Gwangju 61005Korea Laser and Plasma Research Institute Shahid Beheshti UniversityTehranIran Advanced Photonics Research Institute GISTGwangju 61005Korea Institute for Research in Electronics and Applied Physics and Department of Physics University of MarylandCollege ParkMaryland 20742USA

High-power terahertz radiation was observed to be emitted from a gas jet irradiated by 100-terawatt-class laser pulses in the laser-wakefield acceleration of *** emitted terahertz radiation was characterized in terms of its spectrum,polarization,and energy dependence on the accompanying electron bunch energy and charge under various gas target *** a nitrogen target,more than 4 mJ of energy Was produced at<10 THz with a laser-to-terahertz conversion efficiency of~0.15%.Such strong terahertz radiation is hypothesized to be produced from plasma electrons accelerated by the ponderomotive force of the laser and the plasma wakefelds on the time scale of the laser pulse duration and plasma *** model is examined with analytic calculations and particle-in-cell simulations to better understand the generation mechanism of high-energy terahertz radiation in laser-wakefield acceleration.

关键词： laser polarization acceleration

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Synergetic effects of shock waves with polydeoxyribonucleotides on rotator cuff tendon tear in a rabbit model

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BIOCELL 2021年第3期45卷 527-536页

作者： DONG HAN kim DONG RAK KWON gi-YOUNG PARK YONG SUK MOON Department of Rehabilitation Medicine Catholic University of Daegu School of MedicineDaegu42472South Korea Department of Anatomy Catholic University of Daegu School of MedicineDaegu42472South Korea

This work aimed to investigate the synergetic therapeutic effects of polydeoxyribonucleotides(PDRN)combined with extracorporeal shock waves therapy(ESWT)and the effects of the therapy according to ESWT sequences on a chronic traumatic full-thickness rotator cuff tear(RCT)in rabbit *** this purpose,thirty-two rabbits were randomly allocated into 4 *** excision was made to create a 5-mm sized full-thickness RCT right proximal to the insertion site on the *** 6 weeks,4 different procedures(normal saline,Group 1;PDRN injection,Group 2;PDRN injection before ESWT,Group 3;PDRN injection after ESWT,Group 4)were *** injection and radial type ESWT were each performed 4 times per *** morphology,Immunohistochemistry,and motion analysis were performed at 4 weeks after *** parameters including tear size,Masson’s trichrome(MT)staining,anti-collagen 1 monoclonal antibody immunostaining(COL-1),proliferating cell nuclear antigen(PCNA),vascular endothelial growth factor(VEGF),anti-platelet endothelial cell adhesion molecule-1 polyclonal antibody(PECAM-1),and motion analysis,were significantly greater in Group 2,Group 3,and Group 4 than in Group *** Group 4,all parameters were significantly greater than in Group 2,and parameters including MT staining,COL-1,PCNA,PECAM-1,and fast walking time were significantly greater than Group *** were no significant differences between Group 2 and Group *** study demonstrated that PDRN injection alone and combined with ESWT were more effective than control treatment and applying ESWT before PDRN injection was also shown to yield better outcomes in parameters including angiogenesis,cell proliferation,and fast walking time in a rabbit model with chronic traumatic full-thickness ***,the application of ESWT before PDRN injection could be recommended for optimal outcomes of the conservative treatments when the patients with full-thickness RCT are not suitable in surgical treatment

关键词： Shoulder Rotator cuff Polydeoxyribonucleotides Extracorporeal shock waves

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Photonic Crystal Fiber Attenuator

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光学学报 2003年第S1期23卷 -页

作者： Joo beom Eom Hokyung kim Jinchae kim Un-Chul Paek Byeong Ha Lee Department of Information and Communications Kwangju Institute of Science and Technology 1 Oryong-dong

We propose a novel fiber attenuator based on photonic crystal fibers. The difference in the modal field diameters of a conventional single mode fiber and a photonic crystal fiber was used. A variable optical attenuato... 详细信息

关键词： photonic crystal fiber variable optical attenuator single mode fiber

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Biliary phytobezoar resulting in intestinal obstruction

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World Journal of Gastroenterology 2013年第1期19卷 133-136页

作者： Yura kim beom Jin Park Min Ju kim Deuk Jae Sung Dong-Sik kim Young-Dong Yu Jeong Hyeon Lee Department of Radiology College of MedicineKorea UniversityAnam HospitalSeoul 136-705South Korea Division of HBP Surgery and Liver Transplantation Department of SurgeryCollege of MedicineKorea UniversityAnam HospitalSeoul 136-705South Korea Department of Pathology College of MedicineKorea UniversityAnam HospitalSeoul 136-705South Korea

Phytobezoar is the most common type of *** is composed of indigestible vegetable matter and is usually found in the *** phytobezoar is extremely rare and difficult to diagnose *** pathogenesis is not clear,and there have been only a few reports of biliary bezoars associated with sphincteric impairmentat the ampulla of ***,we present a report of biliary bezoar that resulted in jejunal *** were unable to identifythe bezoar in the extrahepatic bile duct until it obstructed the small bowel *** our knowledge,this is the first report of small bowel obstruction resulting frommigration of a biliary bezoar.

关键词： Phytobezoar Biliary Intestinal obstruction Choledochoduodenal Fistula Multidetector-row computed tomography

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Texture tailoring and bendability improvement of rolled AZ31 alloy using {10-12} twinning: The effect of precompression levels

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Journal of Magnesium and Alloys 2019年第4期7卷 648-660页

作者： Jong Un Lee Ye Jin kim Sang-Hoon kim Jeong Hun Lee Min-Seong kim Shi-Hoon Choi Byoung gi Moon Young Min kim Sung Hyuk Park School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea Ulsan Regional Division Korea Institute of Industrial TechnologyUlsan 44413Republic of Korea Department of Printed Electronics Engineering Sunchon National UniversitySuncheonJeonnam 57922Republic of Korea Implementation Research Division Korea Institute of Materials ScienceChangwon 51508Republic of Korea

In this study,the texture of a rolled Mg alloy is effectively modified through the application of precompression and subsequent annealing treatment,leading to a remarkable improvement in the bending formability of the alloy at room *** induces lattice reorientation through{10-12}twinning,and annealing treatment reduces the stored strain energy of the precompressed material,which results in the formation of a stable grain structure with two dominant texture *** an increase in precompression,the tensile strain in the outer region of the bending samples is accommodated to a greater extent due to more pronounced{10-12}twinning and basal *** a result,the bending formability of the material at room temperature improves with greater *** variation in microstructure,texture,and bending behavior in relation to the degree of precompression is discussed in detail.

关键词： Magnesium Bending Formability Twinning Texture

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Vaporization reduction characteristics of aqueous ammonia solutions by the addition of ethylene glycol, glycerol and glycine to the CO_2 absorption process

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Journal of Environmental Sciences 2012年第3期24卷 494-498页

作者： Jong-beom Seo Soo-Bin Jeon Je-Young kim Gang-Woo Lee Jong-Hyeon Jung Kwang-Joong Oh Department of Environmental Engineering Pusan National University Busan 609735 Korea. Research Institute of Industrial Science & Technology Pohang 790330 Korea Research & Development Institute of Yoosung Co. Ltd. Ulsan 680070 Korea Faculty of Health Science Daegu Haany University Daegu 712715 Korea

Aqueous ammonia （NH3） solution can be used as an alternative absorption for the control of CO2 emitted from flue gases due to its high absorption capacity, fast absorption rate and low corrosion problem. The emission of CO2 from iron and steel plants requires much attention, as they are higher than those emitted from power plants at a single point source. In the present work, low concentration ammonia liquor, 9 wt.%, was used with various additives to obtain the kinetic properties using the blast furnace gas model. Although a solution with a high ammonia concentration enables high CO2 absorption efficiency, ammonium ions are lost as ammonia vapor, resulting in reduced CO2 absorption due to the lower concentration of the ammonia absorbent. To decrease the vaporization of ammonia, ethylene glycol, glycerol and glycine, which contain more than one hydroxyl radical, were chosen. The experiments were conducted at 313 K similar to the CO2 absorption conditions for the blast furnace gas model.

关键词： ammonia vaporization blast furnace gas ethylene glycol glycerol glycine

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Hydrangeae Dulcis Folium Attenuates Physical Stress by Supressing ACTH-Induced Cortisol in Zebrafish

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Chinese Journal of Integrative Medicine 2020年第2期26卷 130-137页

作者： Junyoung Oh Dong Hyun kim gi-young kim Eun-Jin Park Jong Hoon Ryu Ji Wook Jung Se Jin Park Gwang-Woo kim Seungheon Lee Department of Marine Life Science College of Ocean ScienceJeju National UniversityJeju(63243)Republic of Korea Departme nt of Medicinal Biotech no logy College of Health SciencesDong-A UniversityBusan(604-714)Republic of Korea Department of Food Bioengineering Jeju National UniversityJeju(63243)Republic of Korea Institute of Convergence BioHealth Dong-A UniversityBusan(604-714)Republic of Korea Department of Oriental Pharmaceutical Science College of PharmacyKyung Hee UniversityHoeki-dongDongdaemoon・KuSeoul(130-701)Republic of Korea Kyung Hee East-West Pharmaceutical Research Institute College of PharmacyKyung Hee UniversityHoeki-dongDongdaemoorvKuSeoul(130-701)Republic of Korea Department of Herbal Medicinal Pharmacology College of Herbal Bio-industryDaegu Haany UniversityYugok-dongGyeongsan(712-715)Republic of Korea School of Natural Resources and Environmental Sciences Kangwon National UniversityChuncheon(24341)Republic of Korea Marine Bio Con verge nee Center Gangneung Science&In dustry Promotion AgencyGangneung(25440)Republic of Korea

Objective:To determine the effects of Hydrangeae Dulcis Folium(EHDF)on physical stress,changes in the whole-body cortisol level and behaviour in zebrafish(Danio rerio).Methods:One hundred and seventy-four fish were randomly divided into 4[adrenocorticotropin hormone(ACTH)challenge test:4 fish per group]or 6 groups(behavioural test:10–12 fish per group,whole-body cortisol:4 fish per group).Net handling stress(NHS)was used to induce physical *** were treated with vehicle or EHDF(5–20 mg/L)for 6 min before they were exposed to *** then,fish were sacrificed for collecting body fluid from whole-body or conducted behavioural tests,including novel tank test and open field test,and were evaluated to observe anxiety-like behaviours and *** addition,to elucidate the mode of action of the anti-stress effects of EHDF,ACTH(0.2 IU/g,i.p.)challenge test was ***:The increased anxiety-like behaviours in novel tank test and open field test under stress were prevented by treatment with EHDF at 5–20 mg/L(P<0.05).Moreover,compared with the unstressed group,which was not treated with NHS,the whole-body cortisol level was significantly increased by treatment with NHS(P<0.05).Compared with the NHS-treated stressed control group,pre-treatment with EHDF at concentrations of 5–20 mg/L for 6 min significantly prevented the NHS-increased whole-body cortisol level(P<0.05).In addition,ACTH challenge test showed that EHDF completely blocked the effects of ACTH on cortisol secretion(P<0.05).Conclusion:EHDF may be a good antistress candidate and its mechanism of action may be related to its positive effects on cortisol release.

关键词： net handling stress zebrafish Hydrangeae Dulcis Folium whole-body cortisol behavioural tests

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High prevalence of osteoporosis in patients with gastric adenocarcinoma following gastrectomy

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World Journal of Gastroenterology 2007年第48期13卷 6492-6497页

作者： Jung Sub Lim Sang Bum kim Ho-Yoon Bang gi Jeong Cheon Jong-Inn Lee Department of Pediatrics Korea Cancer Center Hospital Department of Surgery Korea Cancer Center Hospital Department of Nuclear Medicine Korea Cancer Center Hospital

AIM： To evaluate the prevalence and predictive factors of osteoporosis in patients with gastric adenocarcinoma alter gastrectomy.METHODS： The study included 133 patients diagnosed with gastric adenocarcinoma but who did not undergo prior diagnostic work-up for osteoporosis. Bone mineral density （BMD） was measured by dual-energy X-ray absorptiometry （DXA） and vertebral deformity was assessed by plain X-rays. We evaluated the effects of age, sex, body mass index （BMI）, anemia, back pain, vertebral deformity, tumor staging, reconstruction type, and past medical history to determine predictive factors of osteoporosis in these patients.RESULTS： The prevalence of osteoporosis in the lumbar spine was 38.3% （male, 28.9%; female, 54.0%）, and 15.0% in the femoral neck （male, 10.8%; female, 22.0%）. The vertebral deformity rate was 46.6% （male, 43.4%; female, 52.0%）. Age, BMI and hemoglobin correlated with BMD （P 〈 0.01）. In males, anemia and age 〉 64 years were independent predictive factors of osteoporosis in multivariate analysis. In females, back pain was an independent factor for osteoporosis.CONCLUSION： The results of this study revealed that prevalence of osteoporosis and vertebral bone deformity rate were high in gastric cancer patients, regardless of post-gastrectomy duration and operation type. Early diagnosis and a proper management plan must be established in these patients.

关键词： Gastric adenocarcinoma Gastrectomy Bone mineral density Osteoporosis Vertebral deformity Anemia Back pain

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